HIV-indeterminate Western blotting(WB)results are typically obtained in WB confirmatory assays,and the number of indeterminate samples may increase with the detection of HIV infections,which will present considerable ...HIV-indeterminate Western blotting(WB)results are typically obtained in WB confirmatory assays,and the number of indeterminate samples may increase with the detection of HIV infections,which will present considerable challenges for the management of HIV/AIDS.Nucleic acid detection has been used as a laboratory test for screening suspected or indeterminate samples.However,the effectiveness of these assays for the differential diagnosis of HIV-indeterminate WB samples remained undetermined.In this study,210 subjects with HIV-indeterminate WB results were detected from 6360 positive HIV screening samples between 2015 and 2016 in southeastern China,in which HIV-indeterminate WB results accounted for 3.30%.The highest proportion of indeterminate results was observed in pregnant and lying-in women receiving physical examinations(16.67%),followed by that in voluntary blood donors(8.82%).The most common WB band patterns were p24,gpl60 and p24,and gpl60.The follow-up study revealed that the highest negative and positive conversion rates of HIV antibodies were in samples with a single p24 band(80.28%),and with gpl60 and p24 bands(86.21%),respectively.Among the Env,Gag,and Pol antibodies,samples with a Gag band showed the highest negative conversion rate(81.25%),whereas the highest positive conversion rate was observed in samples with an Env band(56.76%).In addition,quantitative and qualitative HIV nucleic acid testing exhibited the highest sensitivity(96.3%)and specificity(97.85%),respectively.Our results indicate a lower proportion of HIV indeterminate WB results in southeastern China compared to previous reports,and the follow-up re-examination of patients with HIV indeterminate results should be performed.Nucleic acid testing facilitates the identification of HIV infections.展开更多
Two-dimensional ferroelectric(2D-FE)materials that characterize the spontaneous ferroelectricity down to monolayer limit and rich ferroic properties arising from FE orderings,have been extensively explored as low-dime...Two-dimensional ferroelectric(2D-FE)materials that characterize the spontaneous ferroelectricity down to monolayer limit and rich ferroic properties arising from FE orderings,have been extensively explored as low-dimensional sensor,electric and memory devices.In current work,group-IV transition metal oxide dihalide MOX_(2)(M=Zr and Hf,X=Cl,Br and I)monolayers have been identified as a new group of 2D-FE materials.Using the comprehensive first-principles calculations combined with finite temperature Monte Carlo(MC)and ab initio molecular dynamics(MD)simulations,we investigate the temperature stability of FE polarization and further uncover the unique properties associated with spontaneous ferroelectricity of MOX_(2) monolayers.In particular,ZrOI_(2) monolayer,a promising 2D-FE material with room temperature stable ferroelectricity,semiconducting electronic structure and optoelectronic response under visible light,offers an ideal material platform to investigate the coupling of intrinsic anisotropy,optical absorption selectivity and spin degree of freedom with 2D ferroelectricity.Typically,significant optical absorption anisotropy and giant linear dichroism effect are predicted for a 2D optical polarizer device based on ZrOI_(2) monolayer,where the adsorption of incident monochromatic linearly polarized light(hv=3.23 eV)along two planar directions with a nearly 100%optical selectivity can be achieved.Moreover,the spin–orbit coupling(SOC)induced spin splitting of valence band edges and out-of-plane textured spin configuration occur in ZrOI_(2) monolayer.In the meanwhile,the unidirectional spin–orbit field protected by C2v wave-vector point group can further create the persistent spin helix(PSH)state,leading to the extraordinarily long spin carrier lifetime.More importantly,the nonvolatile control of PSH state via the electric field induced polarization reversal has also been demonstrated for FE-ZrOI_(2) monolayer,which manifests as a great advantage for applications of ZrOI_(2) as the lowdimensional spin-field effect transistor and all-electric spintronics devices.展开更多
Objective:To explore the effect of carbon ion radiotherapy(CIRT)on the bone marrow adjacent to or within the treatment fields,and to observe the bone marrow toxicities after CIRT alone.Methods:Twenty-one patients with...Objective:To explore the effect of carbon ion radiotherapy(CIRT)on the bone marrow adjacent to or within the treatment fields,and to observe the bone marrow toxicities after CIRT alone.Methods:Twenty-one patients with malignant tumors of different body parts and treated with CIRT in Heavy Ion Center,Wuwei Cancer Hospital were analyzed retrospectively.The data of white blood cells,neutrophils,hemoglobin,platelets,lymphocytes and globulin before treatment,7,14 and 28 d during treatment,and 1 and 3 months after treatment were collected.Hematological toxicities were measured according to the Common Terminology Criteria for Adverse Events(CTCAE,Version 4.03)criteria.Dose-volume histogram parameters were obtained for all patients and analyzed for their correlation with myelosuppression.Univariate analysis was performed for patients’sex,age group,tumor site,radiation dose,and Karnofsky performance score(KPS)was used as an independent factor to find predictors factors for the risk of myelosuppression.Results:CIRT minimized the dose radiated to the bone marrow.Overall,volume receiving 3 GyE(V3)or more of the bone marrow were less than 0.5%,especially V5 less than 0.1%.No patients treated with carbon ion radiotherapy developed grade III or IV myelosuppression.Seven patients(33.3%)developed grade I myelosuppression and one patient(4.8%)developed grade II myelosuppression,and most of them showed reduced white blood cell counts.There were no significant differences in hemoglobin and globulin levels before and after CIRT.Univariate analysis did not find any statistically significant predictors for myelosuppression.Conclusions:CIRT is effective in preserving bone marrow function regardless of tumor site.Patients receiving CIRT alone have a low incidence of grade III myelosuppression and a mild effect on globulins.There was no significant correlation between occurrence of myelosuppression and the dose and site irradiated by CIRT.展开更多
We develop a statistical framework to use the data of night-time-lights(DN)from satellite to augment official GDP measures,and a non-linear substitution relationship between DN and GDP is given.In this paper,we take a...We develop a statistical framework to use the data of night-time-lights(DN)from satellite to augment official GDP measures,and a non-linear substitution relationship between DN and GDP is given.In this paper,we take advantage of DN instead of GDP to measure the imbalance of regional development(IRD)in China by using the method of bi-dimensional decomposition under the population-weighted coefficient of variation.The method enables us to analyze the contributions of DN components to within-region and between-regions inequality under the framework which has been proposed,we can get the conclusion that the imbalance between-regions rather than within-region is the main reason for the influence of IRD for the whole country in China.展开更多
基金supported by grants from the Cultivation of Young Talents Project Fund from the Fujian Provincial Health and Family Planning Commission (Grant No. 2015-ZQN-ZD11)the Pilot Project of Fujian Provincial Department of Science and Technology (Grant No. 2016Y0010)+2 种基金the Jiangsu Provincial Project of Invigorating Health Care through Science, Technology and EducationJiangsu Provincial Medical Youth Talentthe Project of Invigorating Health Care through Science, Technology and Education (Grant No. QNRC2016621)
文摘HIV-indeterminate Western blotting(WB)results are typically obtained in WB confirmatory assays,and the number of indeterminate samples may increase with the detection of HIV infections,which will present considerable challenges for the management of HIV/AIDS.Nucleic acid detection has been used as a laboratory test for screening suspected or indeterminate samples.However,the effectiveness of these assays for the differential diagnosis of HIV-indeterminate WB samples remained undetermined.In this study,210 subjects with HIV-indeterminate WB results were detected from 6360 positive HIV screening samples between 2015 and 2016 in southeastern China,in which HIV-indeterminate WB results accounted for 3.30%.The highest proportion of indeterminate results was observed in pregnant and lying-in women receiving physical examinations(16.67%),followed by that in voluntary blood donors(8.82%).The most common WB band patterns were p24,gpl60 and p24,and gpl60.The follow-up study revealed that the highest negative and positive conversion rates of HIV antibodies were in samples with a single p24 band(80.28%),and with gpl60 and p24 bands(86.21%),respectively.Among the Env,Gag,and Pol antibodies,samples with a Gag band showed the highest negative conversion rate(81.25%),whereas the highest positive conversion rate was observed in samples with an Env band(56.76%).In addition,quantitative and qualitative HIV nucleic acid testing exhibited the highest sensitivity(96.3%)and specificity(97.85%),respectively.Our results indicate a lower proportion of HIV indeterminate WB results in southeastern China compared to previous reports,and the follow-up re-examination of patients with HIV indeterminate results should be performed.Nucleic acid testing facilitates the identification of HIV infections.
基金Authors acknowledge the funding support from the National Science Foundation of China(No.11574244)the Fundamental Research Funds for the Central Universities(No.xzy012020004)+1 种基金supported by funding from the Natural Science Foundation of China(No.61974113)the National Key Research and Development Project(No.2018YFB2202800).The National Supercomputer Center(NSCC)in Tianjin is acknowledged for computational support.
文摘Two-dimensional ferroelectric(2D-FE)materials that characterize the spontaneous ferroelectricity down to monolayer limit and rich ferroic properties arising from FE orderings,have been extensively explored as low-dimensional sensor,electric and memory devices.In current work,group-IV transition metal oxide dihalide MOX_(2)(M=Zr and Hf,X=Cl,Br and I)monolayers have been identified as a new group of 2D-FE materials.Using the comprehensive first-principles calculations combined with finite temperature Monte Carlo(MC)and ab initio molecular dynamics(MD)simulations,we investigate the temperature stability of FE polarization and further uncover the unique properties associated with spontaneous ferroelectricity of MOX_(2) monolayers.In particular,ZrOI_(2) monolayer,a promising 2D-FE material with room temperature stable ferroelectricity,semiconducting electronic structure and optoelectronic response under visible light,offers an ideal material platform to investigate the coupling of intrinsic anisotropy,optical absorption selectivity and spin degree of freedom with 2D ferroelectricity.Typically,significant optical absorption anisotropy and giant linear dichroism effect are predicted for a 2D optical polarizer device based on ZrOI_(2) monolayer,where the adsorption of incident monochromatic linearly polarized light(hv=3.23 eV)along two planar directions with a nearly 100%optical selectivity can be achieved.Moreover,the spin–orbit coupling(SOC)induced spin splitting of valence band edges and out-of-plane textured spin configuration occur in ZrOI_(2) monolayer.In the meanwhile,the unidirectional spin–orbit field protected by C2v wave-vector point group can further create the persistent spin helix(PSH)state,leading to the extraordinarily long spin carrier lifetime.More importantly,the nonvolatile control of PSH state via the electric field induced polarization reversal has also been demonstrated for FE-ZrOI_(2) monolayer,which manifests as a great advantage for applications of ZrOI_(2) as the lowdimensional spin-field effect transistor and all-electric spintronics devices.
基金Science and Technology Bureau of Gansu Province,China(No.2019-0203-SFC-0207).
文摘Objective:To explore the effect of carbon ion radiotherapy(CIRT)on the bone marrow adjacent to or within the treatment fields,and to observe the bone marrow toxicities after CIRT alone.Methods:Twenty-one patients with malignant tumors of different body parts and treated with CIRT in Heavy Ion Center,Wuwei Cancer Hospital were analyzed retrospectively.The data of white blood cells,neutrophils,hemoglobin,platelets,lymphocytes and globulin before treatment,7,14 and 28 d during treatment,and 1 and 3 months after treatment were collected.Hematological toxicities were measured according to the Common Terminology Criteria for Adverse Events(CTCAE,Version 4.03)criteria.Dose-volume histogram parameters were obtained for all patients and analyzed for their correlation with myelosuppression.Univariate analysis was performed for patients’sex,age group,tumor site,radiation dose,and Karnofsky performance score(KPS)was used as an independent factor to find predictors factors for the risk of myelosuppression.Results:CIRT minimized the dose radiated to the bone marrow.Overall,volume receiving 3 GyE(V3)or more of the bone marrow were less than 0.5%,especially V5 less than 0.1%.No patients treated with carbon ion radiotherapy developed grade III or IV myelosuppression.Seven patients(33.3%)developed grade I myelosuppression and one patient(4.8%)developed grade II myelosuppression,and most of them showed reduced white blood cell counts.There were no significant differences in hemoglobin and globulin levels before and after CIRT.Univariate analysis did not find any statistically significant predictors for myelosuppression.Conclusions:CIRT is effective in preserving bone marrow function regardless of tumor site.Patients receiving CIRT alone have a low incidence of grade III myelosuppression and a mild effect on globulins.There was no significant correlation between occurrence of myelosuppression and the dose and site irradiated by CIRT.
基金National Social Science Foundation of China(20BTJ027)。
文摘We develop a statistical framework to use the data of night-time-lights(DN)from satellite to augment official GDP measures,and a non-linear substitution relationship between DN and GDP is given.In this paper,we take advantage of DN instead of GDP to measure the imbalance of regional development(IRD)in China by using the method of bi-dimensional decomposition under the population-weighted coefficient of variation.The method enables us to analyze the contributions of DN components to within-region and between-regions inequality under the framework which has been proposed,we can get the conclusion that the imbalance between-regions rather than within-region is the main reason for the influence of IRD for the whole country in China.