Indoor thermal comfort and passive solar heating technologies have been extensively studied.However,few studies have explored the suitability of passive solar heating technologies based on differentiated thermal comfo...Indoor thermal comfort and passive solar heating technologies have been extensively studied.However,few studies have explored the suitability of passive solar heating technologies based on differentiated thermal comfort demands.This work took the rural dwellings in Northwest China as the research object.First,the current indoor and outdoor thermal environment in winter and the mechanism of residents’differentiated demand for indoor thermal comfort were obtained through tests,questionnaires,and statistical analysis.Second,a comprehensive passive optimized design of existing buildings was conducted,and the validity of the optimized combination scheme was explored using DesignBuilder software.Finally,the suitability of passive solar heating technology for each region in Northwest China was analyzed based on residents’differentiated demand for indoor thermal comfort.The regions were then classified according to the suitability of the technology for these.The results showed that the indoor heating energy consumption was high and the indoor thermal environment was not ideal,yet the solar energy resources were abundant.Indoor comfort temperature indexes that match the functional rooms and usage periods were proposed.For the buildings with the optimized combination scheme,the average indoor temperature was increased significantly and the temperature fluctuation was decreased dramatically.Most regions in Northwest China were suitable for the development of passive solar heating technology.Based on the obtained suitability of the technology for the regions of Northwest China,these were classified into most suitable,more suitable,less suitable,and unsuitable regions.展开更多
A novel meroterpenoid,euphoractone(1),was isolated from the extracts of the roots of Euphorbia fischeriana Steud.Its structure was determined by spectroscopic methods and X-ray crystallography.1 possesses an unusual e...A novel meroterpenoid,euphoractone(1),was isolated from the extracts of the roots of Euphorbia fischeriana Steud.Its structure was determined by spectroscopic methods and X-ray crystallography.1 possesses an unusual ent-abietane-phloroglucinol skeleton.The plausible biosynthetic pathway for 1 was proposed.1 showed inhibitory activities against human lung cancer H23 and H460 cells with the IC_(50)values of 21.07±3.54 and 20.91±4.07 μmol/L.展开更多
A new cytotoxic salannin-class limonoid alkaloid, azadiramide A(1),was isolated from seeds of Azadirachta indica A. Juss. Its structure was elucidated by extensive analysis of spectroscopic data and quantum chemical...A new cytotoxic salannin-class limonoid alkaloid, azadiramide A(1),was isolated from seeds of Azadirachta indica A. Juss. Its structure was elucidated by extensive analysis of spectroscopic data and quantum chemical calculation. Compound 1 is a rare salannin-class limonoid alkaloid. To our best knowledge, only two compounds belonging to this type were so far found. It showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC_(50) value of 2.70±0.63 μmol/L.展开更多
A photoinduced reaction of potassium alkyltrifluoroborates,sulfur dioxide,and para-quinone methides under visible light irradiation at room temperature is developed,giving rise to diarylmethyl alkylsulfones in moderat...A photoinduced reaction of potassium alkyltrifluoroborates,sulfur dioxide,and para-quinone methides under visible light irradiation at room temperature is developed,giving rise to diarylmethyl alkylsulfones in moderate to good yields.This reaction works well under photocatalysis with a broad substrate scope by using DABCO·(SO_(2))_(2)as the source of sulfur dioxide.Mechanistic study shows that this transformation is initiated by alkyl radicals generated in situ from potassium alkyltrifluoroborates in the presence of photocatalyst.The subsequent insertion of sulfur dioxide and radical 1,6-addition of para-quinone methides with alkylsulfonyl radical intermediates afford the corresponding diarylmethyl alkylsulfones.展开更多
Four new limonoid-type nortriterpenoids, 1-detigloyl-1-O-methacryloylsalannin(1), 28-deoxo-2,3-dihydronimbolide(2), 12-acetoxy-3-O-acetyl-7-O-tigloylvilasinin(3) and 12-acetoxy-3-Oacetyl-7-O-methacryloylvilasinin(4), ...Four new limonoid-type nortriterpenoids, 1-detigloyl-1-O-methacryloylsalannin(1), 28-deoxo-2,3-dihydronimbolide(2), 12-acetoxy-3-O-acetyl-7-O-tigloylvilasinin(3) and 12-acetoxy-3-Oacetyl-7-O-methacryloylvilasinin(4), along with five known ones, were isolated from seeds of Azadirachta indica A. Juss. Their structures were elucidated by various spectroscopic methods, including UV, IR, MS, NMR, X-ray crystallography, quantum chemical calculation, as well as by comparison of their spectroscopic data with those reported. In the in vitro cytotoxic assay, 2 showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC_(50) value of 7.68±1.74 μmol/L, and 5 inhibited growth of human cervical cancer Hela cell line, melanoma A375 cell line and promyelocytic leukemia HL-60 cell line, with IC_(50) 12.00±2.08, 17.44±2.11, and 13.95±5.74 μmol/L, respectively.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.52078419 and 51678483)supported by the Doctoral Dissertation Innovation Fund of Xi’an University of Technology(310–252072116).
文摘Indoor thermal comfort and passive solar heating technologies have been extensively studied.However,few studies have explored the suitability of passive solar heating technologies based on differentiated thermal comfort demands.This work took the rural dwellings in Northwest China as the research object.First,the current indoor and outdoor thermal environment in winter and the mechanism of residents’differentiated demand for indoor thermal comfort were obtained through tests,questionnaires,and statistical analysis.Second,a comprehensive passive optimized design of existing buildings was conducted,and the validity of the optimized combination scheme was explored using DesignBuilder software.Finally,the suitability of passive solar heating technology for each region in Northwest China was analyzed based on residents’differentiated demand for indoor thermal comfort.The regions were then classified according to the suitability of the technology for these.The results showed that the indoor heating energy consumption was high and the indoor thermal environment was not ideal,yet the solar energy resources were abundant.Indoor comfort temperature indexes that match the functional rooms and usage periods were proposed.For the buildings with the optimized combination scheme,the average indoor temperature was increased significantly and the temperature fluctuation was decreased dramatically.Most regions in Northwest China were suitable for the development of passive solar heating technology.Based on the obtained suitability of the technology for the regions of Northwest China,these were classified into most suitable,more suitable,less suitable,and unsuitable regions.
基金financially supported by the National Natural Science Foundation of China(No.81673530)Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(No.2017BT01Y036)。
文摘A novel meroterpenoid,euphoractone(1),was isolated from the extracts of the roots of Euphorbia fischeriana Steud.Its structure was determined by spectroscopic methods and X-ray crystallography.1 possesses an unusual ent-abietane-phloroglucinol skeleton.The plausible biosynthetic pathway for 1 was proposed.1 showed inhibitory activities against human lung cancer H23 and H460 cells with the IC_(50)values of 21.07±3.54 and 20.91±4.07 μmol/L.
基金supported by grants from Thousand Young Talents Program of China and the National Natural Science Foundation of China (No. 81673530)
文摘A new cytotoxic salannin-class limonoid alkaloid, azadiramide A(1),was isolated from seeds of Azadirachta indica A. Juss. Its structure was elucidated by extensive analysis of spectroscopic data and quantum chemical calculation. Compound 1 is a rare salannin-class limonoid alkaloid. To our best knowledge, only two compounds belonging to this type were so far found. It showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC_(50) value of 2.70±0.63 μmol/L.
基金Financial support from the National Natural Science Foundation of China(Nos.22007017 and 21871053)the Talents'Startup Fund of Gannan Medical University(No.QD201831)+3 种基金the Education Bureau of Jiangxi Province(No.GJJ190799)the Research Fund of Gannan Medical University(No.ZD201905)the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2019R01005)the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(No.2020ZD04)。
文摘A photoinduced reaction of potassium alkyltrifluoroborates,sulfur dioxide,and para-quinone methides under visible light irradiation at room temperature is developed,giving rise to diarylmethyl alkylsulfones in moderate to good yields.This reaction works well under photocatalysis with a broad substrate scope by using DABCO·(SO_(2))_(2)as the source of sulfur dioxide.Mechanistic study shows that this transformation is initiated by alkyl radicals generated in situ from potassium alkyltrifluoroborates in the presence of photocatalyst.The subsequent insertion of sulfur dioxide and radical 1,6-addition of para-quinone methides with alkylsulfonyl radical intermediates afford the corresponding diarylmethyl alkylsulfones.
基金supported by grants from Thousand Young Talents Program of China and National Natural Science Foundation of China (No. 81673530)
文摘Four new limonoid-type nortriterpenoids, 1-detigloyl-1-O-methacryloylsalannin(1), 28-deoxo-2,3-dihydronimbolide(2), 12-acetoxy-3-O-acetyl-7-O-tigloylvilasinin(3) and 12-acetoxy-3-Oacetyl-7-O-methacryloylvilasinin(4), along with five known ones, were isolated from seeds of Azadirachta indica A. Juss. Their structures were elucidated by various spectroscopic methods, including UV, IR, MS, NMR, X-ray crystallography, quantum chemical calculation, as well as by comparison of their spectroscopic data with those reported. In the in vitro cytotoxic assay, 2 showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC_(50) value of 7.68±1.74 μmol/L, and 5 inhibited growth of human cervical cancer Hela cell line, melanoma A375 cell line and promyelocytic leukemia HL-60 cell line, with IC_(50) 12.00±2.08, 17.44±2.11, and 13.95±5.74 μmol/L, respectively.