Research Progress of HPV L1 Capsid Protein in Prediction of Cervical Lesions

Cervical cancer is one of the most common malignant gynecological tumors and has the second highest incidence of all malignancies in females.Chronic and persistent infection with High Risk Human Papillomavirus(HR-HPV)is the main cause of cervical cancer.There is a distinct lack of methodology by which to determine whether cervical epithelial dysplasia is cancerous following HPV infection.HPV L1 capsid protein is a major structural protein of human papillomavirus(HPV),and it is the main target of the local cellular immune response aiming to combat human papillomavirus after HPV infection within cervical cells.Greater understanding of HPV L1 capsid protein and its association with cervical cytology,histopathology,patient age and human papillomavirus viral load has the potential to contribute toward improved the diagnosis and management of cervical cancer,providing useful information for gynecological clinicians in the hope of improving patient treatment and quality of life.This article reviews the predictive utility of HPV L1 capsid protein for cervical lesions.

Comparison of mood state in severe pelvic organ prolapse patients before and after surgery

Objective:This study aimed to compare the mood state of patients with severe pelvic organ prolapse(POP)before and after surgery.Methods:This prospective study enrolled 100 patients with severe POP who were surgically treated between October 2016 and February 2019.The clinical severity of POP was evaluated using the POP Quantification(POPQ)System.Mood state evaluation,using the Hamilton anxiety(HAMA)and the Hamilton depression(HAMD)scale,was performed preoperatively and at 3 and 6 months postoperatively.Results:The POP-Q stage was significantly improved postoperatively(P<0.05).Preoperatively,the patients had varying degrees of anxiety symptoms(mean HAMA score,11.94
5.59 points)and depression symptoms(mean HAMD score,5.56
2.58 points);these scores were significantly decreased at 3 months(mean HAMA score,4.67
2.02 points;mean HAMD score,3.58
1.61 points)and 6 months postoperatively(mean HAMA score,4.88
2.57 points;mean HAMD score,3.38
1.60 points)(P<0.05).There were no differences in the HAMD and HAMA scores in both traditional prolapse surgery patients and mesh pelvic reconstruction patients preoperatively and at 3 and 6 months postoperatively(P>0.05).Conclusions:Patients with severe POP have different anxiety and depression symptoms preoperatively.Successful individualized surgical treatment is effective for improving the clinical severity of severe POP and might alleviate or improve POP-related anxiety or depression symptoms.