Studies in the northern South China Sea(SCS)basement remain important for understanding the evolution of the Southeast Asian continental margin.Due to a thick cover of sediments and scarce borehole penetration,little ...Studies in the northern South China Sea(SCS)basement remain important for understanding the evolution of the Southeast Asian continental margin.Due to a thick cover of sediments and scarce borehole penetration,little is known about the age and tectonic affinity of this basement.In this study,an integrated study of zircon U-Pb geochronology,Hf isotopes,and whole-rock major and trace elements on seven basement granitoids from seven boreholes of Qiongdongnan Basin has been carried out.New zircon U-Pb results for these granitoids present middle-late Permian((270.0±1.2)Ma;(253±3.4)Ma),middle to late Triassic((246.2±3.4)Ma;(239.3±0.96)Ma;(237.9±0.99)Ma;(228.9±1.0)Ma)and Late Cretaceous ages((120.6±0.6)Ma).New data from this study,in combination with the previous dataset,indicates that granitoid ages in northern SCS basement vary from 270 Ma to 70.5 Ma,with three age groups of 270–196 Ma,162–142 Ma,and 137–71 Ma,respectively.Except for the late Paleozoic-Mesozoic rocks in the basement of the northern SCS,a few old zircon grains with the age of(2708.1±17)Ma to(2166.6±19)Ma provide clues to the existence of the pre-Proterozoic components.The geochemical signatures indicate that the middle Permian-early Cretaceous granitoids from the Qiongdongnan Basin are I-type granites formed in a volcanic arc environment,which were probably related to the subduction of the Paleo-Pacific Plate.展开更多
Dear Editor,Available evidence regarding the most suitable treatment strategies for hepatocellular carcinoma(HCC)with inferior vena cava tumor thrombus(IVCTT)is extremely limited,and the median overall survival time f...Dear Editor,Available evidence regarding the most suitable treatment strategies for hepatocellular carcinoma(HCC)with inferior vena cava tumor thrombus(IVCTT)is extremely limited,and the median overall survival time for these patients after liver resection is only 17.76 months[1].Other local or systemic treatments for HCC with IVCTT result in a median overall survival time ranging from 5.88 to 15.36 months[1–3].Thus,new therapeutic strategies are urgently needed to improve the survival of HCC patients with IVCTT.Chimeric antigen receptor(CAR)T-cell therapy has seen success in treating B-cell neoplasms with impressive outcomes[4].However,this therapy alone has shown limited efficacy on solid tumors,such as HCC[5].展开更多
A recent study published in Nature by Zoch et al.identifies a novel MIWI2-associated protein SPOCD1 and shows its requirement for piRNA-guided young transposable elements(TEs)methylation and silencing.1 This research ...A recent study published in Nature by Zoch et al.identifies a novel MIWI2-associated protein SPOCD1 and shows its requirement for piRNA-guided young transposable elements(TEs)methylation and silencing.1 This research provided the first mechanistic insights into how piRNA directs de novo DNA methylation in male mammals(Fig.1).展开更多
基金The National Natural Science Foundation of China under contract No.42072181。
文摘Studies in the northern South China Sea(SCS)basement remain important for understanding the evolution of the Southeast Asian continental margin.Due to a thick cover of sediments and scarce borehole penetration,little is known about the age and tectonic affinity of this basement.In this study,an integrated study of zircon U-Pb geochronology,Hf isotopes,and whole-rock major and trace elements on seven basement granitoids from seven boreholes of Qiongdongnan Basin has been carried out.New zircon U-Pb results for these granitoids present middle-late Permian((270.0±1.2)Ma;(253±3.4)Ma),middle to late Triassic((246.2±3.4)Ma;(239.3±0.96)Ma;(237.9±0.99)Ma;(228.9±1.0)Ma)and Late Cretaceous ages((120.6±0.6)Ma).New data from this study,in combination with the previous dataset,indicates that granitoid ages in northern SCS basement vary from 270 Ma to 70.5 Ma,with three age groups of 270–196 Ma,162–142 Ma,and 137–71 Ma,respectively.Except for the late Paleozoic-Mesozoic rocks in the basement of the northern SCS,a few old zircon grains with the age of(2708.1±17)Ma to(2166.6±19)Ma provide clues to the existence of the pre-Proterozoic components.The geochemical signatures indicate that the middle Permian-early Cretaceous granitoids from the Qiongdongnan Basin are I-type granites formed in a volcanic arc environment,which were probably related to the subduction of the Paleo-Pacific Plate.
基金This clinical study(NCT02395250)was supported by the Research Fund of the State Key Laboratory of Oncogenes and Related Genes(91-15-04)the Program of Shanghai Subject Chief Scientist(No.16XD1402600)+3 种基金the National Natural Science Foundation(Nos.81502672,82222047,82073039,and 82070619)the Program of Shanghai Academic/Technology Research Leader(No.22XD1423100)the Shanghai Science and Technology Innovation Action Plan(No.16DZ1910700)Shanghai Science and Technology Commission Grant(No.23ZR1439000).
文摘Dear Editor,Available evidence regarding the most suitable treatment strategies for hepatocellular carcinoma(HCC)with inferior vena cava tumor thrombus(IVCTT)is extremely limited,and the median overall survival time for these patients after liver resection is only 17.76 months[1].Other local or systemic treatments for HCC with IVCTT result in a median overall survival time ranging from 5.88 to 15.36 months[1–3].Thus,new therapeutic strategies are urgently needed to improve the survival of HCC patients with IVCTT.Chimeric antigen receptor(CAR)T-cell therapy has seen success in treating B-cell neoplasms with impressive outcomes[4].However,this therapy alone has shown limited efficacy on solid tumors,such as HCC[5].
基金Research in this paper was supported by the National Natural Science Foundation of China (Grant No. 41602251), the Chinese Postdoc Fund, No.58 General Fund, 2015 (No. 2015M582636) and the Research Fund for New Teachers of Xi'an Jiaotong University. We are grateful to CNOOC Research Institute for providing the seismic profiles. We also thank anonymous reviewers for their careful and insightful suggestions on the paper.
基金supported by the Startup Funding to E.Z.S.from the Westlake Education Foundation.
文摘A recent study published in Nature by Zoch et al.identifies a novel MIWI2-associated protein SPOCD1 and shows its requirement for piRNA-guided young transposable elements(TEs)methylation and silencing.1 This research provided the first mechanistic insights into how piRNA directs de novo DNA methylation in male mammals(Fig.1).