This paper deals with the communication problem in the distributed system, considering the limited battery power in the wireless network and redundant transmission among nodes. We design an event-triggered model predi...This paper deals with the communication problem in the distributed system, considering the limited battery power in the wireless network and redundant transmission among nodes. We design an event-triggered model predictive control(ET-MPC) strategy to reduce the unnecessary communication while promising the system performance. On one hand, for a linear discrete time-invariant system, a triggering condition is derived based on the Lyapunov stability. Here, in order to further reduce the communication rate, we enforce a triggering condition only when the Lyapunov function will exceed its value at the last triggered time, but an average decrease is guaranteed. On the other hand, the feasibility is ensured by minimizing and optimizing the terminal constrained set between the maximal control invariant set and the target terminal set. Finally, we provide a simulation to verify the theoretical results. It's shown that the proposed strategy achieves a good trade-off between the closed-loop system performance and communication rate.展开更多
Myoclonus dystonia syndrome(MDS)is an inherited movement disorder,and most MDS-related mutations have so far been found in theε-sarcoglycan(SGCE)coding gene.By generating SGCE-knockout(KO)and human 237 C>T mutatio...Myoclonus dystonia syndrome(MDS)is an inherited movement disorder,and most MDS-related mutations have so far been found in theε-sarcoglycan(SGCE)coding gene.By generating SGCE-knockout(KO)and human 237 C>T mutation knock-in(KI)mice,we showed here that both KO and KI mice exerted typical movement defects similar to those of MDS patients.SGCE promoted filopodia development in vitro and inhibited excitatory synapse formation both in vivo and in vitro.Loss of function of SGCE leading to excessive excitatory synapses that may ultimately contribute to MDS pathology.Indeed,using a zebrafish MDS model,we found that among 1700 screened chemical compounds,Vigabatrin was the most potent in readily reversing MDS symptoms of mouse disease models.Our study strengthens the notion that mutations of SGCE lead to MDS and most likely,SGCE functions to brake synaptogenesis in the CNS.展开更多
基金supported by the National Natural Science Foundation of China(61233004,61590924,61521063)
文摘This paper deals with the communication problem in the distributed system, considering the limited battery power in the wireless network and redundant transmission among nodes. We design an event-triggered model predictive control(ET-MPC) strategy to reduce the unnecessary communication while promising the system performance. On one hand, for a linear discrete time-invariant system, a triggering condition is derived based on the Lyapunov stability. Here, in order to further reduce the communication rate, we enforce a triggering condition only when the Lyapunov function will exceed its value at the last triggered time, but an average decrease is guaranteed. On the other hand, the feasibility is ensured by minimizing and optimizing the terminal constrained set between the maximal control invariant set and the target terminal set. Finally, we provide a simulation to verify the theoretical results. It's shown that the proposed strategy achieves a good trade-off between the closed-loop system performance and communication rate.
基金supported by National Natural Science Foundation of China(31630028,91632305,and 91632303)the Fund for Distinguished Young Scholars of National Natural Science Foundation of China(81425009 and 81425007)+1 种基金the National Basic Science Research Program of China(2012CB933900 and 2015CB755600)the Strategic Priority Research Program(B)of China(XDB02050500)。
文摘Myoclonus dystonia syndrome(MDS)is an inherited movement disorder,and most MDS-related mutations have so far been found in theε-sarcoglycan(SGCE)coding gene.By generating SGCE-knockout(KO)and human 237 C>T mutation knock-in(KI)mice,we showed here that both KO and KI mice exerted typical movement defects similar to those of MDS patients.SGCE promoted filopodia development in vitro and inhibited excitatory synapse formation both in vivo and in vitro.Loss of function of SGCE leading to excessive excitatory synapses that may ultimately contribute to MDS pathology.Indeed,using a zebrafish MDS model,we found that among 1700 screened chemical compounds,Vigabatrin was the most potent in readily reversing MDS symptoms of mouse disease models.Our study strengthens the notion that mutations of SGCE lead to MDS and most likely,SGCE functions to brake synaptogenesis in the CNS.
