Detection and analysis of serum bile acid profile in patients with colonic polyps

BACKGROUND Analyzing the variations in serum bile acid(BA)profile can provide a certain biological basis for early warning and prevention of various diseases.There is currently no comprehensive study on the relationship between the serum BA profile and colonic polyps.AIM To study the serum BA profile detection results of patients with colonic polyps,and analyze the correlation between BA and colonic polyps.METHODS From January 1,2022,to June 1,2023,204 patients with colonic polyps who were diagnosed and treated at Zhongda Hospital Southeast University were chosen as the study subjects,and 135 non-polyp people who underwent physical examination were chosen as the control group.Gathering all patients'clinical information,typical biochemical indicators,and BA profile.RESULTS Compared with the control group,the serum levels of taurocholic acid,glycocholic acid,glycochenodeoxycholic acid,and taurochenodeoxycholic acid in the colonic polyp group were significantly higher than those in the control group,while the content of deoxycholic acid(DCA)was lower than that in the control group(P<0.05).When colonic polyps were analyzed as subgroups,it was shown that there was a strong correlation between changes in the BA profile and polyp diameter,location,morphology,pathological kind,etc.CONCLUSION The serum BA profile showed significant changes in patients with colonic polyps,with a significant increase in primary conjugated BA content and a decrease in secondary free bile acid DCA content.There is a certain correlation between primary free BA and pathological parameters of polyps.

轻质耐高温吸波/隔热复合材料研究综述

吸波材料广泛应用于各类飞行器,可以有效降低雷达散射截面(RCS),从而提高其生存及突防能力。随着飞行器速度的逐渐变快,其对吸波材料提出隔热的要求。此外,受有效载荷限制,还需具备轻质的特点。该文介绍各类耐高温吸波材料、轻质隔热材料以及隔热/吸波复合材料的研究现状,分析耐高温吸波材料的性能提升办法及吸波机制、轻质隔热材料的优缺点,最后展望轻质耐高温吸波材料的研究趋势。

Double-tract reconstruction is superior to esophagogastrostomy in controlling reflux esophagitis and enhancing quality of life after proximal gastrectomy:Results from a prospective randomized controlled clinical trial in China

Objective:The aim of this study was to prospectively compare double-tract reconstruction(DTR)and esophagogastrostomy(EG)after proximal gastrectomy(PG)regarding the incidence of reflux esophagitis,quality of life(QOL),nutritional status and surgical safety.Methods:This study was a randomized controlled trial.Patients eligible for PG were enrolled and randomly assigned to the EG group and DTR group.The characteristics of patients,parameters for surgical safety,incidence of reflux esophagitis,nutrition status and QOL were collected and compared between the two groups.Univariate analysis and multivariate analysis were performed to determine the significant factors affecting the incidence of reflux esophagitis after PG.Results:Thirty-seven patients of the EG group and 36 patients of the DTR group were enrolled.The incidence of reflux esophagitis was significantly lower in the DTR group than in the EG group(8.3%vs.32.4%,P=0.019).The DTR group demonstrated a more favorable QOL than the EG group after PG.The nutritional status was balanced within the EG group and the DTR group.The operation time was longer in the DTR group than in the EG group(191 min vs.221 min,P=0.001),while surgical safety was similar in the two groups.Conclusions:Our research demonstrated that DTR is superior to EG after PG in terms of the incidence of reflux esophagitis and provides a more satisfactory QOL without increasing surgical complications or sacrificing nutritional status.

基于模态匹配和正交抑制的微机电陀螺闭环控制技术研究

模态匹配和力反馈控制可以在不牺牲检测带宽的情况下,利用机械谐振放大特性有效提高微机电陀螺信噪比、改善陀螺性能。结合一款高Q值对称式四质量敏感结构的陀螺表头,在陀螺动力学平均模型基础上,通过对检测模态同相分量和正交分量的控制,实现陀螺的闭环检测控制。基于静电负刚度原理,通过改变陀螺敏感结构梳齿与质量块之间的电压,构建实时正交抑制系统和精确模态匹配环节,推导出陀螺的静电刚度矩阵,完成了对正交耦合信号的实时抑制和驱动、检测模态的精确模态匹配并且实现对两环节的解耦控制。实测结果显示,陀螺频差由24 Hz缩小到0.05 Hz以内,全温条件下,陀螺的正交耦合量由3(°)/s抑制到0.01(°)/s,陀螺全温零偏稳定性由初始的11.48(°)/h改善到1.95(°)/h,验证了实时正交抑制和模态匹配等技术对提升陀螺性能的具体效果。

PTPRD/PTPRT mutation correlates to treatment outcomes of immunotherapy and immune landscape in pan-cancers

Objective: PTPRD and PTPRT are phosphatases of the JAK-STAT pathway related to immunotherapy.However, the role and mechanism of PTPRD and PTPRT mutations in multiple cancers remains unclear.Methods: Clinical data and PTPRD/PTPRT mutation information from 12 cohorts were collected and classified as a discovery cohort and three validation cohorts. The association between PTPRD/PTPRT mutations and immunotherapeutic efficacy was analyzed. Then, the association between PTPRD/PTPRT mutation and immune profiles was analyzed using The Cancer Genome Atlas(TCGA) cohort.Results: A total of 2,392 patients across 20 cancer types were included in this study. Our results showed that patients harboring PTPRD/PTPRT mutation, especially co-mutations, had a significantly elevated response rate to immunotherapy in multiple cancers. Patients with PTPRD/PTPRT mutation had a higher objective response rate(ORR)(P=0.002), longer overall survival(OS)(P=0.005) and progression-free survival(PFS)(P=0.038).Importantly, the above findings were further verified in validation cohorts. In addition, we found that the PTPRD/PTPRT co-mutations(co-mut) subgroup exhibited an immune-activated phenotype, the wild-type subgroup tended to have an immune-desert phenotype, and the uni-mutation(uni-mut) subgroup might have an immune-mixed phenotype. Our further analyses suggested that combining programmed cell death ligand 1(PDL1) expression and PTPRD/PTPRT mutation can be used to screen patients who may benefit from immunotherapy.Conclusions: PTPRD/PTPRT mutation could serve as a potential predictive biomarker for cancer immunotherapy.

The Study of Helium Variations in Star Clusters Using China Space Station Telescope

The China Space Station Telescope(CSST)is a 2 m space-based optical-UV telescope.Its primary goal is to carry out a high-resolution photometric imaging survey of a 17,500 square degree sky area using the on board Survey Camera.With its wide field of view(1.1 square degrees)and a mosaic imager containing 640 million pixels,studying the different populations of stars within star clusters is highly feasible.The aim of this study is to assess the CSST's ability to distinguish between stellar populations with varying helium abundance levels,with the help of Modules for Experiments in Stellar Astrophysics.The results of the CSST's photometry for these different populations are presented by transferring the models into the CSST Survey Camera photometric system.The findings confirm that helium-enriched stellar populations will have unique patterns in the color-magnitude diagrams under the CSST photometric system,compared to normal stellar populations.The CSST,with its filters and wide field of view of the Survey Camera,provides a new avenue for the study of multiple populations in star clusters.

Comparative Transcriptome Analysis of Salt-Stress-Responsive Genes in Rice Roots

Soil salinity greatly impairs plant growth and crop productivity.Rice(Oryza sativa L.)is a salt-sensitive crop.To better understand the molecular mechanisms of salt tolerance in roots,the BGISEQ-500 sequencing platform was employed to elucidate transcriptome changes in rice roots after 0,3,24,and 72 h of salt stress.The results showed that root K+content decreased and Na+content increased rapidly after the initial stage of salt stress,but that fresh and dry weight in root did not significantly reduce.Compared to the control(no salt stress),1,292,453,and 486 differentially expressed genes(DEGs)were upregulated,respectively,and 939,894,and 646 DEGs were downregulated,respectively,after 3,24,and 72 h of salt treatment.The number of DEGs was higher during the early stage of salt stress(3 h)than in later stages(24 and 72 h).A number of DEGs involved in the response and adaptation to salt stress were related to protein kinase and calcium-binding,plant hormone signaling and metabolism,transcriptional regulation,metabolic pathways,antioxidant activity,and ion transport.Many of these DEGs were activated during the early stage of salt stress(3 h).The present study reports candidate salt-stressresponsive genes with the potential to genetically improve salt tolerance in rice elsewhere.

2011—2020年武汉市东西湖区乙型病毒性肝炎流行病学分析

目的 掌握2011—2020年武汉市东西湖区乙型病毒性肝炎(乙肝)的流行病学特征,为制定乙肝防控策略提供科学依据。方法 从中国疾病预防控制信息系统下载2011—2020年报告的所有乙肝病例信息,采取描述性流行病学方法开展分析。结果 2011—2020年东西湖区共报告2 693例乙肝病例,年均报告发病率为52.87/10万,年均发病率呈先上升后下降的趋势(趋势χ^(2)=150.27,P<0.01)。发病无明显季节性,男性发病高于女性,男女性别比为2.15∶1(χ^(2)=27.62,P<0.01);职业分布以家务及待业为主,占53.95%;发病年龄以15~<75岁为主,15岁以下人群发病较少。结论 乙肝是东西湖区高发传染病,发病整体趋势呈现先升高后下降,男性、15~<75岁人群为高发人群,在继续巩固儿童乙肝疫苗常规免疫接种的同时,还应做好15岁以上人群强化免疫的工作。

带应急漂浮系统直升机水上迫降性能研究

针对直升机水上迫降问题,以光滑粒子动力学方法离散水域进行建模,发展了机身着水载荷的理论分析模型。以带柔性气囊直升机构型的水上迫降为算例,开展了仿真分析。仿真计算结果与试验数据的对比显示,机身过载和气囊连接带的载荷的计算误差均在18%以内,验证了仿真模型的分析精度,可用于支持民用直升机水上迫降过程的强度和结构设计。从提高直升机生存率的角度出发,开展了不同着水工况下的仿真计算,对机身姿态角、重心位置等因素对各项着水载荷的影响进行了深入分析,给出了直升机水上迫降时的建议机身姿态。研究成果可为直升机水上迫降适航取证提供技术支持。

基于相似度的保障资源相似性识别计算方法研究

直升机保障资源仍普遍存在型号多、种类杂、功能单一和体积庞大等问题,整体上落后于直升机装备发展,与当前高强度、全疆域、快速部署的保障理念相违背,制约着直升机航空兵部队的整体战斗力和快速机动能力。通过融合Jaccard与余弦方式,首次提出了直升机保障资源相似度识别方法以识别异形保障资源中各个属性的相似度,为后续保障资源优化提供输入。

Depth of tumor invasion and tumor-occupied portions of stomach are predictive factors of intra-abdominal metastasis

Objective： Diagnostic laparoscopy is recommended for the pretherapeutic staging of gastric cancer to detect any unexpected or unconfirmed intra-abdominal metastasis. The aim of this study was to evaluate the role and indications of diagnostic laparoscopy in the detection of intra-abdominal metastasis. Methods： Standard diagnostic laparoscopy with peritoneal cytology examination was performed prospectively on patients who were clinically diagnosed with primary local advanced gastric cancer （CT≥2M0）. We calculated the rate of intra-abdominal metastases identified by diagnostic laparoscopy, and examined the relationship between peritoneal dissemination （P） and cytology results （CY）. Split-sample method was applied to find clinical risk factors for intra-abdominal metastasis. Multivariate logistic regression analysis and receiver-operator characteristic （ROC） analysis were performed in training set to find out risk factors ofintra-abdominal metastasis, and then validate it in testing set. Results： Out of 249 cM0 patients, 51 （20.5%） patients with intra-abdominal metastasis were identified by diagnostic laparoscopy, including 20 （8.0%） P1CY1, 17 （6.8%） POCY1 and 14 （5.6%） P1CY0 patients. In the training set, multivariate logistic regression analysis and ROC analysis showed that the depth of tumor invasion on computer tomography （CT） scan ≥21 mm and tumor-occupied 〉2 portions of stomach are predictive factors of metastasis. In the testing set, when diagnostic laparoscopy was performed on patients who had one or two of these risk factors, the sensitivity and positive predictive value for detecting intra-abdominal metastasis were 90.0% and 32.1%, respectively. Conclusions： According to our results, depth of tumor invasion and tumor-occupied portions of stomach are predictive factors ofintra-abdominal metastasis.

Construction and external validation of a nomogram that predicts lymph node metastasis in early gastric cancer patients using preoperative parameters

Objective: To create a nomogram to predict the incidence of lymph node metastasis(LNM) in early gastric cancer(EGC) patients and to externally validate the nomogram.Methods: To construct the nomogram,we retrospectively analyzed a primary cohort of 272 EGC patients.Univariate analysis and a binary logistic regression were performed.A nomogram predicting the incidence of LNM in EGC patients was created.The discrimination ability of the nomogram was measured using the concordance index(c-index),and the nomogram was also calibrated.Then,another prospective cohort of 81 patients was analyzed to validate the nomogram.Results: In the primary cohort,LNM was pathologically confirmed in 37(13.6%) patients.In multivariate analysis,the presence of an ulcer,the maximum lesion diameter observed via gastroscopy,the thickness of the lesion observed via endoscopic ultrasonography,and the presence of enlarged lymph nodes on computed tomography(CT) were independent risk factors for LNM.A nomogram was then created based on the regression model with the c-index of 0.905,and the calibration curve of the nomogram fell approximately on the ideal 45-degree line.The cut-off score of the nomogram was 110,and the sensitivity,specificity,positive predictive and negative predictive values of the nomogram in the primary cohort were 81.1%,86.0%,47.6% and 96.7%,respectively,and in the prospective validation cohort were 75.0%,91.0%,60.0% and 95.5%,respectively.The calibration curve of the external validation cohort was almost on the 45-degree line.Conclusions: We developed an effective nomogram predicting the incidence of LNM for EGC patients.

Diagnostic value of negative enrichment and immune fluorescence in situ hybridization for intraperitoneal free cancer cells of gastric cancer

Objective:To explore the intraperitoneal free cancer cell(IFCC)detection value of negative enrichment and immune fluorescence in situ hybridization(NEimFISH)on chromosomes(CEN)8/17.Methods:To verify the reliability of NEimFISH,29 gastric cancer tumors,their adjacent tissues and greater omental tissues were tested.Our study then included 105 gastric cancer patients for IFCC.We defined patients as IFCC-positive if a signal was detected,regardless of the detailed cancer cell numbers.A comparison of clinicopathological features was conducted among IFCC groups.We also compared the diagnosis value and peritoneal recurrence predictive value among different detection methods.The comparison of IFCC number was also conducted among different groups.Results:A cutoff of 2.5 positive cells could distinguish all benign tissue samples and 97%of malignant tissue samples in our study.Compared to intestinal gastric cancer,patients with diffuse gastric cancer tended to have more IFCCs(6 vs.4,P=0.002).The IFCC counts were often higher in the lymphovascular invasion positive group than negative group(3 vs.1,P=0.022).All IFCC samples that were considered positive using conventional cytology were also found to be positive using NEimFISH.When compared to conventional cytology and paraffin pathology,NEimFISH had a higher IFCC positive rate(68.9%)and higher one-year peritoneal recurrence predictive value with area under the curve(AUC)of 0.922.Conclusions:Gastric cancer could be effectively diagnosed by NEimFISH.The IFCC number found using NEimFISH on CEN8/17 is closely associated with Lauren type and vascular invasion of cancer.NEimFISH is a reliable detection modality with a higher positive detection rate,higher one-year peritoneal recurrence predictive value and quantitative features for IFCC of gastric cancer.

Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial

Background： The ACTS-GC study had shown postoperative adiuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer. Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision. Methods： We have commenced a randomized phase III trial in December 2016 to evaluate S-I plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer. A total of 564 patients will be accrued from 13 Chinese institutions in two years. The primary endpoint is 3-year relapse-free survival. The secondary endpoints are 5-year overall survival, proportion of patients who complete the postoperative chemotherapy and incidence of adverse events. Ethic and dissemination： The trial has been approved by the institutional review board of each participating institution and it was activated on December, 2016. The enrollment will be finished in December, 2018. Patient＇s follow-up will be ended until December, 2023. Trial registration： ClinicalTrials.gov, identifier： NCT02867839. Registered on August 4, 2016.

小型多旋翼飞行器总体参数设计方法研究

论述了小型多旋翼飞行器总体参数设计方法,分析了不同尺寸等级小型多旋翼飞行器的总体参数并进行了归纳与分类,分析并总结了多旋翼地面效应/着陆方式等与飞行器高度的关系,基于六旋翼飞行器算例对相邻螺旋桨间的气动干扰进行了建模评估,实现了参数的快速设计,通过算例对本文所提出的方法进行了验证,证明了所提出的设计方法可提高多旋翼飞行器总体设计效率。

有人/无人协同作战中直升机的作用分析

在当前新军事变革的推动下,现代战争向立体化方向发展,有人/无人机协同作战已然成为了未来战争的主要方式。直升机作为一种低空火力平台,是一体化战争中夺取低空、超低空战场控制权的主要力量,在现代战争中具有不可取代的地位和作用。文章阐述了直升机在各种协同编队中起到的重要作用;总结分析了实现直升机对无人机指挥控制的关键技术;最后对我国有人/无人协同作战的发展提出了几点建议。

卫星拒止情况下低精度惯导系统航姿算法研究

在卫星拒止情况下,低精度MEMS惯导系统由于惯性器件性能较差,无法长时间保持姿态精度。从重力矢量及飞行器的动力学特性出发,提出了一种基于动态检测和Kalman数据融合的航姿算法。该算法从导航与飞控一体化的理念出发,实时判断飞行器机动和飞控状态,在低动态时利用Kalman滤波器对水平加速度和惯性解算的姿态角进行数据融合,估计和修正水平姿态误差,从而提高水平姿态精度。经过飞行仿真验证,该算法可有效完成飞行器的动态检测,并保证在系统机动情况下水平姿态误差在2°以内。

Implementation of quantum phase gate between two atoms via Rydberg antiblockade and adiabatic passage

Combining adiabatic passage and Rydberg antiblockade, we propose a scheme to implement a two-qubit phase gate between two Rydberg atoms. Detuning parameters between frequencies of atomic transitions and those of the corresponding driving lasers are carefully chosen to offset the blockade effect of two Rydberg atoms, so that an effective Hamiltonian,representing a single-photon detuning L-type three-level system and concluding the quantum state of two Rydberg atoms excited simultaneously, is obtained. The adiabatic-passage technique, based on the effective Hamiltonian, is adopted to implement a two-atom phase gate by using two time-dependent Rabi frequencies. Numerical simulations indicate that a high-fidelity two-qubit p-phase gate is constructed and its operation time does not have to be controlled accurately. Besides,owing to the long coherence time of the Rydberg state, the phase gate is robust against atomic spontaneous emission.

Evaluating Helium Variations By Modeling Red Giant Branch Bump of Large Magellanic Cluster NGC 1978

Many evidences show that the Multiple Population(MP)features exist not only in old clusters but also in intermediate-age clusters in the Megallanic Clouds(MCs),which are characterized by star-to-star abundance scatter of several elements,including helium(He).The red giant branch bump(RGBB)’s photometric properties are proved to be related to the variation in helium abundances of the member stars in star clusters.We use the"Modules for Experiments in Stellar Astrophysics"(MESA)stellar evolution code to calculate the evolution sequences of stars along the red giant branch(RGB)with changing helium content.Following the RGB sequences,we then generate a luminosity function of the RGB stars within the grid of input helium abundances,which are compared with the observational data of an intermediate-age MC cluster NGC 1978.

Whispering Gallery Mode Lasing Performance's Evolution of Floating GaN Microdisks Varying with Their Thickness

Optical gain and loss of microcavity greatly affect the quality of lasing,how to improve optical gain and decrease optical loss is of great significance for the preparation of laser.In this study,four types standard microdisks with different thicknesses of 2.2μm,1.9μm,1.7μm,and 1.45μm were fabricated by micromachining technology process to modulate optical gain and loss of microdisk lasing.The whispering gallery mode lasing in the ultraviolet range of Ga N microdisk devices was investigated for these devices in order to clarify the effect of microdisk thickness on device characteristics.The quality factor Q and lasing mode number for different thicknesses are calculated from the stimulated spectra.The lifetimes of the exciton combination properties of the devices were observed using time-resolved PL spectroscopy.The lasing modes are modulated,and the lifetime decreases,while the Q factor of the devices first increases and then decreases with decreasing thickness.All these results are induced by optical gain and loss competition.