Analyzing the Combination Effects of Repetitive Transcranial Magnetic Stimulation and Motor Control Training on Balance Function and Gait in Patients with Stroke-Induced Hemiplegia

Objective:To analyze the effects of repetitive transcranial magnetic stimulation combined with motor control training on the treatment of stroke-induced hemiplegia,specifically focusing on the impact on patients’balance function and gait.Methods:Fifty-two cases of hemiplegic stroke patients were randomly divided into two groups,26 in the control group and 26 in the observation group,using computer-generated random grouping.All participants underwent conventional treatment and rehabilitation training.In addition to these,the control group received repetitive transcranial magnetic pseudo-stimulation therapy+motor control training,while the observation group received repetitive transcranial magnetic stimulation therapy+motor control training.The balance function and gait parameters of both groups were compared before and after the interventions and assessed the satisfaction of the interventions in both groups.Results:Before the invention,there were no significant differences in balance function scores and each gait parameter between the two groups(P>0.05).However,after the intervention,the observation group showed higher balance function scores compared to the control group(P<0.05).The observation group also exhibited higher step speed and step frequency,longer step length,and a higher overall satisfaction level with the intervention compared to the control group(P<0.05).Conclusion:The combination of repetitive transcranial magnetic stimulation and motor control training in the treatment of stroke-induced hemiplegia has demonstrated positive effects.It not only improves the patient’s balance function and gait but also contributes to overall physical rehabilitation.

Study on the Effect of Repetitive Peripheral Magnetic Stimulation Combined with Conventional Rehabilitation Measures on Shoulder Dysfunction in Early Stroke

Objective:To study the effect of repetitive peripheral magnetic stimulation(rPMS)combined with conventional rehabilitation measures on shoulder dysfunction in early stroke.Methods:60 patients with shoulder dysfunction in early stroke were selected,and all of them were admitted to our hospital from August 2021 to August 2023.The patients were randomly grouped into a control group(conventional rehabilitation measures intervention,30 cases)and an intervention group(rPMS and conventional rehabilitation measures intervention,30 cases)according to the lottery method.The pain scores,shoulder mobility,and motor function scores of the two groups were compared.Results:The pain score was lower in the intervention group,and the shoulder mobility and motor function scores were higher in the intervention group(P<0.05)as compared to that of the control group.Conclusion:The effect of combining rPMS and conventional rehabilitation measures in treating shoulder dysfunction in early stroke was remarkable and should be popularized.

Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma

Objective:Pancreatic ductal adenocarcinoma(PDAC)is a highly malignant gastrointestinal cancer with a 5-year survival rate of only 9%.Of PDAC patients,15%-20%are eligible for radical surgery.Gemcitabine is an important chemotherapeutic agent for patients with PDAC;however,the efficacy of gemcitabine is limited due to resistance.Therefore,reducing gemcitabine resistance is essential for improving survival of patients with PDAC.Identifying the key target that determines gemcitabine resistance in PDAC and reversing gemcitabine resistance using target inhibitors in combination with gemcitabine are crucial steps in the quest to improve survival prognosis in patients with PDAC.Methods:We constructed a human genome-wide CRISPRa/dCas 9 overexpression library in PDAC cell lines to screen key targets of drug resistance based on sgRNA abundance and enrichment.Then,co-IP,ChIP,ChIP-seq,transcriptome sequencing,and qPCR were used to determine the specific mechanism by which phospholipase D1(PLD1)confers resistance to gemcitabine.Results:PLD1 combines with nucleophosmin 1(NPM1)and triggers NPM1 nuclear translocation,where NPM1 acts as a transcription factor to upregulate interleukin 7 receptor(IL7R)expression.Upon interleukin 7(IL-7)binding,IL7R activates the JAK1/STAT5 signaling pathway to increase the expression of the anti-apoptotic protein,BCL-2,and induce gemcitabine resistance.The PLD1 inhibitor,Vu0155069,targets PLD1 to induce apoptosis in gemcitabine-resistant PDAC cells.Conclusions:PLD1 is an enzyme that has a critical role in PDAC-associated gemcitabine resistance through a non-enzymatic interaction with NPM1,further promoting the downstream JAK1/STAT5/Bcl-2 pathway.Inhibiting any of the participants of this pathway can increase gemcitabine sensitivity.

Hybrid Seasonal Prediction of Meridional Temperature Gradient Associated with“Warm Arctic-Cold Eurasia”

The meridional gradient of surface air temperature associated with“Warm Arctic–Cold Eurasia”(GradTAE)is closely related to climate anomalies and weather extremes in the mid-low latitudes.However,the Climate Forecast System Version 2(CFSv2)shows poor capability for GradTAE prediction.Based on the year-to-year increment approach,analysis using a hybrid seasonal prediction model for GradTAE in winter(HMAE)is conducted with observed September sea ice over the Barents–Kara Sea,October sea surface temperature over the North Atlantic,September soil moisture in southern North America,and CFSv2 forecasted winter sea ice over the Baffin Bay,Davis Strait,and Labrador Sea.HMAE demonstrates good capability for predicting GradTAE with a significant correlation coefficient of 0.84,and the percentage of the same sign is 88%in cross-validation during 1983−2015.HMAE also maintains high accuracy and robustness during independent predictions of 2016−20.Meanwhile,HMAE can predict the GradTAE in 2021 well as an experiment of routine operation.Moreover,well-predicted GradTAE is useful in the prediction of the large-scale pattern of“Warm Arctic–Cold Eurasia”and has potential to enhance the skill of surface air temperature occurrences in the east of China.

Construction of phosphorus-doping with spontaneously developed selenium vacancies: Inducing superior ion-diffusion kinetics in hollow Cu_(2)Se@C nanospheres for efficient sodium storage

Achieving high-efficiency sodium storage in metal selenides is still severely constrained in consideration of their inferior electronic conductivity and inadequate Na^(+)insertion pathways and active sites.Heteroatom doping accompanied by spontaneously developed lattice defects can effectively tune electronic structure of metal selenides,which give a strong effect to motivate fast charge transfer and Na^(+)accessibility.Herein,we finely designed and successfully constructed a fascinating phosphorus-doped Cu_(2)Se@C hollow nanosphere with abundant vacancy defects(Cu_(2)P_(x)Se_(1-x)@C)through a combination strategy of selenization of Cu_(2)O nanosphere template,self-polymerization of dopamine,and subsequent phosphorization treatment.Such exquisite composite possesses enriched active sites,superior conductivity,and sufficient Na^(+)insertion channel,which enable much faster Na^(+)diffusion rates and more remarkable pseudocapacitive features,Satisfyingly,the Cu_(2)P_(x)Se_(1-x)@C composites manifest the supernormal sodium-storage capabilities,that is,a reversible capacity of 403.7 mA h g^(-1) at 1.0 A g^(-1) over 100 cycles,and an ultrastable cyclic lifespan over 1000 cycles at 20.0 A g^(-1) with a high capacity-retention of about249.7 mA h g^(-1).The phase transformation of the Cu_(2)P_(x)Se_(1-x)@C involving the intercalation of Na^(+)into Cu_(2)Se and the following conversion of NaCuSe to Cu and Na2Se were further demonstrated through a series of ex-situ characterization methods.DFT results demonstrate that the coexistence of phosphorusdoping and vacancy defects within Cu_(2)Se results in the reduction of Na^(+)adsorption energy from-1.47to-1.56 eV improving the conductivity of Cu_(2)Se to further accelerate fast Na^(+)mobility.

SIRT4通过抑制GLS2表达增强肝细胞癌对索拉菲尼敏感性的研究

目的:探索Sirtuin4(SIRT4)调控肿瘤谷氨酰胺代谢的机制,明确SIRT4对肝癌细胞干性及索拉菲尼治疗敏感性的影响。方法:通过实时定量PCR(real-time quantitative reverse transcription PCR,qRT-PCR)和免疫组织化学染色检测SIRT4在肝癌中的m RNA和蛋白表达水平。免疫印迹及细胞成球实验检测肿瘤细胞干性,细胞计数实验(CCK-8)和平板克隆实验检测肝癌细胞索拉菲尼治疗敏感性。免疫共沉淀检测SIRT4对蛋白的去乙酰化作用。结果:在肝癌的临床样本组织和细胞系中,SIRT4的表达显著低于癌旁组织和正常肝细胞。在体外实验中,过表达SIRT4能够明显降低肝癌细胞的成球数量(P<0.01)和干性标志物表达,并使索拉菲尼治疗的肝癌细胞克隆数和OD_(450)值进一步下降(均P<0.01)。机制研究表明,SIRT4通过去乙酰化降低谷氨酰胺合成酶2(glutamine synthase 2,GLS2)的表达,进而抑制肝癌细胞中谷氨酰胺的分解代谢,从而调节肝癌细胞的干性和对索拉菲尼的敏感性。结论:SIRT4在肝癌组织中表达显著降低,能够通过降低谷氨酰胺分解代谢,进而抑制肝癌细胞的干性并增强其对索拉菲尼的敏感性。

Significantly enhanced ion-migration and sodium-storage capability derived by strongly coupled dual interfacial engineering in heterogeneous bimetallic sulfides with densified carbon matrix

The development of highly efficient sodium-ion batteries depends critically on the successful exploitation of advanced anode hosts that is capable of overcoming sluggish reaction kinetics while also withstanding severe structural deformation triggered by the large radius of Na^(+)-insertion.Herein,a hierarchically hybrid material with hetero-Co_(3)S_(4)/NiS hollow nanosphere packaged into a densified N-doped carbonmatrix(Co_(3)S_(4)/NiS@N-C)was designed and fabricated utilizing CoNi-glycerate as the self-sacrifice template,making the utmost of the synergistic effect of hetero-Co_(3)S_(4)/NiS with strong electric field and rich reaction active-sites together with the densified outer-carbon scaffolds with remarkable electronic conductivity and robust mechanical toughness.As anticipated,as-fabricated Co_(3)S_(4)/NiS@N-C anode affords remarkable specific capacity,prolonged cycle lifespan up to 2400 cycles with an only 0.05%fading each cycle at 20.0 A g^(−1),and excellent rate feature(354.9 mAh g^(−1)at 30.0 A g^(−1)),one of the best performances for most existing Co_(3)S_(4)/NiS-based anodes.Ex situ structural characterizations in tandem with theoretical analysis demonstrate the reversible insertion-conversion mechanism of initially proceeding with Na^(+)de-/intercalation and superior heterogeneous interfacial reaction behavior with strong Na^(+)-adsorption ability.Further,sodium-ion full cell and hybrid capacitor based on Co_(3)S_(4)/NiS@N-C anode exhibit impressive electrochemical characteristics on cycling performance and rate capability,showcasing its outstanding feasibility toward practical use.

Psychological Analysis of Adolescent Internet Addiction

The rapid development of the network had a huge psychological impact on people＇ s life, ideas, and especially makes prominent phenomenon of mental disorder with the network, it has become attention of sociology, psychology, research of clinical industry. In recent years, research on the phenomenon of Internet addiction focused on qualitative descriptions and study of the theoretical phenomenon, their research focused on the popularity of the first network, the U.S. conducted the most extensive study and makes more online survey. China started this study later, and lack of systematic research on the network psychology, which just mostly understanding the aspect of the phenomenon and countermeasures of stating intemet addiction, or to explore from a single aspect （such as： age, gender, etc.）, it lack of theoretical studies of the psychological mechanisms and motives behind the addictive behavior on the network.

Meteorological influences on co-occurrence of O_(3) and PM_(2.5)pollution and implication for emission reductions in Beijing-Tianjin-Hebei

Co-occurrence of surface ozone(O_(3))and fine particulate matter(PM_(2.5))pollution(CP)was frequently observed in Beijing-Tianjin-Hebei(BTH).More than 50%of CP days occurred during April-May in BTH,and the CP days reached up to 11 in two months of 2018.The PM_(2.5)or O_(3) concentration associated with CP was lower than but close to that in O_(3) and PM_(2.5)pollution,indicating compound harms during CP days with double-high concentrations of PM_(2.5)and O_(3).CP days were significantly facilitated by joint effects of the Rossby wave train that consisted of two centers associated with the Scandinavia pattern and one center over North China as well as a hot,wet,and stagnant environmental condition in BTH.After 2018,the number of CP days decreased sharply while the meteorological conditions did not change significantly.Therefore,changes in meteorological conditions did not really contribute to the decline of CP days in 2019 and 2020.This implies that the reduction of PM_(2.5)emission has resulted in a reduction of CP days(about 11 days in 2019 and 2020).The differences in atmospheric conditions revealed here were helpful to forecast the types of air pollution on a daily to weekly time scale.The reduction in PM_(2.5)emission was the main driving factor behind the absence of CP days in 2020,but the control of surface O_(3) must be stricter and deeper.

Process study on adsorption of glycerin from saline wastewater by strong base anion resin

A physicochemical method was used to adsorb glycerin in saline wastewater by strong base anion resin(D201).Boric acid,a kind of weak acid,can combine with glycerin,and a specific complex can be produced,which possess bigger molecule than glycerin.Then,this specific complex could be adsorbed by strong base anion resin.Via the experiment,the equation of adsorption isotherm with D201 at 20℃ can be shown by lgx/m=1.74lgCe–5.72;for column test with simulative glycerin wastewater,the treatment capability was more than nine bed volumes,and 39.77 mg glycerin could be removed by per gram resin.When the NaCl concentration was 10 g/L,five bed volumes of simulative wastewater could be treated,and the adsorb mass was 29.09 mg/g.When the NaCl concentration was 30 g/L,only three bed volumes of simulative wastewater could be treated,and the adsorb mass was 14.83 mg/g.