In this study,a new tannic acid adsorbent(ethylene glycol diglycidyl ether crosslinked tannic acid,TAEGDE)for adsorptive removal of dyes from water was prepared using EGDE as a cross-linking agent.The resultant TA-EGD...In this study,a new tannic acid adsorbent(ethylene glycol diglycidyl ether crosslinked tannic acid,TAEGDE)for adsorptive removal of dyes from water was prepared using EGDE as a cross-linking agent.The resultant TA-EGDE was in particulate form with rough surface morphology and a diameter ranging from 10 to 30μm.The adsorption performance of the TA-EGDE was evaluated in a flow-through mode using water samples contaminated with methylene blue(MB)and two-component mixed dyes,respectively.The TA-EGDE provided adsorption capacity up to 721.8 mg·g^(-1)at 65°C for MB.It showed a high removal efficiency(99%)of MB(50 mg·L^(-1))from the water sample and could recovery 90%of the adsorbed MB by eluting with acidic ethanol aqueous solution.The excellent adsorption of MB and neutral red on the TA-EGDE may be the result of the synergy of electrostatic interaction andπ-πinteraction.Furthermore,the TA-EGDE could separate dyes from water samples contaminated with twocomponent mixed dyes with a separation coefficient ranging from 1.8 to 36.5.The anionic TA-EGDE would be an effective adsorbent to remove and recycle dyes from the contaminated water.展开更多
This study aimed to evaluate the efficacy and safety of mycophenolate mofetil(MMF)or tacrolimus(TAC)compared with azathioprine(AZA)as maintenance therapy for active lupus nephritis(ALN).Patients with ALN who responded...This study aimed to evaluate the efficacy and safety of mycophenolate mofetil(MMF)or tacrolimus(TAC)compared with azathioprine(AZA)as maintenance therapy for active lupus nephritis(ALN).Patients with ALN who responded to 24 weeks of induction treatment were enrolled.Patients who received MMF or TAC as induction therapy continued MMF or TAC treatment during the maintenance period,whereas those who received intravenous cyclophosphamide were subjected to AZA treatment.The primary endpoint was the incidence of renal relapse.Secondary endpoints included extrarenal flares and composite endpoints(deaths,end-stage renal disease,or doubling of serum creatinine levels).A total of 123 ALN patients(47 in the MMF group,37 in the TAC group,and 39 in the AZA group)were enrolled.The median follow-up time was 60 months.Ten MMF-treated patients,ten TAC-treated patients,and eight AZA-treated patients experienced renal relapses(P=0.844).The cumulative renal relapse rates in the MMF group(P=0.934)and TAC group(P=0.673)were similar to the renal relapse rate in the AZA group.No significant difference in the incidence of severe adverse event was observed among the groups.Long-term maintenance therapies with MMF or TAC might have similarly low rates of renal relapse and similar safety profiles compared with AZA.展开更多
Good dispersibility of graphene in a medium or matrix is a critical issue in practical applications.In this work,graphene was functionalized using N-(4-hydroxyl phenyl)maleimide(4-HPM)via the Diels—Alder(DA)reaction ...Good dispersibility of graphene in a medium or matrix is a critical issue in practical applications.In this work,graphene was functionalized using N-(4-hydroxyl phenyl)maleimide(4-HPM)via the Diels—Alder(DA)reaction by a one-step catalyst-free approach.The optimal reaction condition was found to be 90℃for 12 h using dimethytformamide(DMF)as the solvent.FTIR,Raman spectroscopy,XPS and EDS proved that 4-HPM moieties were successfully grafted onto the surface of graphene.UVvis and TGA confirmed that the grafting amount of 4-HPM was 3.75%-3.97%based on the mass of graphene.Functionalized graphene showed excellent dispersion stability when dispersed in common solvents such as ethanol,DMF,water,tetrahydrofuran and pxylene.Meanwhile,functionalized graphene also exhibited pH sensitivity in aqueous due to the phenolic hydroxyls from the 4-HPM moieties.As a result of good dispersion stability and pH sensitivity,compared with graphene,functionalized graphene had better adsorption capacity for methylene blue(MB)from aqueous solution.展开更多
文摘In this study,a new tannic acid adsorbent(ethylene glycol diglycidyl ether crosslinked tannic acid,TAEGDE)for adsorptive removal of dyes from water was prepared using EGDE as a cross-linking agent.The resultant TA-EGDE was in particulate form with rough surface morphology and a diameter ranging from 10 to 30μm.The adsorption performance of the TA-EGDE was evaluated in a flow-through mode using water samples contaminated with methylene blue(MB)and two-component mixed dyes,respectively.The TA-EGDE provided adsorption capacity up to 721.8 mg·g^(-1)at 65°C for MB.It showed a high removal efficiency(99%)of MB(50 mg·L^(-1))from the water sample and could recovery 90%of the adsorbed MB by eluting with acidic ethanol aqueous solution.The excellent adsorption of MB and neutral red on the TA-EGDE may be the result of the synergy of electrostatic interaction andπ-πinteraction.Furthermore,the TA-EGDE could separate dyes from water samples contaminated with twocomponent mixed dyes with a separation coefficient ranging from 1.8 to 36.5.The anionic TA-EGDE would be an effective adsorbent to remove and recycle dyes from the contaminated water.
基金The present study was supported by the National Natural Science Foundation of China(No.81170671)Shanghai Health and Family Planning Committee Hundred Talents Program(No.2018BR37).
文摘This study aimed to evaluate the efficacy and safety of mycophenolate mofetil(MMF)or tacrolimus(TAC)compared with azathioprine(AZA)as maintenance therapy for active lupus nephritis(ALN).Patients with ALN who responded to 24 weeks of induction treatment were enrolled.Patients who received MMF or TAC as induction therapy continued MMF or TAC treatment during the maintenance period,whereas those who received intravenous cyclophosphamide were subjected to AZA treatment.The primary endpoint was the incidence of renal relapse.Secondary endpoints included extrarenal flares and composite endpoints(deaths,end-stage renal disease,or doubling of serum creatinine levels).A total of 123 ALN patients(47 in the MMF group,37 in the TAC group,and 39 in the AZA group)were enrolled.The median follow-up time was 60 months.Ten MMF-treated patients,ten TAC-treated patients,and eight AZA-treated patients experienced renal relapses(P=0.844).The cumulative renal relapse rates in the MMF group(P=0.934)and TAC group(P=0.673)were similar to the renal relapse rate in the AZA group.No significant difference in the incidence of severe adverse event was observed among the groups.Long-term maintenance therapies with MMF or TAC might have similarly low rates of renal relapse and similar safety profiles compared with AZA.
基金the National Natural Science Foundation of China(Grant No.51573211)for financial support.
文摘Good dispersibility of graphene in a medium or matrix is a critical issue in practical applications.In this work,graphene was functionalized using N-(4-hydroxyl phenyl)maleimide(4-HPM)via the Diels—Alder(DA)reaction by a one-step catalyst-free approach.The optimal reaction condition was found to be 90℃for 12 h using dimethytformamide(DMF)as the solvent.FTIR,Raman spectroscopy,XPS and EDS proved that 4-HPM moieties were successfully grafted onto the surface of graphene.UVvis and TGA confirmed that the grafting amount of 4-HPM was 3.75%-3.97%based on the mass of graphene.Functionalized graphene showed excellent dispersion stability when dispersed in common solvents such as ethanol,DMF,water,tetrahydrofuran and pxylene.Meanwhile,functionalized graphene also exhibited pH sensitivity in aqueous due to the phenolic hydroxyls from the 4-HPM moieties.As a result of good dispersion stability and pH sensitivity,compared with graphene,functionalized graphene had better adsorption capacity for methylene blue(MB)from aqueous solution.
