Perovskite solar cells(PSCs) have demonstrated excellent photovoltaic performance which currently rival the long-standing silicon solar cells’ efficiency. However, the relatively poor device operational stability of ...Perovskite solar cells(PSCs) have demonstrated excellent photovoltaic performance which currently rival the long-standing silicon solar cells’ efficiency. However, the relatively poor device operational stability of PSCs still limits their future commercialization. Binary sulfide is a category of materials with promising optoelectrical properties, which shows the potential to improve both the efficiency and stability of PSCs.Here we demonstrate that the inorganic tin monosulfide(Sn S) can be an efficient dopant in 2,2’,7,7’-tet rakis(N,N-di-p-methoxy-phenylamine)-9,9’-spirobifluorene(spiro-OMe TAD) to form a composite hole transport layer(HTL) for PSCs. Sn S nanoparticles(NPs) synthesized through a simple chemical precipitation method exhibit good crystallization and suitable band matching with the perovskites. The introduction of Sn S NPs in Spiro-OMTAD HTLs enhanced charge extraction, reduced trap state density, and shallowed trap state energy level of the devices based on the composite HTLs. Therefore, the resulting solar cells employing Sn S-doped spiro-OMe TAD HTLs delivered an improved stabilized power output efficiency of 21.75% as well as enhanced long-term stability and operational stability. Our results provide a simple method to modify the conventional spiro-OMe TAD and obtain PSCs with both high efficiency and good stability.展开更多
Hypomyelination leukodystrophies constitute a group of heritable white matter disorders exhibiting defective myelin development.Initially identified as a lysosomal protein,the TMEM106B D252N mutant has recently been a...Hypomyelination leukodystrophies constitute a group of heritable white matter disorders exhibiting defective myelin development.Initially identified as a lysosomal protein,the TMEM106B D252N mutant has recently been associated with hypomyelination.However,how lysosomal TMEM106B facilitates myelination and how the D252N mutation disrupts that process are poorly understood.We used superresolution Hessian structured illumination microscopy(Hessian-SIM)and spinning discconfocal structured illumination microscopy(SD-SIM)to find that the wild-type TMEM106B protein is targeted to the plasma membrane,filopodia,and lysosomes in human oligodendrocytes.The D252N mutation reduces the size of lysosomes in oligodendrocytes and compromises lysosome changes upon starvation stress.Most importantly,we detected reductions in the length and number of filopodia in cells expressing the D252N mutant.PLP1 is the most abundant myelin protein that almost entirely colocalizes with TMEM106B,and coexpressing PLP1 with the D252N mutant readily rescues the lysosome and filopodia phenotypes of cells.Therefore,interactions between TMEM106B and PLP1 on the plasma membrane are essential for filopodia formation and myelination in oligodendrocytes,which may be sustained by the delivery of these proteins from lysosomes via exocytosis.展开更多
Electrospun nanofbers(NFs)are directly produced by electrospinning technology.They are useful in a series of applications such as excellent performance in biosensing and environmental monitoring,due to their large spe...Electrospun nanofbers(NFs)are directly produced by electrospinning technology.They are useful in a series of applications such as excellent performance in biosensing and environmental monitoring,due to their large specifc surface area and high porosity.The wide range of materials used provide a solid foundation and core guarantee for electrospun NFs to sense,which are used in a variety of polymers,small molecules,colloidal particles,and composites.Biosensing primarily aims at small biomolecules,biomacromolecules,wearable human motion monitoring,and food safety testing.Environmental monitoring encompasses the detection of gases,humidity,volatile organic compounds,and monitoring the degradation of heavy metal ions.We aim to sort out some recent research for electrospun NFs in the sensing area,which may inspire emerging smart sensing devices and bring a novel approach for biomedical development and environmental remediation.We highlight the powerful applications of electrospun NFs in the rapidly growing feld of wearable electronic devices,which may spur the industry’s novel perspectives on the development of wearables.Finally,we point out some unresolved difculties in the sensing feld for electrospun NFs and propose possible and novel ideas for this development.展开更多
基金supported by the Special Funds for the Development of Strategic Emerging Industries in Shenzhen(JCYJ20190808152609307)Shenzhen Science and Technology Research Program (JCYJ20180507182057026)the Natural Science Foundation of Hubei Province,China (2019AAA020)。
文摘Perovskite solar cells(PSCs) have demonstrated excellent photovoltaic performance which currently rival the long-standing silicon solar cells’ efficiency. However, the relatively poor device operational stability of PSCs still limits their future commercialization. Binary sulfide is a category of materials with promising optoelectrical properties, which shows the potential to improve both the efficiency and stability of PSCs.Here we demonstrate that the inorganic tin monosulfide(Sn S) can be an efficient dopant in 2,2’,7,7’-tet rakis(N,N-di-p-methoxy-phenylamine)-9,9’-spirobifluorene(spiro-OMe TAD) to form a composite hole transport layer(HTL) for PSCs. Sn S nanoparticles(NPs) synthesized through a simple chemical precipitation method exhibit good crystallization and suitable band matching with the perovskites. The introduction of Sn S NPs in Spiro-OMTAD HTLs enhanced charge extraction, reduced trap state density, and shallowed trap state energy level of the devices based on the composite HTLs. Therefore, the resulting solar cells employing Sn S-doped spiro-OMe TAD HTLs delivered an improved stabilized power output efficiency of 21.75% as well as enhanced long-term stability and operational stability. Our results provide a simple method to modify the conventional spiro-OMe TAD and obtain PSCs with both high efficiency and good stability.
基金supported by the National Natural Science Foundation of China(81925022,61827825,32227802,92054301)the Fundamental Research Center Project of the National Natural Science Foundation of China(T2288102)+4 种基金the National Science and Technology Major Project Program(2022YFC3400600)Beijing Natural Science Foundation Key Research Topics(Z20J00059)UMHS-PUHSC Joint Institute for Translational and Clinical Research(BMU2019JI009)Beijing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases(BZ0317)China Postdoctoral Science Foundation(2021M690465)。
文摘Hypomyelination leukodystrophies constitute a group of heritable white matter disorders exhibiting defective myelin development.Initially identified as a lysosomal protein,the TMEM106B D252N mutant has recently been associated with hypomyelination.However,how lysosomal TMEM106B facilitates myelination and how the D252N mutation disrupts that process are poorly understood.We used superresolution Hessian structured illumination microscopy(Hessian-SIM)and spinning discconfocal structured illumination microscopy(SD-SIM)to find that the wild-type TMEM106B protein is targeted to the plasma membrane,filopodia,and lysosomes in human oligodendrocytes.The D252N mutation reduces the size of lysosomes in oligodendrocytes and compromises lysosome changes upon starvation stress.Most importantly,we detected reductions in the length and number of filopodia in cells expressing the D252N mutant.PLP1 is the most abundant myelin protein that almost entirely colocalizes with TMEM106B,and coexpressing PLP1 with the D252N mutant readily rescues the lysosome and filopodia phenotypes of cells.Therefore,interactions between TMEM106B and PLP1 on the plasma membrane are essential for filopodia formation and myelination in oligodendrocytes,which may be sustained by the delivery of these proteins from lysosomes via exocytosis.
基金supported by the National Natural Science Foundation of China (81925022, 31821091, 31327901, 91854112, and 91750203)the National Key Research and Development Program of China (SQ2016YFJC040028, 2016YFC1306201 and 2016YFC0901505)+1 种基金the Beijing Natural Science Foundation (L172003)the UMHSPUHSC Joint Institute for Translational and Clinical Research (BMU2019JI009)。
文摘Electrospun nanofbers(NFs)are directly produced by electrospinning technology.They are useful in a series of applications such as excellent performance in biosensing and environmental monitoring,due to their large specifc surface area and high porosity.The wide range of materials used provide a solid foundation and core guarantee for electrospun NFs to sense,which are used in a variety of polymers,small molecules,colloidal particles,and composites.Biosensing primarily aims at small biomolecules,biomacromolecules,wearable human motion monitoring,and food safety testing.Environmental monitoring encompasses the detection of gases,humidity,volatile organic compounds,and monitoring the degradation of heavy metal ions.We aim to sort out some recent research for electrospun NFs in the sensing area,which may inspire emerging smart sensing devices and bring a novel approach for biomedical development and environmental remediation.We highlight the powerful applications of electrospun NFs in the rapidly growing feld of wearable electronic devices,which may spur the industry’s novel perspectives on the development of wearables.Finally,we point out some unresolved difculties in the sensing feld for electrospun NFs and propose possible and novel ideas for this development.
