Revealing the interlaminar shear failure behavior of unidirectional laminate under combined compression-shear loads

Due to the coupling effects between stresses in different directions,the mechanical behavior of an ad-vanced composite material under multiaxial loading is extremely complex.In this study,the influence of through-thickness compressive stress on the interlaminar shear performance of a carbon fiber-reinforced composite was experimentally investigated.Hollow cylindrical unidirectional laminate specimens were fabricated to conduct combined compression-shear tests,and the fracture morphologies of the specimens were characterized to reveal their failure behavior.The results indicate that a moderate compression load significantly enhanced the shear properties of the laminate by inhibiting crack propagation and improv-ing the friction effect.The shear strength and modulus of a laminate specimen subjected to combined stresses improved up to a maximum of 76%and 231%,respectively,over those of an equivalent specimen subjected to pure shear.However,as the applied through-thickness load approached the compressive strength of the laminate,the specimen shear capacity began to decline owing to the transition of frac-ture mechanisms.Indeed,the specimens exhibited mixed failure modes corresponding to the different stress states,which were induced by the combined effects of through-thickness compressive and shear stresses.As the applied through-thickness compressive stress increased,the dominant failure mode of the laminate specimen changed from fiber-matrix debonding to fiber shearing and then to fiber break-age,resulting in various shear performances.

Study of thermo-fluidic characteristics for geometric-anisotropy Kagome truss-cored lattice

The aim of this paper is to provide a comprehensive comparison of the thermal insulation and heat transfer performance for Kagome truss-cored lattice along two perpendicular orientations OA and OB. Three test conditions are conducted under forced air convection for the titanium sandwich panel fabricated by 3 D printing technology. The thermo-fluidic characteristics are further explored by numerical simulation to reveal the underlying mechanisms of heat transfer enhancement.The results indicate that the orientation OB exhibits better thermal insulation than orientation OA under the identical temperature loading, while the latter outperforms the former by up to 20% higher overall heat transfer performance. In particular, the endwalls and lattice core in orientation OA achieve 9.7% and 22.5% higher area-averaged Nusselt number respectively than that in orientation OB for a given Reynolds number. The heat transfer superiority of orientation OA comes from the unique topology which induces the large scale spiral primary flows, facilitating the heat exchange between the cooling air and the surfaces of sandwich panel. However, the complex flow mixing leads to a maximum of 20% higher friction factor in orientation OA than that in orientation OB.

TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2

Tripartite motif(TRIM)family proteins are important effectors of innate immunity against viral infections.Here we identified TRIM35 as a regulator of TRAF3 activation.Deficiency in or inhibition of TRIM35 suppressed the production of type I interferon(IFN)in response to viral infection.777m35-deficient mice were more susceptible to influenza A virus(IAV)infection than were wild-type mice.TRIM35 promoted the RIG-Imediated signaling by catalyzing Lys63-linked polyubiquitination of TRAF3 and the subsequent formation of a signaling complex with VISA and TBK1.IAV PB2 polymerase countered the innate antiviral immune response by impeding the Lys63-linked polyubiquitination and activation of TRAF3.TRIM35 mediated Lys48-linked polyubiquitination and proteasomal degradation of IAV PB2,thereby antagonizing its suppression of TRAF3 activation.Our in vitro and in vivo findings thus reveal novel roles of TRIM35,through catalyzing Lys63-or Lys48-linked polyubiquitination,in RIG-I antiviral immunity and mechanism of defense against IAV infection.

Opposite effects of miR-155 in the initial and later stages of lipopolysaccharide(LPS)-induced inflammatory response

Although microRNA-155(miR-155)is considered a pro-inflammatory mediator,cumulative evidence indicates that it also has anti-inflammatory effects in macrophages and dendritic cells.In this study,we identified the dramatic expression changes of more than half of potential miR-155-targeted genes upon lipopolysaccharide(LPS)stimulation;223 genes were down-regulated and 85 genes were up-regulated,including suppressor of cytokine signaling 1(SOCS1)and transforming growth factor-β-activated kinase 1-binding protein 2(TAB2),two well-known genes involved in miR-155-mediated regulation of the Toll-like receptor 4(TLR4)signaling pathway.We also found that miR-155 acted as an anti-inflammatory mediator in the initial stage of LPS-induced inflammatory response mainly through repressing TAB2 protein translation,and as a proinflammatory mediator by down-regulating SOCS1 in the later stage.Meanwhile,overexpression of TAB23'untranslated region(UTR)in macrophages promoted the development of endotoxin tolerance by competing for binding with miR-155,which resulted in an elevated expression level of SOCS1 protein.These findings provide new insights for understanding the regulatory mechanisms in fine-tuning of LPS-induced innate immune response.

Non-Fourier heat conduction analysis of a 2-D plate with inner cracks at arbitrary direction angles

This paper investigates the problem of a 2-D plate containing internal cracks at arbitrary angles to the heating surface under thermal shock.The finite difference method is applied to solve the temperature distribution and a difference scheme of the oblique crack is developed.For the first time,a non-Fourier heat transfer analysis method of a 2-D plate with inner cracks at arbitrary direction angles is established.Specifically,for a strip with an inner crack paralleling to the surface,numerical results are compared with the analytical solutions by rotating the boundary,and perfect agreement is obtained.Numerical experiments are further presented to investigate the influence of crack orientation angle and multi-crack distribution on non-Fourier heat conduction.