Systemic antibiotics increase microbiota pathogenicity and oral bone loss

Periodontitis is the most widespread oral disease and is closely related to the oral microbiota.The oral microbiota is adversely affected by some pharmacologic treatments.Systemic antibiotics are widely used for infectious diseases but can lead to gut dysbiosis,causing negative effects on the human body.Whether systemic antibiotic-induced gut dysbiosis can affect the oral microbiota or even periodontitis has not yet been addressed.In this research,mice were exposed to drinking water containing a cocktail of four antibiotics to explore how systemic antibiotics affect microbiota pathogenicity and oral bone loss.The results demonstrated,for the first time,that gut dysbiosis caused by long-term use of antibiotics can disturb the oral microbiota and aggravate periodontitis.Moreover,the expression of cytokines related to Th17 was increased while transcription factors and cytokines related to Treg were decreased in the periodontal tissue.Fecal microbiota transplantation with normal mice feces restored the gut microbiota and barrier,decreased the pathogenicity of the oral microbiota,reversed the Th17/Treg imbalance in periodontal tissue,and alleviated alveolar bone loss.This study highlights the potential adverse effects of long-term systemic antibiotics-induced gut dysbiosis on the oral microbiota and periodontitis.A Th17/Treg imbalance might be related to this relationship.Importantly,these results reveal that the periodontal condition of patients should be assessed regularly when using systemic antibiotics in clinical practice.

Intelligent Spectrum Management Based on Radio Map for Cloud-Based Satellite and Terrestrial Spectrum Shared Networks

Cloud-based satellite and terrestrial spectrum shared networks(CB-STSSN)combines the triple advantages of efficient and flexible net-work management of heterogeneous cloud access(H-CRAN),vast coverage of satellite networks,and good communication quality of terrestrial networks.Thanks to the complementary coverage characteristics,any-time and anywhere high-speed communications can be achieved to meet the various needs of users.The scarcity of spectrum resources is a common prob-lem in both satellite and terrestrial networks.In or-der to improve resource utilization,the spectrum is shared not only within each component but also be-tween satellite beams and terrestrial cells,which intro-duces inter-component interferences.To this end,this paper first proposes an analytical framework which considers the inter-component interferences induced by spectrum sharing(SS).An intelligent SS scheme based on radio map(RM)consisting of LSTM-based beam prediction(BP),transfer learning-based spec-trum prediction(SP)and joint non-preemptive prior-ity and preemptive priority(J-NPAP)-based propor-tional fair spectrum allocation is than proposed.The simulation result shows that the spectrum utilization rate of CB-STSSN is improved and user blocking rate and waiting probability are decreased by the proposed scheme.

Efficient scarless skin regeneration enabled by loading micronized amnion in a bioinspired adhesive wound dressing

Complete skin reconstruction is a hierarchical,physiological assembly process involving healing of the epidermis,dermis,vasculature,nerves,and cutaneous appendages.To date,few works have reported complete skin regeneration,particularly lacking vascular structures and hair follicles after full skin defects.In this study,a hydrogel derived from the skin secretion of Andrias davidianus(SSAD)that features adhesiveness was used as a bioactive scaffold to load micronized amnion(MA).The SSAD hydrogel was found to promote the migration and proliferation of amnion stem cells and human keratinocytes,as well as inhibit their apoptosis in vitro.In a rat full-skin defect model,the regeneration of skin appendages was observed at the wound area,achieving scarless healing.Transcriptome analyses further validated that SSAD could positively regulate cell migration,proliferation,and differentiation.These functions might be attributed to the abundant growth factors present in the SSAD.Synergized by the delivery of MA,SSAD loaded with the MA could achieve a significantly better skin regeneration effect than SSAD or MA used alone,providing a simple yet highly effective means to obtain complete,scarless skin regeneration,suggesting favorable potential for clinical translation.

Bioinspired Andrias davidianus-Derived wound dressings for localized drug-elution

Local drug delivery has received increasing attention in recent years.However,the therapeutic efficacy of local delivery of drugs is still limited under certain scenarios,such as in the oral cavity or in wound beds after resection of tumors.In this study,we introduce a bioinspired adhesive hydrogel derived from the skin secretions of Andrias davidianus(SSAD)as a wound dressing for localized drug elution.The hydrogel was loaded with aminoguanidine or doxorubicin,and its controlled drug release and healing-promoting properties were verified in a diabetic rat palatal mucosal defect model and a C57BL/6 mouse melanoma-bearing model,respectively.The results showed that SSAD hydrogels with different pore sizes could release drugs in a controllable manner and accelerate wound healing.Transcriptome analyses of the palatal mucosa suggested that SSAD could significantly upregulate pathways linked to cell adhesion and extracellular matrix deposition and had the ability to recruit keratinocyte stem cells to defect sites.Taken together,these findings indicate that property-controllable SSAD hydrogels could be a promising biofunctional wound dressing for local drug delivery and promotion of wound healing.

Joint UE Location Energy-Efficient Resource Management in Integrated Satellite and Terrestrial Networks

Integrated satellite and terrestrial networks can be used to solve communication problems in natural disasters,forestry monitoring and control,and military communication.Unlike traditional communication methods,integrated networks are effective solutions because of their advantages in communication,remote sensing,monitoring,navigation,and all-weather seamless coverage.Monitoring,urban management,and other aspects will also have a wide range of applications.This study first builds an integrated network overlay model,and divides the satellite network into two categories:terrestrial network end users and satellite network end users.The energy efficiency,throughput,and signal-to-noise ratio(SINR)are deduced and analyzed.In this paper,we discuss the influence of various factors,such as transmit power,number of users,size of the protected area,and terminal position,on energy efficiency and SINR.A satellite-sharing scheme with a combination of the user location and an exclusion zone with high energy efficiency and anti-jamming capability is proposed to provide better communication quality for end users in integrated satellite and terrestrial networks.