Unravelling lineage plasticity and cellular contribution to hepatocytes provides valuable information for understanding sources that fuel homeostatic renewal of the liver(Miyajima et al.,2014).In the adult stage,hepat...Unravelling lineage plasticity and cellular contribution to hepatocytes provides valuable information for understanding sources that fuel homeostatic renewal of the liver(Miyajima et al.,2014).In the adult stage,hepatocytes are mainly self-renewed through cell division(Schaub et al.,2014;Tarlow et al.,2014;Yanger et al.,2014).Under severe injury or when hepatocyte proliferation is significantly impaired,cholangiocytes or biliary epithelial cells contribute to hepatocytes(Raven et al.,2017;Deng et al.,2018).展开更多
基金supported by the National Key Research and Development Program of China(2018YFA0107900 and 2018YFA0108100)the National Science Foundation of China(31730112 and 31625019)the China Postdoctoral Innovative Talent Support Program。
文摘Unravelling lineage plasticity and cellular contribution to hepatocytes provides valuable information for understanding sources that fuel homeostatic renewal of the liver(Miyajima et al.,2014).In the adult stage,hepatocytes are mainly self-renewed through cell division(Schaub et al.,2014;Tarlow et al.,2014;Yanger et al.,2014).Under severe injury or when hepatocyte proliferation is significantly impaired,cholangiocytes or biliary epithelial cells contribute to hepatocytes(Raven et al.,2017;Deng et al.,2018).
