To investigate the influence factors of hemorrhage and stroke with retriever with Solitaire AB stent in patients with acute intracranial artery occlusion.Methods:A retrospective of 43 cases of patients with acute intr...To investigate the influence factors of hemorrhage and stroke with retriever with Solitaire AB stent in patients with acute intracranial artery occlusion.Methods:A retrospective of 43 cases of patients with acute intracranial artery occlusion for endovascular treatment with Solitaire AB stent enrolled from March 2016 to June 2018 in our hospital,combining the characteristics of the patients of our city,through the clinical baseline data statistical analysis,complications screening of risk factors of complications.Results:There were 81.4%of patients who were dredged totally.The incidences of cerebral hemorrhage and infarction were 18.6%and 16.3%,cerebral hemorrhage group compared with control group,diabetes,blood pressure,revascularized time,NIHSS score,ASPECTS score had statistically significant differences,when infarction group compared with control group,age,opening time,ASITN_SIR score and grade of mTICI had statistically significant differences.Conclusion:Mechanical thrombectomy with Solitaire AB stent in patients with acute intracranial artery occlusion,the occurred of complications associated with various clinical factors,and the occurrence of complications seriously affect the prognosis of patients,therefore,selecting the indications strictly,and adopt individualized treatment to reduce complications.展开更多
目的:探讨采用后路关节间复位融合技术治疗寰枢椎旋转脱位的临床效果。方法:回顾性分析2020年11月至2022年10月收治的7例寰枢椎旋转脱位患者的临床资料。男4例,女3例,年龄6~54岁,平均(28.1±17.8)岁。其中2例曾行后路复位内固定术...目的:探讨采用后路关节间复位融合技术治疗寰枢椎旋转脱位的临床效果。方法:回顾性分析2020年11月至2022年10月收治的7例寰枢椎旋转脱位患者的临床资料。男4例,女3例,年龄6~54岁,平均(28.1±17.8)岁。其中2例曾行后路复位内固定术后复位丢失。所有患者行后入路寰枢椎关节间撑开复位内固定术,术后对全部病例进行复查及临床随访,分析术后影像学及症状学指标的改善情况。结果:全部7例患者均顺利完成手术。术后3 d CT提示C1-C2夹角、寰齿间距(ADI)、齿状凸尖至钱氏线距离(DCL)、寰齿后间距,即椎管直径(p-ADI)均较术前改善,差异有统计学意义(P<0.05)。术后6个月随访时日本骨科协会(JOA)腰椎评分较术前显著提高,差异有统计学意义(P<0.05)。所有患者中未见植入物失败,融合器塌陷、移位及复位丢失,感染等并发症发生。结论:寰枢椎旋转脱位可通过后路寰枢椎关节间撑开复位融合术达到良好复位。展开更多
As a family of cationic host defense peptides,defensins are mainly synthesized by Paneth cells,neutrophils,and epithelial cells,contributing to host defense.Their biological functions in innate immunity,as well as the...As a family of cationic host defense peptides,defensins are mainly synthesized by Paneth cells,neutrophils,and epithelial cells,contributing to host defense.Their biological functions in innate immunity,as well as their structure and activity relationships,along with their mechanisms of action and therapeutic potential,have been of great interest in recent years.To highlight the key research into the role of defensins in human and animal health,we first describe their research history,structural features,evolution,and antimicrobial mechanisms.Next,we cover the role of defensins in immune homeostasis,chemotaxis,mucosal barrier function,gut microbiota regulation,intestinal development and regulation of cell death.Further,we discuss their clinical relevance and therapeutic potential in various diseases,including infectious disease,inflammatory bowel disease,diabetes and obesity,chronic inflammatory lung disease,periodontitis and cancer.Finally,we summarize the current knowledge regarding the nutrient-dependent regulation of defensins,including fatty acids,amino acids,microelements,plant extracts,and probiotics,while considering the clinical application of such regulation.Together,the review summarizes the various biological functions,mechanism of actions and potential clinical significance of defensins,along with the challenges in developing defensins-based therapy,thus providing crucial insights into their biology and potential clinical utility.展开更多
Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and entrain each other,and thus affect host health and immune-mediated diseases.Here,we systematically review the current understa...Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and entrain each other,and thus affect host health and immune-mediated diseases.Here,we systematically review the current understanding linking dietary nutrients to gut microbiota-host immune interactions,emphasizing how this axis might influence host immunity in health and diseases.Of relevance,we highlight that the implications of gut microbiota-targeted dietary intervention could be harnessed in orchestrating a spectrum of immune-associated diseases.展开更多
The gut microbiota is comprised of a diverse array of microorganisms that interact with immune system and exert crucial roles for the health.Changes in the gut microbiota composition and functionality are associated w...The gut microbiota is comprised of a diverse array of microorganisms that interact with immune system and exert crucial roles for the health.Changes in the gut microbiota composition and functionality are associated with multiple diseases.As such,mobilizing a rapid and appropriate antimicrobial response depending on the nature of each stimulus is crucial for maintaining the balance between homeostasis and inflammation in the gut.Major players in this scenario are antimicrobial peptides(AMP),which belong to an ancient defense system found in all organisms and participate in a preservative co-evolution with a complex microbiome.Particularly increasing interactions between AMP and microbiota have been found in the gut.Here,we focus on the mechanisms by which AMP help to maintain a balanced microbiota and advancing our understanding of the circumstances of such balanced interactions between gut microbiota and host AMP.This review aims to provide a comprehensive overview on the interplay of diverse antimicrobial responses with enteric pathogens and the gut microbiota,which should have therapeutic implications for different intestinal disorders.展开更多
In biological responses,fatty acids(FA)are absorbed and metabolized in the form of substrates for energy production.The molecular structures(number of double bonds and chain length)and composition of dietary FA impact...In biological responses,fatty acids(FA)are absorbed and metabolized in the form of substrates for energy production.The molecular structures(number of double bonds and chain length)and composition of dietary FA impact digestion,absorption and metabolism,and the biological roles of FA.Recently,increasing evidence indicates that FA are essentially utilized as an energy source and are signaling molecules that exert physiological activity of gut microbiota and immune responses.In addition,FA could serve as natural ligands for orphan G protein-coupled receptors(GPCR),also called free fatty acid receptors(FFAR),which intertwine metabolic and immune systems via multiple mechanisms.The present review explores the recent findings on FA absorption and its impact on gut health,particularly addressing the mechanism by which dietary FA potentially influences intestinal microbiota and epithelial functions.Also,this work attempts to uncover research ideas for devising future strategies for manipulating the composition of dietary FA to regulate gut health and support a normal immune system for metabolic and immune disorders.展开更多
Dear editor,Endotoxic shock usually results from infection-induced physiologic, pathologic, and biologic abnormalities(Singer et al., 2016). Undeniably, it is still a profoundly damaging and life-threatening condition...Dear editor,Endotoxic shock usually results from infection-induced physiologic, pathologic, and biologic abnormalities(Singer et al., 2016). Undeniably, it is still a profoundly damaging and life-threatening condition for many individuals(Guan et al., 2019;Ding et al., 2021). Studies have shown that it is associated with the accumulation of apoptotic markers(Kayagaki et al., 2015;Zong et al., 2019).展开更多
Heat stress is a very universal stress event in recent years.Various lines of evidence in the past literatures indicate that gut microbiota composition is susceptible to variable temperature.A varied microbiota is nec...Heat stress is a very universal stress event in recent years.Various lines of evidence in the past literatures indicate that gut microbiota composition is susceptible to variable temperature.A varied microbiota is necessary for optimal regulation of host signaling pathways and disrupting microbiota-host homeostasis that induces disease pathology.The microbiota-gut-brain axis involves an interactive mode of communication between the microbes colonizing the gut and brain function.This review summarizes the effects of heat stress on intestinal function and microbiota-gut-brain axis.Heat stress negatively affects intestinal immunity and barrier functions.Microbiota-gut-brain axis is involved in the homeostasis of the gut microbiota,at the same time,heat stress affects the metabolites of microbiota which could alter the function of microbiota-gut-brain axis.We aim to bridge the evidence that the microbiota is adapted to survive and thrive in an extreme environment.Additionally,nutritional strategies for alleviating intestinal heat stress are introduced.展开更多
This study mainly focuses on revealing an ancient water landscape at the Longcheng site in the northern Chaohu Lake Basin using very highresolution(VHR)GeoEye-1 imagery.First,prior to classification,the GeoEye-1 image...This study mainly focuses on revealing an ancient water landscape at the Longcheng site in the northern Chaohu Lake Basin using very highresolution(VHR)GeoEye-1 imagery.First,prior to classification,the GeoEye-1 image was processed following atmospheric and geometric correction.The supervised classification was carried out in order to show the land-cover situation in the Longcheng area.The overall classification accuracy was 89.98%,with a kappa coefficient of 0.87.The moat system around the city walls was discovered by using rule-based objectoriented segmentation of the postclassified image,and the other walls of ancient Longcheng were manually identified from the pansharpened VHR GeoEye-1 image.Finally,a map of the ancient water landscape containing the ancient city,wall and moat at the Longcheng site was produced.This paper demonstrates that VHR remote sensing has the ability to uncover an ancient water landscape and provide new insights for archaeological and paleoenvironmental studies.展开更多
文摘To investigate the influence factors of hemorrhage and stroke with retriever with Solitaire AB stent in patients with acute intracranial artery occlusion.Methods:A retrospective of 43 cases of patients with acute intracranial artery occlusion for endovascular treatment with Solitaire AB stent enrolled from March 2016 to June 2018 in our hospital,combining the characteristics of the patients of our city,through the clinical baseline data statistical analysis,complications screening of risk factors of complications.Results:There were 81.4%of patients who were dredged totally.The incidences of cerebral hemorrhage and infarction were 18.6%and 16.3%,cerebral hemorrhage group compared with control group,diabetes,blood pressure,revascularized time,NIHSS score,ASPECTS score had statistically significant differences,when infarction group compared with control group,age,opening time,ASITN_SIR score and grade of mTICI had statistically significant differences.Conclusion:Mechanical thrombectomy with Solitaire AB stent in patients with acute intracranial artery occlusion,the occurred of complications associated with various clinical factors,and the occurrence of complications seriously affect the prognosis of patients,therefore,selecting the indications strictly,and adopt individualized treatment to reduce complications.
文摘目的:探讨采用后路关节间复位融合技术治疗寰枢椎旋转脱位的临床效果。方法:回顾性分析2020年11月至2022年10月收治的7例寰枢椎旋转脱位患者的临床资料。男4例,女3例,年龄6~54岁,平均(28.1±17.8)岁。其中2例曾行后路复位内固定术后复位丢失。所有患者行后入路寰枢椎关节间撑开复位内固定术,术后对全部病例进行复查及临床随访,分析术后影像学及症状学指标的改善情况。结果:全部7例患者均顺利完成手术。术后3 d CT提示C1-C2夹角、寰齿间距(ADI)、齿状凸尖至钱氏线距离(DCL)、寰齿后间距,即椎管直径(p-ADI)均较术前改善,差异有统计学意义(P<0.05)。术后6个月随访时日本骨科协会(JOA)腰椎评分较术前显著提高,差异有统计学意义(P<0.05)。所有患者中未见植入物失败,融合器塌陷、移位及复位丢失,感染等并发症发生。结论:寰枢椎旋转脱位可通过后路寰枢椎关节间撑开复位融合术达到良好复位。
基金We gratefully acknowledge the financial support provided by the Zhejiang Provincial Key R&D Program of China(2021C02008)the China Agriculture Research System of MOF and MARA(CARS-35)+3 种基金the National Natural Science Foundation of China(Grant Nos.32002185,31930057 and U21A20249)the National Key R&D Program(2018YFA0507802)Taishan Industrial Leading Talents ProjectProgram from National Center of Technology Innovation for Pigs for this study。
文摘As a family of cationic host defense peptides,defensins are mainly synthesized by Paneth cells,neutrophils,and epithelial cells,contributing to host defense.Their biological functions in innate immunity,as well as their structure and activity relationships,along with their mechanisms of action and therapeutic potential,have been of great interest in recent years.To highlight the key research into the role of defensins in human and animal health,we first describe their research history,structural features,evolution,and antimicrobial mechanisms.Next,we cover the role of defensins in immune homeostasis,chemotaxis,mucosal barrier function,gut microbiota regulation,intestinal development and regulation of cell death.Further,we discuss their clinical relevance and therapeutic potential in various diseases,including infectious disease,inflammatory bowel disease,diabetes and obesity,chronic inflammatory lung disease,periodontitis and cancer.Finally,we summarize the current knowledge regarding the nutrient-dependent regulation of defensins,including fatty acids,amino acids,microelements,plant extracts,and probiotics,while considering the clinical application of such regulation.Together,the review summarizes the various biological functions,mechanism of actions and potential clinical significance of defensins,along with the challenges in developing defensins-based therapy,thus providing crucial insights into their biology and potential clinical utility.
基金supported by the National Key Research and Development Program of China(2021YFD1300700,2021YFD1300201,2022YFA1304201)the National Natural Science Foundation of China(32225047,U22A20510,32125036,32172750,31972596,31902170,31630074,32272916,32102567)+4 种基金the Laboratory of Lingnan Modern Agriculture Project(NT2021005)the China Agricultural Research System of MOF and MARA(CARS-35)the Key Research and Development Project of Hainan Province(ZDYF2021XDNY177)the 111 Project(B16044)the Program for Shaanxi Science and Technology(2022KJXX-13).
文摘Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and entrain each other,and thus affect host health and immune-mediated diseases.Here,we systematically review the current understanding linking dietary nutrients to gut microbiota-host immune interactions,emphasizing how this axis might influence host immunity in health and diseases.Of relevance,we highlight that the implications of gut microbiota-targeted dietary intervention could be harnessed in orchestrating a spectrum of immune-associated diseases.
基金funded by the National Natural Science Foundation of China(Grant No.31702123 and 31630075)Zhejiang Provincial Natural Science Foundation of China(Grant No.LZ20C170005)Fundamental Research Funds for the Central Universities(Grant No.2020-KYY-517102-0001)
文摘The gut microbiota is comprised of a diverse array of microorganisms that interact with immune system and exert crucial roles for the health.Changes in the gut microbiota composition and functionality are associated with multiple diseases.As such,mobilizing a rapid and appropriate antimicrobial response depending on the nature of each stimulus is crucial for maintaining the balance between homeostasis and inflammation in the gut.Major players in this scenario are antimicrobial peptides(AMP),which belong to an ancient defense system found in all organisms and participate in a preservative co-evolution with a complex microbiome.Particularly increasing interactions between AMP and microbiota have been found in the gut.Here,we focus on the mechanisms by which AMP help to maintain a balanced microbiota and advancing our understanding of the circumstances of such balanced interactions between gut microbiota and host AMP.This review aims to provide a comprehensive overview on the interplay of diverse antimicrobial responses with enteric pathogens and the gut microbiota,which should have therapeutic implications for different intestinal disorders.
基金funded by Zhejiang Provincial Key R&D Program of China(2021C02008)the National Natural Science Foundation of China(Grant Nos.31630075,32002185,and 31860648)Zhejiang Provincial Natural Science Foundation of China(Grant No.LQ21C170002)。
文摘In biological responses,fatty acids(FA)are absorbed and metabolized in the form of substrates for energy production.The molecular structures(number of double bonds and chain length)and composition of dietary FA impact digestion,absorption and metabolism,and the biological roles of FA.Recently,increasing evidence indicates that FA are essentially utilized as an energy source and are signaling molecules that exert physiological activity of gut microbiota and immune responses.In addition,FA could serve as natural ligands for orphan G protein-coupled receptors(GPCR),also called free fatty acid receptors(FFAR),which intertwine metabolic and immune systems via multiple mechanisms.The present review explores the recent findings on FA absorption and its impact on gut health,particularly addressing the mechanism by which dietary FA potentially influences intestinal microbiota and epithelial functions.Also,this work attempts to uncover research ideas for devising future strategies for manipulating the composition of dietary FA to regulate gut health and support a normal immune system for metabolic and immune disorders.
基金This work was supported by the National Natural Science Foundation of China(32002185 and 31630075)Zhejiang Provincial Natural Science Foundation of China(LQ21C170002)China Postdoctoral Science Foundation(2020M671741).
文摘Dear editor,Endotoxic shock usually results from infection-induced physiologic, pathologic, and biologic abnormalities(Singer et al., 2016). Undeniably, it is still a profoundly damaging and life-threatening condition for many individuals(Guan et al., 2019;Ding et al., 2021). Studies have shown that it is associated with the accumulation of apoptotic markers(Kayagaki et al., 2015;Zong et al., 2019).
基金supported by National Natural Science Foundation of China(Grant Nos.32022079,31630075,and 31702123)Zhejiang Provincial Natural Science Foundation of China(Grant No.LZ20C170005)Fundamental Research Funds for the Central Universities(Grant No.2020-KYY-517102-0001)。
文摘Heat stress is a very universal stress event in recent years.Various lines of evidence in the past literatures indicate that gut microbiota composition is susceptible to variable temperature.A varied microbiota is necessary for optimal regulation of host signaling pathways and disrupting microbiota-host homeostasis that induces disease pathology.The microbiota-gut-brain axis involves an interactive mode of communication between the microbes colonizing the gut and brain function.This review summarizes the effects of heat stress on intestinal function and microbiota-gut-brain axis.Heat stress negatively affects intestinal immunity and barrier functions.Microbiota-gut-brain axis is involved in the homeostasis of the gut microbiota,at the same time,heat stress affects the metabolites of microbiota which could alter the function of microbiota-gut-brain axis.We aim to bridge the evidence that the microbiota is adapted to survive and thrive in an extreme environment.Additionally,nutritional strategies for alleviating intestinal heat stress are introduced.
基金supported by funding from National Natural Science Foundation of China[grant number 41271427].
文摘This study mainly focuses on revealing an ancient water landscape at the Longcheng site in the northern Chaohu Lake Basin using very highresolution(VHR)GeoEye-1 imagery.First,prior to classification,the GeoEye-1 image was processed following atmospheric and geometric correction.The supervised classification was carried out in order to show the land-cover situation in the Longcheng area.The overall classification accuracy was 89.98%,with a kappa coefficient of 0.87.The moat system around the city walls was discovered by using rule-based objectoriented segmentation of the postclassified image,and the other walls of ancient Longcheng were manually identified from the pansharpened VHR GeoEye-1 image.Finally,a map of the ancient water landscape containing the ancient city,wall and moat at the Longcheng site was produced.This paper demonstrates that VHR remote sensing has the ability to uncover an ancient water landscape and provide new insights for archaeological and paleoenvironmental studies.
