Photonic Dirac cone and topological transition in a moving dielectric slab

The moving media theory is applied to a photonic confined structure which is a continuous dielectric slab waveguide with the uniaxial anisotropy and without the discrete translational symmetry.The moving effect not only brings about non-reciprocity to the whole photonic band structure in the co-moving and counter-moving directions,but also leads to the topological transition of local degenerate points within the band diagram.We demonstrate through calculation that the type-ⅡDirac point can be turned into type-ⅠDirac point when the uniaxial slab is moving over certain speed.Our results provide a new approach to regulate the topology of degeneracy for two-dimensional photonic bands in the continuous translational symmetry condition.

Erratum to:Discovery of Chrysoeriol,a PI3K-AKT-mTOR Pathway Inhibitor with Potent Antitumor Activity against Human Multiple Myeloma Cells In Vitro

The authors examined the original data of their work and noticed a misuse of the image of the bands of AKT and actin in fig.2A(as shown below on the upper panel).The error occurred during the preparation of the manuscript,mainly due to the wrongly labeling of image items or folders inadvertently.The correct one is shown in fig.2 on the lower panel.The authors sincerely apologize for the mistake and confirm that the change does not affect the scientific conclusion of the published work.

EBV-associated lymphoproliferative disease post-CAR-T cell therapy

Epstein–Barr virus(EBV)-associated lymphoproliferative diseases(EBV-LPDs)are common complications that occur after solid organ transplantation or allogeneic hematopoietic stem-cell transplantation(HSCT).However,their occurrence and treatment post-chimeric antigen receptor-modified T(CAR-T)cell therapy has not been reported.Two patients had been diagnosed with EBV-positive aggressive B-cell lymphoma and experienced relapses after multiple lines of treatment.After receiving CAR-T cell therapy in tandem with autologous HSCT,the patients achieved complete remission.However,with a median time of 38.5 months after CAR-T cell therapy,B-cell-derived EBV-LPDs were diagnosed,and they were relieved through the administration of immune checkpoint inhibitor or B-cell-depleting agents.Collectively,our report suggests that EBV-LPDs may represent a long-term adverse event after CAR-T cell therapy,especially in patients who previously had EBV-positive disorders,and they can be resolved by immune normalization strategy or B-cell depleting therapy.

法治视域下孟连县边民互市贸易现状研究——以孟连县勐啊村为例

随着近年经济全球化、贸易全球化的快速发展,云南省普洱市孟连县勐啊村与缅甸邦康之间的边境贸易活动也随之日益活跃,为促进当地经济繁荣发展提供了重要的途径。然而,随着边民互市贸易的快速发展,边贸活动也伴随着跨国交易复杂、贸易不规范、跨境犯罪、贸易纠纷、法律监管难度大等诸多问题,而相关法律的运用成为了保障边民互市、维护边境稳定的关键。以勐啊村及周边地区边民互市存在的相关法律问题为切入点,分析目前边民互市中面临的问题并提出相应的解决策略。

Self-assembled supramolecular immunomagnetic nanoparticles throughπ-πstacking strategy for the enrichment of circulating tumor cells

Owing to their high-specific binding toward targets as well as fast and convenient separation operations,immunomagnetic beads(IMBs)are widely used in the capture and detection of circulating tumor cells(CTCs).To construct the IMBs,surface modifications are generally performed to functionalize the magnetic cores(e.g.Fe_(3)O_(4)nanoparticles),and the employed surface modification strategies normally influence the structure and functions of the prepared IMBs in return.Different from the existing work,we proposed the use of supramolecular layer-by-layer(LBL)self-assembly strategy to construct the IMBs.In general,owing to theπ-πstacking interactions,the polydopamine,graphene oxide and‘molecular glue’γ-oxo-1-pyrenebutyric acid were self-assembled on Fe_(3)O_(4)nanoparticles sequentially,thereby accomplishing the integration of different functional components onto magnetic cores to prepare the self-assembled supramolecular immunomagnetic beads(ASIMBs).The ASIMBs showed high sensitivity,specificity and good biocompatibility to the model CTCs and low nonspecific adsorption to the negative cells(∼93%for MCF-7 cells and 17%for Jurkat cells).Meanwhile,ASIMBs possessed a remarkable potential to screen the rare MCF-7 cells out of large amounts of interfering Jurkat cells with the capture efficiency of 75-100%or out of mouse whole blood with the capture efficiency of 20-90%.The captured cells can be further recultured directly without any more treatment,which showed huge applicability of the ASIMBs for in vitro detection in clinical practices.

Metallaaromatics Containing Main-group Heteroatoms

Metallaaromatics are metallacycles that are derived from the formal replacement of a carbon atom in the framework of organic aromatics with a metal fragment. As an important subclass of metallaaromatics, metallaaromatics that contain main-group heteroatoms have attracted considera- ble attention. In the past ten years, we have developed several new methods to construct metallaaromatics as well as those containing main-group het- eroatoms, such as metallapyridine, metallapyridinium, metallapyridyne, metallafuran, metallabenzothiazole, metallabenzoxazole, metallabenzthiophene, aza-metallapentalene and some novel tricyclic/tetracyclic metallaaromatics. In addition, interesting reactions such as the first hetero-Diels Aider reaction between 1-metalla-1,3-dienes and nitriles, the first intramolecular nucleophilic aromatic substitution （SNAr） reaction of metallabenzene, and the first iodine-mediated electrophilic cyclizations of a metallabenzene complex were demonstrated. In this account, recent and novel approaches for their synthesis and property analyses are summarized. The structural diversity and unique properties of metallaaromatics containing main-group heteroatoms will strongly inspire further investigation of these species and provide a wide range of potential applications.

Synthesis, Characterization and Electrochemical Properties of 4,5-Diazafluoren-9-yl or Fluoren-9-yl Terminated Homobimetallic Ruthenium and Osmium Allenylidene, AlkynyI-Allenylidene Complexes

A variety of rigid ruthenium and osmium allenylidene, ruthenium alkynyl-allenylidene complexes have been prepared. These allenylidene complexes were derived from 9-ethynyl-9-fluorenol and 9-hydroxy-9-ethynyl-4,5-diazafluorene in the presence of cis-OsCl2（dppm）2 and cis-RuCl2（dppe）2. The respective products have been fully characterized by 1H, 13C, 31P NMR spectrometry, IR spectrometry, elemental analysis, and UV/Vis spectrophotometry. Moreover, electrochemical studies reveal that the dinuclear complexes display a quasi-reversible redox behavior and a moderate electronic communication between the two metal centers in 8a. UV–vis studies show a remarkable absorption in the region （λmax = 300-700 nm） for these complexes.

pH-responsive superstructures prepared via the assembly of Fe_(3)O_(4) amphipathic Janus nanoparticles

The strategy of using Fe_(3)O_(4) amphiphilic Janus nanoparticles(Fe_(3)O_(4)@AJNPs)bearing b-cyclodextrin(b-CD)and aminopyridine(APD)functionalized polymethyl methacrylate(PGMA)to construct pH-stimuli responsive co-assemblies through host-guest interactions between b-CD and APD was proposed.The spherical co-assemblies with an average diameter about 210nm were excellent magnetic responsive and quite stable even up to 2 months in deionized water.The pH-liable capability of these co-assemblies was revealed by disassembly of the formed superstructures with destruction of the built inclusion complexes.The disassembly process was monitored by SEM,TEM,DLS and fluorescent molecules probe.After disassembly of the co-assemblies caused by protonation of nitrogens in APD,hydrophobic PGMA-APD lacking of interactions with the Fe_(3)O_(4)@AJNPs chains was precipitated,and the remained Fe_(3)O_(4)@AJNPs turned to re-assemble to selfassemblies.Besides,the recyclable Fe_(3)O_(4)@APJNs could reassembly with additional PGMA-APD to build co-assemblies with a uniform morphology for several times.These pH-sensitive co-assemblies with high stability,good magnetic responsiveness and cytocompatibility could be used as pH-responsive vehicles within which to encapsulate drugs for subsequent controlled release.