Magmatic-tectonic response of the South China Craton to the Paleo-Pacific subduction during the Triassic:a new viewpoint based on Well NK-1

The Nansha Block(NB)is one of the blocks separated from the southern margin of the South China Craton(SCC)by the western Pacific subduction,which contains rich information of geodynamic and tectonic transformation.To reveal the essence of western Paleo-Pacific subduction during the Triassic period,Well NK-1 in this block was selected for petrographic study,and published research data from other cooperative teams were compared.A double-cycle pattern of basic to neutral magmatic volcanism was established,and 36 lithological rhythmic layers and representative cryptoexplosive breccia facies and welded tuff bands were identified.Combined with a reanalysis of published geochronological data,geochemical elements,and isotope geochemistry,we found that the rock assemblages could be divided into an intermediate-acid dacite(DA)series(SiO_(2)>65%)and basaltic(BA)series(Co<40μg/g),which was formed during the early Late Triassic((218.6±3.2)–(217.9±3.5)Ma).BA exhibits obvious calc-alkaline island-arc magmatic properties:(^(87)Sr/^(86)Sr)_i ratio ranging 0.70377–0.71118(average:0.70645),^(147)Sm/^(144)Nd ratio ranging 0.119–0.193(average:0.168),and chondrite-normalized rare earth element(REE)curves being flat,while DA exhibits remarkable characteristics of subducted island-arc andesitic magma:(^(87)Sr/^(86)Sr)_i ratio(0.70939–0.71129;average:0.71035),εNd(t)value(-6.2–-4.8;average:-5.6)andε_(Hf)(t)value(-2.9–-1.7,average:-2.2)show obvious crust-mantle mixing characteristics.BA and DA reveal typical characteristics of island-arc magma systems and typeⅡenriched mantle(EM-Ⅱ)magma.BA magma was likely resulted from the process whereby the continental crust frontal accretionary wedge was driven by the Paleo-Pacific slab subduction into the deep and began to melt,resulting in a large amount of melt(fluid)joined the asthenosphere on the side of the continental margin.In contrast,DA magma was likely resulted from the process whereby the plate front was forced to bend with increasing subduction distance,which triggered the upwelling of the asthenosphere near the continent and subsequently led to the partial melting of the lithospheric mantle and lower crust due to continuous underplating.The lithospheric thinning environment in the study area at the end of Triassic created suitable conditions for the separation between the NB and SCC,which provided an opportunity for the formation of the early intracontinental rift during the later expansion of the South China Sea(SCS).

Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications

Osteoporosis is a common skeletal disease,affecting-200 million people around the world.As a complex disease,osteoporosis is influenced by many factors,including diet(e.g.calcium and protein intake),physical activity,endocrine status,coexisting diseases and genetic factors.In this review,we first summarize the discovery from genome-wide association studies(GWASs)in the bone field in the last 12 years.To date,GWASs and meta-analyses have discovered hundreds of loci that are associated with bone mineral density(BMD),osteoporosis,and osteoporotic fractures.However,the GWAS approach has sometimes been criticized because of the small effect size of the discovered variants and the mystery of missing heritability,these two questions could be partially explained by the newly raised conceptual models,such as omnigenic model and natural selection.Finally,we introduce the clinical use of GWAS findings in the bone field,such as the identification of causal clinical risk factors,the development of drug targets and disease prediction.Despite the fruitful GWAS discoveries in the bone field,most of these GWAS participants were of European descent,and more genetic studies should be carried out in other ethnic populations to benefit disease prediction in the corresponding population.

Last glacial terrestrial vegetation record of leaf wax n-alkanols in the northern South China Sea:Contrast to scenarios from longchain n-alkanes

Long-chain n-alkanols and n-alkanes in core sediments from the northern South China Sea(SCS)were measured to make a comparison during terrestrial vegetation reconstruction from~42 ka to~7 ka.The results showed that terrestrial vegetation record from long-chain n-alkanes matched well with previous studies in nearby cores,showing that more C_(4)plants developed during the Last Glacial Maximum(LGM)and C_(3)plants dominated in the interglacial period.However,these scenarios were not revealed by terrestrial vegetation reconstruction using long-chain n-alkanols,which showed C_(3)plant expansion during the LGM.The discrepancy during the interglacial period could be attributed to the aerobic degradation of functionalized long-chain n-alkanols in the oxygen-rich bottom water,resulting in poor preservation of terrestrial vegetation signals.On the other hand,the different advantages of functionalized n-alkanols and non-functional n-alkanes to record local and distal vegetation signals,respectively,may offer a potential explanation for the contradiction during the LGM when the SCS was characterized by low-oxygen deep water.Nevertheless,large variations on n-alkyl lipid compositions in C_(3)/C_(4)plants could play a part in modulating sedimentary long-chain n-alkanols and n-alkanes toward different vegetation signals,thereby suggesting that caution must be taken in respect to the terrestrial vegetation reconstruction using long-chain n-alkanes and long-chain n-alkanols.

A comparative study of the intestinal digestive characteristics of diferent feeds for Holstein cows

This experiment was conducted with lactating Chinese Holstein cows to study the nutritional value of local protein feed resources.A three-step method(TSP)and a modifed three-step method(MTSP)were used to measure the in vitro digestibility of rumen undegraded protein(RUP)for 11 feedstufs and correlation.Eleven experimental feeds were chosen and air-dried to investigate the efects of diferent growth periods and varieties on nutrition value and RUP digestibility.The small intestinal digestibility of RUP by TSP in concentrated feed was determined to be higher than that of roughage,approximately 65%.The highest concentrate(79%)was SBM(soybean mean),while the lowest was corn(65%).The proportions of DDGS(with soluble wine lees)and SFM(sunfower meal)were 70.9 and 74.9%,respectively.ASS(alfalfa mowed at the squaring stage)had the highest small intestinal digestibility of RUP(55%)among roughages,and WCS(whole-plant corn silage)had the lowest digestibility(40.5%).When the small intestinal digestibility of RUP was determined using the MTSP method,it exhibited similar results to the TSP method.Nevertheless,the values were generally higher,and there was a strong signifcant correlation between them(R2=0.967,P<0.01).The comparative study of these two methods help us have a better understanding of small intestine digestibility of diferent feeds,make a reasonable feed formula to efectively prevent diseases.

Building a High-Performance Graph Storage on Top of Tree-Structured Key-Value Stores

Graph databases have gained widespread adoption in various industries and have been utilized in a range of applications,including financial risk assessment,commodity recommendation,and data lineage tracking.While the principles and design of these databases have been the subject of some investigation,there remains a lack of comprehensive examination of aspects such as storage layout,query language,and deployment.The present study focuses on the design and implementation of graph storage layout,with a particular emphasis on tree-structured key-value stores.We also examine different design choices in the graph storage layer and present our findings through the development of TuGraph,a highly efficient single-machine graph database that significantly outperforms well-known Graph DataBase Management System(GDBMS).Additionally,TuGraph demonstrates superior performance in the Linked Data Benchmark Council(LDBC)Social Network Benchmark(SNB)interactive benchmark.

Factors influencing peak bone mass gain

Bone mass is a key determinant of osteoporosis and fragility fractures.Epidemiologic studies have shown that a 10%increase in peak bone mass(PBM)at the population level reduces the risk of fracture later in life by 50%.Low PBM is possibly due to the bone loss caused by various conditions or processes that occur during adolescence and young adulthood.Race,gender,and family history(genetics)are responsible for the majority of PBM,but other factors,such as physical activity,calcium and vitamin D intake,weight,smoking and alcohol consumption,socioeconomic status,age at menarche,and other secondary causes(diseases and medications),play important roles in PBM gain during childhood and adolescence.Hence,the optimization of lifestyle factors that affect PBM and bone strength is an important strategy to maximize PBM among adolescents and young people,and thus to reduce the low bone mass or osteoporosis risk in later life.This review aims to summarize the available evidence for the common but important factors that influence bone mass gain during growth and development and discuss the advances of developing high PBM.

Significant difference between sirolimus and paclitaxel nanoparticles in antiproliferation effect in normoxia and hypoxia: The basis of better selection of atherosclerosis treatment

Compared with paclitaxel,sirolimus has been more used in the treatment of vascular restenosis gradually as an anti-proliferative drug,but few basic studies have elucidated its mechanism.The anti-proliferative effects of sirolimus or paclitaxel have been demonstrated by numerous studies under normoxia,but few studies have been achieved focusing hypoxia.In this study,porcine carotid artery injury model and classical cobalt chloride hypoxia cell model were established.Sirolimus nanoparticles(SRM-NPs),paclitaxel nanoparticles(PTX-NPs)and blank nanoparticles(Blank-NPs)were prepared respectively.The effect of RPM-NPs on the degree of stenosis,proliferative index and the expression of PCNA after 28 days of porcine carotid artery injury model was evaluated.Compared with saline group and SRM groups,SRM-NPs group suppressed vascular stenosis,proliferative index and the expression of PCNA(P<0.01 and P<0.05).Endothelial cell(EC)and smooth muscle cell(SMC)were pre-treated with cobaltous chloride,followed by SRM-NPs,PTX-NPs,Blank-NPs or PBS control treating,the effects on cell proliferation,HIF-1 expression and glycolysis were detected.SRM-NPs could inhibit EC and SMC proliferation under hypoxia,while PTX-NPs couldn't(P<0.001).Significant differences between sirolimus and paclitaxel NPs in anti-proliferation effect under normoxia and hypoxia may due to the different inhibitory effects on HIF-1αexpression and glycolysis.In conclusion,these results suggest that sirolimus can inhibit the proliferation of hypoxic cells more effectively than paclitaxel.These observations may provide a basis for understanding clinical vascular stenosis therapeutic differences between rapamycin and paclitaxel.

A Comparative Analysis on Weibo and Twitter

Weibo is the Twitter counterpart in China that has attracted hundreds of millions of users. We crawled an almost complete Weibo user network that contains 222 million users and 27 billion links in 2013. This paper analyzes the structural properties of this network, and compares it with a Twitter user network. The topological properties we studied include the degree distributions, connected components, distance distributions, reciprocity,clustering coefficient, Page Rank centrality, and degree assortativity. We find that Weibo users have a higher diversity index, higher Gini index, but a lower reciprocity and clustering coefficient for most of the nodes. A surprising observation is that the reciprocity of Weibo is only about a quarter of the reciprocity of the Twitter user network. We also show that Weibo adoption rate correlates with economic development positively, and Weibo network can be used to quantify the connections between provinces and regions in China. In particular, point-wise mutual information is shown to be accurate in quantifying the strength of connections. We developed an interactive analyzing software framework for this study, and released the data and code online.

Prmt1 upregulated by Hdc deficiency aggravates acute myocardial infarction via NETosis

Neutrophils are mobilized and recruited to the injured heart after myocardial infarction,and neutrophil count has been clinically implicated to be associated with coronary disease severity.Histidine decarboxylase(HDC)has been implicated in regulating reactive oxidative species(ROS)and the differentiation of myeloid cells.However,the effect of HDC on neutrophils after myocardial infarction remains unclear.Here,we found that neutrophils were disorderly recruited into the ischemic injured area of the myocardium of Hdc deficiency(Hdc^(−/−))mice.Moreover,Hdc deficiency led to attenuated adhesion but enhanced migration and augmented ROS/neutrophil extracellular traps(NETs)production in neutrophils.Hdc^(−/−)mouse-derived NETs promoted cardiomyocyte death and cardiac fibroblast proliferation/migration.Furthermore,protein arginine methyltransferase 1(PRMT1)was increased in Hdc^(−/−)mouse-derived neutrophils but decreased with exogenous histamine treatment.Its expression could be rescued by blocking histamine receptor 1(H1R),inhibiting ATP synthesis or reducing SWItch/sucrose non fermentable(SWI/SNF)chromatin remodeling complex.Accordingly,histamine or MS023 treatment could decrease ROS and NETs ex vivo,and ameliorated cardiac function and fibrosis,along with the reduced NETs in plasma in vivo.Together,our findings unveil the role of HDC in NETosis by histamine–H1R–ATP–SWI/SNF–PRMT1–ROS signaling and provide new biomarkers and targets for identifying and tuning the detrimental immune state in cardiovascular disease.

Numerical study on the heat transfer performance of coaxial shallow borehole heat exchanger

In the present work,a numerical investigation on the coaxial shallow borehole heat exchanger based on Com-putational Fluid Dynamics(CFD)technique in Hefei city of China has been performed.The effects of design parameters,including inlet flow rate,inlet fluid temperature,inner pipe material and outer pipe diameter,on the heat transfer performance were systematically studied.Besides,the thermal behavior along the pipe has been carefully examined with focus on the thermal short-circuiting phenomena.When the fluid inlet velocity is less than the critical value,the turbulence intensity increases and the Nusselt number increases with the inlet flow rate increasing.However,there is sufficient time for heat transfer between the fluid in inner pipe and outer pipe because of low flow rates,leading to large heat loss,i.e.,thermal short-circuiting phenomenon.It is found that with the inlet flow rate increasing,the heat transfer increases first and then decreases,and the rate of reduction slows down gradually.When the inlet flow rate increases,the pumping power undergoes exponential growth.As the inlet temperature increasing,the heat transfer decreases almost linearly.Moreover,when the soil temperature at the top of the casing is lower than that of the fluid in the casing,heat is transferred from the fluid in the casing to the soil,and the heat loss increases with the increase of the inlet fluid temperature.The material of inner pipe with high heat conductivity would result in large heat loss under the influence of thermal short-circuiting.The heat load increases while the pumping power required decreases with the increasing of outer pipe diameter.This study is very beneficial for the coaxial shallow borehole exchanger designs and energy conservation of buildings.