Tubulointerstitial fibrosis(TIF)is one of the main pathological features of various progressive renal damages and chronic kidney diseases.Mesenchymal stromal cells(MSCs)have been verified with significant improvement ...Tubulointerstitial fibrosis(TIF)is one of the main pathological features of various progressive renal damages and chronic kidney diseases.Mesenchymal stromal cells(MSCs)have been verified with significant improvement i the therapy of fibrosis diseases,but the mechanism is still unclear.We attempted to explore the new mechanism and therapeutic target of MSCs against renal fibrosis based on renal proteomics.TIF model was induced by adenine gavage.Bone marrow derived MSCs was injected by tail vein after modeling.展开更多
目的探讨斜口鞘在微通道经皮肾镜碎石取石术(mPCNL)治疗肾铸型结石中的临床疗效及优势。方法前瞻性收集25例利用平口鞘和31例利用斜口鞘行m PCNL的肾铸型结石患者临床资料,包括患者基本信息、结石平均CT值、手术时间、碎石时间、术后并...目的探讨斜口鞘在微通道经皮肾镜碎石取石术(mPCNL)治疗肾铸型结石中的临床疗效及优势。方法前瞻性收集25例利用平口鞘和31例利用斜口鞘行m PCNL的肾铸型结石患者临床资料,包括患者基本信息、结石平均CT值、手术时间、碎石时间、术后并发症(出血、发热、肾功能不全)、一期清石率以及术后住院时间等,综合分析比较治疗效果。结果平口鞘组和斜口鞘组在患者年龄、结石肾积水深度、结石最大径、结石平均CT值、术前尿路感染等方面均无显著差异,并在术前术后血红蛋白差值、术后并发症、一期清石率、术后住院天数上均无差异,但斜口鞘组较平口鞘组具有更短的碎石取石时间[85(62,95)min vs. 103(74,118)min]。结论斜口鞘有助于提高mPCNL处理肾铸型结石的碎石取石效率,是治疗复杂性肾结石的一种安全、有效的手术技巧改进。展开更多
Earthquake investigations have shown that near-fault pulse-like(NF-P)ground motions have unique characteristics compared to near-fault non-pulse-like(NF-NP)and far-field(FF)ground motions.It is necessary to study the ...Earthquake investigations have shown that near-fault pulse-like(NF-P)ground motions have unique characteristics compared to near-fault non-pulse-like(NF-NP)and far-field(FF)ground motions.It is necessary to study the seismic response of pile-supported wharf(PSW)structures under NF-P ground motions.In this study,a three-dimensional finite element numerical model is created to simulate a PSW.By imparting three types of ground motion,the engineering demand parameters(EDPs)of PSW under NF-P ground motions were analyzed and compared,in which EDPs are the maximum displacement and bending moment of the piles.Twenty intensity measures(IMs)were selected to characterize the properties of ground motions.The correlation between IMs and EDPs was explored.The results show that the piles present larger displacement and bending moment under NF-P ground motions compared to NF-NP and FF ground motions.None of the IMs have a high correlation with EDPs under NF-P ground motions,and these IMs are more applicable to FF ground motions.The correlation coefficients between EDPs and IMs under three types of ground motion were obtained,which will provide a valuable reference for the seismic design of PSWs.展开更多
文摘Tubulointerstitial fibrosis(TIF)is one of the main pathological features of various progressive renal damages and chronic kidney diseases.Mesenchymal stromal cells(MSCs)have been verified with significant improvement i the therapy of fibrosis diseases,but the mechanism is still unclear.We attempted to explore the new mechanism and therapeutic target of MSCs against renal fibrosis based on renal proteomics.TIF model was induced by adenine gavage.Bone marrow derived MSCs was injected by tail vein after modeling.
文摘目的探讨斜口鞘在微通道经皮肾镜碎石取石术(mPCNL)治疗肾铸型结石中的临床疗效及优势。方法前瞻性收集25例利用平口鞘和31例利用斜口鞘行m PCNL的肾铸型结石患者临床资料,包括患者基本信息、结石平均CT值、手术时间、碎石时间、术后并发症(出血、发热、肾功能不全)、一期清石率以及术后住院时间等,综合分析比较治疗效果。结果平口鞘组和斜口鞘组在患者年龄、结石肾积水深度、结石最大径、结石平均CT值、术前尿路感染等方面均无显著差异,并在术前术后血红蛋白差值、术后并发症、一期清石率、术后住院天数上均无差异,但斜口鞘组较平口鞘组具有更短的碎石取石时间[85(62,95)min vs. 103(74,118)min]。结论斜口鞘有助于提高mPCNL处理肾铸型结石的碎石取石效率,是治疗复杂性肾结石的一种安全、有效的手术技巧改进。
基金National Natural Science Foundation of China under Grant Nos.42072310 and 51808307。
文摘Earthquake investigations have shown that near-fault pulse-like(NF-P)ground motions have unique characteristics compared to near-fault non-pulse-like(NF-NP)and far-field(FF)ground motions.It is necessary to study the seismic response of pile-supported wharf(PSW)structures under NF-P ground motions.In this study,a three-dimensional finite element numerical model is created to simulate a PSW.By imparting three types of ground motion,the engineering demand parameters(EDPs)of PSW under NF-P ground motions were analyzed and compared,in which EDPs are the maximum displacement and bending moment of the piles.Twenty intensity measures(IMs)were selected to characterize the properties of ground motions.The correlation between IMs and EDPs was explored.The results show that the piles present larger displacement and bending moment under NF-P ground motions compared to NF-NP and FF ground motions.None of the IMs have a high correlation with EDPs under NF-P ground motions,and these IMs are more applicable to FF ground motions.The correlation coefficients between EDPs and IMs under three types of ground motion were obtained,which will provide a valuable reference for the seismic design of PSWs.
