DearEditor,Identifying novel glioma-driven signaling molecules and exploring the corresponding molecularly targeted therapies are essential for better and effcient glioma therapy.YME1L(YME1 Like 1 ATPase),a primary me...DearEditor,Identifying novel glioma-driven signaling molecules and exploring the corresponding molecularly targeted therapies are essential for better and effcient glioma therapy.YME1L(YME1 Like 1 ATPase),a primary member of the AAA family of ATPase,is located at the inner mitochondrial membrane(Anand et al.,2014;MacVicar et al.,2019;Ohba et al.,2020).YME1L is essential for maintaining mitochondrial morphology,function,and plasticity(Anand et al.,2014;MacVicar et al.,2019;Ohba et al.,2020).YME1L assembles into a homo-oligomeric complex within the inner mitochondrial membrane(Anand et al.,2014;MacVicar et al.,2019;Ohba et al.,2020).Moreover,YME1L can degrade mitochondrial proteins,including lipid-transferring proteins,IM translocation proteins.展开更多
Background and Aims:Gallbladder polyp(GBP)assessment aims to identify the early stages of gallbladder carcinoma.Many studies have analyzed the risk factors for malignant GBPs.In this retrospective study,we aimed to es...Background and Aims:Gallbladder polyp(GBP)assessment aims to identify the early stages of gallbladder carcinoma.Many studies have analyzed the risk factors for malignant GBPs.In this retrospective study,we aimed to establish a more accurate predictive model for potential neoplastic polyps in patients with GBPs.Methods:We devel-oped a nomogram-based model in a training cohort of 233 GBP patients.Clinical information,ultrasonographic find-ings,and blood test findings were analyzed.Mann-Whitney U test and multivariate logistic regression analyses were used to identify independent predictors and establish the nomogram model.An internal validation was conducted in 225 consecutive patients.Performance and clinical bene-fit of the model were evaluated using receiver operating characteristic curves and decision curve analysis(DCA),re-spectively.Results:Age,cholelithiasis,carcinoembryonic antigen,polyp size,and sessile shape were confirmed as independent predictors of GBP neoplastic potential in the training group.Compared with five other proposed predic-tion methods,the established nomogram model presented better discrimination of neoplastic GBPs in the training co-hort(area under the curve[AUC]:0.846)and the validation cohort(AUC:0.835).DCA demonstrated that the greatest clinical benefit was provided by the nomogram compared with the other five methods.Conclusions:Our developed preoperative nomogram model can successfully be used to evaluate the neoplastic potential of GBPs based on simple clinical variables that maybe useful for clinical decision-making.展开更多
基金supported by Key Research and Development Program of Jiangsu Province(No.BE2019652)Changzhou intemational cooperation program(Cz20200039)+1 种基金Development Program of Changzhou City(CE20205024)National Natural Science Foundation of China(Grant Nos.81922025,81974388,82171461 and 81771457).
文摘DearEditor,Identifying novel glioma-driven signaling molecules and exploring the corresponding molecularly targeted therapies are essential for better and effcient glioma therapy.YME1L(YME1 Like 1 ATPase),a primary member of the AAA family of ATPase,is located at the inner mitochondrial membrane(Anand et al.,2014;MacVicar et al.,2019;Ohba et al.,2020).YME1L is essential for maintaining mitochondrial morphology,function,and plasticity(Anand et al.,2014;MacVicar et al.,2019;Ohba et al.,2020).YME1L assembles into a homo-oligomeric complex within the inner mitochondrial membrane(Anand et al.,2014;MacVicar et al.,2019;Ohba et al.,2020).Moreover,YME1L can degrade mitochondrial proteins,including lipid-transferring proteins,IM translocation proteins.
基金supported by the National Natural Science Foundation of China(81702323 and 81672469)the Changzhou Medical Innovation Team(CCX201807)the Changzhou Sci&Tech Program(CE20165020).
文摘Background and Aims:Gallbladder polyp(GBP)assessment aims to identify the early stages of gallbladder carcinoma.Many studies have analyzed the risk factors for malignant GBPs.In this retrospective study,we aimed to establish a more accurate predictive model for potential neoplastic polyps in patients with GBPs.Methods:We devel-oped a nomogram-based model in a training cohort of 233 GBP patients.Clinical information,ultrasonographic find-ings,and blood test findings were analyzed.Mann-Whitney U test and multivariate logistic regression analyses were used to identify independent predictors and establish the nomogram model.An internal validation was conducted in 225 consecutive patients.Performance and clinical bene-fit of the model were evaluated using receiver operating characteristic curves and decision curve analysis(DCA),re-spectively.Results:Age,cholelithiasis,carcinoembryonic antigen,polyp size,and sessile shape were confirmed as independent predictors of GBP neoplastic potential in the training group.Compared with five other proposed predic-tion methods,the established nomogram model presented better discrimination of neoplastic GBPs in the training co-hort(area under the curve[AUC]:0.846)and the validation cohort(AUC:0.835).DCA demonstrated that the greatest clinical benefit was provided by the nomogram compared with the other five methods.Conclusions:Our developed preoperative nomogram model can successfully be used to evaluate the neoplastic potential of GBPs based on simple clinical variables that maybe useful for clinical decision-making.
