[Objectives]This study was conducted to discuss the mechanism of the blood sugar-lowering effect of Cyclocarya paliurus extract.[Methods]With C.paliurus leaves as the raw material,the ethyl acetate-butyl acetate micro...[Objectives]This study was conducted to discuss the mechanism of the blood sugar-lowering effect of Cyclocarya paliurus extract.[Methods]With C.paliurus leaves as the raw material,the ethyl acetate-butyl acetate microwave extraction process of C.paliurus was studied.With the yield of C.paliurus extract as an evaluation index,single-factor experiments were carried out on such 6 factors as the dry C.paliurus leaf powder size,solid-to-liquid ratio,extraction time,microwave frequency,microwave power,and microwave extraction time,and the extraction and purification process was further optimized by response surface analysis.The normal mice and the hyperglycemic mice modeled by alloxan were injected with C.paliurus extract to study the blood sugar-lowering effects of different groups of C.paliurus extract.[Results]The optimal process combination for the extraction of C.paliurus leaves was obtained:dry C.paliurus powder size 90-100 mesh,solid-to-liquid ratio 1∶20(g/ml),extraction time 192 min,microwave frequency 2500 MHz,microwave power 490 W,and extraction time 248 s.Under these conditions,the yield of C.paliurus extract reached the maximum,95.10%,reaching 99.83%of the predicted value.The blood sugar-lowering test on mice showed that the C.paliurus extract had a good effect on lowering blood sugar,indicating that C.paliurus extract can improve the free radical scavenging capacity to a certain extent.[Conclusions]This study provides certain reference for the in-depth study of the physiological effects of C.paliurus extract and the comprehensive development and utilization of C.paliurus extract.展开更多
With the continuous development of science and technology,the role of rare and precious metal resources in medical treatment,economy and strategy has become increasingly prominent.This paper reviewed the application r...With the continuous development of science and technology,the role of rare and precious metal resources in medical treatment,economy and strategy has become increasingly prominent.This paper reviewed the application research of rare precious metal rubidium(Rb)in the field of medicine and health,mainly including the application significance of Rb in the field of medical and health,typical applications and problems in the field of medicine and health,and the important research significance of the research and development of medicine.展开更多
基金High-level Innovation Team and Outstanding Scholar Project of Guangxi Colleges and Universities(2019-52)"Qihuang Project"High-level Talent Team Cultivation Project of Guangxi University of Chinese Medicine(2018002)2019 Nanning City Level Scientific Research and Technology Development Planning Project(20193115)。
文摘[Objectives]This study was conducted to discuss the mechanism of the blood sugar-lowering effect of Cyclocarya paliurus extract.[Methods]With C.paliurus leaves as the raw material,the ethyl acetate-butyl acetate microwave extraction process of C.paliurus was studied.With the yield of C.paliurus extract as an evaluation index,single-factor experiments were carried out on such 6 factors as the dry C.paliurus leaf powder size,solid-to-liquid ratio,extraction time,microwave frequency,microwave power,and microwave extraction time,and the extraction and purification process was further optimized by response surface analysis.The normal mice and the hyperglycemic mice modeled by alloxan were injected with C.paliurus extract to study the blood sugar-lowering effects of different groups of C.paliurus extract.[Results]The optimal process combination for the extraction of C.paliurus leaves was obtained:dry C.paliurus powder size 90-100 mesh,solid-to-liquid ratio 1∶20(g/ml),extraction time 192 min,microwave frequency 2500 MHz,microwave power 490 W,and extraction time 248 s.Under these conditions,the yield of C.paliurus extract reached the maximum,95.10%,reaching 99.83%of the predicted value.The blood sugar-lowering test on mice showed that the C.paliurus extract had a good effect on lowering blood sugar,indicating that C.paliurus extract can improve the free radical scavenging capacity to a certain extent.[Conclusions]This study provides certain reference for the in-depth study of the physiological effects of C.paliurus extract and the comprehensive development and utilization of C.paliurus extract.
基金Supported by National Talent Project of"Youth Qihuang Scholars"(2020)High-level Innovation Team Project of Guangxi Colleges and Universities(2019-52)。
文摘With the continuous development of science and technology,the role of rare and precious metal resources in medical treatment,economy and strategy has become increasingly prominent.This paper reviewed the application research of rare precious metal rubidium(Rb)in the field of medicine and health,mainly including the application significance of Rb in the field of medical and health,typical applications and problems in the field of medicine and health,and the important research significance of the research and development of medicine.