Flavonoids,which are a diverse class of phytonutrients,are used by organisms to respond to nearly all abiotic stresses and are beneficial for human health.Glycosyltransferase,used during the last step of flavonoid bio...Flavonoids,which are a diverse class of phytonutrients,are used by organisms to respond to nearly all abiotic stresses and are beneficial for human health.Glycosyltransferase,used during the last step of flavonoid biosynthesis,is important in flavonoid enrichment.However,little is known about glycosyltransferase in the orchid Dendrobium catenatum(D.officinale).In this study,we isolated a novel C-glycosyltransferase(designated DcaCGT)from the orchid D.catenatum by identifying and analyzing 82 putative genes in the GT1 family.DcaCGT could specifically catalyze not only di-C-glycosylation but also O-glycosylation.Apart from the normal function of catalyzing 2-hydroxynaringenin and phloretin to the respective di-C-glycosides,DcaCGT also catalyzes apigenin to cosmosiin.Targeted metabolic profiling of the substrates(2-hydroxynaringenin,phloretin,and apigenin)and products(vitexin,isovitexin,vicenin-2,nothofagin,3’,5’-di-C-glucosylphloretin,and cosmosiin)in different tissues showed that vicenin-2 was the most abundant product of this novel enzyme.Cosmosiin was detected in flowers and flower buds.We also established that DcaCGT functions expanded throughout the evolution of D.catenatum.Residual OGT activity may help D.catenatum resist drought stress.Our study illustrates the function,origin,and differentiation of DcaCGT and provides insights into glycosylation and molecular propagation processes,which can be used to improve the production of flavonoids by the cultivated medicinal plant D.catenatum.展开更多
The difficulty of early diagnosis,high tumor heterogeneity,and high recurrence and metastasis rates lead to an unsatisfactory treatment status for hepatocellular carcinoma(HCC).HCC is a typical inflammation-driven tum...The difficulty of early diagnosis,high tumor heterogeneity,and high recurrence and metastasis rates lead to an unsatisfactory treatment status for hepatocellular carcinoma(HCC).HCC is a typical inflammation-driven tumor.Chronic inflammation allows nascent tumors to escape immunosurveillance.Chemokines are small,soluble,secreted proteins that can regulate the activation and trafficking of immune cells during inflammation.Several studies have shown that various chemokines with overarching functions disrupt the immune microenvironment during the initiation and progression of HCC.The dysregulated chemokine network in HCC contributes to multiple malignant processes,including angiogenesis,tumor proliferation,migration,invasion,tumor low response,and resistance to immune therapy.Here,we summarize the current studies focusing on the role of chemokines and their receptors in the HCC immune microenvironment,highlighting potential translational therapeutic uses for modulating the chemokine system in HCC.展开更多
Lakes are the main reservoirs of persistent organic pollutants(POPs)from land,atmo sphere and rivers.POPs in lakes undergo complex exchange,transformation,and degradation between water-air-sediment-biota interfaces,wh...Lakes are the main reservoirs of persistent organic pollutants(POPs)from land,atmo sphere and rivers.POPs in lakes undergo complex exchange,transformation,and degradation between water-air-sediment-biota interfaces,which are constrained and regulated by various physical,chemical and biological factors.POPs can affect ecological conditions,chemical properties of water and sedi ments,and biodiversity of the lake system.Therefore,it is important to study the sources,migration,transformation,environmental behavior and ecological impacts of POPs in lake ecosystems.This re view summarizes research progress on detection technologies,diversity and origins,historical records,migration and transformation,distribution patterns,degradation and toxic effects of POPs in lakes.Fi nally,future directions related to POPs in lakes were summarized.展开更多
Wide-bandgap mixed-halide perovskite solar cells(WBG-PSCs)are promising top cells for efficient tandem photovoltaics to achieve high power conversion efficiency(PCE)at low cost.However,the open-circuit voltage(V_(OC))...Wide-bandgap mixed-halide perovskite solar cells(WBG-PSCs)are promising top cells for efficient tandem photovoltaics to achieve high power conversion efficiency(PCE)at low cost.However,the open-circuit voltage(V_(OC))of WBG-PSCs is still unsatisfactory as the V_(OC)-deficit is generally larger than 0.45 V.Herein,we report a buried interface engineering strategy that substantially improves the V_(OC)of WBG-PSCs by inserting amphiphilic molecular hole-selective materials featuring with a cyanovinyl phosphonic acid(CPA)anchoring group between the perovskite and substrate.The assembly and redistribution of CPA-based amphiphilic molecules at the perovskite-substrate buried interface not only promotes the growth of a low-defect crystalline perovskite thin film,but also suppresses the photo-induced halide phase separation.The energy level alignment between wide-bandgap perovskite and the hole-selective layer is further improved by modulating the substituents on the triphenylamine donor moiety(methoxyls for MPA-CPA,methyls for Me PA-CPA,and bare TPA-CPA).Using a 1.68 e V bandgap perovskite,the Me PA-CPA-based devices achieved an unprecedentedly high V_(OC)of 1.29 V and PCE of 22.3%under standard AM 1.5 sunlight.The V_(OC)-deficit(<0.40 V)is the lowest value reported for WBG-PSCs.This work not only provides an effective approach to decreasing the V_(OC)-deficit of WBG-PSCs,but also confirms the importance of energy level alignment at the charge-selective layers in PSCs.展开更多
In autonomous driving systems,perception is pivotal,relying chiefly on sensors like LiDAR and cameras for environmental awareness.LiDAR,celebrated for its detailed depth perception,is being increasingly integrated int...In autonomous driving systems,perception is pivotal,relying chiefly on sensors like LiDAR and cameras for environmental awareness.LiDAR,celebrated for its detailed depth perception,is being increasingly integrated into autonomous vehicles.In this article,we analyze the robustness of four LiDAR-included models against adversarial points under physical constraints.We first introduce an attack technique that,by simply adding a limited number of physically constrained adversarial points above a vehicle,can make the vehicle undetectable by the LiDAR-included models.Experiments reveal that adversarial points adversely affect the detection capabilities of both LiDAR-only and LiDAR–camera fusion models,with a tendency for more adversarial points to escalate attack success rates.Notably,voxel-based models are more susceptible to deception by these adversarial points.We also investigated the impact of the distance and angle of the added adversarial points on the attack success rate.Typically,the farther the victim object to be hidden and the closer to the front of the LiDAR,the higher the attack success rate.Additionally,we have experimentally proven that our generated adversarial points possess good cross-model adversarial transferability and validated the effectiveness of our proposed optimization method through ablation studies.Furthermore,we propose a new plug-and-play,modelagnostic defense method based on the concept of point smoothness.The ROC curve of this defense method shows an AUC value of approximately 0.909,demonstrating its effectiveness.展开更多
Astaxanthin(Ax)and lutein are important fat-soluble pigments and essential nutrients for human and animal health.Haematococcus pluvialis microalga and Phaffia rhodozyma yeast are ideal species for commercial Ax produc...Astaxanthin(Ax)and lutein are important fat-soluble pigments and essential nutrients for human and animal health.Haematococcus pluvialis microalga and Phaffia rhodozyma yeast are ideal species for commercial Ax production.Marigold flowers are a main source of commercial lutein.Dynamics of dietary Ax and lutein in the gastrointestinal tract are similar to lipids,but their activities are tremendously challenged by many physiological and dietary factors;few data are available about these in poultry.Dietary Ax and lutein have insignificant effects on egg production and egg physical properties,but have pronounced effects on yolk color,nutrition,and functionality.The two pigments can also enhance antioxidative capacity and immune function of laying hens.A few studies have shown that Ax and lutein can improve fertilization and hatchability of laying hens.Considering the pigmentation and health benefits of Ax and lutein from hen feed to human food,the commercial availability,chicken yolk improvement,and immune function of Ax and lutein are the focuses of this review.The potential roles of carotenoids in the cytokine storm and gut microbiota are also briefly presented.The bioavailability,metabolism,and deposition of Ax and lutein in laying hens are suggested for future research.展开更多
Solid-state batteries have become a frontrunner in humankind’s pursuit of safe and stable energy storage systems with high energy and power density.Electrolyte materials,currently,seem to be the Achilles’heel of sol...Solid-state batteries have become a frontrunner in humankind’s pursuit of safe and stable energy storage systems with high energy and power density.Electrolyte materials,currently,seem to be the Achilles’heel of solid-state batteries due to the slow kinetics and poor interfacial wetting.Combining the merits of solid inorganic electrolytes(SIEs)and solid polymer electrolytes(SPEs),inorganic/polymer hybrid electrolytes(IPHEs)integrate improved ionic conductivity,great interfacial compatibility,wide electrochemical stability window,and high mechanical toughness and flexibility in one material,having become a sought-after pathway to high-performance all-solid-state lithium batteries.Herein,we present a comprehensive overview of recent progress in IPHEs,including the awareness of ion migration fundamentals,advanced architectural design for better electrochemical performance,and a perspective on unconquered challenges and potential research directions.This review is expected to provide a guidance for designing IPHEs for next-generation lithium batteries,with special emphasis on developing high-voltage-tolerance polymer electrolytes to enable higher energy density and three-dimensional(3D)continuous ion transport highways to achieve faster charging and discharging.展开更多
The application of Si as the anode materials for lithium-ion batteries(LIBs) is still severely hindered by the rapid capacity decay due to the structural damage caused by large volume change(> 300%) during cycling....The application of Si as the anode materials for lithium-ion batteries(LIBs) is still severely hindered by the rapid capacity decay due to the structural damage caused by large volume change(> 300%) during cycling. Herein, a three-dimensional(3 D) aerogel anode of Si@carbon@graphene(SCG) is rationally constructed via a polydopamine-assisted strategy. Polydopamine is coated on Si nanoparticles to serve as an interface linker to initiate the assembly of Si and graphene oxide, which plays a crucial role in the successful fabrication of SCG aerogels. After annealing the polydopamine is converted into N-doped carbon(N-carbon) coatings to protect Si materials. The dual protection from N-carbon and graphene aerogels synergistically improves the structural stability and electronic conductivity of Si, thereby leading to the significantly improved lithium storage properties. Electrochemical tests show that the SCG with optimized graphene content delivers a high capacity(712 m Ah/g at 100 m A/g) and robust cycling stability(402 m Ah/g at 1 A/g after 1500 cycles). Furthermore, the full cell using SCG aerogels as anode exhibits a reversible capacity of 187.6 m Ah/g after 80 cycles at 0.1 A/g. This work provides a plausible strategy for developing Si anode in LIBs.展开更多
基金supported by the 2018 Shaoguan City Science and Technology Plan Project:Special Project of Industry-University-Research Cooperation(no.2018CS11919)2019 Guangdong Province Special Fund for Science and Technology(‘Big project+task list’)Project:Ecological Cultivation and Sustainable Utilization of Danxia Dendrobium officinale,a rare Southern Medicine in Guangdong Province(no.2019gdskjzxzj-zt3-2)+2 种基金Fundamental Research Project of Shenzhen,China(JCYJ20170817105300166)National Key Research and Development Program of China(no.2018YFD1000401)Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization Construction Funds(nos.115/118990050,115/KJG18016A)awarded to Z.-J.L.
文摘Flavonoids,which are a diverse class of phytonutrients,are used by organisms to respond to nearly all abiotic stresses and are beneficial for human health.Glycosyltransferase,used during the last step of flavonoid biosynthesis,is important in flavonoid enrichment.However,little is known about glycosyltransferase in the orchid Dendrobium catenatum(D.officinale).In this study,we isolated a novel C-glycosyltransferase(designated DcaCGT)from the orchid D.catenatum by identifying and analyzing 82 putative genes in the GT1 family.DcaCGT could specifically catalyze not only di-C-glycosylation but also O-glycosylation.Apart from the normal function of catalyzing 2-hydroxynaringenin and phloretin to the respective di-C-glycosides,DcaCGT also catalyzes apigenin to cosmosiin.Targeted metabolic profiling of the substrates(2-hydroxynaringenin,phloretin,and apigenin)and products(vitexin,isovitexin,vicenin-2,nothofagin,3’,5’-di-C-glucosylphloretin,and cosmosiin)in different tissues showed that vicenin-2 was the most abundant product of this novel enzyme.Cosmosiin was detected in flowers and flower buds.We also established that DcaCGT functions expanded throughout the evolution of D.catenatum.Residual OGT activity may help D.catenatum resist drought stress.Our study illustrates the function,origin,and differentiation of DcaCGT and provides insights into glycosylation and molecular propagation processes,which can be used to improve the production of flavonoids by the cultivated medicinal plant D.catenatum.
基金Supported by grants from the National Natural Science Foundation of China(No.81871911[W.H.],No.81772623[L.X.],and No.81972237[L.X.])the National Key Research and Development Program of China(No.2018YFC1312103[L.X.]).
文摘The difficulty of early diagnosis,high tumor heterogeneity,and high recurrence and metastasis rates lead to an unsatisfactory treatment status for hepatocellular carcinoma(HCC).HCC is a typical inflammation-driven tumor.Chronic inflammation allows nascent tumors to escape immunosurveillance.Chemokines are small,soluble,secreted proteins that can regulate the activation and trafficking of immune cells during inflammation.Several studies have shown that various chemokines with overarching functions disrupt the immune microenvironment during the initiation and progression of HCC.The dysregulated chemokine network in HCC contributes to multiple malignant processes,including angiogenesis,tumor proliferation,migration,invasion,tumor low response,and resistance to immune therapy.Here,we summarize the current studies focusing on the role of chemokines and their receptors in the HCC immune microenvironment,highlighting potential translational therapeutic uses for modulating the chemokine system in HCC.
基金supported by the National Natural Science Foundation of China(No.42172336).
文摘Lakes are the main reservoirs of persistent organic pollutants(POPs)from land,atmo sphere and rivers.POPs in lakes undergo complex exchange,transformation,and degradation between water-air-sediment-biota interfaces,which are constrained and regulated by various physical,chemical and biological factors.POPs can affect ecological conditions,chemical properties of water and sedi ments,and biodiversity of the lake system.Therefore,it is important to study the sources,migration,transformation,environmental behavior and ecological impacts of POPs in lake ecosystems.This re view summarizes research progress on detection technologies,diversity and origins,historical records,migration and transformation,distribution patterns,degradation and toxic effects of POPs in lakes.Fi nally,future directions related to POPs in lakes were summarized.
基金supported by the National Natural Science Foundation of China(22179037)Shanghai pilot program for Basic Research(22TQ1400100-1)+3 种基金Shanghai Municipal Science and Technology Major Project(2018SHZDZX03,21JC1401700)the Programmer of Introducing Talents of Discipline to Universities(B16017)the Fundamental Research Funds for the Central Universitiessupport from Royal Society of Chemistry(R23-0749928359)。
文摘Wide-bandgap mixed-halide perovskite solar cells(WBG-PSCs)are promising top cells for efficient tandem photovoltaics to achieve high power conversion efficiency(PCE)at low cost.However,the open-circuit voltage(V_(OC))of WBG-PSCs is still unsatisfactory as the V_(OC)-deficit is generally larger than 0.45 V.Herein,we report a buried interface engineering strategy that substantially improves the V_(OC)of WBG-PSCs by inserting amphiphilic molecular hole-selective materials featuring with a cyanovinyl phosphonic acid(CPA)anchoring group between the perovskite and substrate.The assembly and redistribution of CPA-based amphiphilic molecules at the perovskite-substrate buried interface not only promotes the growth of a low-defect crystalline perovskite thin film,but also suppresses the photo-induced halide phase separation.The energy level alignment between wide-bandgap perovskite and the hole-selective layer is further improved by modulating the substituents on the triphenylamine donor moiety(methoxyls for MPA-CPA,methyls for Me PA-CPA,and bare TPA-CPA).Using a 1.68 e V bandgap perovskite,the Me PA-CPA-based devices achieved an unprecedentedly high V_(OC)of 1.29 V and PCE of 22.3%under standard AM 1.5 sunlight.The V_(OC)-deficit(<0.40 V)is the lowest value reported for WBG-PSCs.This work not only provides an effective approach to decreasing the V_(OC)-deficit of WBG-PSCs,but also confirms the importance of energy level alignment at the charge-selective layers in PSCs.
基金supported by the NSFC(62271280,62222114,61925109 and 62071428),China.
文摘In autonomous driving systems,perception is pivotal,relying chiefly on sensors like LiDAR and cameras for environmental awareness.LiDAR,celebrated for its detailed depth perception,is being increasingly integrated into autonomous vehicles.In this article,we analyze the robustness of four LiDAR-included models against adversarial points under physical constraints.We first introduce an attack technique that,by simply adding a limited number of physically constrained adversarial points above a vehicle,can make the vehicle undetectable by the LiDAR-included models.Experiments reveal that adversarial points adversely affect the detection capabilities of both LiDAR-only and LiDAR–camera fusion models,with a tendency for more adversarial points to escalate attack success rates.Notably,voxel-based models are more susceptible to deception by these adversarial points.We also investigated the impact of the distance and angle of the added adversarial points on the attack success rate.Typically,the farther the victim object to be hidden and the closer to the front of the LiDAR,the higher the attack success rate.Additionally,we have experimentally proven that our generated adversarial points possess good cross-model adversarial transferability and validated the effectiveness of our proposed optimization method through ablation studies.Furthermore,we propose a new plug-and-play,modelagnostic defense method based on the concept of point smoothness.The ROC curve of this defense method shows an AUC value of approximately 0.909,demonstrating its effectiveness.
文摘Astaxanthin(Ax)and lutein are important fat-soluble pigments and essential nutrients for human and animal health.Haematococcus pluvialis microalga and Phaffia rhodozyma yeast are ideal species for commercial Ax production.Marigold flowers are a main source of commercial lutein.Dynamics of dietary Ax and lutein in the gastrointestinal tract are similar to lipids,but their activities are tremendously challenged by many physiological and dietary factors;few data are available about these in poultry.Dietary Ax and lutein have insignificant effects on egg production and egg physical properties,but have pronounced effects on yolk color,nutrition,and functionality.The two pigments can also enhance antioxidative capacity and immune function of laying hens.A few studies have shown that Ax and lutein can improve fertilization and hatchability of laying hens.Considering the pigmentation and health benefits of Ax and lutein from hen feed to human food,the commercial availability,chicken yolk improvement,and immune function of Ax and lutein are the focuses of this review.The potential roles of carotenoids in the cytokine storm and gut microbiota are also briefly presented.The bioavailability,metabolism,and deposition of Ax and lutein in laying hens are suggested for future research.
基金This work was financially supported by the National Natural Science Foundation of China(No.22003017)the National Key R&D Program of China(No.2018YFB1900603)+2 种基金Natural Science Foundation of Guangdong Province(No.2020A1515011506)Xiaoyu JI is thankful for the financial support from the China Scholarship Council(No.201903170199)for his visit to Yale UniversityThe authors thank Prof.Mingjiang ZHONG(Yale University)and Prof.Stephen Z.D.CHENG(University of Akron)for their helpful discussion.
文摘Solid-state batteries have become a frontrunner in humankind’s pursuit of safe and stable energy storage systems with high energy and power density.Electrolyte materials,currently,seem to be the Achilles’heel of solid-state batteries due to the slow kinetics and poor interfacial wetting.Combining the merits of solid inorganic electrolytes(SIEs)and solid polymer electrolytes(SPEs),inorganic/polymer hybrid electrolytes(IPHEs)integrate improved ionic conductivity,great interfacial compatibility,wide electrochemical stability window,and high mechanical toughness and flexibility in one material,having become a sought-after pathway to high-performance all-solid-state lithium batteries.Herein,we present a comprehensive overview of recent progress in IPHEs,including the awareness of ion migration fundamentals,advanced architectural design for better electrochemical performance,and a perspective on unconquered challenges and potential research directions.This review is expected to provide a guidance for designing IPHEs for next-generation lithium batteries,with special emphasis on developing high-voltage-tolerance polymer electrolytes to enable higher energy density and three-dimensional(3D)continuous ion transport highways to achieve faster charging and discharging.
基金financially supported by the National Natural Science Foundation of China (Nos. 51972182 and 61971252)the Shandong Provincial Natural Science Foundation (Nos. ZR2020JQ27 and ZR2019BF008)the Youth Innovation Team Project of Shandong Provincial Education Department (No. 2020KJN015)。
文摘The application of Si as the anode materials for lithium-ion batteries(LIBs) is still severely hindered by the rapid capacity decay due to the structural damage caused by large volume change(> 300%) during cycling. Herein, a three-dimensional(3 D) aerogel anode of Si@carbon@graphene(SCG) is rationally constructed via a polydopamine-assisted strategy. Polydopamine is coated on Si nanoparticles to serve as an interface linker to initiate the assembly of Si and graphene oxide, which plays a crucial role in the successful fabrication of SCG aerogels. After annealing the polydopamine is converted into N-doped carbon(N-carbon) coatings to protect Si materials. The dual protection from N-carbon and graphene aerogels synergistically improves the structural stability and electronic conductivity of Si, thereby leading to the significantly improved lithium storage properties. Electrochemical tests show that the SCG with optimized graphene content delivers a high capacity(712 m Ah/g at 100 m A/g) and robust cycling stability(402 m Ah/g at 1 A/g after 1500 cycles). Furthermore, the full cell using SCG aerogels as anode exhibits a reversible capacity of 187.6 m Ah/g after 80 cycles at 0.1 A/g. This work provides a plausible strategy for developing Si anode in LIBs.