Because CASE (computer aided software engineering) environment is a kind of complex system software, its software architecture is very important. From the viewpoint of software architecture, this paper first presents ...Because CASE (computer aided software engineering) environment is a kind of complex system software, its software architecture is very important. From the viewpoint of software architecture, this paper first presents TBus architectural style, which is a kind of CASE environment architectural style based on ToolBus, then describes the architectural model and system's behavior in formal method, researches and analyzes the corresponding tool structural model. Last the paper implements a TBus architectural instance-LambdaBridge, which proves the validity of ToolBus and TBus architectural styles.展开更多
Peptide nucleic acids(PNAs) are nucleic acidanalogs with the deoxyribose phosphate backbone replaced by pseudo-peptide polymers to which the nucleobases arelinked.The achiral,uncharged and rather flexible properties o...Peptide nucleic acids(PNAs) are nucleic acidanalogs with the deoxyribose phosphate backbone replaced by pseudo-peptide polymers to which the nucleobases arelinked.The achiral,uncharged and rather flexible properties of the peptide backbone permit peptide nucleic acids more potential than oligonucleotides in application to antisenceand antigenic reagents.The process of PNA binding to DNA duplex and forming triplex is the first step of PNA interact-ing with PNA.But there are no PNA.2DNA triplex crystaldata up to date and little has been reported on the structure features and the force of the PNA.2DNA triplex.In thiswork,PNA(T).DNA(AT) triplexes are successfully built and the structures and forces to stabilize the triplex after optimi-zations and molecule dynamics are systematically exam-ined,which are expected to aid in the application of PNAs as anticense and antigene agents.展开更多
Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a transcription factor belonging to the nuclear receptor superfamily that binds to specific response elements. Rosiglitazone, promotes insulin sensitization a...Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a transcription factor belonging to the nuclear receptor superfamily that binds to specific response elements. Rosiglitazone, promotes insulin sensitization and is a synthetic agonist ligand of PPAR-γ. 1 In recent years, a number of studies have shown that triglitazone and piglitazone, which are chemically related to rosiglitazone, can attenuate postinfarction left ventricular remodeling, 2 but there are few studies assessing whether rosiglitazone similarly improves postinfarction left ventricular remodeling and cardiac function. Therefore, the purpose of this study was to determine whether rosiglitazone can improve left ventricular remodeling and cardiac function in a rat model of post-myocardial infarction (MI), and to explore potential underlying mechanisms.展开更多
文摘Because CASE (computer aided software engineering) environment is a kind of complex system software, its software architecture is very important. From the viewpoint of software architecture, this paper first presents TBus architectural style, which is a kind of CASE environment architectural style based on ToolBus, then describes the architectural model and system's behavior in formal method, researches and analyzes the corresponding tool structural model. Last the paper implements a TBus architectural instance-LambdaBridge, which proves the validity of ToolBus and TBus architectural styles.
基金supported by the National Natural Science Foundation of China(Grant Nos.39770418 and 39570395)the Post Doctor Foundation.
文摘Peptide nucleic acids(PNAs) are nucleic acidanalogs with the deoxyribose phosphate backbone replaced by pseudo-peptide polymers to which the nucleobases arelinked.The achiral,uncharged and rather flexible properties of the peptide backbone permit peptide nucleic acids more potential than oligonucleotides in application to antisenceand antigenic reagents.The process of PNA binding to DNA duplex and forming triplex is the first step of PNA interact-ing with PNA.But there are no PNA.2DNA triplex crystaldata up to date and little has been reported on the structure features and the force of the PNA.2DNA triplex.In thiswork,PNA(T).DNA(AT) triplexes are successfully built and the structures and forces to stabilize the triplex after optimi-zations and molecule dynamics are systematically exam-ined,which are expected to aid in the application of PNAs as anticense and antigene agents.
文摘Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a transcription factor belonging to the nuclear receptor superfamily that binds to specific response elements. Rosiglitazone, promotes insulin sensitization and is a synthetic agonist ligand of PPAR-γ. 1 In recent years, a number of studies have shown that triglitazone and piglitazone, which are chemically related to rosiglitazone, can attenuate postinfarction left ventricular remodeling, 2 but there are few studies assessing whether rosiglitazone similarly improves postinfarction left ventricular remodeling and cardiac function. Therefore, the purpose of this study was to determine whether rosiglitazone can improve left ventricular remodeling and cardiac function in a rat model of post-myocardial infarction (MI), and to explore potential underlying mechanisms.
