Analysis of the Clinical Interventions for Falls in Elderly Patients in the Community From 2002 To 2022:A Bibliometric Analysis

Objective:To analyze and provide a comprehensive overview of the knowledge structure and research hotspots of clinical interventions for falls in elderly patients in the community.Methods:The search for publications related to clinical interventions for falls in elderly patients in the community from 2002 to 2022 was conducted on the Web of Science Core Collection(WoSCC)database.VOSviewers,CiteSpace,and the R package“bibliometrix”were used to conduct this bibliometric analysis.Results:2091 articles from 70 countries,primarily the United States and Australia,were included.The number of publications related to clinical interventions for falls in elderly patients is increasing yearly.The main research institutions in this field were the University of Sydney,Harvard University,and the University of California.BioMed Central(BMC)Geriatrics was the most popular journal in this field and Journals of the American Geriatrics Society was the most co-cited journal.These publications came from 8984 authors among which author Lord SR had published the most papers and author Tinetti Me had the most co-citations.The main keywords in this research field were“balance,”“exercise,”and“risk factor.”Conclusion:This was the first bibliometric study that comprehensively summarized the research hot spots and development of clinical interventions for falls in elderly patients in the community.This paper aims to provide a reference for scholars and researchers in this particular field.

Potential treatment with Chinese and Western medicine targeting NSP14 of SARS-CoV-2

The outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a serious global health threat.This raises an urgent need for the development of effective drugs against the deadly disease.SARS-CoV-2 non-structural protein 14(NSP14)carrying RNA cap guanine N7-methyltransferase and 30-50 exoribonuclease activities could be a potential drug target for intervention.NSP14 of SARS-CoV-2 shares 98.7%of similarity with the one(PDB 5NFY)of acute respiratory syndrome(SARS)by ClustalW.Then,the SARS-CoV-2 NSP14 structures were modelled by Modeller 9.18 using SARS NSP14(PDB 5NFY)as template for virtual screening.Based on the docking score from AutoDock Vina1.1.2,18 small molecule drugs were selected for further evaluation.Based on the 5 ns MD simulation trajectory,binding free energy(DG)was calculated by MM/GBSA method.The calculated binding free energies of Saquinavir,Hypericin,Baicalein and Bromocriptine for the N-terminus of the homology model wereà37.2711±3.2160,à30.1746±3.1914,à23.8953±4.4800,andà34.1350±4.3683 kcal/mol,respectively,while the calculated binding free energies wereà60.2757±4.7708,à30.9955±2.9975,à46.3099±3.5689,andà59.8104±3.5389 kcal/mol,respectively,when binding to the C-terminus.Thus,the compounds including Saquinavir,Hypericin,Baicalein and Bromocriptine could bind to the N-terminus and C-terminus of the homology model of the SARS-CoV-2 NSP14,providing a candidate drug against SARS-CoV-2 for further study.

Forecast Grain “Three Quantities” Based on Grey GM (1, 1) and Promote the Structural Reform of Grain Supply Side

As a special product, the cultivation and production of grain directly affect the consumption of people, which has an important influence on the development of social economy and the national economy and people’s livelihood. Firstly, the present situation of grain production is analyzed, and the problems facing the structural reform of grain supply side in China are analyzed from grain output and its import and export volume. Secondly, we use grey GM (1, 1) model to predict grain output and consumption, grain import and export volume and all kinds of grain crops output in China, and then analyze the future trend of grain production in China. Finally, we put forward construction of grain branding, rational allocation of grain planting varieties, construction of traceability system for grain production, further grain processing and development of “Internet agriculture” industrial model to promote structural reform of grain supply side.

A light-weight on-line action detection with hand trajectories for industrial surveillance

Most of the intelligent surveillances in the industry only care about the safety of the workers.It is meaningful if the camera can know what,where and how the worker has performed the action in real time.In this paper,we propose a light-weight and robust algorithm to meet these requirements.By only two hands'trajectories,our algorithm requires no Graphic Processing Unit(GPU)acceleration,which can be used in low-cost devices.In the training stage,in order to find potential topological structures of the training trajectories,spectral clustering with eigengap heuristic is applied to cluster trajectory points.A gradient descent based algorithm is proposed to find the topological structures,which reflects main representations for each cluster.In the fine-tuning stage,a topological optimization algorithm is proposed to fine-tune the parameters of topological structures in all training data.Finally,our method not only performs more robustly compared to some popular offline action detection methods,but also obtains better detection accuracy in an extended action sequence.

Forecast of Maize Production in Henan Province

Considering the influence of meteorological factors on maize production, in order to improve the yield of maize in Henan Province, a grey combination model is constructed to predict the yield of maize in Henan Province. Firstly, the yield of maize in 2017 is obtained by GM (1, 1) model;secondly, the trend yield of maize is obtained by HP filter method, then the meteorological yield of maize is obtained, and the yield of maize reduction is determined according to the meteorological yield. Combined with Markov model, the maize yield reduction in various cities in Henan Province is forecasted. Finally, based on the reduction of production, policy recommendations are made for maize production in Henan Province.

Analysis of Maize Production Efficiency Based on DEA-Malmquist Indexes: A Case Study of Henan Province

In order to improve the production efficiency of maize in Henan, China, the HP (High-Pass) filter method is used to obtain the maize trend yield. Secondly, the Malmquist index method is used to analyze the changes of TFP (Total Factor Productivity) of maize in 18 cities in Henan Province in the past 11 years. Finally, the amount of slack in maize input and output is analyzed. The results show that the research and development level of advanced technology of maize production in Henan Province has been improved to some extent in recent years;the advanced technology in various regions has not been fully promoted and utilized;there is a certain degree of relaxation in the input of various elements of maize;the resource allocation is unreasonable, and there is a certain amount of space for saving.

Multilevel Correlation Analysis of Influencing Factors on Grain Total Factor Productivity in Main Grain Producing Provinces of China

In order to analyze the influencing factors of TFP (the abbreviation of Total Factor Productivity) deeply, this paper calculates and decomposes the TFP of the main grain producing provinces in China from 2006 to 2015 by the DEA-Malmquist index model. On the basis of this, the grey correlation analysis model based on super-efficiency DEA is used to quantitatively analyze the influencing factors of total factor productivity, technological progress and technical efficiency. The results show that the proportion of grain sowing, the level of food economic development, the level of grain mechanization, the average scale of operations and the level of fertilizer using have the most influence on grain total factor productivity. Finally, according to the results of the analysis, some suggestions are put forward to improve the TFP of different provinces in the main grain producing areas.

纳米线存储器

意义：计算机上的存储器在断电时经常出现数据丢失。闪存等设备虽然没有这一问题，但其处理数据的速度有限。

基于Bi-LSTM和CRF的药品不良反应抽取模型构建

【目的】提出处理社会媒体上不规范文本的方法,以提高社会媒体中药品不良反应抽取效果。【方法】基于TensorFlow深度学习框架,将LSTM和CRF结合,借助LSTM能利用上下文信息的特性,通过CRF层考虑输出标记的依赖关系,构建基于Bi-LSTM和CRF的药品不良反应抽取模型。【结果】在Twitter数据集上开展系列实验,结果表明与传统CRF、前向LSTM、后向LSTM和Bi-LSTM相比,Bi-LSTM-CRF可以取得最高的F-measure值(0.7963)。【局限】实验数据源相对单一,未来可以在多个数据源上验证Bi-LSTM-CRF方法的有效性。【结论】结合LSTM和CRF能够有效处理社会媒体上不规范文本,所构建的模型可较好识别不良反应实体,辅助相关部门进行决策。

The Interpretation of Seismogenic Fault of the Maduo Mw 7.3Earthquake,Qinghai Based on Remote Sensing Images——A Branch of the East Kunlun Fault System

On May 22,2021,a Mw 7.3 earthquake occurred in Maduo County,Qinghai Province with the epicenter of 34.59°N,98.34°E.The distribution of aftershocks and surface ruptures suggested that the seismogenic structure might be the Jiangcuo fault(JF),~70 km south of East Kunlun fault(EKLF).Due to the high altitude and sparse human habitats,there are very few researches on the Jiangcuo fault,which makes us know little about the deformation features and even the geometry of Jiangcuo fault.In this study,we used the high-resolution pre-earthquake satellite images to interpret the spatial distribution and geometry of the Jiangcuo fault.Our results show that the Jiangcuo fault strikes nearly east,extending 180-km-long from Eling Lake to east of Changmahe Town.Based on the geometric features,the Jiangcuo fault could be divided into three segments characterized as the linear structures,fault valleys,scarps and systematic offset of channels.The boundary between Bayan Har Block and Qaidam Block is presented as a wide deformation zone named of Kunlun belt that is composed of East Kunlun fault and several branch faults around Anemaqen Mountain.Geometric analysis and deep lithosphere structure around Maduo County suggest that the Jiangcuo fault should be one of branch of East Kunlun fault at south,where the Kunlun fault developed as a giant flower structure.In addition,the seismic hazards potential of Jiangcuo fault should be given enough attention in the future,because west of the Jiangcuo fault,there is a rupture gap between the co-seismic surface ruptures of the 2001 Kunlun,2021 Maduo and 1937 Huashixia Earthquakes.

Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA

Group 3 innate lymphoid cells(ILC3s)play critical roles in innate immunity and gut homeostasis.However,how ILC3 homeostasis is regulated remains elusive.Here,we identified a novel circular RNA,circZbtb20,that is highly expressed in ILC3s and required for their maintenance and function.CircZbtb20 deletion causes reduced ILC3 numbers,increasing susceptibility to C.rodentium infection.Mechanistically,circZbtb20 enhances the interaction of Alkbh5 with Nr4a1 mRNA,leading to ablation of the m6A modification of Nr4a1 mRNA to promote its stability.Nr4a1 initiates Notch2 signaling activation,which contributes to the maintenance of ILC3 homeostasis.Deletion of Alkbh5 or Nr4a1 also impairs ILC3 homeostasis and increases susceptibilities to bacterial infection.Thus,our findings reveal an important role of circular RNA in the regulation of innate lymphoid cell homeostasis.

Fiber-Shaped Triboiontronic Electrochemical Transistor

Contact electrification-activated triboelectric potential offers an efficient route to tuning the transport properties in semiconductor devices through electrolyte dielectrics,i.e.,triboiontronics.Organic electrochemical transistors(OECTs)make more effective use of ion injection in the electrolyte dielectrics by changing the doping state of the semiconductor channel.However,the mainstream flexible/wearable electronics and OECT-based devices are usually modulated by electrical signals and constructed in conventional geometry,which lack direct and efficient interaction between the external environment and functional electronic devices.Here,we demonstrate a fiber-shaped triboiontronic electrochemical transistor with good electrical performances,including a current on/off ratio as high as≈1286 with off-current at~nA level,the average threshold displacements(D_(th))of 0.3 mm,the subthreshold swing corresponding to displacement(SS_(D))at 1.6 mm/dec,and excellent flexibility and durability.The proposed triboiontronic electrochemical transistor has great potential to be used in flexible,functional,and smart self-powered electronic textile.