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Compound Danshen tablets downregulate amyloid protein precursor mRNA expression in a transgenic cell model of Alzheimer's disease Effects and a comparison with donepezil 被引量:8
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作者 Ren'an Qin Desheng Zhou +4 位作者 Jiajun Wang Hua Hu Yang Yang xiaoxuan yao Xiaopeng Sun 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第9期659-663,共5页
After gene mutation, the pcDNA3.1/APP595/596 plasmid was transfected into HEK293 cells to establish a cell model of Alzheimer's disease. The cell model was treated with donepezil or compound Danshen tablets after cul... After gene mutation, the pcDNA3.1/APP595/596 plasmid was transfected into HEK293 cells to establish a cell model of Alzheimer's disease. The cell model was treated with donepezil or compound Danshen tablets after culture for 72 hours. Reverse transcription-PCR showed that the mRNA expression of amyloid protein precursor decreased in all groups following culture for 24 hours, and that there was no significant difference in the amount of decrease between donepezil and compound Danshen tablets. Our results suggest that compound Danshen tablets can reduce expression of the mRNA for amyloid protein precursor in a transgenic cell model of Alzheimer's disease, with similar effects to donepezil. 展开更多
关键词 amyloid protein precursor Alzheimer’s disease transgenic cell model compound Danshen tablets Chinese medicine neural regeneration
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