Buried pipelines are an essential component of the urban infrastructure of modern cities.Traditional buried pipes are mainly made of metal materials.With the development of material science and technology in recent ye...Buried pipelines are an essential component of the urban infrastructure of modern cities.Traditional buried pipes are mainly made of metal materials.With the development of material science and technology in recent years,non-metallic pipes,such as plastic pipes,ceramic pipes,and concrete pipes,are increasingly taking the place of pipes made from metal in various pipeline networks such as water supply,drainage,heat,industry,oil,and gas.The location technologies for the location of the buried metal pipeline have become mature,but detection and location technologies for the non-metallic pipelines are still developing.In this paper,current trends and future perspectives of detection and location of buried non-metallic pipelines are summarized.Initially,this paper reviews and analyzes electromagnetic induction technologies,electromagnetic wave technologies,and other physics-based technologies.It then focuses on acoustic detection and location technologies,and finally introduces emerging technologies.Then the technical characteristics of each detection and location method have been compared,with their strengths and weaknesses identified.The current trends and future perspectives of each buried non-metallic pipeline detection and location technology have also been defined.Finally,some suggestions for the future development of buried non-metallic pipeline detection and location technologies are provided.展开更多
Over the last decade,oncolytic virus(OV)therapy has shown its promising potential in tumor treatment.The fact that not every patient can benefit from it highlights the importance for defining biomarkers that help pred...Over the last decade,oncolytic virus(OV)therapy has shown its promising potential in tumor treatment.The fact that not every patient can benefit from it highlights the importance for defining biomarkers that help predict patients’responses.As particular self-amplifying biotherapeutics,the anti-tumor effects of OVs are highly dependent on the host factors for viral infection and replication.By using weighted gene co-expression network analysis(WGCNA),we found matrix remodeling associated 8(MXRA8)is positively correlated with the oncolysis induced by oncolytic virus M1(OVM).展开更多
基金Supported by Downhole Intelligent Measurement and Control Science and Technology Innovation Team of Southwest Petroleum University(Grant No.2018CXTD04)National Natural Science Foundation of China(Grant Nos.61701085,51974273)+1 种基金Chengdu Municipal international science and technology cooperation project of China(Grant Nos.2020-GH02-00016-HZ)2020 National Mountain Highway Engineering Technology Research Center Open Fund Project(Grant No.GSGZJ-2020-01).
文摘Buried pipelines are an essential component of the urban infrastructure of modern cities.Traditional buried pipes are mainly made of metal materials.With the development of material science and technology in recent years,non-metallic pipes,such as plastic pipes,ceramic pipes,and concrete pipes,are increasingly taking the place of pipes made from metal in various pipeline networks such as water supply,drainage,heat,industry,oil,and gas.The location technologies for the location of the buried metal pipeline have become mature,but detection and location technologies for the non-metallic pipelines are still developing.In this paper,current trends and future perspectives of detection and location of buried non-metallic pipelines are summarized.Initially,this paper reviews and analyzes electromagnetic induction technologies,electromagnetic wave technologies,and other physics-based technologies.It then focuses on acoustic detection and location technologies,and finally introduces emerging technologies.Then the technical characteristics of each detection and location method have been compared,with their strengths and weaknesses identified.The current trends and future perspectives of each buried non-metallic pipeline detection and location technology have also been defined.Finally,some suggestions for the future development of buried non-metallic pipeline detection and location technologies are provided.
基金We acknowledge Dr.Zhe Liu of the Guangdong Provincial Center for Disease Control and Prevention for his assistance with cryo-EM.Miss.Liumei Wu and Miss.Jing Tang assisted with transfection assay and RNA-scope assay.This work was supported by the National Natural Science Foundation of China(No.81973342,82073883,81772675,81903652,and 81802536)the National Key R&D Program of China(2021YFA0909800)the Science and Technology Program of Guangzhou(No.201707020003).
文摘Over the last decade,oncolytic virus(OV)therapy has shown its promising potential in tumor treatment.The fact that not every patient can benefit from it highlights the importance for defining biomarkers that help predict patients’responses.As particular self-amplifying biotherapeutics,the anti-tumor effects of OVs are highly dependent on the host factors for viral infection and replication.By using weighted gene co-expression network analysis(WGCNA),we found matrix remodeling associated 8(MXRA8)is positively correlated with the oncolysis induced by oncolytic virus M1(OVM).
