Degradation of differently processed Mg-based implants leads to distinct foreign body reactions(FBRs)through dissimilar signaling pathways

Mg alloys have mechanical properties compatible with human bones.However,their rapid degradation and associated foreign body reactions in vivo significantly limit their application for human implants.In this study,three differently processed Mg alloys,pure Mg(PM),cold extruded Mg alloy AZ31(CE AZ31),and fully annealed AZ31 Mg alloy(FA AZ31)were comparatively investigated for their potential as implants using a rat model.All three implanted Mg alloys do not show any impact on hepato-and renal function,nor any signs of observable changes to vital organs.Proteomics analysis of tissues directly contacting the implants 2.5 months post implantation revealed that FA AZ31 activates very few inflammation and immune associated signaling pathways;while the CE AZ31 and PM produce more significant inflammatory responses as confirmed by cytokine array analyses.Further,FA AZ31 activated pathways for cell organization and development that may improve the recovery of injured tissues.Structurally,EBSD analysis reveals that the FA AZ31 alloy has a higher ratio of first-order pyramidal orientated(10–11){10–1–2}grain texture with a value of 0.25,while PM and CE AZ31 alloys have lower ratios of first-order pyramidal orientated texture with the values of 0.16 and 0.17,respectively.This is associated with recovery and recrystallisation during annealing which promotes grain texture which exhibits enhanced degradation behaviours and induces a more limited immune response in vivo.In conclusion,the FA AZ31 demonstrated better biocompatibility and corrosion resistance and is a promising candidate for metal-based degradable implants which warrants further investigation.

Two-Dimensional Tellurium:Progress,Challenges,and Prospects

Since the successful fabrication of two-dimensional(2D)tellurium(Te)in 2017,its fascinating properties including a thickness dependence bandgap,environmental stability,piezoelectric effect,high carrier mobility,and photoresponse among others show great potential for various applications.These include photodetectors,field-effect transistors,piezoelectric devices,modulators,and energy harvesting devices.However,as a new member of the 2D material family,much less known is about 2D Te compared to other 2D materials.Motivated by this lack of knowledge,we review the recent progress of research into 2D Te nanoflakes.Firstly,we introduce the background and motivation of this review.Then,the crystal structures and synthesis methods are presented,followed by an introduction to their physical properties and applications.Finally,the challenges and further development directions are summarized.We believe that milestone investigations of 2D Te nanoflakes will emerge soon,which will bring about great industrial revelations in 2D materials-based nanodevice commercialization.

Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells

Yamanaka 因素(Oct3/4， Sox2， Klf4， c-Myc ) 高度在胚胎的茎(ES ) 被表示房间，和他们的在表示上能在老鼠和人的体的房间导致 pluripotency，显示这些因素调整为 ES 房间 pluripotency 必要的发展发信号网络。然而，发信号的小径的全身的分析由 Yamanaka 因素调整了充分还没被描述了。在这研究，我们鉴别一个整个染色体上的内长的 Yamanaka 因素的目标倡导者在 E14.1 鼠标 ES 房间用薄片(染色质 immunoprecipitation ) 放大 -on-chip，并且我们发现这四个因素共同占据 58 个倡导者。有趣地，当 Oct4 和 Sox2 作为核心因素被分析时， Klf4 工作了为发展规定提高核心因素，而 c-Myc 似乎在调整新陈代谢起一个不同作用。小径分析表明 Yamanaka 因素一起调整由 16 条发展发信号小径，其九条在 ES 房间代表更早未知的小径组成的一个发展发信号网络，包括 apoptosis 和房间周期小径。我们进一步从在老鼠 ES 房间检验 Yamanaka 因素的最近的研究分析了数据。有趣地，这分析也揭示了 16 条发展发信号小径， 14 条小径重叠，由这研究揭示了，尽管有目标基因和发信号的小径由每个单个 Yamanaka 因素调整了在这二数据集之间显著地不同。我们建议 Yamanaka 因素极其调整由约十二条关键发展发信号小径组成也维持 ES 房间并且可能的 pluripotency 导致 pluripotent 干细胞的一个发展发信号网络。

More synergetic cooperation of Yamanaka factors in induced pluripotent stem cells than in embryonic stem cells

在 pluripotency 的正式就职的核心管理者最近在体的房间 reprogramming 期间被发现了的 Yamanaka 因素的角色。我们的以前的学习发现 Yamanaka 因素在维持胚胎的茎(ES ) 房间 pluripotency 调整一个发展发信号网络。这里，我们完全证实 reprogrammed 导致了 pluripotent 茎(iPS ) 细胞并且由薄片薄片试金在这些细胞分析了 Yamanaka 因素的全球倡导者占有。我们发现 565 基因的倡导者是由在 iPS 房间的四个 Yamanaka 因素的合作界限， 10 褶层增加什么时候与他们在 ES 房间的绑定相比。，在 ES 房间 Oct4， Sox2，或 Klf4 在 iPS 房间在激活并且镇压的基因同等地散布的一个单个 Yamanaka 因素占据的倡导者在激活的主要在镇压基因和 c-Myc 散布了。薄片薄片数据的小径分析表明 Yamanaka 因素在 iPS 房间， 12 在之中是普通的调整了 16 条发展发信号小径， 4 与在 ES 房间调整的小径相比是唯一的。我们进一步在 iPS 房间分析了另一最近出版的薄片薄片数据集并且观察了类似的结果，显示出为揭示 pluripotency 维护和新生的性质的薄片薄片正小径分析的力量。下次，我们试验性地测试了压抑的发信号小径之一并且发现它的抑制确实改进了房间 reprogramming 的效率。一起拿，我们建议有一个核心为 pluripotency 必要的发展发信号网络与 TGF- ，刺猬， Wnt，是的 p53 压抑(殷) 管理者和 Jak-STAT，房间周期，焦点的粘附， adherens 连接作为活跃(杨) ；并且 Yamanaka 因素 synergistically 在 Yin-Yang 调整他们导致 pluripotency 的平衡方法。

Unveiling the mechanism of charge compensation in Li_(2)Ru_(x)Mn_(1-x)O_(3)by tracking atomic structural evolution

The relationship between the structural evolution and redox of Li-rich transition-metal layered oxides(LLOs)cathodes remains ambiguous,obstructing the development of high-performance lithium-ion(Li^(+))battery.Herein,the coherent effects of local atomic and electronic structure in Li_(2)Ru_(x)Mn_(1-x)O_(3)(LRMO)with a wide voltage window(1.3–4.8 V)is identified by in situ X-ray absorption fine spectroscopy(XAFS)and chemometrics.We not only skillfully separated the redox active structures to track the electrochemical path,but also visualized the coupling mechanism between the evolution of Ru-Ru dimer and the(de)excitation of cations and anions.Furthermore,introducing manganese triggers the“heterogeneity”of coordination environment and electronic structure between Ru and Mn after discharge to 3 V.The change of thermodynamic and kinetic paths affects the relithiation,and further leads to the hysteresis of the anion activation structure relaxation of Li_(2)Ru_(0.4)Mn_(0.6)O_(3)relative to Li_(2)RuO_(3)(LRO).Additionally,it is demonstrated that the high charge cut-off voltage restrains the relaxation of anionic active structure in LRO from a new perspective through comparative experiments.Our work associates the evolution of atomic structure with charge compensation and negative electrochemical reactions such as voltage hysteresis(VH)and capacity attenuation,deepening the understanding electrochemical reaction mechanism of LLOs during the first cycle and providing a theoretical support for the further design and synthesis of high-efficiency cathodes.

Thermosetting resin modified asphalt:A comprehensive review

Thermosetting resins have advantages such as high strength,corrosion resistance,and aging resistance,and have excellent prospects for practical application as asphalt modifiers.In order to promote the research of thermosetting resin modified asphalt,to provide direction for its further research,this paper reviews the research progress of thermosetting resin modified asphalt in recent years.The material composition,modification mechanism,and curing behavior of epoxy asphalt,thermosetting polyurethane modified asphalt,unsaturated polyester modified asphalt,and other thermosetting resin modified asphalts are overviewed.Different types of thermosetting resin modified asphalt have different performances,the performance advantages of different thermosetting resin modified asphalts are summarized.At the same time,the existing problems in thermosetting resin modified asphalt and further research directions are provided.Encouraging researchers to produce thermosetting resin modified asphalts using waste or bio-based materials,and to study the recycling technologies and life cycle assessment of thermosetting resin modified asphalt.This paper provides a reference for the study of thermosetting resin modified asphalt.

The Refined Schwarz-Pick Estimates for Positive Real Part Holomorphic Functions in Several Complex Variables

In this article,the refined Schwarz-Pick estimates for positive real part holomorphic functions p(x)=p(0)+Σ_(m=k)^(∞)D^(M)p(0)(x^(m))/m!:G→Care given,where k is a positive integer,and G is a balanced domain in complex Banach spaces.In particular,the results of first order Fréchet derivative for the above functions and higher order Frechet derivatives for positive real part holomorphic functions p(x)=p(0)+Σ_(s=1)^(∞)D^(sk)p(0)(x^(sk))/(sk)!:G→Care sharp for G=B,where B is the unit ball of complex Banach spaces or the unit ball of complex Hilbert spaces.Their results reduce to the classical result in one complex variable,and generalize some known results in several complex variables.

Construction of Hefei advanced light facility begins

On September 20, 2023, the commencement ceremony for the HefeiAdvanced Light Facility (HALF) was held in Hefei. The event was hosted by theNational Synchrotron Radiation Laboratory (NSRL) at the University of Scienceand Technology of China (USTC). HALF is a cutting-edge fourth-generation synchrotron radiation light source in the low- energy region, which is located in GangjiTown, Changfeng, within the Future Science City of Hefei. As one of the nationallarge research infrastructures, HALF is financially supported by both the centralgovemment of China and Anhui Province. The construction is scheduled to becompleted by September 2028.

持久性有机污染物在经口暴露介质中的生物可及性研究进展

持久性有机污染物(persistent organic pollutants,POPs)因在环境中难以降解并对人体健康造成危害而受到广泛关注.POPs主要通过食物、灰尘和土壤等经口介质暴露进入人体,不同暴露介质中POPs的生物可及性存在较大差异,常规基于食品、灰尘等基质中POPs总浓度的暴露风险评估可能会高估人体实际暴露水平和由此产生的健康风险.体外胃肠模拟实验测定生物可及性是目前广泛用于预测POPs生物有效性的方法.POPs的生物可及性受到体外实验方法、介质性质、消化条件以及污染物性质等多种因素的影响.本文总结了目前使用的生物可及性研究方法,详细分析了各因素的影响规律和机制,发现食物的营养成分和烹调方式、灰尘/土壤的粒径组成与有机质含量、消化酶的种类和含量、污染物的疏水性等是影响其生物可及性的重要因素,并对生物可及性在人类暴露和健康风险评估中的应用进行了归纳,为准确评估POPs的人体暴露风险提供了重要的理论基础.

多复变数全纯映射精细的Bohr定理

本文首先建立不依赖自同构从复Banach空间平衡域到Cn单位多圆柱上一定限制条件下全纯映射精细的范数型Bohr定理及复Banach空间X上单位球到复Banach空间Y上单位球全纯映射精细的泛函型Bohr定理.其次,给出有界对称域上全纯映射精细的Bohr定理.最后,得到J*代数单位球上全纯映射精细的Bohr定理.所得结果将一维的Bohr定理推广至高维.

The Sharp Estimates of all Homogeneous Expansions for a Class of Quasi-convex Mappings on the Unit Polydisk in C^n

In this paper,the sharp estimates of all homogeneous expansions for f are established,where f(z) = (f1(z),f2(z),··· ,fn(z)) is a k-fold symmetric quasi-convex mapping defined on the unit polydisk in Cn and Dtk+1fp(0)(ztk+1) (tk + 1)! = n l1,l2,···,ltk+1=1 |apl1l2···ltk+1|ei θpl1+θpl2+···+θpltk+1t k+1 zl1zl2 ··· zltk+1,p = 1,2,··· ,n.Here i = √?1,θplq ∈ (-π,π] (q = 1,2,··· ,tk + 1),l1,l2,··· ,ltk+1 = 1,2,··· ,n,t = 1,2,···.Moreover,as corollaries,the sharp upper bounds of growth theorem and distortion theorem for a k-fold symmetric quasi-convex mapping are established as well.These results show that in the case of quasi-convex mappings,Bieberbach conjecture in several complex variables is partly proved,and many known results are generalized.

Sharp Distortion Theorems for a Subclass of Biholomorphic Mappings Which Have a Parametric Representation in Several Complex Variables

In this paper, the sharp distortion theorems of the Fr′echet-derivative type for a subclass of biholomorphic mappings which have a parametric representation on the unit ball of complex Banach spaces are established, and the corresponding results of the above generalized mappings on the unit polydisk in C^n are also given. Meanwhile, the sharp distortion theorems of the Jacobi determinant type for a subclass of biholomorphic mappings which have a parametric representation on the unit ball with an arbitrary norm in C^n are obtained, and the corresponding results of the above generalized mappings on the unit polydisk in C^n are got as well. Thus, some known results in prior literatures are generalized.

Fekete and Szeg problem in one and higher dimensions

In this paper, we establish the Fekete and Szeg inequality for a class of holomorphic functions in the unit disk, and then we extend this result to a class of holomorphic mappings on the unit ball in a complex Banach space or on the unit polydisk in C^n.

Vacancy manipulating of molybdenum carbide MXenes to enhance Faraday reaction for high performance lithium-ion batteries

“Intrinsic”strategies for manipulating the local electronic structure and coordination environment of defect-regulated materials can optimize electrochemical storage performance.Nevertheless,the structure–activity relationship between defects and charge storage is ambiguous,which may be revealed by constructing highly ordered vacancy structures.Herein,we demonstrate molybdenum carbide MXene nanosheets with customized in-plane chemical ordered vacancies(Mo_(1.33)CT_(x)),by utilizing selective etching strategies.Synchrotron-based X-ray characterizations reveal that Mo atoms in Mo1.33CTx show increased average valence of+4.44 compared with the control Mo_(2)CT_(x).Benefited from the introduced atomic active sites and high valence of Mo,Mo_(1.33)CT_(x)achieves an outstanding capacity of 603 mAh·g^(−1)at 0.2 A·g^(−1),superior to most original MXenes.Li+storage kinetics analysis and density functional theory(DFT)simulations show that this optimized performance ensues from the more charge compensation during charge–discharge process,which enhances Faraday reaction compared with pure Mo_(2)CT_(x).This vacancy manipulation provides an efficient way to realize MXene’s potential as promising electrodes.

Low temperature specific heat of 12442-type KCa2Fe4As4F2 single crystals

Low-temperature specific heat(SH)is measured for the 12442-type KCa2Fe4As4F2 single crystal under different magnetic fields.A clear SH jump with the height of?C/T|Tc=130 mJ mol-1 K-2 is observed at the superconducting transition temperature Tc.It is found that the electronic SH coefficient?γ(H)quickly increases when the field is in the low-field region below 3T and then considerably slows down the increase with a further increase in the field,which indicates a rather strong anisotropy or multi-gap feature with a small minimum in the superconducting gap(s).The temperature-dependent SH data indicate the presence of the T2 term,which supplies further information and supports the picture with a line-nodal gap structure.Moreover,the onset point of the SH transition remains almost unchanged under the field as high as 9 T,which is similar to that observed in cuprates,and places this system in the middle between the BCS limit and the Bose-Einstein condensation.

Exotic ferromagnetism in the two-dimensional quantum material C3N

The search for and study of exotic quantum states in novel low-dimensional quantum materials have triggered extensive research in recent years. Here, we systematically study the electronic and magnetic structures in the newly discovered two-dimensional quantum material C3N within the framework of density functional theory. The calculations demonstrate that C3N is an indirect-band semiconductor with an energy gap of 0.38 eV, which is in good agreement with experimental observations. Inter- estingly, we find van Hove singularities located at energies near the Fermi level, which is half that of graphene. Thus, the Fermi energy easily approaches that of the singularities, driving the system to ferromagnetism, under charge carrier injection, such as electric field gating or hydrogen doping. These findings not only demonstrate that the emergence of magnetism stems from the itinerant electron mechanism rather than the effects of local magnetic impurities, but also open a new avenue to de- signing field-effect transistor devices for possible realization of an insulator-ferromagnet transition by tuning an external electric field.

Sharp distortion theorems for a subclass of close-to-convex mappings

我们介绍班强烈在一个复杂 Banach 空格的联合起来的球的顺序的 close-to-convex mappings，然后，我们在 n 在复杂 Hilbert 空间 X 或单位 polydisc 的联合起来的球为 mappings 的这个班给锋利的失真定理。作为应用，一条锋利的生长定理为强烈，顺序的 close-to-convex mappings 被获得。

On the Refined Esitmates of All Homogeneous Expansions for a Subclass of Biholomorphic Starlike Mappings in Several Complex Variables

The refined estimates of all homogeneous expansions for a subclass of biholomorphic starlike mappings are mainly established on the unit ball in complex Banach spaces or the unit polydisk in C^(n) with a unified method.Especially the results are sharp if the above mappings are further k-fold symmetric starlike mappings or k-fold symmetric starlike mappings of orderα.The obtained results unify and generalize the corresponding results in some prior literatures.

Sharp distortion theorems for some subclasses of star like mappings on Bnp in Cn

We mainly establish the distortion theorems of Jacobi determinant for three subclasses of starlike mappings on Bpn,where Bp={z=(z1,……,zn)T∈Cn:∑nl=1|zl|p<1}p>1.In particular,the above distortion theorems are sharp if Bpn is the unit polydisk in Cn.Our results reduce to the corresponding classical results in one dimension of complex function theory.

The Estimates of All Homogeneous Expansions for a Subclass of ε Quasi-convex Mappings in Several Complex Variables

The authors obtain the estimates of all homogeneous expansions for a subclass of ε quasi-convex mappings on the unit ball in complex Banach spaces. Moreover, the estimates of all homogeneous expansions for the above generalized mappings on the unit polydisk in Cnare also obtained. Especially, the above estimates are only sharp for a subclass of starlike mappings, quasi-convex mappings and quasi-convex mappings of type A. The results are the generalization of many known results.