Evaluation of the extent and progression of liver fibrosis and cirrhosis is of critical importance in the management and prognosis of patients with chronic hepatitis B.Due to the limitation of liver biopsy,non-invasiv...Evaluation of the extent and progression of liver fibrosis and cirrhosis is of critical importance in the management and prognosis of patients with chronic hepatitis B.Due to the limitation of liver biopsy,non-invasive methods,especially liver stiffness measurement (LSM) by vibration controlled transient elastography,have been developed and widely applied for liver fibrosis assessment.LSM aims to reduce,but not to substitute,the need for liver biopsy for fibrosis/cirrhosis diagnosis.While LSM may have potential utility in monitoring treatment response,its applications in prediction of liver complications in terms of portal hypertension and esophageal varices,as well as disease prognosis,have been gradually validated.Here,we review the latest clinical applications of LSM in patients with chronic hepatitis B.展开更多
基金This study was funded by the National Science and Technology Major Project(2013ZX10002004 to YPC)the Dean's Fund of Nanfang Hospital(2015C022 to XEL)
文摘Evaluation of the extent and progression of liver fibrosis and cirrhosis is of critical importance in the management and prognosis of patients with chronic hepatitis B.Due to the limitation of liver biopsy,non-invasive methods,especially liver stiffness measurement (LSM) by vibration controlled transient elastography,have been developed and widely applied for liver fibrosis assessment.LSM aims to reduce,but not to substitute,the need for liver biopsy for fibrosis/cirrhosis diagnosis.While LSM may have potential utility in monitoring treatment response,its applications in prediction of liver complications in terms of portal hypertension and esophageal varices,as well as disease prognosis,have been gradually validated.Here,we review the latest clinical applications of LSM in patients with chronic hepatitis B.
