Objective:The aim of the study was to screen the differentially expressed genes of Peutz-Jeghers syndrome (PJS) and colorectal carcinoma (CRC).Methods:This study used cDNA microarray to comparatively analyze the gene ...Objective:The aim of the study was to screen the differentially expressed genes of Peutz-Jeghers syndrome (PJS) and colorectal carcinoma (CRC).Methods:This study used cDNA microarray to comparatively analyze the gene expression profiles of 4 cases of PJS combined with colorectal adenocarcinoma vs.normal mucosae.The cDNA microarray contained 8064 human genes,and then using RT-PCR to test three genes of all.Results:The experimental data showed that fourteen genes were differentially expressed,which were up-regulated in PJS.Fifty-one genes expressions were altered in CRCs,of which 32 were up-regulated,as compared to the normal mucosae.In addition,5 genes were similarly altered in both PJS and CRCs.RT-PCR analyses confirmed the cDNA microarray data for three of those genes:LATS2,APC and MADH4.Conclusion:LCN2,USP4,GRO3,HYAL1 and APC-these differentially expressed genes likely represent biomarkers for early detection of CRC and may be potential therapeutic targets.展开更多
Statics are big challenges for the processing of deep reflection seismic data. In this paper several different statics solutions have been implemented in the processing of deep reflection seismic data in South China a...Statics are big challenges for the processing of deep reflection seismic data. In this paper several different statics solutions have been implemented in the processing of deep reflection seismic data in South China and their corresponding results have been compared in order to find proper statics solutions. Either statics solutions based on tomographic principle or combining the low-frequency components of field statics with the high-frequency ones of refraction statics can provide reasonable statics solutions for deep reflection seismic data in South China with very rugged surface topography, and the two statics solutions can correct the statics anomalies of both long spatial wavelengths and short ones. The surface-consistent residual static corrections can serve as the good compensations to the several kinds of the first statics solutions. Proper statics solutions can improve both qualities and reso- lutions of seismic sections, especially for the reflections of Moho in the upmost mantle.展开更多
基金Supported by the grants from Funded Project based by the Health Innovation of the Xiamen Municipal Science and Technology Programme (No.3502Z20084031)Medical Technology Innovation Project of Nanjing Military Region (No.09MA066)
文摘Objective:The aim of the study was to screen the differentially expressed genes of Peutz-Jeghers syndrome (PJS) and colorectal carcinoma (CRC).Methods:This study used cDNA microarray to comparatively analyze the gene expression profiles of 4 cases of PJS combined with colorectal adenocarcinoma vs.normal mucosae.The cDNA microarray contained 8064 human genes,and then using RT-PCR to test three genes of all.Results:The experimental data showed that fourteen genes were differentially expressed,which were up-regulated in PJS.Fifty-one genes expressions were altered in CRCs,of which 32 were up-regulated,as compared to the normal mucosae.In addition,5 genes were similarly altered in both PJS and CRCs.RT-PCR analyses confirmed the cDNA microarray data for three of those genes:LATS2,APC and MADH4.Conclusion:LCN2,USP4,GRO3,HYAL1 and APC-these differentially expressed genes likely represent biomarkers for early detection of CRC and may be potential therapeutic targets.
基金supported by the Foundation of Institute of Geology,Chinese Academy of Geological Sciences (No. J1315)the 3D Geological Mapping Project (No. D1204)the SinoProbe-02 project of China
文摘Statics are big challenges for the processing of deep reflection seismic data. In this paper several different statics solutions have been implemented in the processing of deep reflection seismic data in South China and their corresponding results have been compared in order to find proper statics solutions. Either statics solutions based on tomographic principle or combining the low-frequency components of field statics with the high-frequency ones of refraction statics can provide reasonable statics solutions for deep reflection seismic data in South China with very rugged surface topography, and the two statics solutions can correct the statics anomalies of both long spatial wavelengths and short ones. The surface-consistent residual static corrections can serve as the good compensations to the several kinds of the first statics solutions. Proper statics solutions can improve both qualities and reso- lutions of seismic sections, especially for the reflections of Moho in the upmost mantle.
