Clinical significance of elevation of serum CA125 level in patients with metastatic bladder carcinoma

Objective： To explore the clinical significance of the examination of serum CA125 level of patients with metastatic bladder carcinoma. Methods： Electrochemiluminescence technique was used to examine the serum CA125 concentration of 58 cases with metastatic bladder cancer. 30 cases of superficial bladder cancer and 8 cases of other urological diseases were collected as the control group. Results： Serum CA125 level in 39 （67.2%） out of 58 cases ranged from 36.7 U/mL to 1485.6 U/mL （mean 496.3 U/mL）, being higher than normal （〈 35 U/mL）. Serum CA125 level of metastatic bladder cancer patients was 324.5 U/mL, significantly higher than that in control group （P 〈 0.001）. Serum CA125 level of 10 patients after transurethral resection operation was significantly lower than that before operation （P 〈 0.05）. Serum CA125 level of 16 patients who refused further treatment significantly increased from 450.4 U/mL, to 505.8 U/mL （P = 0.041） 3 months after discharge from the hospital. Serum CA125 level of 17 patients significantly decreased from 475.8 U/L to 237.9 U/mL （P 〈 0.001 ） after bilateral iliac-artedal embolism treatment. Conclusion： CA125 may be a valuable marker for the judgment of advanced metastatic bladder cancer.

Present and future of functionalized Cu current collectors for stabilizing lithium metal anodes

Li metal has been recognized as the most promising anode materials for next-generation high-energy-density batteries,however,the inherent issues of dendrite growth and huge volume fluctuations upon Li plating/stripping normally result in fast capacity fading and safety concerns.Functionalized Cu current collectors have so far exhibited significant regulatory effects on stabilizing Li metal anodes(LMAs),and hold a great practical potential owing to their easy fabrication,low-cost and good compatibility with the existing battery technology.In this review,a comprehensive overview of Cu-based current collectors,including planar modified Cu foil,3D architectured Cu foil and nanostructured 3D Cu substrates,for Li metal batteries is provided.Particularly,the design principles and strategies of functionalized Cu current collectors associated with their functionalities in optimizing Li plating/stripping behaviors are discussed.Finally,the critical issues where there is incomplete understanding and the future research directions of Cu current collectors in practical LMAs are also prospected.This review may shed light on the critical understanding of current collector engineering for high-energy-density Li metal batteries.

Nutrition and Health Monitoring and Evaluation of the NIPRCES in China

Good nutritional status in childhood serves as the foundation for lifelong health.Malnutrition during childhood can not only impede children’s growth and development,but also lead to a higher incidence of chronic diseases in adulthood,thereby increasing the socioeconomic burden.In order to improve the nutritional and health status of children living in economically underdeveloped rural areas,the Chinese government implemented the Nutrition Improvement Program for Rural Compulsory Education Students(NIPRCES)in November 2011(1).The central government provides nutritional meal subsidies to rural compulsory education students in underdeveloped counties.Initially,NIPRCES covered rural area of 699 national pilot counties across 22 provincial-level administrative divisions(PLADs)in the central and western regions of China.By 2021,the program expanded to encompass 727 national pilot counties and 1,010 local pilot counties spanning 28 provinces in the eastern,central,and western regions of China,serving more than 36 million students.

互不挖角协议的垄断风险与管理:以企业反垄断合规为视角

竞业限制已经无法解决企业间互相挖角引发的人才争夺难题,为了避免同行业恶意挖角,互不挖角协议成为企业间控制人才流失、抑制用工成本的创新方式。但互不挖角协议带来的限制人才、阻碍人力资源市场自由竞争问题受到各国反垄断执法机构重点关注。互不挖角协议在形式上有纯粹型与附属型之别,在反垄断法律属性上有合法与违法之异,构成垄断协议与滥用市场支配地位是其主要法律风险。各国对具有排除、限制竞争效果的互不挖角协议处罚严厉,风险外溢时企业往往难以承担高额罚款甚至刑事责任。企业要洞悉互不挖角协议的合规风险重点,完善企业反垄断合规制度对风险进行管理。发挥政府监管对企业合规的激励作用,以最终实现企业人力资源市场的健康有序发展。

Advances in the Emerging Gradient Designs of Li Metal Hosts

Developing host has been recognized a potential countermeasure to circumvent the intrinsic drawbacks of Li metal anode(LMA),such as uncontrolled dendrite growth,unstable solid electrolyte interface,and infinite volume fluctuations.To realize proper Li accommodation,particularly bottom-up deposition of Li metal,gradient designs of host materials including lithiophilicity and/or conductivity have attracted a great deal of attention in recent years.However,a critical and specialized review on this quickly evolving topic is still absent.In this review,we attempt to comprehensively summarize and update the related advances in guiding Li nucleation and deposition.First,the fundamentals regarding Li deposition are discussed,with particular attention to the gradient design principles of host materials.Correspondingly,the progress of creating diferent gradients in terms of lithiophilicity,conductivity,and their hybrid is systematically reviewed.Finally,future challenges and perspective on the gradient design of advanced hosts towards practical LMAs are provided,which would provide a useful guidance for future studies.