Thermal and exhumation history of the Songnan Low Uplift,Qiongdongnan Basin:constraints from the apatite fission-track and zircon(U-Th)/He thermochronology

Significant advancements have been made in the study of Mesozoic granite buried hills in the Songnan Low Uplift(SNLU)of the Qiongdongnan Basin.These findings indicate that the bedrock buried hills in this basin hold great potential for exploration.Borehole samples taken from the granite buried hills in the SNLU were analyzed using apatite fission track(AFT)and zircon(U-Th)/He data to unravel the thermal history of the basement rock.This information is crucial for understanding the processes of exhumation and alteration that occurred after its formation.Thermal modeling of a sample from the western bulge of the SNLU revealed a prolonged cooling event from the late Mesozoic to the Oligocene period(~80-23.8 Ma),followed by a heating stage from the Miocene epoch until the present(~23.8 Ma to present).In contrast,the sample from the eastern bulge experienced a more complex thermal history.It underwent two cooling stages during the late Mesozoic to late Eocene period(~80-36.4 Ma)and the late Oligocene period(~30-23.8 Ma),interspersed with two heating phases during the late Eocene to early Oligocene period(~36.4-30 Ma)and the Miocene epoch to recent times(~23.8-0 Ma),respectively.The differences in exhumation histories between the western and eastern bulges during the late Eocene to Oligocene period in the SNLU can likely be attributed to differences in fault activity.Unlike typical passive continental margin basins,the SNLU has experienced accelerated subsidence after the rifting phase,which began around 5.2 Ma ago.The possible mechanism for this abnormal post-rifting subsidence may be the decay or movement of the deep thermal source and the rapid cooling of the asthenosphere.Long-term and multi-episodic cooling and exhumation processes play a key role in the alteration of bedrock and contribute to the formation of reservoirs.On the other hand,rapid post-rifting subsidence(sedimentation)promotes the formation of cap rocks.

Zircon U-Pb geochronology,Hf isotopes,and geochemistry constraints on the age and tectonic affinity of the basement granitoids from the Qiongdongnan Basin,northern South China Sea

Studies in the northern South China Sea(SCS)basement remain important for understanding the evolution of the Southeast Asian continental margin.Due to a thick cover of sediments and scarce borehole penetration,little is known about the age and tectonic affinity of this basement.In this study,an integrated study of zircon U-Pb geochronology,Hf isotopes,and whole-rock major and trace elements on seven basement granitoids from seven boreholes of Qiongdongnan Basin has been carried out.New zircon U-Pb results for these granitoids present middle-late Permian((270.0±1.2)Ma;(253±3.4)Ma),middle to late Triassic((246.2±3.4)Ma;(239.3±0.96)Ma;(237.9±0.99)Ma;(228.9±1.0)Ma)and Late Cretaceous ages((120.6±0.6)Ma).New data from this study,in combination with the previous dataset,indicates that granitoid ages in northern SCS basement vary from 270 Ma to 70.5 Ma,with three age groups of 270–196 Ma,162–142 Ma,and 137–71 Ma,respectively.Except for the late Paleozoic-Mesozoic rocks in the basement of the northern SCS,a few old zircon grains with the age of(2708.1±17)Ma to(2166.6±19)Ma provide clues to the existence of the pre-Proterozoic components.The geochemical signatures indicate that the middle Permian-early Cretaceous granitoids from the Qiongdongnan Basin are I-type granites formed in a volcanic arc environment,which were probably related to the subduction of the Paleo-Pacific Plate.

Combined local therapy and CAR-GPC3 T-cell therapy in advanced hepatocellular carcinoma:a proof-of-concept treatment strategy

Dear Editor,Available evidence regarding the most suitable treatment strategies for hepatocellular carcinoma(HCC)with inferior vena cava tumor thrombus(IVCTT)is extremely limited,and the median overall survival time for these patients after liver resection is only 17.76 months[1].Other local or systemic treatments for HCC with IVCTT result in a median overall survival time ranging from 5.88 to 15.36 months[1–3].Thus,new therapeutic strategies are urgently needed to improve the survival of HCC patients with IVCTT.Chimeric antigen receptor(CAR)T-cell therapy has seen success in treating B-cell neoplasms with impressive outcomes[4].However,this therapy alone has shown limited efficacy on solid tumors,such as HCC[5].

Tectonic subsidence of the Zhu I Sub-basin in the Pearl River Mouth Basin, northern South China Sea

The Pearl River Mouth Basin, which is situated on the northern margin of the South China Sea, has attracted great attention not only because of its tectonic setting but also because of its abundant hydrocarbon resources. We have analyzed the Cenozoic tectonic subsidence history of 4 drilled wells and 43 artificial wells from the Zhu 1 Sub-basin of the Pearl River Mouth Basin by back-stripping, using newly interpreted seismic profiles. We also calculated the average tectonic sub- sidence rates of the four sags in the Zhu 1 Sub-basin. The rifting and post-rifting stages are separated by abrupt changes in the tectonic subsidence curves and average subsidence rates. In the eastem sags of the Zhu 1 Sub- basin, tectonic subsidence started to slow at ca. 30 Ma, compared with ca. 23.8 Ma in the western sags. This probably corresponds to the timing of break-up and suggests that tiffing in the Pearl River Mouth Basin ended earlier in the eastern sags than in the western sags. Anomalously accelerated tectonic subsidence occurred at 17.5-16.4 Ma during the post-tiffing stage, with average subsidence rates as high as 301.9 m/Myr. This distin- guishes the Pearl River Mouth Basin from classical Atlantic passive continental marginal basins, which demonstrate exponentially decaying post-rift tectonic subsidence.

Thermal-history reconstruction of the Baiyun Sag in the deep-water area of the Pearl River Mouth Basin, northern South China Sea

The Baiyun Sag, located in the deep-water area of the northern South China Sea, is the largest and deepest subbasin in the Pearl River Mouth Basin and one of the most important hydrocarbon-accumulation depression areas in China. Thermal history is widely thought to be of great importance in oil and gas potential assessment of a basin as it controls the timing of hydrocarbon generation and expulsion from the source rock. In order to unravel the paleo-heat flow of the Baiyun Sag, we first analyzed tectonic subsidence of 55 pseudo-wells constructed based on newly interpreted seismic profiles, along with three drilled wells. We then carried out thermal modeling using the multi-stage finite stretching method and calibrated the results using collected present-day vitrinite reflectance data and temperature data. Results indicate that the first and second heating of the Baiyun Sag after 49 Ma ceased at 33.9 Ma and 23 Ma. Reconstructed average basal paleo- heat flow values at the end of the rifting periods are -57.7- 86.2 mW/m2 and -66.7-97.3 mW/m2, respectively. Following the last heating period at 23 Ma, the study area has undergone a persistent thermal attenuation phase, and basal heat flow has cooled down to ～64.0-79.2 mW/m2 at present.

How mammalian piRNAs instruct de novo DNA methylation of transposons

A recent study published in Nature by Zoch et al.identifies a novel MIWI2-associated protein SPOCD1 and shows its requirement for piRNA-guided young transposable elements(TEs)methylation and silencing.1 This research provided the first mechanistic insights into how piRNA directs de novo DNA methylation in male mammals(Fig.1).