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正电超分子手性介质的点击构筑及氨基酸高效拆分——化学实验课程思政探索与实践 被引量:1
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作者 杜延麒 李汝婧 +3 位作者 杨纪同 李媛 靳晓宁 王勇 《大学化学》 CAS 2023年第4期58-67,共10页
手性是生命的本质属性,分子手性与生命现象的精细调控息息相关。不同对映体药物的药理、毒理高度差异化。面对快速增长的手性药物市场,发展高效精准手性拆分策略,已成为当前医药领域的迫切需求。本实验面向新工科2.0,首次提出构建“手... 手性是生命的本质属性,分子手性与生命现象的精细调控息息相关。不同对映体药物的药理、毒理高度差异化。面对快速增长的手性药物市场,发展高效精准手性拆分策略,已成为当前医药领域的迫切需求。本实验面向新工科2.0,首次提出构建“手性拆分工坊”综合实验构想。利用点击化学绿色合成策略实现单正电环糊精的高效接枝,构筑正电超分子手性介质,探讨基于分子间弱相互作用的手性识别机制,藉此发展外消旋氨基酸衍生物的高效色谱手性拆分方法,优化手性色谱分离条件,获得丹磺酰氨基酸的精准拆分规律。实验立足新工科化学专业建设,涵盖绿色合成、仪器分析、物化机制和无机材料等基础化学知识,并融合前沿技术理论及产业应用,打造课程思政引导的化学专业人才培养新范式。 展开更多
关键词 正电环糊精 绿色点击化学 课程思政 化学实验
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Natural polymers-enhanced double-network hydrogel as wearable flexible sensor with high mechanical strength and strain sensitivity
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作者 Zhijie Zhao Xiao Fan +4 位作者 Shuoxuan Wang xiaoning jin Junjie Li Yuping Wei Yong Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第6期178-183,共6页
Conductive hydrogels have shown great prospects as wearable flexible sensors.Nevertheless,it is still a challenge to construct hydrogel-based sensor with great mechanical strength and high strain sensitivity.Herein,an... Conductive hydrogels have shown great prospects as wearable flexible sensors.Nevertheless,it is still a challenge to construct hydrogel-based sensor with great mechanical strength and high strain sensitivity.Herein,an ion-conducting hydrogel was fabricated by introducing gelatin-dialdehydeβ-cyclodextrin(Gel-DACD)into polyvinyl alcohol-borax(PVA-borax)hydrogel network.Natural Gel-DACD network acted as mechanical deformation force through non-covalent cross-linking to endow the polyvinyl alcoholborax/gelatin-dialdehydeβ-cyclodextrin hydrogel(PGBCDH)with excellent mechanical stress(1.35 MPa),stretchability(400%),toughness(1.84 MJ/m3)and great fatigue resistance(200%strain for 100 cycles).Surprisingly,PGBCDH displayed good conductivity of 0.31 S/m after adding DACD to hydrogel network.As sensor,it showed rapid response(168 ms),high strain sensitivity(gage factor(GF)=8.57 in the strain range of 200%-250%)and reliable sensing stability(100%strain for 200 cycles).Importantly,PGBCDHbased sensor can accurately monitor complex body movements(knee,elbow,wrist and finger joints)and large-scale subtle movements(speech,swallow,breath and facial expressions).Thus,PGBCDH shows great potential for human monitoring with high precision. 展开更多
关键词 Conductive hydrogel Double network GELATIN Dialdehydeβ-cyclodextrin Sensor
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A survey of autoencoder-based recommender systems 被引量:11
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作者 Guijuan ZHANG Yang LIU xiaoning jin 《Frontiers of Computer Science》 SCIE EI CSCD 2020年第2期430-450,共21页
In the past decade,recommender systems have been widely used to provide users with personalized products and services.However,most traditional recommender systems are still facing a challenge in dealing with the huge ... In the past decade,recommender systems have been widely used to provide users with personalized products and services.However,most traditional recommender systems are still facing a challenge in dealing with the huge volume,complexity,and dynamics of information.To tackle this challenge,many studies have been conducted to improve recommender system by integrating deep learning techniques.As an unsupervised deep learning method,autoencoder has been widely used for its excellent performance in data dimensionality reduction,feature extraction,and data reconstruction.Meanwhile,recent researches have shown the high efficiency of autoencoder in information retrieval and recommendation tasks.Applying autoencoder on recommender systems would improve the quality of recommendations due to its better understanding of users,demands and characteristics of items.This paper reviews the recent researches on autoencoder-based recommender systems.The differences between autoencoder-based recommender systems and traditional recommender systems are presented in this paper.At last,some potential research directions of autoencoder-based recommender systems are discussed. 展开更多
关键词 RECOMMENDER system autoencoder DEEP LEARNING DATA MINING
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