Physical layer key generation(PKG)technology leverages the reciprocal channel randomness to generate the shared secret keys.The low secret key capacity of the existing PKG schemes is due to the reduction in degree-of-...Physical layer key generation(PKG)technology leverages the reciprocal channel randomness to generate the shared secret keys.The low secret key capacity of the existing PKG schemes is due to the reduction in degree-of-freedom from multipath fading channels to multipath combined channels.To improve the wireless key generation rate,we propose a multipath channel diversity-based PKG scheme.Assisted by dynamic metasurface antennas(DMA),a two-stage multipath channel parameter estimation algorithm is proposed to efficiently realize super-resolution multipath parameter estimation.The proposed algorithm first estimates the angle of arrival(AOA)based on the reconfigurable radiation pattern of DMA,and then utilizes the results to design the training beamforming and receive beamforming to improve the estimation accuracy of the path gain.After multipath separation and parameter estimation,multi-dimensional independent path gains are utilized for generating secret keys.Finally,we analyze the security and complexity of the proposed scheme and give an upper bound on the secret key capacity in the high signal-to-noise ratio(SNR)region.The simulation results demonstrate that the proposed scheme can greatly improve the secret key capacity compared with the existing schemes.展开更多
The open and broadcast nature of wireless channels leads to the inherent security problem of information leakage in wireless communication.We can utilize endogenous security functions to resolve this problem.The funda...The open and broadcast nature of wireless channels leads to the inherent security problem of information leakage in wireless communication.We can utilize endogenous security functions to resolve this problem.The fundamental solution is channel-based mechanisms,like physical layer secret keys.Unfortunately,current investigations have not fully exploited the randomness of wireless channels,making secret key rates not high.Consequently,user data can be encrypted by reducing the data rate to match the secret key rate.Based on the analysis of the endogenous wireless security principle,we proposed that the channel-based endogenous secret key rate can nearly match the maximum data rate in the fast-fading environments.After that,we validated the proposition in an instantiation system with multiple phase shift keying(MPSK)inputs from the perspectives of both theoretical analysis and simulation experiments.The results indicate that it is possible to accomplish the onetime pad without decreasing the data rate via channelbased endogenous keys.Besides,we can realize highspeed endogenously secure transmission by introducing independent channels in the domains of frequency,space,or time.The conclusions derived provide a new idea for wireless security and promote the application of the endogenous security theory.展开更多
Energy saving and emission reduction for railway systems should not only be studied from a technical perspective but should also be focused on management and economics. On the basis of relevant trainscheduling models ...Energy saving and emission reduction for railway systems should not only be studied from a technical perspective but should also be focused on management and economics. On the basis of relevant trainscheduling models for train operation management, in this paper we introduce an extended multi-objective trainscheduling optimization model considering locomotive assignment and segment emission constraints for energy saving. The objective of setting up this model is to reduce the energy and emission cost as well as total passenger- time. The decision variables include continuous variables such as train arrival and departure time, and binary vari- ables such as locomotive assignment and segment occu- pancy. The constraints are concerned with train movement, trip time, headway, and segment emission, etc. To obtain a non-dominated satisfactory solution on these objectives, a fuzzy multi-objective optimization algorithm is employed to solve the model. Finally, a numerical example is performed and used to compare the proposed model with the existing model. The results show that the proposed model can reduce the energy consumption, meet exhausts emission demands effectively by optimal locomotive assignment, and its solution methodology is effective.展开更多
Spectral efficiency(SE) and energy efficiency(EE) in secure communications is of primary importance due to the fact that 5 G wireless networks aim to achieve high throughput,low power consumption and high level of sec...Spectral efficiency(SE) and energy efficiency(EE) in secure communications is of primary importance due to the fact that 5 G wireless networks aim to achieve high throughput,low power consumption and high level of security.Nevertheless,maximizing SE and EE are not achievable simultaneously.In this paper,we investigate the SE and EE tradeoff for secure transmission in cognitive relay networks where all nodes are randomly distributed.We first introduce the opportunistic relay selection policy,where each primary transmitter communicates with the primary receiver with the help of a secondary user as a relay.Then,we evaluate the secure SE and secure EE of the primary network based on the outage probabilities analysis.Thirdly,by applying a unified SE-EE tradeoff metric,the secure SE and EE tradeoff problem is formulated as the joint secure SE and EE maximization problem.Considering the non-concave feature of the objective function,an iterative algorithm is proposed to improve secure SE and EE tradeoff.Numerical results show that the opportunistic relay selection policy is always superior to random relay selection policy.Furthermore,the opportunistic relay selection policy outperforms conventional direct transmission policy when faced with small security threat(i.e.,for smaller eavesdropper density).展开更多
Amphotericin B(AmB)is an amphiphilic drug commonly formulated in liposomes and administered intravenously to treat systemic fungal infections.Recent studies on the liposomal drug product have shed light on the AmB agg...Amphotericin B(AmB)is an amphiphilic drug commonly formulated in liposomes and administered intravenously to treat systemic fungal infections.Recent studies on the liposomal drug product have shed light on the AmB aggregation status in the bilayer,which heat treatment(curing)modifies.Although toxicity was found related to aggregation status-loose aggregates significantly more toxic than tight aggregates-the precise mechanism linking aggregation and toxicitywas notwell understood.This study directlymeasured drug release rate fromvarious AmB liposomal preparations made with modified curing protocols to evaluate correlations among drug aggregation state,drug release,and in vitro toxicity.UV–Vis spectroscopy of these products detected unique curing-induced changes in the UV spectral features:a∼25nm blue-shift of the main absorption peak(λ_(max))in aqueous buffer and a decrease in the OD_(346)/OD_(322) ratio upon thermal curing,reflecting tighter aggregation.In vitro release testing(IVRT)data showed,by applying and fitting first-order release kinetic models for one or two pools,that curing impacts two significant changes:a 3–5-fold drop in the overall drug release rate and a ten-fold decrease in the ratio between the loosely aggregated and the tightly aggregated,more thermodynamically stable drug pool.The kinetic data thus corroborated the trend independently deduced from the UV–Vis spectral data.The in vitro toxicity assay indicated a decreased toxicity with curing,as shown by the significantly increased concentration,causing half-maximal potassium release(TC50).The data suggest that the release of AmB requires dissociation of the tight complexes within the bilayer and that the reduced toxicity relates to this slower rate of dissociation.This study demonstrates the relationship between AmB aggregation status within the lipid bilayer and drug release(directly measured rate constants),providing a mechanistic link between aggregation status and in vitro toxicity in the liposomal formulations.展开更多
When Internet of Things(IoT)nodes access the network through wireless channels,the network is vulnerable to spoofing attacks and the Sybil attack.However,the connection of massive devices in IoT makes it difficult to ...When Internet of Things(IoT)nodes access the network through wireless channels,the network is vulnerable to spoofing attacks and the Sybil attack.However,the connection of massive devices in IoT makes it difficult to manage and distribute keys,thus limiting the application of traditional high-level authentication schemes.Compared with the high-level authentication scheme,the physical layer authentication scheme realizes the lightweight authentication of users by comparing the wireless channel characteristics of adjacent packets.However,traditional physical layer authentication schemes still adopt the one-to-one authentication method,which will consume numerous network resources in the face of large-scale IoT node access authentication.In order to realize the secure access authentication of IoT nodes and regional intrusion detection with low resource consumption,we propose a physical layer authentication mechanism based on convolution neural network(CNN),which uses the deep characteristics of channel state information(CSI)to identify sending nodes in different locations.Specifically,we obtain the instantaneous CSI data of IoT sending nodes at different locations in the pre-set area,and then feed them into CNN for training to procure a model for IoT node authentication.With its powerful ability of data analysis and feature extraction,CNN can extract deep Spatio-temporal environment features of CSI data and bind them with node identities.Accordingly,an authentication mechanism which can distinguish the identity types of IoT nodes located in different positions is established to authenticate the identity of unknown nodes when they break into the pre-set area.Experimental results show that this authentication mechanism can still achieve 94.7%authentication accuracy in the case of a low signalto-noise ratio(SNR)of 0 dB,which means a significant improvement in authentication accuracy and robustness.展开更多
Teleseismic body wave traveltime tomography is used to inverse the three-dimensional seismic velocity structure beneath Shizigou in the western Qaidam basin. The travel time are picked from the continuous observation ...Teleseismic body wave traveltime tomography is used to inverse the three-dimensional seismic velocity structure beneath Shizigou in the western Qaidam basin. The travel time are picked from the continuous observation data on a small seismic array of stations deployed during 2004-2007. The tomographic results obtained indicate that a NW-trending low velocity anomaly just beneath the target region insert northeastwards with a high dip angle. In the north, northeast and east of the low velocity anomaly, some high-velocity anomalies distribute with the same strike and coverage as those of Shizigou anticline.展开更多
The Hengduan Mountains Region(HMR) is essential for the future ecological protection, clean energy production,Sichuan-Xizang and Yunnan-Xizang railways, and other major infrastructure projects in China. The distributi...The Hengduan Mountains Region(HMR) is essential for the future ecological protection, clean energy production,Sichuan-Xizang and Yunnan-Xizang railways, and other major infrastructure projects in China. The distributions of climate and vegetation exhibit significant regional differentiation and vertical zonality due to the rugged longitudinal ranges and gorges and the complex disaster-prone environments in HMR. Therefore, it is urgent to develop the climate-vegetation regionalization in HMR to effectively satisfy the national requirements such as agricultural production and ecological protection, mountain disaster risk prevention, and major project construction. We here develop a new scheme of climate-vegetation regionalization with the latest demarcation outcome of HMR, the ground observation from 122 meteorological stations in HMR and its surrounding areas during 1990–2019, and the high-precision remote sensing data of land cover types. The new scheme first constructs the regionalization index system, fully considering the extraordinarily complicated geomorphic pattern of mountains and valleys, the scarcity of meteorological observations, and the remarkable differentiation of climate and vegetation in HMR. The system consists of three primary regionalization indices(i.e., days with daily average temperature steady above 10°C, aridity index, and main vegetation types, dividing the temperature zones, moisture regions, and vegetation subregions, respectively) and three auxiliary indices of the accumulated temperature above 10°C, and the temperatures in January and July. Then, the HMR is divided into five temperature zones, 20 moisture regions, and 55 vegetation subregions. Compared with previous regionalization schemes, the new scheme optimizes the climate spatial interpolation model of thin plate smoothing spline suitable for the unique terrain in HMR. Moreover, the disputed division index threshold between different climatic zones(regions) is scientifically clarified using geographical detectors. Specifically, the stepwise downscaling pane division method is initially proposed to determine the zoning boundary, alleviating the excessive dependence of the traditional zoning method on subjective experience.Besides, the scheme considers the typical regional characteristics of the complex underlying surface and the high gradient zone of climate-vegetation distribution types in HMR. Consequently, the transition zone with quick climate changes between the plateau temperate and mid-subtropical zones is divided into mountainous subtropics, taking into account the spatial distribution characteristics of climate-vegetation regionalization indices. The regionalization scheme will provide practically theoretical support for agricultural production, ecological protection, major project construction, disaster prevention and relief efforts, and other socioeconomic activities in HMR, serving as a classic case of climate-vegetation regionalization for the alpine and canyon regions with intricate underlying surface, striking regional differences, and lack of ground observations.展开更多
The water snail Pomacea canaliculata retracts the discoidal and multi-layered operculum to protect the soft body from being attacked by predators,and releases it when threats lifted.However,the duration of the opercul...The water snail Pomacea canaliculata retracts the discoidal and multi-layered operculum to protect the soft body from being attacked by predators,and releases it when threats lifted.However,the duration of the operculum retraction is usually less than that of the operculum protraction.In this paper,we elucidate the biological compliant mechanism of the operculum.By using confocal laser scanning microscopy,we find that the operculum has compliant sandwiched layers between hard layers.The layered structure results in a compliant mechanism with a bidirectional stiffness for the locking and unlocking processes of the operculum.A mathematical model is derived to rationalize the bidirectional stiffness mechanism of the operculum.In addition,we carry out the experiments on the locking and unlocking processes.The experimental results show that the locking tension is about two-fifths of the unlocking tension of the operculum.Moreover,based on the mechanical properties of the operculum with the layered structure,we designed an operculum-inspired structure,which may have a variety of potential applications in combined driving patterns.展开更多
Physical layer key generation(PKG)technology leverages reciprocal channel randomness to generate shared secret keys.However,multipath fading at the receiver may degrade the correlation between legitimate uplink and do...Physical layer key generation(PKG)technology leverages reciprocal channel randomness to generate shared secret keys.However,multipath fading at the receiver may degrade the correlation between legitimate uplink and downlink channels,resulting in a low key generation rate(KGR).In this paper,we propose a PKG scheme based on the pattern-reconfigurable antenna(PRA)to boost the secret key capacity.First,we propose a reconfigurable intelligent surface(RIS)based PRA architecture with the capability of flexible and reconfigurable antenna patterns.Then,we present the PRA-based PKG protocol to improve the KGR via mitigation of the effects of multipath fading.Specifically,a novel algorithm for estimation of the multipath channel parameters is proposed based on atomic norm minimization.Thereafter,a novel optimization method for the matching reception of multipath signals is formulated based on the improved binary particle swarm optimization(BPSO)algorithm.Finally,simulation results show that the proposed scheme can resist multipath fading and achieve a high KGR compared to existing schemes.Moreover,our findings indicate that the increased degree of freedom of the antenna patterns can significantly increase the secret key capacity.展开更多
Permafrost is one of the largest elements of the terrestrial cryosphere and is extremely sensitive to climate change.Based on mean annual ground temperature(MAGT)data from 189 boreholes on the Qinghai–Tibet Plateau(Q...Permafrost is one of the largest elements of the terrestrial cryosphere and is extremely sensitive to climate change.Based on mean annual ground temperature(MAGT)data from 189 boreholes on the Qinghai–Tibet Plateau(QTP),terrain factors,and climate data from China Meteorological Forcing Dataset,we propose a new mean annual ground air temperature(MAGAT)statistical model between meteorological parameters with subsurface temperatures to simulate permafrost distribution and variation of MAGT on the QTP over the past three decades(1981–2010).Validation of the model with MAGT data from 13 boreholes and permafrost maps of the QTP indicated that the MAGAT model is applicable to simulate the distribution and evolution of permafrost on the QTP.Simulation results show that the spatiotemporal MAGT of permafrost significantly increased by 0.37℃,or 0.25℃/10 yr,and the total area of permafrost decreased by 2.48×10^(5)km^(2) on the QTP over the past three decades.Regionally,the changes of permafrost in the southwestern QTP were greater than other regions of the QTP.展开更多
Based on numerous microfossils in Mesozoic of North Carnarvon Basin in Australia,the Mesozoic paleoclimate and paleoenvironment were analyzed,the paleogeographic background and development model of Mesozoic high-quali...Based on numerous microfossils in Mesozoic of North Carnarvon Basin in Australia,the Mesozoic paleoclimate and paleoenvironment were analyzed,the paleogeographic background and development model of Mesozoic high-quality source rocks were investigated and discussed.Variation of microfossil species and their relative contents in Mesozoic different intervals indicates changes of paleoclimate and paleoenvironment.The paleoclimate shows a cycle variation of aridehumidearidehumid,the regression occurred in the Early TriassiceLate Triassic and the transgression occurred in the Late TriassiceLate Cretaceous.Four sedimentary facieses including delta facies,littoral facies,restricted sea facies and open sea facies were developed in the Mesozoic.The open sea was mainly developed in the Early Triassic,the delta was distributed in the MiddleeLate Triassic,the restricted sea was especially well developed in the Jurassic,and the restricted sea and open sea were mainly distributed in the Cretaceous.Characteristics of microfossil assemblage in these four sedimentary facies are dramatically different.From the delta facies,littoral facies,restricted sea facies to open sea facies,content of pollen gradually decreases,but content of the dinoflagellate+acritarch gradually increases.The delta facies and littoral facies are dominated by the pollen.In the restricted sea facies,content of the pollen is equivalent to that of the dinoflagellate+acritarch.The open sea facies is dominated by the dinoflagellate and acritarch.Supply of sediment and formation of organic matter are influenced by the paleoclimate and paleoenvironment,and type of organic matter is controlled by the microfossil assemblage.Based on the palaeogeographic background,paleoclimatic condition and microfossil assemblage,two developmental models of the Mesozoic source rocks such as the development model of terrestrial organic matter under the background of large delta and the development model of mixed organic matter under the background of the restricted sea,were proposed.展开更多
Suppose that 0→ I→ A→ A/I→ 0 is a tracially quasidiagonal extension of C*-algebras. In this paper, the authors give two descriptions of the K_0, K_1 index maps which are induced by the above extension and show tha...Suppose that 0→ I→ A→ A/I→ 0 is a tracially quasidiagonal extension of C*-algebras. In this paper, the authors give two descriptions of the K_0, K_1 index maps which are induced by the above extension and show that for any ∈ > 0, any τ in the tracial state space of A/I and any projection p ∈ A/I(any unitary u ∈ A/I), there exists a projection p ∈ A(a unitary u ∈ A) such that |τ(p)-τ(π(p))| < ∈(|τ(u)-τ(π(u))| < ∈).展开更多
Na_(3)(VO)_(2)(PO_(4))_(2)F(NVPOF)has been considered as one potential candidate for sodium-ion batteries because of its high operating voltage and theoretical capacity.However,the poor intrinsic electronic conductivi...Na_(3)(VO)_(2)(PO_(4))_(2)F(NVPOF)has been considered as one potential candidate for sodium-ion batteries because of its high operating voltage and theoretical capacity.However,the poor intrinsic electronic conductivity significantly restricts its widespread application.In response to this drawback,we adopt the optimization strategy of tuning the morphology and structure to boost the electrical conductivity and mitigate the capacity fading.In this paper,NVPOF microspheres with unique porous yolk-shell structure were fabricated via a facile one-step solvothermal method for the first time.By monitoring the morphological evolution with time-dependent experiments,the self-sacrifice and Ostwald ripening mechanism from rough spheres to yolk-shell structure was revealed.Benefited from the favorable interwoven nanosheets shell,inner cavity and porous core structure,the resulting NVPOF electrode exhibits superior rate capability of 63 m A h g^(-1)at 20 C as well as outstanding long-cycling performance with the capacity retention up to 92.1%over 1000 cycles at 5 C.展开更多
Dear editors,Colorectal cancer(CRC)is the second leading cause of cancer deaths in developed countries[1].The malignant transformation from small clumps to cancer takes about 10 years[2].This study aimed to characteri...Dear editors,Colorectal cancer(CRC)is the second leading cause of cancer deaths in developed countries[1].The malignant transformation from small clumps to cancer takes about 10 years[2].This study aimed to characterize proteomic dynamics associated with CRC development and progres-sion,and identify novel therapeutic targets for intercepting the underlying oncogenic processes.We have optimized pressure cycling technology(PCT)coupled with data-independent acquisition mass spectrometry(DIA-MS)for robust and reproducible proteomic analysis of biopsy-level formalin-fixed paraffin-embedded(FFPE)tissues[3].展开更多
基金supported in part by the National Natural Science Foundation of China(No.U22A2001)the National Key Research and Development Program of China(No.2022YFB2902202,No.2022YFB2902205)。
文摘Physical layer key generation(PKG)technology leverages the reciprocal channel randomness to generate the shared secret keys.The low secret key capacity of the existing PKG schemes is due to the reduction in degree-of-freedom from multipath fading channels to multipath combined channels.To improve the wireless key generation rate,we propose a multipath channel diversity-based PKG scheme.Assisted by dynamic metasurface antennas(DMA),a two-stage multipath channel parameter estimation algorithm is proposed to efficiently realize super-resolution multipath parameter estimation.The proposed algorithm first estimates the angle of arrival(AOA)based on the reconfigurable radiation pattern of DMA,and then utilizes the results to design the training beamforming and receive beamforming to improve the estimation accuracy of the path gain.After multipath separation and parameter estimation,multi-dimensional independent path gains are utilized for generating secret keys.Finally,we analyze the security and complexity of the proposed scheme and give an upper bound on the secret key capacity in the high signal-to-noise ratio(SNR)region.The simulation results demonstrate that the proposed scheme can greatly improve the secret key capacity compared with the existing schemes.
基金funded by the National Key R&D Program of China under Grant 2017YFB0801903the National Natural Science Foundation of China under Grant 61871404,61701538,61521003Doctoral Fund of Ministry of Education of China under Grant 2019M663994。
文摘The open and broadcast nature of wireless channels leads to the inherent security problem of information leakage in wireless communication.We can utilize endogenous security functions to resolve this problem.The fundamental solution is channel-based mechanisms,like physical layer secret keys.Unfortunately,current investigations have not fully exploited the randomness of wireless channels,making secret key rates not high.Consequently,user data can be encrypted by reducing the data rate to match the secret key rate.Based on the analysis of the endogenous wireless security principle,we proposed that the channel-based endogenous secret key rate can nearly match the maximum data rate in the fast-fading environments.After that,we validated the proposition in an instantiation system with multiple phase shift keying(MPSK)inputs from the perspectives of both theoretical analysis and simulation experiments.The results indicate that it is possible to accomplish the onetime pad without decreasing the data rate via channelbased endogenous keys.Besides,we can realize highspeed endogenously secure transmission by introducing independent channels in the domains of frequency,space,or time.The conclusions derived provide a new idea for wireless security and promote the application of the endogenous security theory.
基金supported by the National Natural Science Foundation of China (No. 71101007)the National High Technology Research and Development Program of China (No. 2011AA110502)State Key Laboratory of Rail Traffic Control and Safety of Beijing Jiaotong University Program (RCS2010ZZ001)
文摘Energy saving and emission reduction for railway systems should not only be studied from a technical perspective but should also be focused on management and economics. On the basis of relevant trainscheduling models for train operation management, in this paper we introduce an extended multi-objective trainscheduling optimization model considering locomotive assignment and segment emission constraints for energy saving. The objective of setting up this model is to reduce the energy and emission cost as well as total passenger- time. The decision variables include continuous variables such as train arrival and departure time, and binary vari- ables such as locomotive assignment and segment occu- pancy. The constraints are concerned with train movement, trip time, headway, and segment emission, etc. To obtain a non-dominated satisfactory solution on these objectives, a fuzzy multi-objective optimization algorithm is employed to solve the model. Finally, a numerical example is performed and used to compare the proposed model with the existing model. The results show that the proposed model can reduce the energy consumption, meet exhausts emission demands effectively by optimal locomotive assignment, and its solution methodology is effective.
文摘Spectral efficiency(SE) and energy efficiency(EE) in secure communications is of primary importance due to the fact that 5 G wireless networks aim to achieve high throughput,low power consumption and high level of security.Nevertheless,maximizing SE and EE are not achievable simultaneously.In this paper,we investigate the SE and EE tradeoff for secure transmission in cognitive relay networks where all nodes are randomly distributed.We first introduce the opportunistic relay selection policy,where each primary transmitter communicates with the primary receiver with the help of a secondary user as a relay.Then,we evaluate the secure SE and secure EE of the primary network based on the outage probabilities analysis.Thirdly,by applying a unified SE-EE tradeoff metric,the secure SE and EE tradeoff problem is formulated as the joint secure SE and EE maximization problem.Considering the non-concave feature of the objective function,an iterative algorithm is proposed to improve secure SE and EE tradeoff.Numerical results show that the opportunistic relay selection policy is always superior to random relay selection policy.Furthermore,the opportunistic relay selection policy outperforms conventional direct transmission policy when faced with small security threat(i.e.,for smaller eavesdropper density).
基金financially supported by the Offi ce of Research and Standards, Office of Generic Drugs, CDER at the FDA (75F40120C00055)
文摘Amphotericin B(AmB)is an amphiphilic drug commonly formulated in liposomes and administered intravenously to treat systemic fungal infections.Recent studies on the liposomal drug product have shed light on the AmB aggregation status in the bilayer,which heat treatment(curing)modifies.Although toxicity was found related to aggregation status-loose aggregates significantly more toxic than tight aggregates-the precise mechanism linking aggregation and toxicitywas notwell understood.This study directlymeasured drug release rate fromvarious AmB liposomal preparations made with modified curing protocols to evaluate correlations among drug aggregation state,drug release,and in vitro toxicity.UV–Vis spectroscopy of these products detected unique curing-induced changes in the UV spectral features:a∼25nm blue-shift of the main absorption peak(λ_(max))in aqueous buffer and a decrease in the OD_(346)/OD_(322) ratio upon thermal curing,reflecting tighter aggregation.In vitro release testing(IVRT)data showed,by applying and fitting first-order release kinetic models for one or two pools,that curing impacts two significant changes:a 3–5-fold drop in the overall drug release rate and a ten-fold decrease in the ratio between the loosely aggregated and the tightly aggregated,more thermodynamically stable drug pool.The kinetic data thus corroborated the trend independently deduced from the UV–Vis spectral data.The in vitro toxicity assay indicated a decreased toxicity with curing,as shown by the significantly increased concentration,causing half-maximal potassium release(TC50).The data suggest that the release of AmB requires dissociation of the tight complexes within the bilayer and that the reduced toxicity relates to this slower rate of dissociation.This study demonstrates the relationship between AmB aggregation status within the lipid bilayer and drug release(directly measured rate constants),providing a mechanistic link between aggregation status and in vitro toxicity in the liposomal formulations.
基金This work was supported by National Natural Science Foundation of China(No.61871404,61801435).
文摘When Internet of Things(IoT)nodes access the network through wireless channels,the network is vulnerable to spoofing attacks and the Sybil attack.However,the connection of massive devices in IoT makes it difficult to manage and distribute keys,thus limiting the application of traditional high-level authentication schemes.Compared with the high-level authentication scheme,the physical layer authentication scheme realizes the lightweight authentication of users by comparing the wireless channel characteristics of adjacent packets.However,traditional physical layer authentication schemes still adopt the one-to-one authentication method,which will consume numerous network resources in the face of large-scale IoT node access authentication.In order to realize the secure access authentication of IoT nodes and regional intrusion detection with low resource consumption,we propose a physical layer authentication mechanism based on convolution neural network(CNN),which uses the deep characteristics of channel state information(CSI)to identify sending nodes in different locations.Specifically,we obtain the instantaneous CSI data of IoT sending nodes at different locations in the pre-set area,and then feed them into CNN for training to procure a model for IoT node authentication.With its powerful ability of data analysis and feature extraction,CNN can extract deep Spatio-temporal environment features of CSI data and bind them with node identities.Accordingly,an authentication mechanism which can distinguish the identity types of IoT nodes located in different positions is established to authenticate the identity of unknown nodes when they break into the pre-set area.Experimental results show that this authentication mechanism can still achieve 94.7%authentication accuracy in the case of a low signalto-noise ratio(SNR)of 0 dB,which means a significant improvement in authentication accuracy and robustness.
基金supported by Special Fund for National Oil and Gas (XQ-2004-01)International Program for Science and Technology Cooperation (2006DFA21350).
文摘Teleseismic body wave traveltime tomography is used to inverse the three-dimensional seismic velocity structure beneath Shizigou in the western Qaidam basin. The travel time are picked from the continuous observation data on a small seismic array of stations deployed during 2004-2007. The tomographic results obtained indicate that a NW-trending low velocity anomaly just beneath the target region insert northeastwards with a high dip angle. In the north, northeast and east of the low velocity anomaly, some high-velocity anomalies distribute with the same strike and coverage as those of Shizigou anticline.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA23090302)the Second Tibetan Plateau Scientific Expedition and Research Program(STEP)(Grant No.2019QZKK0903)。
文摘The Hengduan Mountains Region(HMR) is essential for the future ecological protection, clean energy production,Sichuan-Xizang and Yunnan-Xizang railways, and other major infrastructure projects in China. The distributions of climate and vegetation exhibit significant regional differentiation and vertical zonality due to the rugged longitudinal ranges and gorges and the complex disaster-prone environments in HMR. Therefore, it is urgent to develop the climate-vegetation regionalization in HMR to effectively satisfy the national requirements such as agricultural production and ecological protection, mountain disaster risk prevention, and major project construction. We here develop a new scheme of climate-vegetation regionalization with the latest demarcation outcome of HMR, the ground observation from 122 meteorological stations in HMR and its surrounding areas during 1990–2019, and the high-precision remote sensing data of land cover types. The new scheme first constructs the regionalization index system, fully considering the extraordinarily complicated geomorphic pattern of mountains and valleys, the scarcity of meteorological observations, and the remarkable differentiation of climate and vegetation in HMR. The system consists of three primary regionalization indices(i.e., days with daily average temperature steady above 10°C, aridity index, and main vegetation types, dividing the temperature zones, moisture regions, and vegetation subregions, respectively) and three auxiliary indices of the accumulated temperature above 10°C, and the temperatures in January and July. Then, the HMR is divided into five temperature zones, 20 moisture regions, and 55 vegetation subregions. Compared with previous regionalization schemes, the new scheme optimizes the climate spatial interpolation model of thin plate smoothing spline suitable for the unique terrain in HMR. Moreover, the disputed division index threshold between different climatic zones(regions) is scientifically clarified using geographical detectors. Specifically, the stepwise downscaling pane division method is initially proposed to determine the zoning boundary, alleviating the excessive dependence of the traditional zoning method on subjective experience.Besides, the scheme considers the typical regional characteristics of the complex underlying surface and the high gradient zone of climate-vegetation distribution types in HMR. Consequently, the transition zone with quick climate changes between the plateau temperate and mid-subtropical zones is divided into mountainous subtropics, taking into account the spatial distribution characteristics of climate-vegetation regionalization indices. The regionalization scheme will provide practically theoretical support for agricultural production, ecological protection, major project construction, disaster prevention and relief efforts, and other socioeconomic activities in HMR, serving as a classic case of climate-vegetation regionalization for the alpine and canyon regions with intricate underlying surface, striking regional differences, and lack of ground observations.
基金supported by National Natural Science Foundation of China(Grant No.52275298,and No.51905556)Pandeng Plan of Guangdong Province(Grant No.52910001,and No.11220004)Shenzhen Science and Technology Program(Grant No.GXWD2021B03,No.20220817165030002,and No.ZDSYS20210623091808026).
文摘The water snail Pomacea canaliculata retracts the discoidal and multi-layered operculum to protect the soft body from being attacked by predators,and releases it when threats lifted.However,the duration of the operculum retraction is usually less than that of the operculum protraction.In this paper,we elucidate the biological compliant mechanism of the operculum.By using confocal laser scanning microscopy,we find that the operculum has compliant sandwiched layers between hard layers.The layered structure results in a compliant mechanism with a bidirectional stiffness for the locking and unlocking processes of the operculum.A mathematical model is derived to rationalize the bidirectional stiffness mechanism of the operculum.In addition,we carry out the experiments on the locking and unlocking processes.The experimental results show that the locking tension is about two-fifths of the unlocking tension of the operculum.Moreover,based on the mechanical properties of the operculum with the layered structure,we designed an operculum-inspired structure,which may have a variety of potential applications in combined driving patterns.
基金Project supported by the National Key Research and Development Program of China(Nos.2022YFB2902202,2022YFB2902205)the National Natural Science Foundation of China(No.U22A2001)。
文摘Physical layer key generation(PKG)technology leverages reciprocal channel randomness to generate shared secret keys.However,multipath fading at the receiver may degrade the correlation between legitimate uplink and downlink channels,resulting in a low key generation rate(KGR).In this paper,we propose a PKG scheme based on the pattern-reconfigurable antenna(PRA)to boost the secret key capacity.First,we propose a reconfigurable intelligent surface(RIS)based PRA architecture with the capability of flexible and reconfigurable antenna patterns.Then,we present the PRA-based PKG protocol to improve the KGR via mitigation of the effects of multipath fading.Specifically,a novel algorithm for estimation of the multipath channel parameters is proposed based on atomic norm minimization.Thereafter,a novel optimization method for the matching reception of multipath signals is formulated based on the improved binary particle swarm optimization(BPSO)algorithm.Finally,simulation results show that the proposed scheme can resist multipath fading and achieve a high KGR compared to existing schemes.Moreover,our findings indicate that the increased degree of freedom of the antenna patterns can significantly increase the secret key capacity.
基金This study was supported by the National Natural Science Foundation of China under Grant[No.41330634]the STS Project of the Chinese Academy of Sciences under Grant[No.HHS-TSS-STS-1502].
文摘Permafrost is one of the largest elements of the terrestrial cryosphere and is extremely sensitive to climate change.Based on mean annual ground temperature(MAGT)data from 189 boreholes on the Qinghai–Tibet Plateau(QTP),terrain factors,and climate data from China Meteorological Forcing Dataset,we propose a new mean annual ground air temperature(MAGAT)statistical model between meteorological parameters with subsurface temperatures to simulate permafrost distribution and variation of MAGT on the QTP over the past three decades(1981–2010).Validation of the model with MAGT data from 13 boreholes and permafrost maps of the QTP indicated that the MAGAT model is applicable to simulate the distribution and evolution of permafrost on the QTP.Simulation results show that the spatiotemporal MAGT of permafrost significantly increased by 0.37℃,or 0.25℃/10 yr,and the total area of permafrost decreased by 2.48×10^(5)km^(2) on the QTP over the past three decades.Regionally,the changes of permafrost in the southwestern QTP were greater than other regions of the QTP.
基金The work was supported by the National Science and Technology Major Project of China(No.2011ZX05030).
文摘Based on numerous microfossils in Mesozoic of North Carnarvon Basin in Australia,the Mesozoic paleoclimate and paleoenvironment were analyzed,the paleogeographic background and development model of Mesozoic high-quality source rocks were investigated and discussed.Variation of microfossil species and their relative contents in Mesozoic different intervals indicates changes of paleoclimate and paleoenvironment.The paleoclimate shows a cycle variation of aridehumidearidehumid,the regression occurred in the Early TriassiceLate Triassic and the transgression occurred in the Late TriassiceLate Cretaceous.Four sedimentary facieses including delta facies,littoral facies,restricted sea facies and open sea facies were developed in the Mesozoic.The open sea was mainly developed in the Early Triassic,the delta was distributed in the MiddleeLate Triassic,the restricted sea was especially well developed in the Jurassic,and the restricted sea and open sea were mainly distributed in the Cretaceous.Characteristics of microfossil assemblage in these four sedimentary facies are dramatically different.From the delta facies,littoral facies,restricted sea facies to open sea facies,content of pollen gradually decreases,but content of the dinoflagellate+acritarch gradually increases.The delta facies and littoral facies are dominated by the pollen.In the restricted sea facies,content of the pollen is equivalent to that of the dinoflagellate+acritarch.The open sea facies is dominated by the dinoflagellate and acritarch.Supply of sediment and formation of organic matter are influenced by the paleoclimate and paleoenvironment,and type of organic matter is controlled by the microfossil assemblage.Based on the palaeogeographic background,paleoclimatic condition and microfossil assemblage,two developmental models of the Mesozoic source rocks such as the development model of terrestrial organic matter under the background of large delta and the development model of mixed organic matter under the background of the restricted sea,were proposed.
基金supported by the National Key Research and Development Program of China(2018YFA0209303)the National Natural Science Foundation of China(22025202 and 51972165)Natural Science Foundation of Jiangsu Province(BK20202003)。
基金supported by the National Natural Science Foundation of China(Nos.11871375,11371279,11601339)Zhejiang Provincial Natural Science Foundation of China(No.LY13A010021)
文摘Suppose that 0→ I→ A→ A/I→ 0 is a tracially quasidiagonal extension of C*-algebras. In this paper, the authors give two descriptions of the K_0, K_1 index maps which are induced by the above extension and show that for any ∈ > 0, any τ in the tracial state space of A/I and any projection p ∈ A/I(any unitary u ∈ A/I), there exists a projection p ∈ A(a unitary u ∈ A) such that |τ(p)-τ(π(p))| < ∈(|τ(u)-τ(π(u))| < ∈).
基金financially supported by the National Natural Science Foundation of China(No.51972259)the Hubei Provincial Natural Science Foundation of China(No.2019CFB519)+1 种基金the Fundamental Research Funds for the Central Universities(No.WUT:2020Ⅲ015GX)the National innovation and entrepreneurship training program for Undergraduate(No.201910497011)。
文摘Na_(3)(VO)_(2)(PO_(4))_(2)F(NVPOF)has been considered as one potential candidate for sodium-ion batteries because of its high operating voltage and theoretical capacity.However,the poor intrinsic electronic conductivity significantly restricts its widespread application.In response to this drawback,we adopt the optimization strategy of tuning the morphology and structure to boost the electrical conductivity and mitigate the capacity fading.In this paper,NVPOF microspheres with unique porous yolk-shell structure were fabricated via a facile one-step solvothermal method for the first time.By monitoring the morphological evolution with time-dependent experiments,the self-sacrifice and Ostwald ripening mechanism from rough spheres to yolk-shell structure was revealed.Benefited from the favorable interwoven nanosheets shell,inner cavity and porous core structure,the resulting NVPOF electrode exhibits superior rate capability of 63 m A h g^(-1)at 20 C as well as outstanding long-cycling performance with the capacity retention up to 92.1%over 1000 cycles at 5 C.
基金supported by the National Key Research and Development Program of China(Grant No.2017YFC0908200),National Natural Science Founda-tion of China(Grant No.81972270,81972492,32027801,21904107),the Zhejiang Provincial Science Foundation for Distinguished Young Scholars(Grant No.LR19C050001),Hangzhou Agriculture and Society Advancement Program(Grant No.20190101A04)and 2019 Zhejiang University Academic Award for Outstanding Doctoral Candidates to YK.S(Grant No.2019071).
文摘Dear editors,Colorectal cancer(CRC)is the second leading cause of cancer deaths in developed countries[1].The malignant transformation from small clumps to cancer takes about 10 years[2].This study aimed to characterize proteomic dynamics associated with CRC development and progres-sion,and identify novel therapeutic targets for intercepting the underlying oncogenic processes.We have optimized pressure cycling technology(PCT)coupled with data-independent acquisition mass spectrometry(DIA-MS)for robust and reproducible proteomic analysis of biopsy-level formalin-fixed paraffin-embedded(FFPE)tissues[3].
