Existence and Uniqueness Results for a Fully Third-Order Boundary Value Problem

The boundary value problems of the third-order ordinary differential equation have many practical application backgrounds and their some special cases have been studied by many authors. However, few scholars have studied the boundary value problems of the complete third-order differential equations u′′′(t) = f (t,u(t),u′(t),u′′(t)). In this paper, we discuss the existence and uniqueness of solutions and positive solutions of the fully third-order ordinary differential equation on [0,1] with the boundary condition u(0) = u′(1) = u′′(1) = 0. Under some inequality conditions on nonlinearity f some new existence and uniqueness results of solutions and positive solutions are obtained.

Hydrometallurgical detoxification and recycling of electric arc furnace dust

Electric arc furnace dust(EAFD)is a hazardous waste but can also be a potential secondary resource for valuable metals,such as Zn and Fe.Given the increased awareness of carbon emission reduction,energy conservation,and environmental protection,hydrometallurgical technologies for the detoxification and resource use of EAFD have been developing rapidly.This work summarizes the generation mechanisms,compositions,and characteristics of EAFD and presents a critical review of various hydrometallurgical treatment methods for EAFD,e.g.,acid leaching,alkaline leaching,salt leaching,and pretreatment–enhanced leaching methods.Simultaneously,the phase transformation mechanisms of zinc-containing components in acid and alkali solutions and pretreatment processes are expounded.Finally,two novel combined methods,i.e.,oxygen pressure sulfuric acid leaching combined with composite catalyst preparation,and synergistic roasting of EAFD and municipal solid waste incineration fly ash combined with alkaline leaching,are proposed,which can provide future development directions to completely recycling EAFD by recovering valuable metals and using zinc residue.

Enhanced photocatalytic performance of iron oxides@HTCC fabricated from zinc extraction tailings for methylene blue degradation:Investigation of the photocatalytic mechanism

Photocatalytic processes are efficient methods to solve water contamination problems,especially considering dyeing wastewater disposal.However,high-efficiency photocatalysts are usually very expensive and have the risk of heavy metal pollution.Recently,an iron oxides@hydrothermal carbonation carbon(HTCC)heterogeneous catalyst was prepared by our group through co-hydrothermal treatment of carbohydrates and zinc extraction tailings of converter dust.Herein,the catalytic performance of the iron oxides@HTCC was verified by a nonbiodegradable dye,methylene blue(MB),and the catalytic mechanism was deduced from theoretical simulations and spectroscopic measurements.The iron oxides@HTCC showed an excellent synergy between photocatalysis and Fenton-like reactions.Under visible-light illumination,the iron oxides@HTCC could be excited to generate electrons and holes,reacting with H_(2)O_(2)to produce·OH radicals to oxidize and decompose organic pollutants.The removal efficiency of methylene blue over iron oxides@HTCC at 140 min was 2.86 times that of HTCC.The enhanced catalytic performance was attributed to the advantages of iron oxides modification:(1)promoting the excitation induced by photons;(2)improving the charge transfer.Furthermore,the iron oxides@HTCC showed high catalytic activity in a wide pH value range of 2.3-10.4,and the MB removal efficiency remained higher than 95% after the iron oxides@HTCC was recycled 4 times.The magnetically recyclable iron oxides@HTCC may provide a solution for the treatment of wastewater from the textile industry.

Dating of zircon from high-grade rocks:Which is the most reliable method?

Magmatic zircon in high-grade metamorphic rocks is often characterized by complex textures as revealed by cathodoluminenscence(CL) that result from multiple episodes of recrystallization,overgrowth,Pb-loss and modifications through fluid-induced disturbances of the crystal structure and the original U-Th-Pb isotopic systematics.Many of these features can be recognized in 2-dimensionaI CL images,and isotopic analysis of such domains using a high resolution ion-microprobe with only shallow penetration of the zircon surface may be able to reconstruct much of the magmatic and complex postmagmatic history of such grains.In particular it is generally possible to find original magmatic domains yielding concordant ages.In contrast,destructive techniques such as LA-ICP-MS consume a large volume,leave a deep crater in the target grain,and often sample heterogeneous domains that are not visible and thus often yield discordant results which are difficult to interpret.We provide examples of complex magmatic zircon from a southern Indian granulite terrane where SHRIMP Ⅱ and LA-ICP-MS analyses are compared.The SHRIMP data are shown to be more precise and reliable,and we caution against the use of LA-ICP-MS in deciphering the chronology of complex zircons from high-grade terranes.

Geochronology and geochemistry of mafic dykes in the Helanshan complex: Implications for Mesozoic tectonics in the North China Craton

The Helanshan tectonic belt(HTB) is a major tectonic divide between the Alxa and Ordos blocks in the North China Craton. The geochronology and petrogenesis of the mafic dykes in the northern HTB are keys to understanding the tectonic evolution of this belt. The mafic dykes, intruded into the Neoarchean-Paleoproterozoic metamorphic basement, are mainly composed of diabase with a mineral assemblage of plagioclase(45%-60%), pyroxene(25%-35%), minor quartz and Fe-Ti oxides. The LA-ICPMS U-Pb analysis of zircon grains from representative dykes yield a weighted mean age of 206 ± 1.9 Ma, which represents the crystallization age of the dyke. The diabases show high contents of Fe_2 O_3~T(11.88-17.55 wt.%), low contents of SiO_2(45.65-50.95 wt.%) and MgO(3.31-5.50 wt.%) with low Mg#(=100×MgO/(MgO + FeO) atomic ration) of 33-44. They are characterized by enrichment of light rare earth elements(LREEs) and large ion lithophile elements(LILEs)(e.g., Rb, Ba and Pb), and slight depletion of high field strength elements(HFSEs). These features suggest that the magma has undergone extensive fractionation of olivine and pyroxene but only minor crustal contamination during its evolution. Their high Sm contents and La/Sm ratios, and low Sm/Yb ratios indicate that magma from which the dykes formed was derived from low degree(about 5%) partial melting of an enriched garnet + spinel lherzolite mantle source. Together with regional geology, these geochemical and geochronological data suggest that the mafic dykes in the HTB were formed in an intracontinental extensional setting during the late Triassic.

Audio Zero-Watermark Scheme Based on Discrete Cosine Transform-Discrete Wavelet TransformSingular Value Decomposition

Traditional watermark embedding schemes inevitably modify the data in a host audio signal and lead to the degradation of the host signal.In this paper,a novel audio zero-watermarking algorithm based on discrete wavelet transform(DWT),discrete cosine transform(DCT),and singular value decomposition(SVD) is presented.The watermark is registered by performing SVD on the coefficients generated through DWT and DCT to avoid data modification and host signal degradation.Simulation results show that the proposed zero-watermarking algorithm is strongly robust to common signal processing methods such as requantization,MP3 compression,resampling,addition of white Gaussian noise,and low-pass filtering.

Relay-intercropping soybean with maize maintains soil fertility and increases nitrogen recovery efficiency by reducing nitrogen input

Optimized nitrogen(N)management can increase N-use efficiency in intercropping systems.Legume-nonlegume intercropping systems can reduce N input by exploiting biological N fixation by legumes.Measurement of N utilization can help in dissecting the mechanisms underlying N uptake and utilization in legume-nonlegume intercropping systems.An experiment was performed with three planting patterns:monoculture maize(MM),monoculture soybean(SS),and maize-soybean relay intercropping(IMS),and three N application levels:zero N(NN),reduced N(RN),and conventional N(CN)to investigate crop N uptake and utilization characteristics.N recovery efficiency and 15N recovery rate of crops were higher under RN than under CN,and those under RN were higher under intercropping than under the corresponding monocultures.Compared with MM,IMS showed a lower soil N-dependent rate(SNDR)in 2012.However,the SNDR of MM rapidly declined from 86.8%in 2012 to 49.4%in 2014,whereas that of IMS declined slowly from 75.4%in 2012 to 69.4%in 2014.The interspecific N competition rate(NCRms)was higher under RN than under CN,and increased yearly.Soybean nodule dry weight and nitrogenase activities were respectively 34.2%and 12.5%higher under intercropping than in monoculture at the beginning seed stage.The amount(Ndfa)and ratio(%Ndfa)of soybean N2 fixation were significantly greater under IS than under SS.In conclusion,N fertilizer was more efficiently used under RN than under CN;in particular,the relay intercropping system promoted N fertilizer utilization in comparison with the corresponding monocultures.An intercropping system helps to maintain soil fertility because interspecific N competition promotes biological N fixation by soybean by reducing N input.Thus,a maize-soybean relay intercropping system with reduced N application is sustainable and environmentally friendly.

Targeting Gut Microbiota Dysbiosis: Potential Intervention Strategies for Neurological Disorders

It is well known that the gut microbiota plays an extremely important role in modulating host physiological functions such as immunity and metabolic homeostasis.In recent years,accumulated evidence has revealed that the gut microbiota can regulate the functions of the central nervous system(CNS)through the gut-brain axis,which provides a novel insight into the interactions between the gut and brain.This review focuses on the molecular mechanism of the crosstalk between the gut microbiota and the brain via the gut-brain axis,and on the onset and development of neurological disorders triggered by gut microbiota dysbiosis.These topics are followed by a critical analysis of potential intervention strategies targeting gut microbiota dysbiosis,including the use of probiotics,prebiotics,synbiotics,and diets.While research on the microbiota-gut-brain axis is still in its relative infancy,clarifying the molecular mechanism that underlies how the gut microbiota regulates neurological functions not only holds the promise of revealing potentially novel pathogeneses of neurological disorders,but also may lead to the development of potential diagnosis biomarkers and intervention strategies targeting microbiota dysbiosis for neurological disorders.

Geochemistry, geochronology and Hf isotope of granitoids in the Chinese Altai: Implications for Paleozoic tectonic evolution of the Central Asian Orogenic Belt

The Chinese Altai in northwestern Xinjiang has numerous outcrops of granitoids which provide critical information on accretionary orogenic processes and crustal growth of the Central Asian Orogenic Belt.Zircon U-Pb ages, Hf-isotopic compositions and whole-rock geochemistry of monzogranite and granodiorites in the Qinghe County are employed to elucidate Paleozoic tectonics of the Chinese Altai. Granodiorites have crystallization ages of 424.6 ± 3.1 Ma(MSWD = 0.23) and 404.0 ± 3.4 Ma(MSWD = 0.18);monzogranite was emplaced in the early Permian with a crystallization age of 293.7 ± 4.6 Ma(MSWD = 1.06). Both granodiorites and monzogranite are I-type granites with A/CNK ratios of 0.92 -0.97 and 1.03 -1.06, respectively. They also show similar geochemical features of high HREE and Y contents, low Sr contents and Sr/Y ratios, as well as enrichment of Cs, Rb, Th and U, and depletion of Nb, Ta, P and Ti.These geochemical features indicate that the monzogranite and granodiorites were formed in an arc setting related to subduction. The gneissic monzogranites display high SiO_2 and K_2 O contents, and belong to the high-K calc-alkaline series. In the chondrite normalized REE distribution pattern, the monzogranite samples exhibit enrichment of LREE with strong negative Eu anomalies(σE u =0.44 -0.53), zircon εHf(t) values from +7.24 to +12.63 and two-stage Hf model ages of 463 -740 Ma. This suggests that the monzogranite was generated from the mixing of pelitic and mantle material. The granodiorite samples are calc-alkaline granites with lower contents of Si O_2 and Na_2 O + K_2 O, higher contents of TiO_2, Fe_2O_3~t, MgO and CaO compared to the monzogranite samples. They also show enrichment of LREE and moderate negative Eu anomalies(σE u= 0.54 =0.81), as well as slightly higher differentiation of LREE than that of HREE. The425 Ma granodiorite has zircon εHf(t) values from -0.51 to +1.98 and two-stage Hf model ages of 1133 -1240 Ma, whereas the 404 Ma granodiorite displays those of +2.52 to +7.50 and 816 -1071 Ma.Geochemistry and zircon Hf isotopic compositions indicate that granodiorites were formed by partial melting of juvenile lower crust. Together with regional geology and previous data, the geochemical and geochronological data of the monzogranite and granodiorites from this study suggest long-lived subduction and accretion along the Altai Orogen during ca. 425 -294 Ma.

Novel Zero-Watermarking Scheme Based on DWT-DCT

Essential characteristics for watermark registration and detection without data modification can be used in anaudio zero-watermarking scheme.In this paper,a novel audio zero-watermarking scheme based on discrete wavelet transform(DWT) and discrete cosine transform(DCT) is presented.Thewatermark is registered by comparing the mean absolute values of the adjacent frame coefficients after DWT and DCT.Simulation results show that the proposed scheme is stronglyrobusttocommon attacks such as AWGN,downsampling,low-pass filtering,requantization,and MP3 compression.A performance analysis of the proposed scheme shows that all bit error rates after attacks are zero.

Mechanical,expansion and rheological properties of circulating fluidized bed fly ash based ecological cement:A critical review

Circulating fluidized bed fly ash(CFBFA)is a solid waste product from circulating fluidized bed(CFB)boilers in power plants,and the storage of CFBFA is increasingly become an environmental problem.Previous scholars have made contributions to improve the resource utilization of CFBFA.Especially,ecological cement is prepared by CFBFA,which is more conducive to its large-scale utilization.In recent years,a lot of effort has been paid to improve the properties of ecological cement containing CFBFA.In this work,the physicochemical properties of CFBFA are introduced,and recent research progress on the mechanical,expansion,and rheological properties of CFBFA based ecological cement(CEC)is extensively reviewed.The problem of over-expansion of f-CaO is summarized,which limits the scale application of CFBFA in ecological cement.Hence,the challenge for f-CaO in CFBFA to compensate for cement volume shrinkage is proposed,which is beneficial to the utilization of CFBFA in ecological cement,and the reduction of CO_(2) emissions from the cement industry.In addition,the environmental performance,durability,and economy of CEC should be valued in future research,especially the environmental performance,because the CFBFA contains heavy metals,such as Cr,As,which may pollute groundwater.

Robust entry guidance using multi-segment linear pseudospectral model predictive control

This paper presents a robust entry guidance algorithm for the high lift-to-drag ratio entry vehicle that employs the recently developed pseudospectral model predict control in a segmented manner. Here, the guidance commands are the longitudinal liftto-drag(L/D) and bank reversal commands, which are calculated by successively solving multiple segment linear algebraic equations. These equations are derived using the linear pseudospectral method, control parametrization and calculus of variations. The method uses orthogonal polynomials and computes the updates through a series of analytical formulae, which makes it accurate and computationally effective. Moreover, it is able to adjust the number of bank reversals by providing the precise bank reversal point so as to fully exploit the potential of lateral maneuver.The method also employs proportional navigation and polynomial guidance after the last bank reversal to meet multiple terminal constraints. High-fidelity numerical simulations with various destinations are carried out to demonstrate its applicability. Furthermore, Monte Carlo simulations are also conducted to show that the proposed algorithm consistently offers very stable and robust performances and has superior performances in computational efficiency, guidance accuracy and lateral trajectory shaping capability in comparison with other typical methods.

Influence of adverse weather on drivers’ perceived risk during car following based on driving simulations

Adverse weather has a considerable impact on the behavior of drivers,which puts vehicles and drivers in hazardous situations that can easily cause traffic accidents.This research examines how drivers'perceived risk changes during car following under different adverse weather conditions by using driving simulation experiment.An expressway road scenario was built in a driving simulator.Eleven types of weather conditions,including clear sky,four levels of fog,four levels of rain and two levels of snow,were designed.Furthermore,to simulate the carfollowing behavior,three car-following situations were designed according to the motion of the lead car.Seven car-following indicators were extracted based on risk homeostasis theory.Then,the entropy weight method was used to integrate the selected indicators into an index to represent the drivers'perceived risk.Multiple linear regression was applied to measure the influence of adverse weather conditions on perceived risk,and the coefficients were considered as indicators.The results demonstrate that both the weather conditions and road type have significant effects on car-following behavior.Drivers'perceived risk tends to increase with the worsening weather conditions.Under conditions of extremely poor visibility,such as heavy dense fog,the measured drivers'perceived risk is low due to the difficulties in vehicle operation and limited visibility.

Structural Design and Performance Analysis of a Deep-Water Ball Joint Seal

To overcome the current difficulties of high-precision machining and the high manufacturing and maintenance costs of spherical seals for deep-water drilling ball joints,a new spherical seal technique is proposed in this paper.The spherical seal is mainly composed of silicone rubber and polytetrafluoroethylene(PTFE).Rational structural design makes the seal independent from the ball and other components,making it easy to replace if leakage occurs at its surface.PTFE can elastically deform over a certain deformation range,which guarantees that two sealing surfaces fit tightly together.O-Ring and PTFE elasticity makes up for any lack of accuracy during spherical machining and decreases the machining precision requirements for spherical surfaces.Using a finite element technique and nonlinear theory,the performance of the spherical seal under the influence of various factors is determined.The results show that the spherical seal designed in this paper exhibits excellent sealing performance under lowtemperature and high-pressure conditions.The spherical seal,a combination of an O-ring and PTFE,has the advantages of cheap manufacturing and maintenance costs and excellent sealing performance.

Coupled Electromagnetic-Thermal-Fluidic Analysis of Permanent Magnet Synchronous Machines with a Modified Model

The researches on the heat generation and dissipa-tion of the permanent magnet synchronous machines(PMSMs)are integrated problems involving multidisciplinary studies of electromagnetism,thermomechanics,and computational fluid dynamics.The governing equations of the multi-physical prob-lems are coupled and hard to be solved and illustrated.The high accuracy mathematical model in the algebraically integral con-servative forms of the coupled fields is established and computed in this paper.And the equation coupling with the fluid flow and the temperature variation is modified to improve the positive definiteness and the symmetry of the global stiffness matrix.The computational burden is thus reduced by the model modification.A 20kW 4500rpm permanent magnet synchronous machine(PMSM)is taken as the prototype,and the calculation results are validated by experimental ones.

囊性纤维化跨膜转导调节子(CFTR)对肺癌A549细胞恶性特性的影响研究

背景与目的肺癌发病率逐年上升,有必要寻找新型的治疗靶点,而最新研究发现囊状纤维化跨膜转导调节子(cystic fibrosis transmembrane conductance regulator,CFTR)与多种肿瘤的发生和恶性转化有关。本研究探讨CFTR对肺癌A549细胞恶性特性的影响。方法应用CCK8细胞增殖实验、细胞划痕实验、Transwell细胞侵袭实验以及克隆形成实验等方法分别检测CFTR的表达对非小细胞肺癌A549细胞的增殖、迁移、侵袭等细胞恶性特性的影响。同时通过免疫印迹(Western blot)分析CFTR基因表达对肿瘤干细胞相关转录因子表达的影响。结果过表达CFTR基因显著抑制A549细胞的增殖、迁移、侵袭和克隆形成等肿瘤恶性特征,而RNA干扰A549细胞CFTR的表达导致细胞上述特征的明显增强。免疫印迹实验进一步发现CFTR基因过表达抑制A549细胞中干细胞相关转录因子SOX2和OCT3/4,以及细胞表面CD133蛋白的表达;相反,RNA干扰A549细胞中CFTR基因的表达增加SOX2、OCT4和CD133的表达。然而,免疫印迹和流式细胞术发现CFTR基因表达对A549细胞肺癌干细胞标志乙醛脱氢酶1的表达和阳性细胞数量无显著影响。结论 CFTR基因在肺癌A549细胞中具有抑制细胞恶性特征的作用,提示其可能是肺腺癌治疗的一个新的靶点,但其对其他肺腺癌细胞的作用与分子机制还有待进一步研究。

国产高压辊磨机在有色矿山的应用及分析

高压辊磨机是一种节能性强,高效的辊磨技术形式,当前在国内外都得到广泛的重视。本文主要对国产高压辊磨机的工作原理,技术特点等进行分析,并对高压辊磨机在有色矿山的应用进行阐述。

Driving Style Recognition Based on Driver Behavior Questionnaire

The ability to classify driver behavior lays the foundation for more advanced driver assistance systems. The present study aims to research driver pattern and classification feature. Driver behavior self-reported investigation was conducted with standardized driver behavior questionnaire (DBQ) by 225 nonprofessional drivers on the internet in Beijing. Questionnaire’s reliability was verified by statistics analysis. Confirmatory factor analysis (CFA) was used to analyze the underlying factor structure. Speed advantage, space occupation, the contend right of way and the contend space advantage were extracted from the ques-tionnaire results to quantify driver characteristics. Based on fuzzy C-means (FCM) algorithm and taking the four factors as pattern features, the number of driver classification distribution was discussed. Then the number of driver classification was determined by statistical indices. The comparison of classification results with the survey finding on whether the driver occurred in traffic accidents within five years shows that the classification result is the same as the actual driving conditions. Finally, correlation between the demographic and types of driving behavior has been analyzed. Female were more likely than male to careful driving, and the older the driver and the less driving experience, the more careful and moderate driving behavior is.

Identification of tumorigenic risk genes in human placenta-derived mesenchymal stem cells treated with 3-methylcholanthrene

Mesenchymal stem cells(MSCs)capable of tumour topotaxis have been served as cellular vehicles to deliver anti-tumour agents.As cellular components of the tumour microenvironment,MSCs also affect tumour progression.However,the tumour transformation-related genes of MSCs remain unclear since either tumorigenic or tumour suppressor effects within these cells have been researched.Hence,we aimed to identify potential biomarkers indicative of tumorigenic risk by RNA-seq analysis of human placenta tissue-derived MSCs(hPTMSCs)exposed to the carcinogenic agent,3-methylcholanthrene(3-MC).Twenty-nine tumour transformation-related genes and three pluripotency-related genes were appraised as differentially expressed genes(DEGs)in hPTMSCs.Overexpression of sfrp1 led to reduced cell viability,migration,and colony formation in A549.In contrast,the overexpression of ptgs2 exerted the opposite effect.These results indicate that A549 cells with high ptgs2 expression but low sfrp1 expression may have a more potential tumorigenic capacity.Taken together,this study suggests that ptgs2 and sfrp1 may be tumorigenic risk genes.