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Data Driven Vibration Control:A Review
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作者 Weiyi Yang Shuai Li xin luo 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第9期1898-1917,共20页
With the ongoing advancements in sensor networks and data acquisition technologies across various systems like manufacturing,aviation,and healthcare,the data driven vibration control(DDVC)has attracted broad interests... With the ongoing advancements in sensor networks and data acquisition technologies across various systems like manufacturing,aviation,and healthcare,the data driven vibration control(DDVC)has attracted broad interests from both the industrial and academic communities.Input shaping(IS),as a simple and effective feedforward method,is greatly demanded in DDVC methods.It convolves the desired input command with impulse sequence without requiring parametric dynamics and the closed-loop system structure,thereby suppressing the residual vibration separately.Based on a thorough investigation into the state-of-the-art DDVC methods,this survey has made the following efforts:1)Introducing the IS theory and typical input shapers;2)Categorizing recent progress of DDVC methods;3)Summarizing commonly adopted metrics for DDVC;and 4)Discussing the engineering applications and future trends of DDVC.By doing so,this study provides a systematic and comprehensive overview of existing DDVC methods from designing to optimizing perspectives,aiming at promoting future research regarding this emerging and vital issue. 展开更多
关键词 Data driven vibration control(DDVC) data science designing method feedforward control industrial robot input shaping optimizing method residual vibration
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Influence of thermomechanical treatment on recrystallization and softening resistance of Cu-6.5Fe-0.3Mg alloy
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作者 Zhen-xia LIU Da-wei YUAN +5 位作者 xin luo Lan-hao WANG Jin-shui CHEN Hui-ming CHEN Xiang-peng XIAO Bin YANG 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2024年第9期2900-2917,共18页
The recrystallization and softening resistance of a Cu-6.5Fe-0.3Mg(mass fraction,%)alloy prepared by Process 1(cold rolling heat treatment)and Process 2(hot/cold rolling heat treatment)were studied using Vickers hardn... The recrystallization and softening resistance of a Cu-6.5Fe-0.3Mg(mass fraction,%)alloy prepared by Process 1(cold rolling heat treatment)and Process 2(hot/cold rolling heat treatment)were studied using Vickers hardness tests,tensile tests,scanning electron microscopy and transmission electron microscopy.The softening temperature,hardness and tensile strength of the alloy prepared by Process 2 were 110°C,HV 15 and 114 MPa higher,respectively,than those of the alloy prepared by Process 1 after aging at 300°C.The recrystallization activation energy of the alloys prepared by Process 1 and Process 2 were 72.83 and 98.11 kJ/mol,respectively.The pinning effects of the precipitates of the two alloys on grain boundaries and dislocations were basically the same.The softening mechanism was mainly attributed to the loss of dislocation strengthening.The higher Fe fiber density inhibited the average free migration path of dislocations and grain boundary migration in the alloy,which was the main reason for higher softening temperature of the alloy prepared by Process 2. 展开更多
关键词 Cu−6.5Fe−0.3Mg alloy hot rolling recrystallization activation energy softening mechanism dislocation strengthening
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A Novel Tensor Decomposition-Based Efficient Detector for Low-Altitude Aerial Objects With Knowledge Distillation Scheme
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作者 Nianyin Zeng xinyu Li +2 位作者 Peishu Wu Han Li xin luo 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第2期487-501,共15页
Unmanned aerial vehicles(UAVs) have gained significant attention in practical applications, especially the low-altitude aerial(LAA) object detection imposes stringent requirements on recognition accuracy and computati... Unmanned aerial vehicles(UAVs) have gained significant attention in practical applications, especially the low-altitude aerial(LAA) object detection imposes stringent requirements on recognition accuracy and computational resources. In this paper, the LAA images-oriented tensor decomposition and knowledge distillation-based network(TDKD-Net) is proposed,where the TT-format TD(tensor decomposition) and equalweighted response-based KD(knowledge distillation) methods are designed to minimize redundant parameters while ensuring comparable performance. Moreover, some robust network structures are developed, including the small object detection head and the dual-domain attention mechanism, which enable the model to leverage the learned knowledge from small-scale targets and selectively focus on salient features. Considering the imbalance of bounding box regression samples and the inaccuracy of regression geometric factors, the focal and efficient IoU(intersection of union) loss with optimal transport assignment(F-EIoU-OTA)mechanism is proposed to improve the detection accuracy. The proposed TDKD-Net is comprehensively evaluated through extensive experiments, and the results have demonstrated the effectiveness and superiority of the developed methods in comparison to other advanced detection algorithms, which also present high generalization and strong robustness. As a resource-efficient precise network, the complex detection of small and occluded LAA objects is also well addressed by TDKD-Net, which provides useful insights on handling imbalanced issues and realizing domain adaptation. 展开更多
关键词 Attention mechanism knowledge distillation(KD) object detection tensor decomposition(TD) unmanned aerial vehicles(UAVs)
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Enhancing Na^(+) diffusion dynamics and structural stability of O3-NaMn_(0.5)Ni_(0.5)O_(2)cathode by Sc and Zn dual-substitution
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作者 Bin-bin WANG Yi-ming FENG +8 位作者 xin luo Qun HUANG Zi-xing HOU Ya-qin WU Peng-yu WANG Yu-yang QI Qing-fei MENG Wei-feng WEI Liang-jun ZHOU 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2024年第10期3344-3357,共14页
Sc and Zn were introduced into O3-NaMn_(0.5)Ni_(0.5)O_(2)(NaMN)using the combination of solution combustion and solid-state method.The effect of Sc and Zn dual-substitution on Na^(+) diffusion dynamics and structural ... Sc and Zn were introduced into O3-NaMn_(0.5)Ni_(0.5)O_(2)(NaMN)using the combination of solution combustion and solid-state method.The effect of Sc and Zn dual-substitution on Na^(+) diffusion dynamics and structural stability of NaMN was investigated.The physicochemical characterizations suggest that the introduction of Sc and Zn broaden Na^(+) diffusion channels and weaken the Na—O bonds,thereby facilitating the diffusion of sodium ions.Simulations indicate that the Sc and Zn dual-substitution decreases the diffusion barrier of Na-ions and improves the conductivity of the material.The dual-substituted NaMn_(0.5)Ni_(0.4)Sc_(0.04)Zn_(0.04)O_(2)(Na MNSZ44)cathode delivers impressive cycle stability with capacity retention of 71.2%after 200 cycles at 1C and 54.8%after 400 cycles at 5C.Additionally,the full cell paired with hard carbon anode exhibits a remarkable long-term cycling stability,showing capacity retention of 64.1%after 250 cycles at 1C.These results demonstrate that Sc and Zn dual-substitution is an effective strategy to improve the Na^(+) diffusion dynamics and structural stability of NaMN. 展开更多
关键词 layered oxide cathode Sc and Zn dual-substitution structural stability Na^(+)diffusion dynamics
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SDGNN: Symmetry-Preserving Dual-Stream Graph Neural Networks
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作者 Jiufang Chen Ye Yuan xin luo 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第7期1717-1719,共3页
Dear Editor,This letter proposes a symmetry-preserving dual-stream graph neural network(SDGNN) for precise representation learning to an undirected weighted graph(UWG). Although existing graph neural networks(GNNs) ar... Dear Editor,This letter proposes a symmetry-preserving dual-stream graph neural network(SDGNN) for precise representation learning to an undirected weighted graph(UWG). Although existing graph neural networks(GNNs) are influential instruments for representation learning to a UWG, they invariably adopt a unique node feature matrix for illustrating the sole node set of a UWG. 展开更多
关键词 REPRESENTATION PRESERVING undirected
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Hydroxysafflor yellow A induced ferroptosis of Osteosarcoma cancer cells by HIF-1α/HK2 and SLC7A11 pathway
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作者 YIWEN ZHU LIU YANG +4 位作者 YING YU YING XIONG PING XIAO XIAO FU xin luo 《Oncology Research》 SCIE 2024年第5期899-910,共12页
Osteosarcoma is a very serious primary bone cancer with a high death rate and a dismal prognosis.Since there is no permanent therapy for this condition,it is necessary to develop a cure.Therefore,this investigation wa... Osteosarcoma is a very serious primary bone cancer with a high death rate and a dismal prognosis.Since there is no permanent therapy for this condition,it is necessary to develop a cure.Therefore,this investigation was carried out to assess the impacts and biological functions of hydroxysafflor yellow A(HYSA)in osteosarcoma cell lines(MG63).In this investigational study,MG63 cells were utilized.Microarray experiments,quantitative polymerase chain reaction(qPCR),immunofluorescent staining,extracellular acidification rate(ECAR),oxygen consumption rate(OCR),glucose consumption,lactate production,and ATP levels,proliferation assay,5-Ethynyl-2′-deoxyuridine(EDU)staining,and Western blot were performed.In MG63 cells,HYSA lowered cell proliferation and metastasis rates,suppressed EDU cell number,and enhanced caspase-3/9 activity levels.HYSA reduced the Warburg effect and induced ferroptosis(FPT)in MG63 cells.Inhibiting ferroptosis diminished HYSA’s anti-cancer activities in MG63 cells.The stimulation of the HIF-1α/SLC7A11 pathway decreased HYSA’s anti-cancer activities in MG63 cells.HIF-1αis one target spot for HYSA in a model of osteosarcoma cancer(OC).HYSA altered HIF-1α’s thermophoretic activity;following binding with HYSA,HIF-1α’s melting point increased from~55°C to~60°C.HYSA significantly enhanced the thermal stability of exogenous WT HIF-1αwhile not affecting Mut HIF-1α,suggesting that ARG-311,GLY-312,GLN-347,and GLN-387 may be involved in the interaction between HIF-1αand HYSA.Conclusively,our study revealed that HYSA induced FPT and reduced the Warburg effect of OC through mitochondrial damage by HIF-1α/HK2/SLC7A11 pathway.HYSA is a possible therapeutic option for OC or other cancers. 展开更多
关键词 Hydroxysafflor yellow A OSTEOSARCOMA HIF-1Α FPT
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Quick Weighing of Passing Vehicles Using the Transfer-Learning-Enhanced Convolutional Neural Network
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作者 Wangchen Yan Jinbao Yang xin luo 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第6期2507-2524,共18页
Transfer learning could reduce the time and resources required by the training of new models and be therefore important for generalized applications of the trainedmachine learning algorithms.In this study,a transfer l... Transfer learning could reduce the time and resources required by the training of new models and be therefore important for generalized applications of the trainedmachine learning algorithms.In this study,a transfer learningenhanced convolutional neural network(CNN)was proposed to identify the gross weight and the axle weight of moving vehicles on the bridge.The proposed transfer learning-enhanced CNN model was expected to weigh different bridges based on a small amount of training datasets and provide high identification accuracy.First of all,a CNN algorithm for bridge weigh-in-motion(B-WIM)technology was proposed to identify the axle weight and the gross weight of the typical two-axle,three-axle,and five-axle vehicles as they crossed the bridge with different loading routes and speeds.Then,the pre-trained CNN model was transferred by fine-tuning to weigh themoving vehicle on another bridge.Finally,the identification accuracy and the amount of training data required were compared between the two CNN models.Results showed that the pre-trained CNN model using transfer learning for B-WIM technology could be successfully used for the identification of the axle weight and the gross weight for moving vehicles on another bridge while reducing the training data by 63%.Moreover,the recognition accuracy of the pre-trained CNN model using transfer learning was comparable to that of the original model,showing its promising potentials in the actual applications. 展开更多
关键词 Bridge weigh-in-motion transfer learning convolutional neural network
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Research on the Application of Psychology in the Ideological and Political Education of Counselors in Higher Vocational Colleges
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作者 xin luo 《Journal of Contemporary Educational Research》 2024年第8期64-69,共6页
As an important base for the training of skilled personnel,the ideological and political education of counselors plays a vital role in the process of personnel training in higher vocational colleges.Based on the analy... As an important base for the training of skilled personnel,the ideological and political education of counselors plays a vital role in the process of personnel training in higher vocational colleges.Based on the analysis of the current situation of ideological and political education of counselors in higher vocational colleges,this paper analyzes the application value and strategies of psychology in ideological and political education,aiming at providing a set of systematic psychological application frameworks for counselors in higher vocational colleges,so as to promote the all-round development of students and realize the fundamental task of cultivating morality and educating people. 展开更多
关键词 Higher vocational colleges COUNSELORS Ideological and political education Mental health education PSYCHOLOGY
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Changes in Water Use Efficiency Caused by Climate Change,CO_(2) Fertilization,and Land Use Changes on the Tibetan Plateau 被引量:2
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作者 Binghao JIA xin luo +1 位作者 Longhuan WANG xin LAI 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第1期144-154,共11页
Terrestrial ecosystem water use efficiency(WUE)is an important indicator for coupling plant photosynthesis and transpiration,and is also a key factor linking the carbon and water cycles between the land and atmosphere... Terrestrial ecosystem water use efficiency(WUE)is an important indicator for coupling plant photosynthesis and transpiration,and is also a key factor linking the carbon and water cycles between the land and atmosphere.However,under the combination of climate change and human intervention,the change in WUE is still unclear,especially on the Tibetan Plateau(TP).Therefore,satellite remote sensing data and process-based terrestrial biosphere models(TBMs)are used in this study to investigate the spatiotemporal variations of WUE over the TP from 2001 to 2010.Then,the effects of land use and land cover change(LULCC)and CO_(2) fertilization on WUE from 1981-2010 are assessed using TBMs.Results show that climate change is the leading contributor to the change in WUE on the TP,and temperature is the most important factor.LULCC makes a negative contribution to WUE(-20.63%),which is greater than the positive contribution of CO_(2) fertilization(11.65%).In addition,CO_(2) fertilization can effectively improve ecosystem resilience on the TP.On the northwest plateau,the effects of LULCC and CO_(2) fertilization on WUE are more pronounced during the driest years than the annual average.These findings can help researchers understand the response of WUE to climate change and human activity and the coupling of the carbon and water cycles over the TP. 展开更多
关键词 water use efficiency gross primary productivity EVAPOTRANSPIRATION Tibetan Plateau carbon and water cycle
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Proximal Alternating-Direction-Method-of-Multipliers-Incorporated Nonnegative Latent Factor Analysis 被引量:2
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作者 Fanghui Bi xin luo +2 位作者 Bo Shen Hongli Dong Zidong Wang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2023年第6期1388-1406,共19页
High-dimensional and incomplete(HDI)data subject to the nonnegativity constraints are commonly encountered in a big data-related application concerning the interactions among numerous nodes.A nonnegative latent factor... High-dimensional and incomplete(HDI)data subject to the nonnegativity constraints are commonly encountered in a big data-related application concerning the interactions among numerous nodes.A nonnegative latent factor analysis(NLFA)model can perform representation learning to HDI data efficiently.However,existing NLFA models suffer from either slow convergence rate or representation accuracy loss.To address this issue,this paper proposes a proximal alternating-directionmethod-of-multipliers-based nonnegative latent factor analysis(PAN)model with two-fold ideas:(1)adopting the principle of alternating-direction-method-of-multipliers to implement an efficient learning scheme for fast convergence and high computational efficiency;and(2)incorporating the proximal regularization into the learning scheme to suppress the optimization fluctuation for high representation learning accuracy to HDI data.Theoretical studies verify that PAN converges to a Karush-KuhnTucker(KKT)stationary point of its nonnegativity-constrained learning objective with its learning scheme.Experimental results on eight HDI matrices from real applications demonstrate that the proposed PAN model outperforms several state-of-the-art models in both estimation accuracy for missing data of an HDI matrix and computational efficiency. 展开更多
关键词 NONNEGATIVE REPRESENTATION CONVERGENCE
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Tensor Distribution Regression Based on the 3D Conventional Neural Networks 被引量:2
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作者 Lin Chen xin luo 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2023年第7期1628-1630,共3页
Dear Editor,This letter presents a novel tensor-distribution-regression model based on 3D conventional neural networks(3D-TDR) with an application to clinical score prediction in aging-related diagnosis. The estimatio... Dear Editor,This letter presents a novel tensor-distribution-regression model based on 3D conventional neural networks(3D-TDR) with an application to clinical score prediction in aging-related diagnosis. The estimation of clinical scores of subjects using brain magnetic resonance imaging(MRI) helps understand the pathological stage of dementia. 展开更多
关键词 estimation PREDICTION NETWORKS
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Cryptocurrency Transaction Network Embedding From Static and Dynamic Perspectives: An Overview 被引量:1
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作者 Yue Zhou xin luo MengChu Zhou 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2023年第5期1105-1121,共17页
Cryptocurrency, as a typical application scene of blockchain, has attracted broad interests from both industrial and academic communities. With its rapid development, the cryptocurrency transaction network embedding(C... Cryptocurrency, as a typical application scene of blockchain, has attracted broad interests from both industrial and academic communities. With its rapid development, the cryptocurrency transaction network embedding(CTNE) has become a hot topic. It embeds transaction nodes into low-dimensional feature space while effectively maintaining a network structure,thereby discovering desired patterns demonstrating involved users' normal and abnormal behaviors. Based on a wide investigation into the state-of-the-art CTNE, this survey has made the following efforts: 1) categorizing recent progress of CTNE methods, 2) summarizing the publicly available cryptocurrency transaction network datasets, 3) evaluating several widely-adopted methods to show their performance in several typical evaluation protocols, and 4) discussing the future trends of CTNE. By doing so, it strives to provide a systematic and comprehensive overview of existing CTNE methods from static to dynamic perspectives,thereby promoting further research into this emerging and important field. 展开更多
关键词 Big data analysis cryptocurrency transaction network embedding(CTNE) dynamic network network embedding network representation static network
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Robotic natural orifice specimen extraction surgery I-type F method vs conventional robotic resection for lower rectal cancer 被引量:2
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作者 Fang Tao Dong-Ning Liu +4 位作者 Peng-Hui He xin luo Chi-Ying Xu Tai-Yuan Li Jin-Yuan Duan 《World Journal of Gastrointestinal Surgery》 SCIE 2023年第10期2142-2153,共12页
BACKGROUND Robotic resection using the natural orifice specimen extraction surgery I-type F method(R-NOSES I-F)is a novel minimally invasive surgical strategy for the treatment of lower rectal cancer.However,the curre... BACKGROUND Robotic resection using the natural orifice specimen extraction surgery I-type F method(R-NOSES I-F)is a novel minimally invasive surgical strategy for the treatment of lower rectal cancer.However,the current literature on this method is limited to case reports,and further investigation into its safety and feasibility is warranted.AIM To evaluate the safety and feasibility of R-NOSES I-F for the treatment of low rectal cancer.METHODS From September 2018 to February 2022,206 patients diagnosed with low rectal cancer at First Affiliated Hospital of Nanchang University were included in this retrospective analysis.Of these patients,22 underwent R-NOSES I-F surgery(RNOSES I-F group)and 76 underwent conventional robotic-assisted low rectal cancer resection(RLRC group).Clinicopathological data of all patients were collected and analyzed.Postoperative outcomes and prognoses were compared between the two groups.Statistical analysis was performed using SPSS software.RESULTS Patients in the R-NOSES I-F group had a significantly lower visual analog score for pain on postoperative day 1(1.7±0.7 vs 2.2±0.6,P=0.003)and shorter postoperative anal venting time(2.7±0.6 vs 3.5±0.7,P<0.001)than those in the RLRC group.There were no significant differences between the two groups in terms of sex,age,body mass index,tumor size,TNM stage,operative time,intrao-perative bleeding,postoperative complications,or inflammatory response(P>0.05).Postoperative anal and urinary functions,as assessed by Wexner,low anterior resection syndrome,and International Prostate Symptom Scale scores,were similar in both groups(P>0.05).Long-term follow-up revealed no significant differences in the rates of local recurrence and distant metastasis between the two groups(P>0.05).CONCLUSION R-NOSES I-F is a safe and effective minimally invasive procedure for the treatment of lower rectal cancer.It improves pain relief,promotes gastrointestinal function recovery,and helps avoid incision-related complications. 展开更多
关键词 Robotic surgery Natural orifice specimen extraction surgery Lower rectal cancer Robotic resection using the natural orifice specimen extraction surgery I-type F method
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Source Quantitative Identification by Reference-Based Cubic Blind Deconvolution Algorithm
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作者 xin luo Zhousuo Zhang +1 位作者 Teng Gong Yongjie Li 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2023年第4期180-195,共16页
The semi-blind deconvolution algorithm improves the separation accuracy by introducing reference information.However,the separation performance depends largely on the construction of reference signals.To improve the r... The semi-blind deconvolution algorithm improves the separation accuracy by introducing reference information.However,the separation performance depends largely on the construction of reference signals.To improve the robustness of the semi-blind deconvolution algorithm to the reference signals and the convergence speed,the reference-based cubic blind deconvolution algorithm is proposed in this paper.The proposed algorithm can be combined with the contribution evaluation to provide trustworthy guidance for suppressing satellite micro-vibration.The normalized reference-based cubic contrast function is proposed and the validity of the new contrast function is theoretically proved.By deriving the optimal step size of gradient iteration under the new contrast function,we propose an efficient adaptive step optimization method.Furthermore,the contribution evaluation method based on vector projection is presented to implement the source contribution evaluation.Numerical simulation analysis is carried out to validate the availability and superiority of this method.Further tests given by the simulated satellite experiment and satellite ground experiment also confirm the effectiveness.The signals of control moment gyroscope and flywheel were extracted,respectively,and the contribution evaluation of vibration sources to the sensitive load area was realized.This research proposes a more accurate and robust algorithm for the source separation and provides an effective tool for the quantitative identification of the mechanical vibration sources. 展开更多
关键词 Quantitative identification Reference-based cubic contrast function Semi-blind deconvolution Satellite micro-vibration Adaptive step size
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Effects of shellfish culture on the community and mortality of zooplankton in a subtropical Bay
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作者 Bijian PANG Hongjun LI +4 位作者 Mingmin LI xin luo Ying CHEN Tianshen LI Wenlu LAN 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2023年第2期458-468,共11页
Spatial and temporal distribution of abundance,community structure and succession,and mortality of zooplankton were examined in a subtropical bay—the Qinzhou Bay,Guangxi,South China,to evaluate the impact of oyster c... Spatial and temporal distribution of abundance,community structure and succession,and mortality of zooplankton were examined in a subtropical bay—the Qinzhou Bay,Guangxi,South China,to evaluate the impact of oyster culture on zooplankton.Data on zooplankton abundance,phytoplankton biomass,and environmental parameters were collected in 12 routine samplings at four sites in the Qinzhou Bay in 2018.Results show that the hydrological environment in the estuary affected the temporal variation of zooplankton of the Qinzhou Bay.However,the oyster culture affected the spatial distributions of zooplankton.The abundance of zooplankton outside the oyster farm was higher than that inside,whereas the mortality outside the oyster farm,on the contrary,was lower than that inside.Oyster culture in the Qinzhou Bay had built a significant impact on the abundance and community composition of zooplankton,and the food shortage caused by the ingestion of oyster might exacerbate the mortality of zooplankton in the Qinzhou Bay.In addition,the large-scale oyster culture increased the spatial heterogeneity of the community structure of zooplankton inside and outside the oyster farms.Findings of this study provide a reference for future policy-making in aquaculture management. 展开更多
关键词 ZOOPLANKTON community structure MORTALITY oyster culture Qinzhou Bay
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Enhanced glucose homeostasis via Clostridium symbiosummediated glucagon-like peptide 1 inhibition of hepatic gluconeogenesis in mid-intestinal bypass surgery
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作者 xin luo Fang Tao +6 位作者 Cai Tan Chi-Ying Xu Zhi-Hua Zheng Qiang Pang Xiang-An He Jia-Qing Cao Jin-Yuan Duan 《World Journal of Gastroenterology》 SCIE CAS 2023年第39期5471-5482,共12页
BACKGROUND The small intestine is known to play a crucial role in the development and remission of diabetes mellitus(DM).However,the exact mechanism by which mid-small intestinal bypass improves glucose metabolism in ... BACKGROUND The small intestine is known to play a crucial role in the development and remission of diabetes mellitus(DM).However,the exact mechanism by which mid-small intestinal bypass improves glucose metabolism in diabetic rats is not fully understood.AIM To elucidate the mechanisms by which mid-small intestinal bypass improves glucose metabolism.METHODS Streptozotocin(STZ)was used to induce DM in Sprague-Dawley(SD)rats at a dose of 60 mg/kg.The rats were then randomly divided into two groups:The mid-small intestine bypass(MSIB)group and the sham group(underwent switch laparotomy).Following a 6-wk recovery period post-surgery,the rats underwent various assessments,including metabolic parameter testing,analysis of liver glycogen levels,measurement of key gluconeogenic enzyme activity,characterization of the gut microbiota composition,evaluation of hormone levels,determination of bile acid concentrations,and assessment of the expression of the intestinal receptors Takeda G protein-coupled receptor 5 and farnesoid X receptor.RESULTS The MSIB group of rats demonstrated improved glucose metabolism and lipid metabolism,along with increased hepatic glycogen content.Furthermore,there was a decrease in the expression of the key gluconeogenic enzymes phosphoenolpyruvate carboxykinase 1 and glucose-6-phosphatase.Importantly,the MSIB group exhibited a substantial increase in the abundances of intestinal Lactobacillus,Clostridium symbiosum,Ruminococcus gnavus,and Bilophila.Moreover,higher levels of secondary bile acids,such as intestinal lithocholic acid,were observed in this group.Remarkably,the changes in the gut microbiota showed a significant correlation with the expression of key gluconeogenic enzymes and glucagon-like peptide 1(GLP-1)at 6 wk postoperatively,highlighting their potential role in glucose regulation.These findings highlight the beneficial effects of mid-small intestine bypass on glucose metabolism and the associated modulation of the gut microbiota.CONCLUSION The findings of this study demonstrate that the introduction of postoperative intestinal Clostridium symbiosum in the mid-small intestine contributes to the enhancement of glucose metabolism in nonobese diabetic rats.This improvement is attributed to the increased inhibition of hepatic gluconeogenesis mediated by GLP-1,resulting in a favorable modulation of glucose homeostasis. 展开更多
关键词 Gut micobiome Glucagon-like peptide-1 Glucose metablism Bile acid Bariatric surgery GLUCONEOGENESIS
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视网膜内质网应激免疫组织化学抗体浓度选择的实验研究
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作者 陈小红 梁婉娇 +7 位作者 黄诗舒 孙晏 罗欣 赖璐 池昭晟 陈梅珠 王云鹏 严伟明 《国际眼科杂志》 CAS 北大核心 2023年第1期32-38,共7页
目的:探索小鼠视网膜色素变性(RP)模型视网膜内质网应激免疫组织化学(IHC)染色抗体的最适浓度,为研究RP发病机制及干预措施提供相应的指标检测方法。方法:给予清洁级健康雄性C57BL/6J小鼠腹腔注射N-甲基-N-亚硝基脲(MNU,60mg/kg)制备RP... 目的:探索小鼠视网膜色素变性(RP)模型视网膜内质网应激免疫组织化学(IHC)染色抗体的最适浓度,为研究RP发病机制及干预措施提供相应的指标检测方法。方法:给予清洁级健康雄性C57BL/6J小鼠腹腔注射N-甲基-N-亚硝基脲(MNU,60mg/kg)制备RP小鼠模型,造模后第7d行视网膜电图(ERG)检测和苏木精-伊红(HE)染色验证造模成功,摘取眼球并采用IHC染色法检测视网膜内质网应激相关蛋白(IRE1、ATF6、PERK、GRP78、Caspase-12)表达情况。结果:IRE1、ATF6、PERK、GRP78、Caspase-12蛋白均在RP小鼠视网膜呈阳性表达,IRE1抗体浓度为1∶1000、ATF6抗体浓度为1∶500和1∶1000(此抗体两种浓度阳性表达无差异,P>0.05)、PERK抗体浓度为1∶1500、GRP78抗体浓度为1∶200、Caspase-12抗体浓度为1∶100时,阳性表达强度适宜,且与各自其余抗体浓度相应蛋白阳性表达均有差异(P<0.05)。结论:内质网应激相关蛋白抗体浓度IRE1为1∶1000、ATF6为1∶500和1∶1000、PERK为1∶1500、GRP78为1∶200、Caspase-12为1∶100时,其在小鼠RP模型视网膜IHC染色阳性表达程度较适宜。 展开更多
关键词 视网膜色素变性 内质网应激 视网膜 小鼠 免疫组织化学染色
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Pressure-dependent electronic,optical,and mechanical properties of antiperovskite X_(3)NP(X=Ca,Mg):A first-principles study
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作者 Chunbao Feng Changhe Wu +8 位作者 xin luo Tao Hu Fanchuan Chen Shichang Li Shengnan Duan Wenjie Hou Dengfeng Li Gang Tang Gang Zhang 《Journal of Semiconductors》 EI CAS CSCD 2023年第10期52-60,共9页
Hydrostatic pressure provides an efficient way to tune and optimize the properties of solid materials without chang-ing their composition.In this work,we investigate the electronic,optical,and mechanical properties of... Hydrostatic pressure provides an efficient way to tune and optimize the properties of solid materials without chang-ing their composition.In this work,we investigate the electronic,optical,and mechanical properties of antiperovskite X_(3)NP(X^(2+)=Ca,Mg)upon compression by first-principles calculations.Our results reveal that the system is anisotropic,and the lat-tice constant a of X_(3)NP exhibits the fastest rate of decrease upon compression among the three directions,which is different from the typical Pnma phase of halide and chalcogenide perovskites.Meanwhile,Ca_(3)NP has higher compressibility than Mg_(3)NP due to its small bulk modulus.The electronic and optical properties of Mg_(3)NP show small fluctuations upon compression,but those of Ca_(3)NP are more sensitive to pressure due to its higher compressibility and lower unoccupied 3d orbital energy.For example,the band gap,lattice dielectric constant,and exciton binding energy of Ca_(3)NP decrease rapidly as the pressure increases.In addition,the increase in pressure significantly improves the optical absorption and theoretical conversion effi-ciency of Ca_(3)NP.Finally,the mechanical properties of X_(3)NP are also increased upon compression due to the reduction in bond length,while inducing a brittle-to-ductile transition.Our research provides theoretical guidance and insights for future experi-mental tuning of the physical properties of antiperovskite semiconductors by pressure. 展开更多
关键词 ANTIPEROVSKITE hydrostatic pressure physical properties first-principles calculations
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Fatal ventricular arrhythmias after osimertinib treatment for lung adenocarcinoma: a case report
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作者 Gui-Gao GUO xin luo +2 位作者 Ke ZHU Ling-Ling LI Yang-Fan OU 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2023年第3期242-246,共5页
Osimertinib,a third-generation epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKIs),is approved globally as the first-line treatment for patients with EGFR mutations(EGFRm:Ex19del/L858R)and T790M resi... Osimertinib,a third-generation epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKIs),is approved globally as the first-line treatment for patients with EGFR mutations(EGFRm:Ex19del/L858R)and T790M resistance mutations in advanced non-small cell lung cancer(NSCLC).[1−3]With its widespread use,the cardiotoxicity of osimertinib has been of great concern.According to the U.S.Food and Drug Administration Adverse Events Reporting System(FAERS),the main cardiac-related adverse events with EGFR-TKIs are heart failure,QT prolongation,atrial fibrillation,acute myocardial infarction and pericardial effusion,and osimertinib has a higher incidence of QT prolongation,heart failure and atrial fibrillation than other EGFR-TKIs. 展开更多
关键词 LUNG ACUTE VENTRICULAR
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Editorial Commentary:Association of Comorbid Asthma and the Efficacy of Bioabsorbable Steroid-eluting Sinus Stents Implanted after Endoscopic Sinus Surgery in Patients with Chronic Rhinosinusitis with Nasal Polyps
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作者 xin luo Xue-kun HUANG +1 位作者 Ya-na ZHANG Qin-tai YANG 《Current Medical Science》 SCIE CAS 2023年第6期1258-1259,共2页
Chronic rhinosinusitis with nasal polyps(CRSw-NP)is a multifactorial and heterogeneous disorder of the sinonasal mucosa,characterized by a high relapse rate after medical and surgical treatments[1].Endoscopic sinus su... Chronic rhinosinusitis with nasal polyps(CRSw-NP)is a multifactorial and heterogeneous disorder of the sinonasal mucosa,characterized by a high relapse rate after medical and surgical treatments[1].Endoscopic sinus surgery(ESS)is the preferred treatment for CRSwNP in patients who have failed to respond to medical therapy[2].However,the postoperative complications will impair the recovery of patients,and accompanying post-operative outpatient visits may contribute to patient discomfort[3]Suppressing postoperative mucosa edema and improving mucosa recovery is critical to reducing the disease relapse after ESS.The steroid-eluting sinus stent(SESS)represents a promising emerging therapy for CRSwNP. 展开更多
关键词 Surgery operative treatment
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