Ionizing radiation is a popular and effective treatment option for glioblastoma(GBM).However,resistance to radiation therapy inevitably occurs during treatment.It is urgent to investigate the mechanisms of radioresist...Ionizing radiation is a popular and effective treatment option for glioblastoma(GBM).However,resistance to radiation therapy inevitably occurs during treatment.It is urgent to investigate the mechanisms of radioresistance in GBM and to find ways to improve radiosensitivity.Here,we found that heat shock protein 90 beta family member 1(HSP90B1)was significantly upregulated in radioresistant GBM cell lines.More importantly,HSP90B1 promoted the localization of glucose transporter type 1,a key rate-limiting factor of glycolysis,on the plasma membrane,which in turn enhanced glycolytic activity and subsequently tumor growth and radioresistance of GBM cells.These findings imply that targeting HSP90B1 may effectively improve the efficacy of radiotherapy for GBM patients,a potential new approach to the treatment of glioblastoma.展开更多
Background Patients with insulo-Sylvian gliomas continue to present with severe morbidity in cognitive functions primarily due to neurosurgeons’lack of familiarity with non-traditional brain networks.We sought to ide...Background Patients with insulo-Sylvian gliomas continue to present with severe morbidity in cognitive functions primarily due to neurosurgeons’lack of familiarity with non-traditional brain networks.We sought to identify the frequency of invasion and proximity of gliomas to portions of these networks.Methods We retrospectively analyzed data from 45 patients undergoing glioma surgery centered in the insular lobe.Tumors were categorized based on their proximity and invasiveness of non-traditional cognitive networks and traditionally eloquent structures.Diffusion tensor imaging tractography was completed by creating a personalized brain atlas using Quicktome to determine eloquent and non-eloquent networks in each patient.Additionally,we prospectively collected neuropsychological data on 7 patients to compare tumor-network involvement with change in cognition.Lastly,2 prospective patients had their surgical plan influenced by network mapping determined by Quicktome.Results Forty-four of 45 patients demonstrated tumor involvement(<1 cm proximity or invasion)with components of non-traditional brain networks involved in cognition such as the salience network(SN,60%)and the central executive network(CEN,56%).Of the seven prospective patients,all had tumors involved with the SN,CEN(5/7,71%),and language network(5/7,71%).The mean scores of MMSE and MOCA before surgery were 18.71±6.94 and 17.29±6.26,respectively.The two cases who received preoperative planning with Quicktome had a postoperative performance that was anticipated.Conclusions Non-traditional brain networks involved in cognition are encountered during surgical resection of insulo-Sylvian gliomas.Quicktome can improve the understanding of the presence of these networks and allow for more informed surgical decisions based on patient functional goals.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.82072765 to X.Q.and 82172667 to X.W.).
文摘Ionizing radiation is a popular and effective treatment option for glioblastoma(GBM).However,resistance to radiation therapy inevitably occurs during treatment.It is urgent to investigate the mechanisms of radioresistance in GBM and to find ways to improve radiosensitivity.Here,we found that heat shock protein 90 beta family member 1(HSP90B1)was significantly upregulated in radioresistant GBM cell lines.More importantly,HSP90B1 promoted the localization of glucose transporter type 1,a key rate-limiting factor of glycolysis,on the plasma membrane,which in turn enhanced glycolytic activity and subsequently tumor growth and radioresistance of GBM cells.These findings imply that targeting HSP90B1 may effectively improve the efficacy of radiotherapy for GBM patients,a potential new approach to the treatment of glioblastoma.
基金supported by a grant from the National Natural Science Foundation of China(81974389)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
文摘Background Patients with insulo-Sylvian gliomas continue to present with severe morbidity in cognitive functions primarily due to neurosurgeons’lack of familiarity with non-traditional brain networks.We sought to identify the frequency of invasion and proximity of gliomas to portions of these networks.Methods We retrospectively analyzed data from 45 patients undergoing glioma surgery centered in the insular lobe.Tumors were categorized based on their proximity and invasiveness of non-traditional cognitive networks and traditionally eloquent structures.Diffusion tensor imaging tractography was completed by creating a personalized brain atlas using Quicktome to determine eloquent and non-eloquent networks in each patient.Additionally,we prospectively collected neuropsychological data on 7 patients to compare tumor-network involvement with change in cognition.Lastly,2 prospective patients had their surgical plan influenced by network mapping determined by Quicktome.Results Forty-four of 45 patients demonstrated tumor involvement(<1 cm proximity or invasion)with components of non-traditional brain networks involved in cognition such as the salience network(SN,60%)and the central executive network(CEN,56%).Of the seven prospective patients,all had tumors involved with the SN,CEN(5/7,71%),and language network(5/7,71%).The mean scores of MMSE and MOCA before surgery were 18.71±6.94 and 17.29±6.26,respectively.The two cases who received preoperative planning with Quicktome had a postoperative performance that was anticipated.Conclusions Non-traditional brain networks involved in cognition are encountered during surgical resection of insulo-Sylvian gliomas.Quicktome can improve the understanding of the presence of these networks and allow for more informed surgical decisions based on patient functional goals.
