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奥希替尼联合贝伐珠单抗在获得性EGFR T790M突变晚期非小细胞肺癌的疗效分析 被引量:9
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作者 顾艳斐 田笑如 +4 位作者 王若天 李小雪 钱坤 李元博 农靖颖 《中国肺癌杂志》 CAS CSCD 北大核心 2022年第12期843-851,共9页
背景与目的奥希替尼是对表皮生长因子受体(epidermal growth factor receptor,EGFR)T790M突变非小细胞肺癌(non-small cell lung cancer,NSCLC)有效的第三代靶向药物。尽管第一代EGFR酪氨酸激酶抑制剂(EGFRtyrosine kinase inhibitors,E... 背景与目的奥希替尼是对表皮生长因子受体(epidermal growth factor receptor,EGFR)T790M突变非小细胞肺癌(non-small cell lung cancer,NSCLC)有效的第三代靶向药物。尽管第一代EGFR酪氨酸激酶抑制剂(EGFRtyrosine kinase inhibitors,EGFR-TKIs)联合贝伐珠单抗治疗可延长无进展生存期(progression-free survival,PFS),但奥希替尼联合贝伐珠单抗的后线疗效在II期研究WJOG8715L中并未得到肯定,目前该联合模式在中国人群中的数据仍非常有限。本研究旨在分析真实世界中奥希替尼联合贝伐珠单抗二线治疗的疗效,评价奥希替尼联合抗血管治疗模式在EGFR T790M获得性耐药突变NSCLC中的二线治疗价值。方法收集2020年1月-2021年8月收治的第一、二代EGFR-TKIs治疗后伴EGFR T790M突变NSCLC患者共42例。16例接受二线奥希替尼联合贝伐珠单抗治疗,另26例接受二线奥希替尼单药治疗。分析患者的治疗效果。结果联合组和单药组客观缓解率(objective response rate,ORR)相当(43.8%vs 50.0%,P=0.694)。两组中位PFS(14.0个月vs 13.0个月,P=0.797)和总生存期(overall survival,OS)(29.0个月vs 26.0个月,P=0.544)均未见统计学差异。Cox回归模型显示前线联合贝伐珠单抗治疗是奥希替尼后线单药或联合治疗PFS(P=0.045)及OS(P=0.023)更短的独立预测因素。结论奥希替尼联合贝伐珠单抗二线治疗相比靶向单药治疗未见更好的疗效。 展开更多
关键词 肺肿瘤 表皮生长因子受体 血管内皮生长因子 奥希替尼 贝伐珠单抗
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拉曼光谱检测技术在早期肺癌诊断方面的研究进展 被引量:5
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作者 田笑如 张毅 《中国肺癌杂志》 CAS CSCD 北大核心 2018年第7期560-564,共5页
肺癌是目前世界范围内发病率和死亡率最高的恶性肿瘤,5年生存率仅18%,伴有远处转移的患者则为5%,而I期非小细胞肺癌患者5年生存率最高达77.9%,因此肺癌的早诊早治是改善预后的关键。拉曼光谱技术作为一种非侵入性的检测技术,可实现对癌... 肺癌是目前世界范围内发病率和死亡率最高的恶性肿瘤,5年生存率仅18%,伴有远处转移的患者则为5%,而I期非小细胞肺癌患者5年生存率最高达77.9%,因此肺癌的早诊早治是改善预后的关键。拉曼光谱技术作为一种非侵入性的检测技术,可实现对癌变组织与正常组织之间分子水平结构差异的检测,从而可用于肺癌的早期诊断。该文综述了拉曼光谱检测技术结合不同组织或体液样本在早期肺癌诊断方面的研究进展。 展开更多
关键词 肺肿瘤 早期诊断 拉曼光谱
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Evolution of the deeply buried Jurassic reservoirs in the southern Junggar Basin, NW China: Evidences from the Well DS-1
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作者 Hanwen Hu Jian Zhang +3 位作者 xiaoru tian Qingong Zhuo Chengzao Jia Zhaojie Guo 《Petroleum Research》 2017年第3期247-263,共17页
The southern Junggar Basin has enormous hydrocarbon mainly from the Jurassic and Permian source rocks,which indicated the importance of exploration of the deeply buried Jurassic reservoirs,therefore,the study of the d... The southern Junggar Basin has enormous hydrocarbon mainly from the Jurassic and Permian source rocks,which indicated the importance of exploration of the deeply buried Jurassic reservoirs,therefore,the study of the deeply buried Upper Jurassic Qigu Formation(J_(3)q)reservoirs in Well DS-1 in the Dushanzi anticline was carried out through microscopic observation and measurement,nuclear magnetic resonance(NMR),scanning electron microscopy(SEM)and high pressure mercury injection.Results showed that the main reservoir storage spaces in the deeply buried Upper Jurassic Qigu Formation reservoirs were fractures and dissolved pores.The J_(3)q reservoirs with low porosity and permeability values of 0e12%and(0e5)×10^(-3)mm^(2) respectively,were generally tight.According to the mercury injection data,heterogeneity existed in the deeply buried Qigu Formation reservoirs with inhomogeneous pores and changeable sizes of pores throats.Pores and pore throats in the silt-fine sandstones of the lower Qigu Formation(J_(3)q^(1))were more big and wide respectively than that in the argillaceous siltstones of the upper Qigu Formation(J_(3)q^(3)).Reservoirs in J_(3)q^(1) had more mobile fluid and better conductivities than reservoirs in J_(3)q^(3).The strong compaction and multistage diagenesis resulted in the tight J_(3)q reservoirs.Anhydrite and quartz cementation,and various authigenetic minerals(e.g.hematite,kaolinite,illite/smectite formation,illite,chlorite and zeolite)filled in the pores.The homogenization temperature of brine inclusions(63.1e161.7℃)in quartz overgrowth indicated the quartz had grown since the late Eocene.Due to the Tian Shan reactivity in the Late Cenozoic,the structure fractures were developed and promoted dissolution by oil and formation water in the reservoirs of J3q1. 展开更多
关键词 Tight reservoirs evolution HETEROGENEITY Fluid inclusion Structure fractures Qigu Formation The Dushanzi anticline Southern Junggar Basin
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