OBJECTIVE:To review and discuss the Chinese and English literature on the use of pain-related evoked potentials(PREP) and short-latency somatosensory EP(SLSEP) in acupuncture research.METHODS:China National Knowledge ...OBJECTIVE:To review and discuss the Chinese and English literature on the use of pain-related evoked potentials(PREP) and short-latency somatosensory EP(SLSEP) in acupuncture research.METHODS:China National Knowledge Infrastructure Database and MEDLINE were searched for the following key words:acupuncture and PREP or SLSEP.RESULTS:Thirty-seven articles were included in the review.Researchers usually use PREPs to study the analgesic effect of acupuncture,observe influential factors,or for mechanistic exploration.In the SLSEP studies,researchers focused on response characteristics of acupuncture,acupoint specificity,and influential factors of the treatment.There were some problems with the study design and conclusions.CONCLUSION:Researchers could use PREP and SLSEP to objectively validate the effects of acupuncture and explore its mechanisms using nerve electrophysiology.Further studies can benefit from observing more acupoints' effects using PREPs or SLSEPs and investigating the placebo effect of acupuncture.展开更多
OBJECTIVE: To analyze the effect of needling acupoints(bilateral vs unilateral) with De Qi using data collected from 501 primary dysmenorrhea(PD) patients participating in multi-center, randomized,controlled trail.MET...OBJECTIVE: To analyze the effect of needling acupoints(bilateral vs unilateral) with De Qi using data collected from 501 primary dysmenorrhea(PD) patients participating in multi-center, randomized,controlled trail.METHODS: De Qi was defined as at least one of the feelings in soreness, numbness, fullness or heaviness at the acupoints when stimulated with needles. The 501 patients were grouped in 3 groups in terms of De Qi or not De Qi in one side(unilateral)or both sides(bilateral) of the body: bilateral De Qi group, unilateral De Qi group, and non-De Qi group. The abdominal pains were measured using visual analog scale(VAS).RESULTS: In 501 patients, 472 acquired De Qi at unilateral acupoints, 24 De Qi at bilateral acupoint,and 5 had no De Qi at any acupoint. The data of non-De Qi group was excluded as the sample was less than 5% of that in the bilateral De Qi group.There was significant difference in the VAS before and after treatment between unilateral and bilateral De Qi group(P < 0.01). After stratified by acupoints, for the patients needled at Sanyinjiao(SP 6)and Xuanzhong(GB 39), VAS scores in the bilateral De Qi group were larger than those in the unilateral De Qi group(P < 0.05).CONCLUSION: Bilateral De Qi was possibly superior to unilateral De Qi in enhancing the immediate analgesic effect of needling the acupoints, but no statistical significance was observed on the pa-tients of needling at non acupoint, which preliminarily suggested this immediate analgesic effect was perhaps along meridians.展开更多
基金Supported by the National Basic Research Program of China(973 Program)-the Effect of De Qi on Acupoint Specific Effect Based on Meridians and its Characteristics and Molecular Response Mechanisms(No.2012CB518506)Research on Acupoint Specificity in Regulating Uterus(No.2006CB504503)+2 种基金Research on Laws of Acupoint Effects(No.2005CB523308)National Natural Science Foundation of China-Traditional Acupuncture Formula for Inducing Labor(Hegu-Sanyinjiao,LI4-SP6)Electro-acupuncture Parameter Optimization and Molecular Response Mechanisms(No.30973793)the Doctoral Program of Higher Education of Ministry Education of China-Research Based on Primary Dysmenorrhea on Electric Characteristics of Acupoints Which Were Different Ones on the Same Meridians or Similar Ones on the Different Meridians(No.20090013110005)
文摘OBJECTIVE:To review and discuss the Chinese and English literature on the use of pain-related evoked potentials(PREP) and short-latency somatosensory EP(SLSEP) in acupuncture research.METHODS:China National Knowledge Infrastructure Database and MEDLINE were searched for the following key words:acupuncture and PREP or SLSEP.RESULTS:Thirty-seven articles were included in the review.Researchers usually use PREPs to study the analgesic effect of acupuncture,observe influential factors,or for mechanistic exploration.In the SLSEP studies,researchers focused on response characteristics of acupuncture,acupoint specificity,and influential factors of the treatment.There were some problems with the study design and conclusions.CONCLUSION:Researchers could use PREP and SLSEP to objectively validate the effects of acupuncture and explore its mechanisms using nerve electrophysiology.Further studies can benefit from observing more acupoints' effects using PREPs or SLSEPs and investigating the placebo effect of acupuncture.
基金Supported by National Basic Research Program of China(973 Program)-the Effect of De Qi on Acupoint Specific Effect Based on Meridians and its Characteristics and Molecular Response Mechanisms(No.2012CB518506)Research on Acupoint Specificity in Regulating Uterus(No.2006CB504503)+2 种基金Research on Laws of Acupoint Effects(No.2005CB523308)National Natural Science Foundation of China Traditional Acupuncture Formula for Inducing Labor(Hegu-Sanyinjiao,LI4-SP6)Electro-acupuncture Parameter Optimization and Molecular Response Mechanisms(No.30973793)the Doctoral Program of Higher Education of Ministry Education of China-Research Based on Primary Dysmenorrhea on Electric Characteristics of Acupoints Which Were Different Ones on the Same Meridians or Similar Ones on the Different Meridians(No.20090013110005)
文摘OBJECTIVE: To analyze the effect of needling acupoints(bilateral vs unilateral) with De Qi using data collected from 501 primary dysmenorrhea(PD) patients participating in multi-center, randomized,controlled trail.METHODS: De Qi was defined as at least one of the feelings in soreness, numbness, fullness or heaviness at the acupoints when stimulated with needles. The 501 patients were grouped in 3 groups in terms of De Qi or not De Qi in one side(unilateral)or both sides(bilateral) of the body: bilateral De Qi group, unilateral De Qi group, and non-De Qi group. The abdominal pains were measured using visual analog scale(VAS).RESULTS: In 501 patients, 472 acquired De Qi at unilateral acupoints, 24 De Qi at bilateral acupoint,and 5 had no De Qi at any acupoint. The data of non-De Qi group was excluded as the sample was less than 5% of that in the bilateral De Qi group.There was significant difference in the VAS before and after treatment between unilateral and bilateral De Qi group(P < 0.01). After stratified by acupoints, for the patients needled at Sanyinjiao(SP 6)and Xuanzhong(GB 39), VAS scores in the bilateral De Qi group were larger than those in the unilateral De Qi group(P < 0.05).CONCLUSION: Bilateral De Qi was possibly superior to unilateral De Qi in enhancing the immediate analgesic effect of needling the acupoints, but no statistical significance was observed on the pa-tients of needling at non acupoint, which preliminarily suggested this immediate analgesic effect was perhaps along meridians.
