In order to accommodate the variety of algorithms with different performance in specific application and improve power efficiency,reconfigurable architecture has become an effective methodology in academia and industr...In order to accommodate the variety of algorithms with different performance in specific application and improve power efficiency,reconfigurable architecture has become an effective methodology in academia and industry.However,existing architectures suffer from performance bottleneck due to slow updating of contexts and inadequate flexibility.This paper presents an H-tree based reconfiguration mechanism(HRM)with Huffman-coding-like and mask addressing method in a homogeneous processing element(PE)array,which supports both programmable and data-driven modes.The proposed HRM can transfer reconfiguration instructions/contexts to a particular PE or associated PEs simultaneously in one clock cycle in unicast,multicast and broadcast mode,and shut down the unnecessary PE/PEs according to the current configuration.To verify the correctness and efficiency,we implement it in RTL synthesis and FPGA prototype.Compared to prior works,the experiment results show that the HRM has improved the work frequency by an average of 23.4%,increased the updating speed by 2×,and reduced the area by 36.9%;HRM can also power off the unnecessary PEs which reduced 51%of dynamic power dissipation in certain application configuration.Furthermore,in the data-driven mode,the system frequency can reach 214 MHz,which is 1.68×higher compared with the programmable mode.展开更多
Oral squamous cell carcinoma(OSCC)is one of the most common cancers worldwide,and with 354864 new cases each year.Cancer metastasis,recurrence,and drug resistance are the main causes to cripples and deaths of OSCC pat...Oral squamous cell carcinoma(OSCC)is one of the most common cancers worldwide,and with 354864 new cases each year.Cancer metastasis,recurrence,and drug resistance are the main causes to cripples and deaths of OSCC patients.As potent growth factors,fibroblast growth factors(FGFs)are frequently susceptible to being hijacked by cancer cells.In this study,we show that FGF8 is upregulated in OSCC tissues and high FGF8 expression is related with a set of clinicopathologic parameters,including age,drinking,and survival time.FGF8 treatment enhances the invasive capability of OSCC cells.Lentivirus-based FGF8 expression promotes OSCC metastasis in a mouse lung metastasis model.Further,mechanistic study demonstrates that FGF8 induces epithelial–mesenchymal transition(EMT)in OSCC cells.These results highlight a pro-metastatic function of FGF8,and underscore the role of FGF8 in OSCC development.展开更多
The Rate Distortion Optimization(RDO)algorithm in High Efficiency Video Coding(HEVC)has many iterations and a large number of calculations.In order to decrease the calculation time and meet the requirements of fast sw...The Rate Distortion Optimization(RDO)algorithm in High Efficiency Video Coding(HEVC)has many iterations and a large number of calculations.In order to decrease the calculation time and meet the requirements of fast switching of RDO algorithms of different scales,an RDO dynamic reconfigurable structure is proposed.First,the Quantization Parameter(QP)and bit rate values were loaded through an H⁃tree Configurable Network(HCN),and the execution status of the array was detected in real time.When the switching request of the RDO algorithm was detected,the corresponding configuration information was delivered.This self⁃reconfiguration implementation method improved the flexibility and utilization of hardware.Experimental results show that when the control bit width was only increased by 31.25%,the designed configuration network could increase the number of controllable processing units by 32 times,and the execution cycle was 50%lower than the same type of design.Compared with previous RDO algorithm,the RDO algorithm implemented on the reconfigurable array based on the configuration network had an average operating frequency increase of 12.5%and an area reduction of 56.4%.展开更多
MicroRNAs (miRNAs) are small, noncoding RNAs which can often act as an oncogene or a tumor suppressor. Several miRNAs are associated with the development of hepatoceUular carcinoma (HCC). We demonstrated that miR-...MicroRNAs (miRNAs) are small, noncoding RNAs which can often act as an oncogene or a tumor suppressor. Several miRNAs are associated with the development of hepatoceUular carcinoma (HCC). We demonstrated that miR-125b significantly suppresses HCC cell proliferation and promotes apoptosis by inhibiting the gene expression of the anti-apoptotic protein, Bcl-2. Bioinformatic analysis indicated that the 3tUTR of Bcl-2 has binding sites for miR-I25b, Luciferase reporter assay confirmed the ability of miR-125b to dramatically suppress Bcl-2 transcription, suggesting that Bcl-2 is a target gene for miR-125b. We concluded that miR-125b acts as a tumor suppressor in hepatic tumor development by targeting Bcl-2 and inducing cancer celt apoptosis.展开更多
Studies on coding genes, miRNAs, and lncRNAs during erythroid development have been performed in recent years. However, analysis focusing on the integration of the three RNA types has yet to be done. In the present st...Studies on coding genes, miRNAs, and lncRNAs during erythroid development have been performed in recent years. However, analysis focusing on the integration of the three RNA types has yet to be done. In the present study, we compared the dynamics of coding genes, miRNA, and IncRNA expression profiles. To explore dynamic changes in erythropoiesis and potential mechanisms that control these changes in the transcriptome level, we took advantage of high throughput sequencing technologies to obtain transcriptome data from cord blood hematopoietic stem cells and the following four erythroid differentiation stages, as well as from mature red blood cells. Results indicated that lncRNAs were promising cell marker candidates for erythroid differentiation. Clustering analysis classified the differentially expressed genes into four subtypes that corresponded to dynamic changes during sternness maintenance, mid-differentiation, and maturation. Integrated analysis revealed that noncoding RNAs potentially participated in controlling blood cell maturation, and especially associated with heine metabolism and responses to oxygen species and DNA damage. These regulatory interactions were displayed in a comprehensive network, thereby inferring correlations between RNAs and their associated functions. These data provided a substantial resource for the study of normal erythropoiesis, which will permit further investigation and understanding of erythroid development and acquired erythroid disorders.展开更多
Cobalt-free Li-rich layered oxides(LLOs)such as Li_(2)MnO_(3) have attracted extensive attention owing to their high specific capacity and low cost.Nonetheless,numerous problems such as continuous voltage fading and c...Cobalt-free Li-rich layered oxides(LLOs)such as Li_(2)MnO_(3) have attracted extensive attention owing to their high specific capacity and low cost.Nonetheless,numerous problems such as continuous voltage fading and capacity decay have become stumbling blocks in its commercial application.In this study,we propose an effective dual-site doping strategy by choosing Mo as the cation and F as the anion to enhance the capacity and cycling performance.The researchdemonstrates that the cycling stability of LLOs enhances with the doping ratio of Mo,and their capacity increases with the doping ratio of F.It is because Mo as a pillar enhances the structural stability and F doping is conducive to the activation of Li;MnO;.What’s more,dual-site doping also promotes the diffusion of Li;and reduces the internal resistance of the electrode.Due to these improvements,the 5F3M sample still maintains a discharge capacity of 190.98 mAh g;after 100 cycles at 200 mA g^(-1),which is much higher than 165.29 mAh g;of the Pristine sample.This discovery provides a new way to develop advanced layered oxide cathodes for both Na-and Li-ion batteries.展开更多
基金supported by the National Natural Science Foundation of China (Nos. 61834005, 61602377, 61772417, 61802304, 61874087)the Shaanxi International Science and Technology Cooperation Program No. 2018KW-006+1 种基金Shaanxi Provincial Key R&D Plan under Grant No. 2017GY-060Shaanxi Province Co-ordination Innovation Project of Science and Technology under Grant No. 2016KTZDGY02-04-02
文摘In order to accommodate the variety of algorithms with different performance in specific application and improve power efficiency,reconfigurable architecture has become an effective methodology in academia and industry.However,existing architectures suffer from performance bottleneck due to slow updating of contexts and inadequate flexibility.This paper presents an H-tree based reconfiguration mechanism(HRM)with Huffman-coding-like and mask addressing method in a homogeneous processing element(PE)array,which supports both programmable and data-driven modes.The proposed HRM can transfer reconfiguration instructions/contexts to a particular PE or associated PEs simultaneously in one clock cycle in unicast,multicast and broadcast mode,and shut down the unnecessary PE/PEs according to the current configuration.To verify the correctness and efficiency,we implement it in RTL synthesis and FPGA prototype.Compared to prior works,the experiment results show that the HRM has improved the work frequency by an average of 23.4%,increased the updating speed by 2×,and reduced the area by 36.9%;HRM can also power off the unnecessary PEs which reduced 51%of dynamic power dissipation in certain application configuration.Furthermore,in the data-driven mode,the system frequency can reach 214 MHz,which is 1.68×higher compared with the programmable mode.
基金supported by grants from the National Natural Science Foundation of China(Nos 82001047,81672674,81872218,81321002,81402245)Research Funding from West China School/Hospital of Stomatology Sichuan University(No.RCDWJS2020-8)the 111 Project of MOE China(Grant No.B14038).
文摘Oral squamous cell carcinoma(OSCC)is one of the most common cancers worldwide,and with 354864 new cases each year.Cancer metastasis,recurrence,and drug resistance are the main causes to cripples and deaths of OSCC patients.As potent growth factors,fibroblast growth factors(FGFs)are frequently susceptible to being hijacked by cancer cells.In this study,we show that FGF8 is upregulated in OSCC tissues and high FGF8 expression is related with a set of clinicopathologic parameters,including age,drinking,and survival time.FGF8 treatment enhances the invasive capability of OSCC cells.Lentivirus-based FGF8 expression promotes OSCC metastasis in a mouse lung metastasis model.Further,mechanistic study demonstrates that FGF8 induces epithelial–mesenchymal transition(EMT)in OSCC cells.These results highlight a pro-metastatic function of FGF8,and underscore the role of FGF8 in OSCC development.
基金Sponsored by the National Natural Science Foundation of China(Grant Nos.61834005,61772417,61802304,61602377,and 61634004)the Shaanxi Province Coordination Innovation Project of Science and Technology(Grant No.2016KTZDGY02-04-02)+1 种基金the Shaanxi Provincial Key R&D Plan(Grant No.2017GY-060)the Shaanxi International Science and Technology Cooperation Program(Grant No.2018KW-006).
文摘The Rate Distortion Optimization(RDO)algorithm in High Efficiency Video Coding(HEVC)has many iterations and a large number of calculations.In order to decrease the calculation time and meet the requirements of fast switching of RDO algorithms of different scales,an RDO dynamic reconfigurable structure is proposed.First,the Quantization Parameter(QP)and bit rate values were loaded through an H⁃tree Configurable Network(HCN),and the execution status of the array was detected in real time.When the switching request of the RDO algorithm was detected,the corresponding configuration information was delivered.This self⁃reconfiguration implementation method improved the flexibility and utilization of hardware.Experimental results show that when the control bit width was only increased by 31.25%,the designed configuration network could increase the number of controllable processing units by 32 times,and the execution cycle was 50%lower than the same type of design.Compared with previous RDO algorithm,the RDO algorithm implemented on the reconfigurable array based on the configuration network had an average operating frequency increase of 12.5%and an area reduction of 56.4%.
基金supported by the National High Technology Research and Development Program of China(No. 2006AA02A107)the Major State Basic Research Program of China(Nos.2009CB521704 and 2010CB945504)the National Nature Science Foundation of China(No.30873031)
文摘MicroRNAs (miRNAs) are small, noncoding RNAs which can often act as an oncogene or a tumor suppressor. Several miRNAs are associated with the development of hepatoceUular carcinoma (HCC). We demonstrated that miR-125b significantly suppresses HCC cell proliferation and promotes apoptosis by inhibiting the gene expression of the anti-apoptotic protein, Bcl-2. Bioinformatic analysis indicated that the 3tUTR of Bcl-2 has binding sites for miR-I25b, Luciferase reporter assay confirmed the ability of miR-125b to dramatically suppress Bcl-2 transcription, suggesting that Bcl-2 is a target gene for miR-125b. We concluded that miR-125b acts as a tumor suppressor in hepatic tumor development by targeting Bcl-2 and inducing cancer celt apoptosis.
文摘Studies on coding genes, miRNAs, and lncRNAs during erythroid development have been performed in recent years. However, analysis focusing on the integration of the three RNA types has yet to be done. In the present study, we compared the dynamics of coding genes, miRNA, and IncRNA expression profiles. To explore dynamic changes in erythropoiesis and potential mechanisms that control these changes in the transcriptome level, we took advantage of high throughput sequencing technologies to obtain transcriptome data from cord blood hematopoietic stem cells and the following four erythroid differentiation stages, as well as from mature red blood cells. Results indicated that lncRNAs were promising cell marker candidates for erythroid differentiation. Clustering analysis classified the differentially expressed genes into four subtypes that corresponded to dynamic changes during sternness maintenance, mid-differentiation, and maturation. Integrated analysis revealed that noncoding RNAs potentially participated in controlling blood cell maturation, and especially associated with heine metabolism and responses to oxygen species and DNA damage. These regulatory interactions were displayed in a comprehensive network, thereby inferring correlations between RNAs and their associated functions. These data provided a substantial resource for the study of normal erythropoiesis, which will permit further investigation and understanding of erythroid development and acquired erythroid disorders.
基金financially supported by the National Natural Science Foundation of China(52004070 and 51874104)the National Key R&D Program of China(2011YFB0700600)。
文摘Cobalt-free Li-rich layered oxides(LLOs)such as Li_(2)MnO_(3) have attracted extensive attention owing to their high specific capacity and low cost.Nonetheless,numerous problems such as continuous voltage fading and capacity decay have become stumbling blocks in its commercial application.In this study,we propose an effective dual-site doping strategy by choosing Mo as the cation and F as the anion to enhance the capacity and cycling performance.The researchdemonstrates that the cycling stability of LLOs enhances with the doping ratio of Mo,and their capacity increases with the doping ratio of F.It is because Mo as a pillar enhances the structural stability and F doping is conducive to the activation of Li;MnO;.What’s more,dual-site doping also promotes the diffusion of Li;and reduces the internal resistance of the electrode.Due to these improvements,the 5F3M sample still maintains a discharge capacity of 190.98 mAh g;after 100 cycles at 200 mA g^(-1),which is much higher than 165.29 mAh g;of the Pristine sample.This discovery provides a new way to develop advanced layered oxide cathodes for both Na-and Li-ion batteries.