The aerodynamics of gas-particle suspensions is simulated as an Euler-Euler two-fluid model in a revolving rotor over a particle bed. The interactions of collisions between the blade and particles and particle-particl...The aerodynamics of gas-particle suspensions is simulated as an Euler-Euler two-fluid model in a revolving rotor over a particle bed. The interactions of collisions between the blade and particles and particle-particle interactions are modeled using the kinetic theory of granular flow(KTGF). The gas turbulence induced by the rotation of the rotor is modeled using the kg-εg model. The flow field of a revolving rotor is simulated using the multiple reference frame(MRF) method. The distributions of velocities, volume fractions, and gas pressure are predicted while the aircraft hovers at different altitudes.The gas pressure decreases from the hub to the tip of the blade, and it is higher at the pressure side than that at the suction side of the rotor. The turbulent kinetic energy of the gas increases toward the blade tip. The volume fraction of particles decreases as the hovering altitude increases. The simulated pressure coefficient is compared with that in experimental measurements.展开更多
MicroRNAs(miRNAs)have been found to play an important role in human tumorigenesis.A study indicates that the plasma level of miR-933 was elevated in patients with dementia.1 Notably,miR-933(RS79402775)may contribute t...MicroRNAs(miRNAs)have been found to play an important role in human tumorigenesis.A study indicates that the plasma level of miR-933 was elevated in patients with dementia.1 Notably,miR-933(RS79402775)may contribute to the reduction of gastric cancer susceptibility.展开更多
The maternally expressed gene 3(MEG3)acts as an antitumor component in different cancer cells.However,MEG3 variant has been shown to confer cancer susceptibility1 and certain polymorphisms within MEG3 are implicated i...The maternally expressed gene 3(MEG3)acts as an antitumor component in different cancer cells.However,MEG3 variant has been shown to confer cancer susceptibility1 and certain polymorphisms within MEG3 are implicated in cancer risk(rs7158663,rs4081134,and rs11160608).2 Moreover,MEG3-TTCC and MEG3-CCCA promote the differentiation of SCs by activating the JAK2/STAT3 signaling pathway in different degrees.3 In particular,the alleles of MEG3(AA,GA+AA)and MEG3(rs7158663)were associated with an increased risk for human liver cancer.4 Moreover,Sirt2 is a specific NAD-dependent histone deacetylase for H4–K16 and has a strong preference for histone H4K16Ac in their deacetylation activity.5 Nevertheless,the functions and mechanism of MEG3 variant on hepatocarcinogenesis have not yet been well-demonstrated.展开更多
In a recent paper published in Nature,Chen et al.provide a new perspective on how glucose tolerance of the offspring is affected by pregestational hyperglycaemia.1 They showed that oocytes isolated from hyperglycemic ...In a recent paper published in Nature,Chen et al.provide a new perspective on how glucose tolerance of the offspring is affected by pregestational hyperglycaemia.1 They showed that oocytes isolated from hyperglycemic mice transmit the impaired glucose homeostasis to the offspring via epigenetic modifications,and insufficiency of oocyte TET3 dioxygenase is indispensable for this process.展开更多
基金Project supported by the National Natural Science Foundation of China(Nos.91752115 and 51776059)
文摘The aerodynamics of gas-particle suspensions is simulated as an Euler-Euler two-fluid model in a revolving rotor over a particle bed. The interactions of collisions between the blade and particles and particle-particle interactions are modeled using the kinetic theory of granular flow(KTGF). The gas turbulence induced by the rotation of the rotor is modeled using the kg-εg model. The flow field of a revolving rotor is simulated using the multiple reference frame(MRF) method. The distributions of velocities, volume fractions, and gas pressure are predicted while the aircraft hovers at different altitudes.The gas pressure decreases from the hub to the tip of the blade, and it is higher at the pressure side than that at the suction side of the rotor. The turbulent kinetic energy of the gas increases toward the blade tip. The volume fraction of particles decreases as the hovering altitude increases. The simulated pressure coefficient is compared with that in experimental measurements.
基金supported by grants from the National Natural Science Foundation of China(No.82073130)the Science and Technology Commission of Shanghai Municipality Shanghai Science and Technology Plan Basic Research Field Project(China)(No.20JC1411400).
文摘MicroRNAs(miRNAs)have been found to play an important role in human tumorigenesis.A study indicates that the plasma level of miR-933 was elevated in patients with dementia.1 Notably,miR-933(RS79402775)may contribute to the reduction of gastric cancer susceptibility.
基金supported by the National Natural Science Foundation of China(No.82073130)the Science and Technology Commission of Shanghai Municipality Shanghai Science and Technology Plan Basic Research Field Project(China)(No.19JC1415200)the Science and Technology Commission of Shanghai Municipality Shanghai Science and Technology Plan Basic Research Field Project(China)(No.20JC1411400).
文摘The maternally expressed gene 3(MEG3)acts as an antitumor component in different cancer cells.However,MEG3 variant has been shown to confer cancer susceptibility1 and certain polymorphisms within MEG3 are implicated in cancer risk(rs7158663,rs4081134,and rs11160608).2 Moreover,MEG3-TTCC and MEG3-CCCA promote the differentiation of SCs by activating the JAK2/STAT3 signaling pathway in different degrees.3 In particular,the alleles of MEG3(AA,GA+AA)and MEG3(rs7158663)were associated with an increased risk for human liver cancer.4 Moreover,Sirt2 is a specific NAD-dependent histone deacetylase for H4–K16 and has a strong preference for histone H4K16Ac in their deacetylation activity.5 Nevertheless,the functions and mechanism of MEG3 variant on hepatocarcinogenesis have not yet been well-demonstrated.
文摘In a recent paper published in Nature,Chen et al.provide a new perspective on how glucose tolerance of the offspring is affected by pregestational hyperglycaemia.1 They showed that oocytes isolated from hyperglycemic mice transmit the impaired glucose homeostasis to the offspring via epigenetic modifications,and insufficiency of oocyte TET3 dioxygenase is indispensable for this process.
