以师范专业认证为契机 推进化学一流专业建设

基于师范专业认证"学生中心、产出导向、持续改进"的理念,以鲁东大学化学专业为例,从培养目标定位、课程体系构建、教学方式改革、课程思政建设、实践能力培养、教学评价改进等方面介绍了一流专业建设的举措及成效,提出了持续改进的方向。

The influence of interstitial brachytherapy with ～(125)I seeds on Caspase-3 and Egr-1 expressions of Lewis lung carcinoma in C57BL mice

Objective:The aim of our study was to explore the influence of interstitial brachytherapy with 125I seeds on Caspase-3 and Egr-1 expressions of Lewis lung carcinoma in C57BL mice.Methods:Model mice of C57BL were planted with Lewis lung cells (LLC) and divided into the treatment group (n=18) and the control group (n=17).In each mouse of the treatment group,two BT-125-1 Model 125I seeds with apparent activity of 9.25 MBq were implanted into the tumor;whereas in each mouse of the control group two dummy seeds were implanted.The mice survival rates of both groups were recorded after 21 days.The tumor weights and dimensions of survived mice were measured,and the tumor volume inhibition rate was calculated.T-test was performed to compare differences of tumor weights and volumes between these two groups.Routine pathological slides of tumor tissue were observed under light microscope.The expression of Caspase-3 was detected by immunohistochemical method and the expression of Egr-1 was detected by RT-PCR method.Results:The survival rates were 88.88% in the treatment group and 70.59% in the control group,the difference had no statistical significance (P > 0.05).The tumor volume inhibition rate was 71.12%.Pathological examination showed degeneration and necrosis of cancer cells at the site nearby the seed in the treated group,but the tumor cells alive were still presented nearby the seed in the control group.The expressions of Caspase-3 and Egr-1 in the treated group were higher than those in the control group (t=12.825,P < 0.01;t=7.039,P < 0.01;respectively).Conclusion:The interstitial brachytherapy with 125I seeds could significantly inhibit the growth of Lewis lung carcinoma of mice.The possible mechanism may be that 125I interstitial brachytherapy can enhance the expressions of Egr-1 and Caspase-3,which could induce tumor cellular apoptosis.

Influence of freeze-thaw damage gradient on stress-strain relationship of stressed concrete

Freeze-thaw damage gradients lead to non-uniform degradation of concrete mechanical properties at different depths.A study was conducted on the stress-strain relationship of stressed concrete with focus on the freeze-thaw damage gradient.The effects of relative freeze-thaw depths,number of freeze-thaw cycles(FTCs)and stress ratios on the stress-strain curves of concrete were analyzed.The test results demonstrated that freeze-thaw damage was more severe in the surface layers of concrete than in the deeper layers.The relative peak stress and strain of concrete degraded bilinearly with increasing depth.The stress-strain relationship of stressed concrete under FTC was established,and it was found to agree with the experimental results.

某测量船远海调测期间疾病谱研究

目的:总结某测量船官兵远海调测期间发生疾病的特点和规律,为更好地执行此类医疗保障任务提供借鉴。方法:回顾某测量船157名官兵2018年3月31日至9月4日执行远海调测任务期间的门诊伤病记录,统计航行时段的病例数据与气象数据,分析发病特点及各系统疾病发病率与温度、湿度、风力、浪高的关系。结果:共436例次伤病员进入统计,发病率前五位由高到低依次为呼吸系统疾病、皮肤病、运动系统伤病、皮肤和软组织损伤、消化系统疾病,占发病总例次的73.9%;其中上呼吸道感染、皮肤和软组织损伤、腰背颈肩痛、过敏性皮炎、癣的构成比分别为19.6%,12.2%,8.9%,5.5%,5.5%。结论:呼吸系统疾病发病率与平均浪高、平均湿度、平均风速呈负相关;皮肤病发病率与平均气温呈正相关、与平均浪高呈负相关;运动系统伤病发病率与平均浪高、平均气温呈负相关,与平均风速呈正相关;皮肤和软组织损伤发病率与平均风速呈正相关;消化系统疾病发病率与平均浪高、平均湿度呈正相关。