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不同转移部位的非小细胞肺癌患者的生存时间比较 被引量:37
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作者 吴炳群 魏慎海 +3 位作者 田进涛 宋小平 胡鹏程 崔永 《中国肺癌杂志》 CAS CSCD 北大核心 2019年第2期105-110,共6页
背景与目的肺癌是全球范围内发病率和死亡率最高的恶性肿瘤,导致其高病死率的主要原因是局部复发和远处转移,而转移部位对患者的预后有一定预测作用,本研究旨在比较不同远处转移部位的非小细胞肺癌(non-small cell lung cancer, NSCLC)... 背景与目的肺癌是全球范围内发病率和死亡率最高的恶性肿瘤,导致其高病死率的主要原因是局部复发和远处转移,而转移部位对患者的预后有一定预测作用,本研究旨在比较不同远处转移部位的非小细胞肺癌(non-small cell lung cancer, NSCLC)患者的生存时间。方法从美国监测、流行病学和最终结果(Surveillance, Epidemiology, and End Result, SEER)数据库中提取出2010年-2014年间确诊的NSCLC患者共117,542例,回顾性分析其远处转移部位与生存时间的关系。结果在确诊的117,542例NSCLC患者中,42,071例(35.8%)患者病史中发生不同程度的远处转移,其中单器官转移26,932例,多器官转移15,139例,分别占转移患者总数的64.0%和36.0%。病史中无转移的患者的中位生存时间是21个月;而在病史中有转移患者中,中位生存时间分别是7个月(肺)、6个月(脑)、5个月(骨)、4个月(肝)、3个月(多器官转移),差异显著(P<0.001,肝转移与多器官转移除外P=0.650);且绝大多数NSCLC患者(88.4%)最终死于肺癌。结论 NSCLC患者远处转移提示预后差,在单器官转移患者中,肺转移预后最佳,肝转移预后最差;多器官转移患者预后差于单器官转移。 展开更多
关键词 肺肿瘤 转移 中位生存时间
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Model Predictive Yaw Control Using Fuzzy-Deduced Weighting Factor for Large-Scale Wind Turbines
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作者 Shuowang Zhang Lingxiang Huang +3 位作者 Dongran song Ke Xu Xuebing Yang xiaoping song 《Energy Engineering》 EI 2021年第2期237-250,共14页
Yaw control system plays an important role in helping large-scale horizontal wind turbines capture the wind energy.To track the stochastic and fast-changing wind direction,the nacelle is rotated by the yaw control sys... Yaw control system plays an important role in helping large-scale horizontal wind turbines capture the wind energy.To track the stochastic and fast-changing wind direction,the nacelle is rotated by the yaw control system.Therein,a difficulty consists in the variation speed of the wind direction much faster than the rotation speed of the nacelle.To deal with this difficulty,model predictive control has been recently proposed in the literature,in which the previewed wind direction is employed into the predictive model,and the estimated captured energy and yaw actuator usage are two contradictive objectives.Since the performance of the model predictive control strat-egy relies largely on the weighting factor that is designed to balance the two objectives,the weighting factor should be carefully selected.In this study,a fuzzy-deduced scheme is proposed to derive the weighting factor of the mod-el predictive yaw control.For the proposed fuzzy-deduced strategy,the variation degree and the increment of the wind direction during the predictive horizon are used as the inputs,and the weighting factor is the output,which is dynamically adjusted.The proposed model predictive yaw control is demonstrated by some simulations using real wind data and its performance is compared with the conventional model predictive control with thefixed weighting factor.Comparison results confirm the outweighing performance of the proposed control strategy over the conventional one. 展开更多
关键词 Wind turbine yaw control weighting factor fuzzy logic control
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Cardiac-Adaptive Conductive Hydrogel Patch Enabling Construction of Mechanical–Electrical Anisotropic Microenvironment for Heart Repair
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作者 xiaoping song Jifeng Zhang +8 位作者 Si Shen Dan Liu Jie Zhang Wenming Yin Genlan Ye Leyu Wang Liu Cai Honghao Hou Xiaozhong Qiu 《Research》 SCIE EI CSCD 2024年第1期489-507,共19页
The biomimetic construction of a microstructural–mechanical–electrical anisotropic microenvironment adaptive to the native cardiac tissue is essential to repair myocardial infarction(MI).Inspired by the 3D anisotrop... The biomimetic construction of a microstructural–mechanical–electrical anisotropic microenvironment adaptive to the native cardiac tissue is essential to repair myocardial infarction(MI).Inspired by the 3D anisotropic characteristic of the natural fish swim bladder(FSB),a novel flexible,anisotropic,and conductive hydrogel was developed for tissue-specific adaptation to the anisotropic structural,conductive,and mechanical features of the native cardiac extracellular matrix.The results revealed that the originally stiff,homogeneous FSB film was tailored to a highly flexible anisotropic hydrogel,enabling its potential as a functional engineered cardiac patch(ECP).In vitro and in vivo experiments demonstrated the enhanced electrophysiological activity,maturation,elongation,and orientation of cardiomyocytes(CMs),and marked MI repair performance with reduced CM apoptosis and myocardial fibrosis,thereby promoting cell retention,myogenesis,and vascularization,as well as improving electrical integration.Our findings offer a potential strategy for functional ECP and provides a novel strategy to bionically simulate the complex cardiac repair environment. 展开更多
关键词 BLADDER thereby PATCH
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基因拷贝数对重组毕赤酵母产谷氨酰胺转胺酶的影响 被引量:2
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作者 宋小平 王雅洁 +3 位作者 蔡晶晶 余银 管利 张宇亭 《生物工程学报》 CAS CSCD 北大核心 2020年第8期1679-1688,共10页
基于毕赤酵母核糖体DNA序列(rDNA),构建多拷贝谷氨酰胺转胺酶基因表达载体pPICZα-rDNAmtg,并转化到表达前导肽(Pro peptide或pro)的宿主菌pGAP9-pro/GS115,得到共表达菌株pro/rDNA-mtg(GS115)。实时荧光定量PCR(qPCR)分析了4株阳性表... 基于毕赤酵母核糖体DNA序列(rDNA),构建多拷贝谷氨酰胺转胺酶基因表达载体pPICZα-rDNAmtg,并转化到表达前导肽(Pro peptide或pro)的宿主菌pGAP9-pro/GS115,得到共表达菌株pro/rDNA-mtg(GS115)。实时荧光定量PCR(qPCR)分析了4株阳性表达菌株中mtg基因拷贝数,进一步研究了不同基因拷贝数对重组毕赤酵母产酶的影响及高产菌株在3 L发酵罐高密度发酵。结果表明,被检测的4株阳性表达菌株中mtg拷贝数分别为2.21、3.36、5.72和7.62(mtg-2c、mtg-3c、mtg-6c和mtg-8c),其发酵产酶能力和蛋白质表达水平为mtg-3c>mtg-2c>mtg-6c>mtg-8c;高密度发酵较低和较高拷贝数的两株菌mtg-3c和mtg-6c,发酵上清的最高酶活和单位菌体酶活分别为3.12U/mL、52.1U/g湿重和2.07U/mL、36.5U/g湿重,其中单位菌体酶活mtg-3c是mtg-6c的1.4倍;mtg-3c纯化酶的最高酶活达到7.21 U/mL,蛋白浓度为437.2μg/mL。通过分析拷贝数对重组毕赤酵母产酶的影响,发现mtg-3c适合pro/rDNA-mtg中pro和mtg共表达,MTG高酶活与菌株较高分泌蛋白有关。 展开更多
关键词 基因拷贝数 毕赤酵母 谷氨酰胺转胺酶 核糖体DNA
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蓝花黄芩内生真菌Aspergillus terreus HQ100X-1次级代谢产物研究
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作者 黄丹 农旭华 +7 位作者 杨建妮 李琛 韩长日 陈光英 宋小平 孙振范 惠阳 陈文豪 《有机化学》 SCIE CAS CSCD 北大核心 2022年第9期2961-2966,共6页
从蓝花黄芩内生真菌土曲霉(Aspergillusterreus)HQ100X-1发酵产物中分离得到2个新化合物[terrustone(1)和asperteretone G (2)], 10个已知化合物(3~12), terrustone (1)为具有4个连续手性中心的三羟基环戊酮类化合物,它们的结构以及绝... 从蓝花黄芩内生真菌土曲霉(Aspergillusterreus)HQ100X-1发酵产物中分离得到2个新化合物[terrustone(1)和asperteretone G (2)], 10个已知化合物(3~12), terrustone (1)为具有4个连续手性中心的三羟基环戊酮类化合物,它们的结构以及绝对构型是通过1D/2D NMR结合电子圆二色谱(ECD)计算来确定.抗菌实验表明,化合物rbrolide R (4)对金黄色葡萄球菌有一定的抑菌活性,其最低抑菌浓度(MIC)值为2.5μg/mL. 展开更多
关键词 蓝花黄芩 土曲霉(Aspergillus terreus) 抗菌活性
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Lithium-assisted exfoliation of pristine graphite for few-layer graphene nanosheets 被引量:5
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作者 Minwei Xu Huiting Sun +4 位作者 Cai Shen Sen Yang Wenxiu Que Yin Zhang xiaoping song 《Nano Research》 SCIE EI CAS CSCD 2015年第3期801-807,共7页
一条帮助锂的途径为太古的石墨的脱落被开发了,它允许很少层 graphene nanosheets 的大规模准备。这个过程包含意外物理插入和脱落,和这个方法准备的 graphene nanosheets 揭示没受到干扰的 sp < 啜 class= “ a-plus-plus ” >... 一条帮助锂的途径为太古的石墨的脱落被开发了,它允许很少层 graphene nanosheets 的大规模准备。这个过程包含意外物理插入和脱落,和这个方法准备的 graphene nanosheets 揭示没受到干扰的 sp < 啜 class= “ a-plus-plus ” > 2 </sup>-hybridized 结构。可能的二拍子的圆舞机制,包含在石墨层和一个随后的 lithiation 过程的边附近被套住的否定费用,被建议在石墨夹层内解释锂的插入。如果必要,现在的脱落能被重复并且更薄(单身者或 23 层) graphene 能在大规模上被完成。这个简单过程为太古的石墨的脱落提供一个有效过程,它可能支持 graphene 的未来应用程序。 展开更多
关键词 石墨层 锂化 薄片 去角质 大规模制备 杂交结构 SP2 负电荷
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Formation process of akaganeite in the simulated wet-dry cycles atmospheric environment 被引量:2
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作者 Haigang Xiao Wei Ye +2 位作者 xiaoping song Yuantai Ma Ying Li 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2018年第8期1387-1396,共10页
In order to clarify the formation mechanism and conditions for akaganeite in long-term exposure, the influence of the former corrosion results on akaganeite formation was investigated by simulated experi- ments in lab... In order to clarify the formation mechanism and conditions for akaganeite in long-term exposure, the influence of the former corrosion results on akaganeite formation was investigated by simulated experi- ments in laboratory. The combination of XRD, FTIR, SEM and EPMA enabled the identification of the rust layer formed on the surface. Accordingly, the nature of the rust layer and the amount of the corrosive species in the rust layer varied with the extension of the exposure. Among them, comparing with the corrosion condition in initial stage, the structure of rust layer after repeated wet-dry cycles was disad- vantage for akaganeite formation. Element CI aggregated at the interface between rust and substrate in the thick part can participate in the formation of akaganeite after the rust layer covered removed. The accumulation effect of salt deposited contributed to akaganeite formation under the condition that salt deposition rate was relatively low. 展开更多
关键词 Carbon steel Atmospheric corrosion Corrosion products Chloride ions
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