Myxobacteria are well known for multicellular social behaviors and valued for biosynthesis of natural products.Myxobacteria social behaviors such as clumping growth severely hamper strain cultivation and genetic manip...Myxobacteria are well known for multicellular social behaviors and valued for biosynthesis of natural products.Myxobacteria social behaviors such as clumping growth severely hamper strain cultivation and genetic manip-ulation.Using Myxococcus xanthus DK1622,we engineered Hu04,which is deficient in multicellular behavior and pigmentation.Hu04,while maintaining nutritional growth and a similar metabolic background,exhibits improved dispersed growth,streamlining operational procedures.It achieves high cell densities in culture and is promising for synthetic biology applications.展开更多
基金supported by the National Key Research and Development Program of China (2021YFC2101000)the Na-tional Natural Science Foundation of China (32070030 and 32301220).
文摘Myxobacteria are well known for multicellular social behaviors and valued for biosynthesis of natural products.Myxobacteria social behaviors such as clumping growth severely hamper strain cultivation and genetic manip-ulation.Using Myxococcus xanthus DK1622,we engineered Hu04,which is deficient in multicellular behavior and pigmentation.Hu04,while maintaining nutritional growth and a similar metabolic background,exhibits improved dispersed growth,streamlining operational procedures.It achieves high cell densities in culture and is promising for synthetic biology applications.
