Government information sharing(GIS)refers to that act of required or provided for duty government information,commercial information and public welfare information,and it is a basic issue of government services.Howeve...Government information sharing(GIS)refers to that act of required or provided for duty government information,commercial information and public welfare information,and it is a basic issue of government services.However,the existing GIS has low transparency and is lack of flexibility between different departments.Aiming at such problems,this paper takes blockchain as a solusion,and systematically summarizes the development of digital GIS,the advantages and challenges of blockchain and its theoretical research and practical applications.Specifically,it reviews e-government interactive structure,big data and other solutions,analyses their imperfections,and puts forward blockchain-based solutions.The blockchain improves government service efficiency and data security,meanwhile it faces challenges in throughput and supervision.In order to meet these challenges,researchers propose solutions based on three data exchange scenarios:government-to-government,government-to-enterprise and government-toindividual.In addition to researches,blockchain-based GIS is put into use.The electronic licensing project of Nanjing(China)government is taken as an example to illustrate that blockchain has the ability to openly and securely verify,track,and exchange data,so as to improve management ability and public service level of government agencies.展开更多
Objective Our study aimed to analyze the expression of miR-564 and TGF-β1 in cancer tissues and the serum of patients with radiation-induced lung injury,and to investigate the relationship between them and radiation-...Objective Our study aimed to analyze the expression of miR-564 and TGF-β1 in cancer tissues and the serum of patients with radiation-induced lung injury,and to investigate the relationship between them and radiation-induced lung injury.Methods In situ hybridization and real-time fluorescence quantitative method were used to detect the expression of miR-564.Additionally,immunohistochemistry and enzyme-linked immunosorbent assay(ELISA)were performed to detect the expression of TGF-β1.Results The overall incidence of acute radiation pneumonia was 55.9%(100/179).The incidence of≥grade 2 radioactive pneumonia was 24.0%(43/179)and that of grade 1 was 31.8%(57/179).The expression of miR-564 in grade≥2 was slightly higher than that in patients without or with grade 1,but there was no statistical difference(P=0.86).The serum level and ratio of miR-564 in patients with grade≥2 were significantly higher than those without or with grade 1(P=0.005,P=0.025,respectively).The expression of TGF-β1 in grade≥2 was significantly higher than that of patients without or with grade 1(P=0.017).The serum levels of TGF-β1 in grade≥2 were significantly higher than those in patients without or with grade 1(P=0.038).Although the ratio of TGF-β1 in radiation pneumonia of grade≥2 was significantly higher than that of without or with grade 1,there was no significant difference(P=0.24).Moreover,patients with higher expression of miR-564 and lower expression of TGF-β1 had better prognosis.Conclusion MiR-564 and TGF-β1 are predictors of radiation-induced lung injury.Monitoring its changing trend can improve the accuracy of predicting radiation-induced lung injury.The levels and ratio of serum miR-564 and TGF-β1 in patients with radiation-induced lung injury are related to the severity of radiationinduced lung injury.展开更多
In human genetics,genome-wide association study (GWAS)is a commonly used method for discovering genes and genetic variants contributing to human traits,usually through statistical examination of the associations betwe...In human genetics,genome-wide association study (GWAS)is a commonly used method for discovering genes and genetic variants contributing to human traits,usually through statistical examination of the associations between whole-genome sequence variants and one specific trait.The first effort in human GWAS,using genotyping data of 96 patients and 50 healthy controls,successfully identified one gene associated with age-related macular degeneration (Haines et al.,2005).展开更多
Existing methods of vehicle re-identification(ReID)focus on training robust models on the fixed data while ignore the diversity in the training data,which limits generalization ability of the models.In this paper,it p...Existing methods of vehicle re-identification(ReID)focus on training robust models on the fixed data while ignore the diversity in the training data,which limits generalization ability of the models.In this paper,it proposes an occlusion based discriminative feature mining(ODFM)method for vehicle re-identification,which increases the diversity of the training set by synthesizing occlusion samples,to simulate the occlusion problem in the real scene.To better train the ReID model on the data with large occlusions,an attention mechanism was introduced in the mainstream network to learn the discriminative features for vehicle images.Experimental results on two public ReID datasets,VeRi-776 and VehicleID verify the effectiveness of the proposed method comparing to the state-of-the-art methods.展开更多
基金supported by Hainan Province Basic and Applied Basic Research Program(Natural Science Field)High-level Talent Project(Grant No.2019RC044).
文摘Government information sharing(GIS)refers to that act of required or provided for duty government information,commercial information and public welfare information,and it is a basic issue of government services.However,the existing GIS has low transparency and is lack of flexibility between different departments.Aiming at such problems,this paper takes blockchain as a solusion,and systematically summarizes the development of digital GIS,the advantages and challenges of blockchain and its theoretical research and practical applications.Specifically,it reviews e-government interactive structure,big data and other solutions,analyses their imperfections,and puts forward blockchain-based solutions.The blockchain improves government service efficiency and data security,meanwhile it faces challenges in throughput and supervision.In order to meet these challenges,researchers propose solutions based on three data exchange scenarios:government-to-government,government-to-enterprise and government-toindividual.In addition to researches,blockchain-based GIS is put into use.The electronic licensing project of Nanjing(China)government is taken as an example to illustrate that blockchain has the ability to openly and securely verify,track,and exchange data,so as to improve management ability and public service level of government agencies.
基金Supported by grants from the Fundamental Research for South-Central University for Nationalities(No.PJS140011604)Chen Xiaoping Foundation Development of Science and Technology of Hubei(No.CXPJJH11800004-015)
文摘Objective Our study aimed to analyze the expression of miR-564 and TGF-β1 in cancer tissues and the serum of patients with radiation-induced lung injury,and to investigate the relationship between them and radiation-induced lung injury.Methods In situ hybridization and real-time fluorescence quantitative method were used to detect the expression of miR-564.Additionally,immunohistochemistry and enzyme-linked immunosorbent assay(ELISA)were performed to detect the expression of TGF-β1.Results The overall incidence of acute radiation pneumonia was 55.9%(100/179).The incidence of≥grade 2 radioactive pneumonia was 24.0%(43/179)and that of grade 1 was 31.8%(57/179).The expression of miR-564 in grade≥2 was slightly higher than that in patients without or with grade 1,but there was no statistical difference(P=0.86).The serum level and ratio of miR-564 in patients with grade≥2 were significantly higher than those without or with grade 1(P=0.005,P=0.025,respectively).The expression of TGF-β1 in grade≥2 was significantly higher than that of patients without or with grade 1(P=0.017).The serum levels of TGF-β1 in grade≥2 were significantly higher than those in patients without or with grade 1(P=0.038).Although the ratio of TGF-β1 in radiation pneumonia of grade≥2 was significantly higher than that of without or with grade 1,there was no significant difference(P=0.24).Moreover,patients with higher expression of miR-564 and lower expression of TGF-β1 had better prognosis.Conclusion MiR-564 and TGF-β1 are predictors of radiation-induced lung injury.Monitoring its changing trend can improve the accuracy of predicting radiation-induced lung injury.The levels and ratio of serum miR-564 and TGF-β1 in patients with radiation-induced lung injury are related to the severity of radiationinduced lung injury.
文摘In human genetics,genome-wide association study (GWAS)is a commonly used method for discovering genes and genetic variants contributing to human traits,usually through statistical examination of the associations between whole-genome sequence variants and one specific trait.The first effort in human GWAS,using genotyping data of 96 patients and 50 healthy controls,successfully identified one gene associated with age-related macular degeneration (Haines et al.,2005).
基金in part by the National Natural Science Foundationof China (Nos. 61976002)Hainan Provincial Natural Science Foundation (GrantNo. 117063)+1 种基金the Natural Science Foundation of Anhui Higher Education Institutions of China(KJ2019A0033)the National Laboratory of Pattern Recognition (NLPR) (201900046).
文摘Existing methods of vehicle re-identification(ReID)focus on training robust models on the fixed data while ignore the diversity in the training data,which limits generalization ability of the models.In this paper,it proposes an occlusion based discriminative feature mining(ODFM)method for vehicle re-identification,which increases the diversity of the training set by synthesizing occlusion samples,to simulate the occlusion problem in the real scene.To better train the ReID model on the data with large occlusions,an attention mechanism was introduced in the mainstream network to learn the discriminative features for vehicle images.Experimental results on two public ReID datasets,VeRi-776 and VehicleID verify the effectiveness of the proposed method comparing to the state-of-the-art methods.
