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Prediction and Analysis of Elevator Traffic Flow under the LSTM Neural Network
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作者 Mo Shi Entao Sun +1 位作者 xiaoyan xu Yeol Choi 《Intelligent Control and Automation》 2024年第2期63-82,共20页
Elevators are essential components of contemporary buildings, enabling efficient vertical mobility for occupants. However, the proliferation of tall buildings has exacerbated challenges such as traffic congestion with... Elevators are essential components of contemporary buildings, enabling efficient vertical mobility for occupants. However, the proliferation of tall buildings has exacerbated challenges such as traffic congestion within elevator systems. Many passengers experience dissatisfaction with prolonged wait times, leading to impatience and frustration among building occupants. The widespread adoption of neural networks and deep learning technologies across various fields and industries represents a significant paradigm shift, and unlocking new avenues for innovation and advancement. These cutting-edge technologies offer unprecedented opportunities to address complex challenges and optimize processes in diverse domains. In this study, LSTM (Long Short-Term Memory) network technology is leveraged to analyze elevator traffic flow within a typical office building. By harnessing the predictive capabilities of LSTM, the research aims to contribute to advancements in elevator group control design, ultimately enhancing the functionality and efficiency of vertical transportation systems in built environments. The findings of this research have the potential to reference the development of intelligent elevator management systems, capable of dynamically adapting to fluctuating passenger demand and optimizing elevator usage in real-time. By enhancing the efficiency and functionality of vertical transportation systems, the research contributes to creating more sustainable, accessible, and user-friendly living environments for individuals across diverse demographics. 展开更多
关键词 Elevator Traffic Flow Neural Network LSTM Elevator Group Control
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氧化还原驱动的高活性Pd/PdO表面界面促进低温甲烷燃烧
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作者 谈源龙 张亚峰 +10 位作者 高雅 马静远 赵晗 顾青青 苏杨 徐晓燕 王爱琴 杨冰 张国旭 刘晓艳 张涛 《Chinese Journal of Catalysis》 SCIE CAS CSCD 2024年第5期242-252,共11页
天然气汽车尾气中尚未充分燃烧的甲烷是一种典型的温室气体之一,其温室效应远超二氧化碳,达到后者的20倍以上.因此,减少甲烷的排放对于有效应对气候变化至关重要.目前,以Pd/Al_(2)O_(3)为基础催化剂的催化燃烧反应,已被证实为减少甲烷... 天然气汽车尾气中尚未充分燃烧的甲烷是一种典型的温室气体之一,其温室效应远超二氧化碳,达到后者的20倍以上.因此,减少甲烷的排放对于有效应对气候变化至关重要.目前,以Pd/Al_(2)O_(3)为基础催化剂的催化燃烧反应,已被证实为减少甲烷排放的最为切实可行的技术手段.深入了解钯基催化剂的活性结构不仅有助于合理设计高效的催化体系,还能在很大程度上减少贵金属钯的使用量.然而,在甲烷燃烧反应过程中,由于氧化还原气氛的复杂性,Pd金属的表面容易转变为不同结构,这增加了研究其活性结构的难度.此外,催化剂的制备方法、载体的性质、预处理的气氛以及温度等因素均会对Pd的价态和粒径效应产生影响,使得Pd基催化剂在甲烷燃烧反应中的活性结构至今仍存在争议.为了深入研究这一问题,本文选用商业化的纳米级γ-Al_(2)O_(3)作为载体,采用易于工业化应用的浸渍法制备了Pd/Al_(2)O_(3)催化剂,并研究其在低温(200-400℃)贫燃条件下的活性结构.球差电镜结果表明,催化剂中的Pd纳米颗粒在不同气氛中经800℃高温预处理后呈现出不同的结构特点.氦气处理后的催化剂中,Pd以完全金属态的形式存在;氧气处理后的催化剂中,Pd以PdO的形式存在;甲烷燃烧反应气处理后的催化剂中,PdO大颗粒上存在金属Pd小颗粒,呈现出“荔枝型”Pd/PdO结构.准原位X射线光电子能谱和原位X射线吸收谱等结果表明,“荔枝型”Pd/PdO结构是在甲烷燃烧反应中受氧化还原气氛诱导形成的.该独特的“荔枝型”Pd/PdO结构的催化剂在300℃甲烷燃烧反应中,表现出337.8μmol gPd^(-1) s^(-1)的反应速率,分别是纯金属Pd和PdO型催化剂反应速率的10.7倍和15.5倍.进一步研究表明,无论催化剂中Pd的初始状态为金属态或是氧化态,高活性的“荔枝型”Pd/PdO结构都可以在较低温度(500℃)的长时间(12 h)甲烷燃烧反应中缓慢生成.通过调节预处理气氛中甲烷与氧气的相对浓度,可以实现689.2μmol gPd-1 s^(-1)的反应速率,高于文献已报道的Pd基催化剂在相似反应条件下的活性.密度泛函理论计算结果表明,相对于金属Pd和PdO,甲烷在Pd/PdO界面处表现出最低(0.40 eV)的自由能势垒,这表明由于界面处金属Pd和PdO的协同作用,甲烷断裂第一个C-H键的解离活化过程更容易发生,从而解释了“荔枝型”Pd/PdO结构高催化活性的来源.综上,本文通过先进的球差电镜和原位光谱表征技术,为深入认识甲烷燃烧钯基催化剂活性结构提供了新的角度.研究发现,反应过程中因气氛诱导而生成的高活性结构可能是重要的活性中心,这一观点不仅有助于理解甲烷燃烧反应的机理,而且可以为其他氧化还原催化体系的研究以及工业催化剂的设计制备提供参考. 展开更多
关键词 原位表征 纳米颗粒 甲烷燃烧 界面
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Sn1Pt单原子合金催化剂在丙烷脱氢反应中的应用 被引量:1
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作者 邢亚楠 康磊磊 +10 位作者 马静远 蒋齐可 苏杨 张盛鑫 徐晓燕 李林 王爱琴 刘智攀 马思聪 刘晓艳 张涛 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2023年第5期164-174,共11页
丙烯是生产聚丙烯、各类丙烷氧化物、丙烯腈的重要化工原料.近年来,随着丙烯需求量日益增长,作为一种专产丙烯的生产方式,丙烷脱氢(PDH)受到了越来越多的关注.PtSn/Al_(2)O_(3)是一种典型的工业丙烷脱氢催化剂,其特征是催化活性会随反... 丙烯是生产聚丙烯、各类丙烷氧化物、丙烯腈的重要化工原料.近年来,随着丙烯需求量日益增长,作为一种专产丙烯的生产方式,丙烷脱氢(PDH)受到了越来越多的关注.PtSn/Al_(2)O_(3)是一种典型的工业丙烷脱氢催化剂,其特征是催化活性会随反应时间的推移而下降,因此需要反复再生以保证丙烯产率.提高PtSn催化剂的稳定性,需要明确反应状态下PtSn的催化性能与其结构之间的关系.然而,Pt和Sn的价态及其相互作用,对制备方法、预还原条件、载体类型等因素非常敏感,此外,从Pt-Sn二元相图来看,二者在高温(~600℃)还原性反应气氛下可形成多种合金结构,因此,PtSn在丙烷脱氢中的活性位结构的认识颇具挑战,目前文献报道结果仍存在争议.本文选用商业化的纳米级γ-Al_(2)O_(3)作为载体,通过利用纳米载体上只能担载有限数量的金属原子和加入过量的第二金属Sn稀释活性金属Pt的方式,得到高分散的PtSn/nano-Al_(2)O_(3)催化剂.当Pt和Sn的负载量分别为0.1 wt%和1 wt%时,其初始丙烯产率可达到47.6 molC_(3)H_(6)gPt^(-1)h^(-1),高于文献已报道的PtSn双金属催化剂,该催化剂经3-10 h活性快速下降期(k_(d-3h):0.11h^(-1))后,表现出较好的稳定性(k_(d-10~40h):0.0026 h^(-1)).球差电镜(AC-HAADF-STEM)表征结果显示,该催化剂经500℃焙烧后,Pt及Sn在Al_(2)O_(3)载体上均呈单原子分散状态;经600℃氢气还原后,Pt团聚为平均直径约0.85 nm的纳米颗粒;通过对其进行能谱点扫分析,发现Pt纳米颗粒上分布有少量的Sn原子,而剩余大量的Sn原子则继续以单原子形式分布在载体上.进一步原位X射线光电子能谱和原位X射线吸收能谱结果证明,该催化剂中纳米颗粒的具体组成为Sn单原子分散在Pt纳米颗粒表面,形成S_(n1)Pt表面单原子合金结构.密度泛函理论理论计算证明了S_(n1)Pt表面单原子合金结构的稳定性及其在丙烷脱氢中的高活性.最后结合原位CO吸附的漫反射红外光谱等表征,揭示了催化剂反应初期活性下降及后期高稳定性的内在原因:催化剂经还原后形成了高活性的S_(n1)Pt表面单原子合金结构,在反应过程中,该结构演变为纯相Pt_(3)Sn金属间化合物,其与周围呈单分散的SnOx物种协同作用,抑制和转移在活性中心上的积碳,进而实现了高稳定性.这种通过单原子表面合金演变得到的Pt_(3)Sn金属间化合物,与传统Pt与Pt_(3)Sn等金属化合物混相共存的工业催化剂相比,可以避免丙烯在催化剂表面单金属Pt平台位点上的深度脱氢和积碳,进而提高了催化剂稳定性.综上,本文从原子水平上为PDH反应中PtSn/Al_(2)O_(3)催化剂的活性位结构及其演化过程提供了新的见解,并为工业催化剂的设计制备提供了理论参考. 展开更多
关键词 丙烷脱氢 丙烯 Pt-Sn催化剂 结构重构 单原子合金
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基于增强CT影像组学的机器学习模型鉴别诊断低风险胃间质瘤 被引量:3
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作者 范莉芳 赵劲松 +3 位作者 吴树剑 徐晓燕 徐争元 傅雨晨 《中国肿瘤临床》 CAS CSCD 北大核心 2023年第8期411-417,共7页
目的:探讨基于增强CT影像组学的机器学习(machine learning,ML)模型鉴别低风险胃间质瘤(gastric stromal tumor,GST)与良性胃黏膜下肿瘤(gastric submucosal tumor,GSMT)的价值。方法:回顾性分析2013年1月至2022年3月皖南医学院弋矶山医... 目的:探讨基于增强CT影像组学的机器学习(machine learning,ML)模型鉴别低风险胃间质瘤(gastric stromal tumor,GST)与良性胃黏膜下肿瘤(gastric submucosal tumor,GSMT)的价值。方法:回顾性分析2013年1月至2022年3月皖南医学院弋矶山医院84例低风险GST及51例良性GSMT患者的临床及影像资料。将患者随机分为训练集(n=94)和测试集(n=41)。基于增强CT静脉期利用ITK-SNAP软件分割图像,AK软件提取影像组学特征,mRMR、Spearman秩相关及LASSO回归对特征降维,建立影像组学标签评分(Radscore)。采用单因素及多因素Logistic回归筛选独立危险因素,使用支持向量机(suppor vector machine,SVM)建立预测模型,用测试集检测模型的泛化能力,受试者工作特征(receiver operating characteristic,ROC)曲线下面积(area under curve,AUC)评估模型效能。结果:多因素分析年龄、形态、生长部位、长径/短径(long diameter,LD/short diameter,SD)及Radscore为独立危险因素,SVM建立预测模型的AUC训练集为0.933、测试集为0.913。结论:基于增强CT影像组学的SVM算法构建的模型能够有效地鉴别低风险GST与良性GSMT,且模型具有较好的泛化能力。 展开更多
关键词 影像组学 机器学习 鉴别诊断 低风险胃间质瘤
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Clay minerals and elemental composition of sediments on different sedimentary units in the northern East China Sea shelf:provenance tracing and genetic mechanism analysis
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作者 xiaoyan xu Yong Zhang +6 位作者 Yanguang Dou Jingyi Cong Beibei Mi Xiaohui Chen Xia Li Chengfen xu Yongyu Ye 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2023年第11期19-34,共16页
The composition,provenance,and genetic mechanism of sediment on different sedimentary units of the East China Sea(ECS)shelf are essential for understanding the depositional dynamics environment in the ECS.The sediment... The composition,provenance,and genetic mechanism of sediment on different sedimentary units of the East China Sea(ECS)shelf are essential for understanding the depositional dynamics environment in the ECS.The sediments in the northern ECS shelf are distributed in a ring-shaped distribution centered on the southwestern Cheju Island Mud.From the inside to the outside,the grain size goes from fine to coarse.Aside from the“grain size effect”,hydrodynamic sorting and mineral composition are important restrictions on the content of rare earth elements(REEs).Based on the grain size,REEs,and clay mineral composition of 300 surface sediments,as well as the sedimentary genesis,the northern ECS shelf is divided into three geochemical zones:southwestern Cheju Island Mud Area(ZoneⅠ),Changjiang Shoal Sand Ridges(ZoneⅡ-1),Sand Ridges of the East China Sea shelf(ZoneⅡ-2).The northern ECS shelf is mostly impacted by Chinese mainland rivers(the Changjiang River and Huanghe River),and the provenance and transport mechanism of sediments of different grain sizes is diverse.The bulk sediments come primarily from the Changjiang River,with some material from the Huanghe River carried by the Yellow Sea Coastal Current and the North Jiangsu Coastal Current,and less from Korean rivers.Among them,surface sediments in the southwestern Cheju Island Mud Area(ZoneⅠ)come mostly from the Changjiang River and partly from the Huanghe River.It was formed by the counterclockwise rotating cold eddies in the northern ECS shelf,which caused the sedimentation and accumulation of the fine-grained sediments of the Changjiang River and the Huanghe River.The Changjiang Shoal Sand Ridges(ZoneⅡ-1)were developed during the early-middle Holocene sea-level highstand.It is the modern tidal sand ridge sediment formed by intense hydrodynamic action under the influence of the Yellow Sea Coastal Current,North Jiangsu Coastal Current,and Changjiang Diluted Water.The surface sediments mainly originate from the Changjiang River and Huanghe River,with the Changjiang River dominating,and the Korean River(Hanjiang River)influencing just a few stations.Sand Ridges of the East China Sea shelf(ZoneⅡ-2)are the relict sediments of the paleo-Changjiang River created by sea invasion at the end of the Last Deglaciation in the Epipleistocene.The clay mineral composition of the surface sediments in the study area is just dominated by the Changjiang River,with the North Jiangsu Coastal Current and the Changjiang Diluted Water as the main transporting currents. 展开更多
关键词 the northern East China Sea shelf rare earth element clay mineral PROVENANCE genetic mechanism
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Application Research of Medical Imaging Practical Teaching Based on Virtual Simulation Teaching Platform
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作者 Yong Zhou Wenbo Jing +3 位作者 Cheng Zhou Yingying Yu Xiaojing Gan xiaoyan xu 《Journal of Contemporary Educational Research》 2023年第5期33-38,共6页
Objective:To explore the application effect of virtual simulation teaching platform in the practical teaching of medical imaging.Methods:A total of 97 students majoring in medical imaging technology of class 2022 were... Objective:To explore the application effect of virtual simulation teaching platform in the practical teaching of medical imaging.Methods:A total of 97 students majoring in medical imaging technology of class 2022 were selected and divided into two groups according to the random number method:control group(n=48)and observation group(n=49).The observation group was under the practical teaching mode based on the virtual simulation teaching platform,while the control group was under the traditional multimedia teaching mode.Questionnaire survey and teaching assessment were carried out after the teaching period,and the application effects of the two teaching modes were compared.Results:The reading and theoretical scores of the students in the observation group were significantly higher than those of the students in the control group(P<0.01);there were statistically significant differences in the results of the questionnaire survey(improved learning interest,improved language expression,improved ability to comprehensively analyze problems,and improved teamwork awareness)between the two groups of students(P<0.05);the students in the observation group were markedly more satisfied with the teaching content,teaching methods,and teaching quality than the students in the control group(P<0.05).Conclusion:The medical imaging practical teaching mode based on virtual simulation platform not only helps improve students’theoretical understanding and practical ability in medical imaging technology,but also improves students’learning interest,language expression ability,ability to comprehensively analyze problems,communication skills,teamwork awareness,and satisfaction with the teaching content,teaching methods,and teaching quality.Therefore,it has wide application value in medical specialty education. 展开更多
关键词 Medical imaging Virtual simulation Practical teaching Problem-oriented
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Experiment Combined with Picture Archiving and Communication System in the Practical Teaching of Medical Imaging
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作者 Yong Zhou Yingying Yu +3 位作者 Wenbo Jing Xiaojing Gan Zhiwei Zhao xiaoyan xu 《Journal of Contemporary Educational Research》 2023年第4期55-60,共6页
Objective:To explore the application effect of virtual simulation experiment combined with picture archiving and communication system(PACS)in medical imaging practical teaching.Methods:97 students from the medical ima... Objective:To explore the application effect of virtual simulation experiment combined with picture archiving and communication system(PACS)in medical imaging practical teaching.Methods:97 students from the medical imaging class of 2022 were divided into two groups;the control group(n=48)was taught by the traditional teaching method,whereas the research group was taught by virtual simulation experiment combined with PACS(n=49).The teaching achievements and teaching effects of the two groups were compared to define the advantages of the two teaching modes.Results:Initially,there were no significant differences in the basic theory,image analysis,report writing,and differential diagnosis scores between the two groups of students(P>0.05);however,after 16 weeks of teaching,the scores of the research group were better than those of the control group(P<0.05);the pass rate of students in the study group(93.88%)was higher than that in the control group(81.25%);the scores of students in the research group in terms of clinical inquiry skills,X-ray/computed tomography/magnetic resonance imaging(X-ray/CT/MRI)operation skills,and doctor-patient communication skills were significantly higher than those in the control group(P<0.05).Conclusion:In medical imaging practical teaching,the application of virtual simulation experiment combined with PACS can effectively address several problems in the traditional teaching mode,including the single teaching method,the single teaching content,and the lack of innovation,and,at the same time,improve students’basic theoretical knowledge,X-ray/CT/MRI operation skills,consultation skills,and doctor-patient communication skills,thereby effectively improving the teaching quality and learning effect. 展开更多
关键词 Medical imaging Virtual simulation experiment PACS system Teaching effect
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Local Discontinuous Galerkin Method for the Time-Fractional KdV Equation with the Caputo-Fabrizio Fractional Derivative 被引量:1
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作者 Huanhuan Wang xiaoyan xu +2 位作者 Junmei Dou Ting Zhang Leilei Wei 《Journal of Applied Mathematics and Physics》 2022年第6期1918-1935,共18页
This paper studies the time-fractional Korteweg-de Vries (KdV) equations with Caputo-Fabrizio fractional derivatives. The scheme is presented by using a finite difference method in temporal variable and a local discon... This paper studies the time-fractional Korteweg-de Vries (KdV) equations with Caputo-Fabrizio fractional derivatives. The scheme is presented by using a finite difference method in temporal variable and a local discontinuous Galerkin method (LDG) in space. Stability and convergence are demonstrated by a specific choice of numerical fluxes. Finally, the efficiency and accuracy of the scheme are verified by numerical experiments. 展开更多
关键词 Caputo-Fabrizio Fractional Derivative Local Discontinuous Galerkin Method STABILITY Error Analysis
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论证质量的变化——师生合作评价教学研究
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作者 徐晓燕 钟悦欣 邵子萌 《Chinese Journal of Applied Linguistics》 2022年第4期491-509,612,共20页
本研究对比了为期一个学期的师生合作评价(TSCA)和经培训的同伴互评(TPRA)教学的有效性。因变量包括简化的Toulmin模式中议论文结构要素的出现频率和论证内容质量的提升。被试来自两个自然班,共81名英语专业大二学生。其中,一个班为TPRA... 本研究对比了为期一个学期的师生合作评价(TSCA)和经培训的同伴互评(TPRA)教学的有效性。因变量包括简化的Toulmin模式中议论文结构要素的出现频率和论证内容质量的提升。被试来自两个自然班,共81名英语专业大二学生。其中,一个班为TPRA组,共40名学生;另一个班为TSCA组,共41名学生。前后测结果显示,相比TPRA组,TSCA组的反方论点和反驳论据的频率显著增加,反方论点、反驳论点和反驳论据的质量更好。 展开更多
关键词 结构要素 Toulmin模式 论证内容 师生合作评价 同伴互评 英语写作
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安罗替尼治疗KRAS突变型晚期肺腺癌1例 被引量:44
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作者 苏雨栋 孟昭婷 +5 位作者 徐晓燕 王心悦 左冉 侯云霞 李凯 陈鹏 《中国肺癌杂志》 CAS CSCD 北大核心 2018年第5期428-430,共3页
近年来,晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者逐渐增多,治疗方法也明显增多,然而,目前对于靶向治疗表皮生长因子受体(epidermal growth factor receptor,EGFR)/间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)耐... 近年来,晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者逐渐增多,治疗方法也明显增多,然而,目前对于靶向治疗表皮生长因子受体(epidermal growth factor receptor,EGFR)/间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)耐药或化疗失败的三线及以上患者,国内外并没有标准的治疗方案,临床治疗效果也不尽如人意,安罗替尼是一种新型小分子多靶点酪氨酸激酶抑制剂,可强效抑制血管内皮细胞生长因子受体(vascular endothelial growth factor receptor,VEGFR)、血小板衍生生长因子受体(platelet-derived growth factor receptor,PDGFR)、纤维母细胞生长因子受体(fibroblast growth factor receptor,FGFR)和c-Kit等多个靶点,ALTER0303是一项关于安罗替尼作为晚期NSCLC三线治疗方案的临床研究,结果显示安罗替尼能显著延长晚期NSCLC患者的总生存期(overall survival,OS)和无进展生存期(progression-free survival,PFS),本文报道安罗替尼治疗KRAS突变型晚期肺腺癌1例。 展开更多
关键词 安罗替尼(Anlotinib) 肺肿瘤 晚期肺癌
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Composite solid electrolyte of Na3PS4-PEO for all-solid-state SnS2/Na batteries with excellent interfacial compatibility between electrolyte and Na metal 被引量:7
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作者 xiaoyan xu Yuanyuan Li +6 位作者 Jun Cheng Guangmei Hou Xiangkun Nie Qing Ai Linna Dai Jinkui Feng Lijie Ci 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2020年第2期73-78,共6页
High ionic conductivity and superior interfacial stability of solid electrolytes at the electrodes are crucial factors for high-performance all-solid-state sodium batteries. Herein, a composite solid electrolyte Na3PS... High ionic conductivity and superior interfacial stability of solid electrolytes at the electrodes are crucial factors for high-performance all-solid-state sodium batteries. Herein, a composite solid electrolyte Na3PS4-polyethylene oxide is synthesized by the solution-phase reaction method with an improved ionic conductivity up to 9.4 × 10-5 S/cm at room temperature. Moreover, polyethylene oxide polymer layer is wrapped homogeneously on the surface of Na3PS4 particles, which could effectively avoid the direct contact between Na3PS4 electrolyte and sodium metal, thus alleviate their side reactions. We demonstrate that all-solid-state battery SnS2/Na with the composite solid electrolyte Na3PS4-polyethylene oxide delivers an enhanced electrochemical performance with 230 m Ah/g after 40 cycles. 展开更多
关键词 COMPOSITE solid ELECTROLYTE NA 3PS4 ALL-SOLID-STATE sodium battery SnS2
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Dimension-Enhanced Ultra-High Performance Liquid Chromatography/Ion Mobility-Quadrupole Time-of-Flight Mass Spectrometry Combined with Intelligent Peak Annotation for the Rapid Characterization of the Multiple Components from Seeds of Descurainia sophia 被引量:1
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作者 Simiao Wang xue Li +7 位作者 Boxue Chen Shitong Li Jiali Wang Jing Wang Mingshuo Yang xiaoyan xu Hongda Wang Wenzhi Yang 《Phyton-International Journal of Experimental Botany》 SCIE 2022年第3期541-567,共27页
The complex composition of herbal metabolites necessitates the development of powerful analytical techniques aimed to identify the bioactive components.The seeds of Descurainia sophia(SDS)are utilized in China as a co... The complex composition of herbal metabolites necessitates the development of powerful analytical techniques aimed to identify the bioactive components.The seeds of Descurainia sophia(SDS)are utilized in China as a cough and asthma relieving agent.Herein,a dimension-enhanced integral approach,by combining ultra-high performance liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry(UHPLC/IMQTOF-MS)and intelligent peak annotation,was developed to rapidly characterize the multicomponents from SDS.Good chromatographic separation was achieved within 38 min on a UPLC CSH C18(2.1×100 mm,1.7μm)column which was eluted by 0.1%formic acid in water(water phase)and acetonitrile(organic phase).Collision-induced dissociation-MS^(2)data were acquired by the data-independent high-definition MS^(E)(HDMS^(E))in both the negative and positive electrospray ionization modes.A major components knockout strategy was applied to improve the characterization of those minor ingredients by enhancing the injection volume.Moreover,a self-built chemistry library was established,which could be matched by the UNIFI software enabling automatic peak annotation of the obtained HDMS^(E)data.As a result of applying the intelligent peak annotation workflows and further confirmation process,a total of 53 compounds were identified or tentatively characterized from the SDS,including 29 flavonoids,one uridine derivative,four glucosides,one lignin,one phenolic compound,and 17 others.Notably,four-dimensional information related to the structure(e.g.,retention time,collision cross section,MS^(1)and MS^(2)data)was obtained for each component by the developed integral approach,and the results would greatly benefit the quality control of SDS. 展开更多
关键词 Descurainia sophia multicomponent characterization ultra-high performance liquid chromatography ion mobility/quadrupole time-of-flight mass spectrometry high-definition MS^(E) flavonoid
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经3种ALK抑制剂及化疗治疗的1例非小细胞肺癌病例报道 被引量:1
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作者 王珏 徐晓燕 +1 位作者 孙岩岩 李卉 《中国肺癌杂志》 CAS CSCD 北大核心 2021年第5期372-376,共5页
棘皮动物微管相关蛋白4(echinoderm microlubule-associated protein-like 4, EML4)和间变淋巴瘤激酶基因(anaplastic lymphoma kinase, ALK)可发生断裂后融合为EML4-ALK基因。对于EML4-ALK阳性非小细胞肺癌(nonsmall cell lung cancer,... 棘皮动物微管相关蛋白4(echinoderm microlubule-associated protein-like 4, EML4)和间变淋巴瘤激酶基因(anaplastic lymphoma kinase, ALK)可发生断裂后融合为EML4-ALK基因。对于EML4-ALK阳性非小细胞肺癌(nonsmall cell lung cancer, NSCLC),一代至三代的ALK抑制剂的使用已显示出显著疗效,很多患者可以从药物治疗中实现长期获益,部分患者在优化的治疗模式下可取得超过7年的长期生存。本例患者为EML4-ALK融合基因阳性肺腺癌,治疗结局却明显不同于其他EML4-ALK融合基因阳性肺癌患者,经过一代至三代ALK抑制剂靶向治疗和化学治疗疾病进展快,耐药时间短,生存期短,获益有限。患者2019年7月15日开始先后口服克唑替尼、色瑞替尼、劳拉替尼靶向治疗,行贝伐珠单抗联合培美曲塞、卡铂化疗2个疗程,于2020年9月10日患者死亡,生存期15个月。同时治疗中表现出ALK抑制剂的常见不良反应。本文分析本例患者的治疗疗效及治疗困境,为EML4-ALK融合基因阳性肺癌患者治疗提供探索方向。 展开更多
关键词 EML4-ALK融合基因 AIK抑制剂 肺肿瘤
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Headspace Solid-Phase Micro-Extraction Gas Chromatography/Mass Spectrometry(HS-SPME-GC/MS)-Based Untargeted Metabolomics Analysis for Comparing the Volatile Components from 12 Panax Herbal Medicines 被引量:1
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作者 Simiao Wang Xiaohang Li +8 位作者 Meiting Jiang Xinlong Wu Yuying Zhao Meiyu Liu xiaoyan xu Huimin Wang Hongda Wang Heshui Yu Wenzhi Yang 《Phyton-International Journal of Experimental Botany》 SCIE 2022年第7期1353-1364,共12页
Quality control of ginseng currently is mainly based on ginsenoside analysis,but rarely focuses on the volatile organic components.In the current work,an untargeted metabolomics approach,by headspace solid-phase micro... Quality control of ginseng currently is mainly based on ginsenoside analysis,but rarely focuses on the volatile organic components.In the current work,an untargeted metabolomics approach,by headspace solid-phase micro-extraction gas chromatography/mass spectrometry(HS-SPME-GC/MS),was elaborated and further employed to holistically compare the compositional difference of the volatile components simultaneously from 12 Panax herbal medicines,which included P.ginseng(PG),P.quinquefolius(PQ),P.notoginseng(PN),red ginseng(PGR),P.ginseng leaf(PGL),P.quinquefolius leaf(PQL),P.notoginseng leaf(PNL),P.ginseng flower(PGF),P.quinquefolius flower(PQF),P.notoginseng flower(PNF),P.japonicus(PJ),and P.japonicus var.major(PJvm).Chromatographic separation was performed on an HP-5MS elastic quartz capillary column using helium as the carrier gas,enabling good resolution within 1 h.We were able to characterize totally 259 volatile compounds,including 82 terpenes(T),46 alcohols(Alc),29 ketones(K),25 aldehydes(Ald),21 esters(E),and the others.By analyzing 90 batches of ginseng samples based on the untargeted metabolomics workflows,236 differential ions were unveiled,and accordingly 36 differential volatile components were discovered.It is the first report that simultaneously compares the compositional difference of volatile components among 12 Panax herbal medicines,and useful information is provided for the quality control of ginseng aside from the well-known ginsenosides. 展开更多
关键词 Headspace solid-phase micro-extraction gas chromatography/mass spectrometry PANAX volatile component untargeted metabolomics
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Effects of Different Cultivation Time of Garden Plants on Soil Chemical Properties and Soil Enzyme Activities 被引量:1
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作者 Yingsen HE Xiaoling ZHANG xiaoyan xu 《Agricultural Biotechnology》 CAS 2018年第3期146-148,共3页
Garden soil test was used to study the effects of different cultivation time of garden plants on soil chemical properties and soil enzyme activities in the garden. The results showed that with the extension of cultiva... Garden soil test was used to study the effects of different cultivation time of garden plants on soil chemical properties and soil enzyme activities in the garden. The results showed that with the extension of cultivation time,the activity of protease,urease and catalase in Ginkgo biloba soil increased significantly,while the activity of protease in other garden plants showed a certain degree of decline,and the activity of urease increased significantly in the soil cultivated Lagerstroemia indica for over 3 years. However,in the soil cultivated the garden plants for less than 3 years,the difference in the activity of urease was relatively small,and the difference in the activity of catalase was relatively significant. 展开更多
关键词 Garden plants Soil CATALASE UREASE PROTEASE
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Effects of Cu Contamination on GSH- Px( Glutathione Peroxidase) Activity of Earthworms( Eisenia fetida ) in Soils
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作者 Yingsen HE xiaoyan xu Bing HE 《Agricultural Biotechnology》 CAS 2015年第5期42-44,共3页
[ Objective] This study aimed to investigate the effects of Cu contamination in soils on GSH-Px ( glutathione peroxidase) activity of earthworms ( Eisenia fetida). [ Method ] By artificial soil contamination metho... [ Objective] This study aimed to investigate the effects of Cu contamination in soils on GSH-Px ( glutathione peroxidase) activity of earthworms ( Eisenia fetida). [ Method ] By artificial soil contamination method, changes in GSH-Px activity of earthworms under different Cu concentrations were investigated [ Result ] In the early exposure period, low-concentration Cu stress activated GSH-Px activity of earthworms to a certain extent; with the extension of extxqsure time and increase of Cu concentration, GSH-Px activity of earthworms showed a decreasing trend; however, under high-concentration Cu stress, there was no remarkable reg- ularity in the reduction of GSH-Px activity of earthworms. [ Conclusion] This study laid a solid foundation for further revealing the synergistic mechanism of antioxidant enzymes of earthworms. 展开更多
关键词 EARTHWORM GSH-PX Copper Enzyme activity
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Research on Fuzzy PID Charging Control of Battery Pack
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作者 xiaoyan xu 《World Journal of Engineering and Technology》 2017年第3期421-427,共7页
Battery groups are widely used in production and life. Optimal charging can not only shorten the charge time, but also improve the performance and life of the battery pack. A constant current or constant voltage charg... Battery groups are widely used in production and life. Optimal charging can not only shorten the charge time, but also improve the performance and life of the battery pack. A constant current or constant voltage charging method is commonly used. This type of method cannot adjust the charge capacity in time according to the change of charging capacity of storage battery, and the charge performance is not high. This paper designs a fuzzy PID controller. In the case of variable load and interference, the battery group can still be charged by the optimal charging current. Through the simulation results, the fuzzy PID controller works well and verifies the feasibility of the charging controller. 展开更多
关键词 BATTERY PACK CHARGE Management FUZZY PID Control
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An Integrated Approach to the Teaching of English Writing 被引量:1
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作者 xiaoyan xu 《Sino-US English Teaching》 2005年第12期37-41,共5页
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The Effectiveness of a Smoking Cessation Intervention Program Based upon a Process Model of Health Motivation
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作者 xiaoyan xu Liyan Zhao David Mellor 《Journal of Psychological Research》 2020年第1期27-34,共8页
The purpose of the present study was to investigate the effect of participation in a health motivation-based intervention program on college students’smoking behavior.One hundred and seventy smokers(mean age=19.0 yea... The purpose of the present study was to investigate the effect of participation in a health motivation-based intervention program on college students’smoking behavior.One hundred and seventy smokers(mean age=19.0 years,151 males)from nine colleges and universities in Chengdu,China were randomly assigned to one of 5 groups that received between one and four sessions of the intervention,or no intervention.The intervention sessions included sequential activities based on the stages of the process model of health motivation.Each group completed questionnaires assessing health motivation and smoking behaviors at pre-test,immediately post-intervention,and at one month follow-up.Analyses indicated that the intervention program did improve participants’health motivation,and that was associated with reduced levels of smoking relative to baseline.The greater the number of sessions,the greater the reduction in smoking. 展开更多
关键词 HEALTH MOTIVATION INTERVENTION PROGRAM SMOKING CESSATION
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Costless-Function Model Predictive Current Control of Seven-Phase PMSM to Improve Dynamic Performance and Suppress Harmonics of Marine Electric Propulsion System
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作者 Xin Li Wei Xie xiaoyan xu 《Journal of Mechanics Engineering and Automation》 2020年第6期170-180,共11页
In order to improve the dynamic performance and suppress current harmonic for seven-phase PMSM(permanent magnet synchronous motor),this paper proposed an MPCC(mode predict current control)scheme based on SVPWM(space v... In order to improve the dynamic performance and suppress current harmonic for seven-phase PMSM(permanent magnet synchronous motor),this paper proposed an MPCC(mode predict current control)scheme based on SVPWM(space vector pulse width modulation)technique.By this scheme,the 14 virtual voltage vectors are first calculated based on the principle:the voltage vector synthesized in the 3rd harmonic subspace and the 5th harmonic subspace should be zero,in each sampling period,the optimal voltage vector is directly selected from the 14 virtual voltage vectors to achieve the best output current performance of seven-phase PMSM.In addition,no cost function related calculations are required in the MPCC scheme,reducing the calculation time and improving the dynamic response of the system.The simulation model of the seven-phase PMSM vector control system is established by using the Simulink tool of MATLAB,and the effectiveness of the scheme will be presented. 展开更多
关键词 Optimal voltage vector seven-phase PMSM MPCC SVPWM harmonic suppress
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