Mechanoluminescent-Triboelectric Bimodal Sensors for Self-Powered Sensing and Intelligent Control

Self-powered flexible devices with skin-like multiple sensing ability have attracted great attentions due to their broad applications in the Internet of Things(IoT).Various methods have been proposed to enhance mechano-optic or electric performance of the flexible devices;however,it remains challenging to realize the display and accurate recognition of motion trajectories for intelligent control.Here,we present a fully self-powered mechanoluminescent-triboelectric bimodal sensor based on micronanostructured mechanoluminescent elastomer,which can patterned-display the force trajectories.The deformable liquid metals used as stretchable electrode make the stress transfer stable through overall device to achieve outstanding mechanoluminescence(with a gray value of 107 under a stimulus force as low as 0.3 N and more than 2000 cycles reproducibility).Moreover,a microstructured surface is constructed which endows the resulted composite with significantly improved triboelectric performances(voltage increases from 8 to 24 V).Based on the excellent bimodal sensing performances and durability of the obtained composite,a highly reliable intelligent control system by machine learning has been developed for controlling trolley,providing an approach for advanced visual interaction devices and smart wearable electronics in the future IoT era.

Emergency Control Strategy Based on Multi-agent Theory under Blackout

The multi-agent theory is introduced and applied in the way to strike the control amount of emergency control according to stability margin, based on which an emergency control strategy of the power system is presented. The multi-agent control structure which is put forward in this article has three layers: system agent, areal agent and local agents. System agent sends controlling execution signal to the load-local agent according to the position and the amount of load shedding upload from areal agent;The areal agent judges whether the power system is stable by monitoring and analyzing the maximum relative power angle. In the condition of instability, determines the position of load-shedding, and the optimal amount of load-shedding according to the stability margin based on the corrected transient energy function, upload control amount to system agent;local-generator agent is mainly used for real-time monitoring the power angle of generator sets and uploading it to the areal agency, local-loads agent control load by receiving the control signal from system agent. Simulations on IEEE39 system show that the proposed control strategy improves the system stability.

水系锌离子电池

水系锌离子电池(AZIBs)具有安全、成本低、理论容量高以及锌储量丰富等优点,在大规模储能应用中极具发展前景,引起人们的广泛关注。近些年,关于AZIBs的相关研究报道增长迅速。然而AZIBs较低的能量密度、较差的离子动力性和较短的循环寿命限制了其实际应用及商业化进程。作者综述分析了近几年关于AZIBs储能系统中正极、负极、电解液以及相关储能机制所遇到的难题及可行性解决方案,为研究者设计和开发高性能AZIBs提供参考。

Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells

The restriction of immunoglobulin(Ig)expression to B lymphocytes is well established.However,several reports have confirmed that the Ig gene can be expressed in many non-B cancer cells and/or some normal cells.Our aim is to determine whether the Ig gene promoter can be activated in non-B cancer cells and to identify the regulatory mechanism for Ig gene expression.Our results show that the Ig promoter of VH4-59 was activated in several non-B cancer cell lines.Moreover,two novel positive regulatory elements,an enhancer-like element at 2800 to 2610 bp and a copromoter-like element at 2610 to 2300 bp,were identified in two epithelial cancer cell lines,HeLa S3 and HT-29.The octamer element(59-ATGCAAAT-39)located in the Ig promoter,a crucial element for B-cell-derived Ig gene transcription,was also very important for non-B-cell-derived Ig gene transcription.More importantly,we confirmed that octamer-related protein-1(Oct-1),but not Oct-2,was a crucial transcriptional factor for Ig gene transcription due to its ability to bind to the octamer element of the Ig promoter in epithelial cancer cells.These results suggested the presence of a distinct regulatory mechanism for Ig gene expression in non-B cancer cells.

Rearrangement and expression of the immunoglobulin μ-chain gene in human myeloid cells

Immunoglobulin （Ig）, a characteristic marker of B cells, has been reported to be expressed in epithelial cells, with a suggested role in their growth and survival. We have previously reported that IgG heavy chain is expressed in acute myeloid leukemia （AML）, but not in the monocytes or neutrophils from patients with non-hematopoietic neoplasms or healthy controls. In the present study, we assessed IgM heavy chain expression and repertoire in human myeloid cells. We detected VHIzDJHp- rearrangement and expression in 7/7 AML cell lines, 7/14 primary myeloblasts from AML patients, and interestingly, 8/20 monocytes and 3/20 neutrophils from patients with non-hematopoietic neoplasms and healthy individuals. We also found evidence of somatic hypermutation of the variable （V） gene segments in AML-derived IgM gene rearrangements but not in IgM from monocytes or neutrophils from patients with non-hematopoietic neoplasms and healthy individuals. Furthermore, IgM VH^DJH~ gene rearrangements in AML cell lines, primary myeloblasts, and monocytes and neutrophils from patients with non-hematopoietic neoplasms showed a restricted V usage and repertoire, whereas the VH^DJH~ gene rearrangements in monocytes and neutrophils from healthy individuals displayed more diversity. Anti-human IgM inhibited cell proliferation, but did not induce apoptosis in AML cell lines. Our findings suggest that AML-derived IgM might be a novel AML-related molecule that is involved in leukemogenesis and AML progression and might serve as a useful molecular marker for designing targeted therapy and monitoring minimal residual disease.

A novel strategy for identifying biomarker in serum of patient with COVID-19 using immune complex

Dear Editor,COVID-19(Coronavirus Disease 2019)is a disease caused by the single-stranded sense RNA virus SARS-CoV-2(severe acute respiratory syndrome coronavirus 2),which has caused a global public health crisis.1 However,so far no effective serum marker has been found as a biomarker for COVID-19 diagnosis,except that viral nucleic acid detection is an effective evidence of SARS-CoV-2 infection.