Forming J-aggregates by organic monomer is a fascinating strategy to urge spectroscopic redshift with respect to that of the monomer.Herein,we designed 1,7-diphenyl-substituted meso–CF_(3)-BDP monomer confirmed by X-...Forming J-aggregates by organic monomer is a fascinating strategy to urge spectroscopic redshift with respect to that of the monomer.Herein,we designed 1,7-diphenyl-substituted meso–CF_(3)-BDP monomer confirmed by X-ray crystallographic analysis.The low-barrier rotation of the–CF_(3)group in meso–CF_(3)-BDP1 significantly enhances the non-radiative efficiency,and the photothermal conversion efficiency(PCE)of the self-assembled nanoparticles(1-NPs:λ_(abs)=746 nm)by J-aggregates was 82%.1-NPs could effectively block cell cycle progression,inhibit cancer cell proliferation and trigger cell apoptosis under low power laser irradiation(0.2 W/cm^(2)).This study proposes an alternate molecular design platform by J-aggregates to promote PCE through the insertion of rotating segment and trigger the cancer cells apoptosis in photothermal therapy at low power laser density.展开更多
Mono- and bis-dialkylaminophenylbuta-1,3-dienyl boron-dipyrromethenes(BODIPYs) 1–12 were synthesized in 36%–42% yields by a Knoevenagel-type condensation. The absorption and emission maxima(labs= 614–739 nm; lem= ...Mono- and bis-dialkylaminophenylbuta-1,3-dienyl boron-dipyrromethenes(BODIPYs) 1–12 were synthesized in 36%–42% yields by a Knoevenagel-type condensation. The absorption and emission maxima(labs= 614–739 nm; lem= 655–776 nm in CHCl3) of 1–12 covered from the visible to the nearinfrared region. Probe 1 was ratiometric Vis p H probes. Such probe was almost non-fluorescent. Upon the protonation of the tertiary amine function of 1, the strong fluorescence(Φf= 0.97) was released and the florescence intensity was dramatically increased by one thousand folds. The sharp isosbestic points were discovered at 590 nm, which was a ratiometric p H probe.展开更多
A dibromo substituted BOPHY derivative(2) was prepared and found to exhibit photo-sensitization capability. Rapid oxidation of 80% DPBF at the first 6 min was observed suggesting that 2 is a superior photo-sensitizer ...A dibromo substituted BOPHY derivative(2) was prepared and found to exhibit photo-sensitization capability. Rapid oxidation of 80% DPBF at the first 6 min was observed suggesting that 2 is a superior photo-sensitizer than methylene blue. The HOMO–LUMO band gap for the lowest energy absorption bands of the BOPHY 1 is smaller than that of PS 2, which is in good agreement with the red shift in the absorption observed between 1 and 2.展开更多
The phosphorus-containing PODIPY 1 as a chemosensor can detect Hg^(2+) by a color change from pink to violet red without the use of any instrumentation. PODIPY 1 was selective to Hg^(2+)with a remarkable absorption ch...The phosphorus-containing PODIPY 1 as a chemosensor can detect Hg^(2+) by a color change from pink to violet red without the use of any instrumentation. PODIPY 1 was selective to Hg^(2+)with a remarkable absorption change, and addition of other relevant metal ions caused almost no absorption change. The new PODIPY dye 1 was sensitive to various concentrations of Hg^(2+). The energy gap between the HOMO and LUMO of the metal complex 1–Hg^(2+)is smaller than that of chemosensor 1, which is in good agreement with the red shift in the absorption observed upon treatment of 1 with Hg^(2+). The 1-based test strips were easily fabricated and low-cost, useful in practical and efficient Hg^(2+)test kits.展开更多
The typical aza-BODIPYs in the dye family are known for bright fluorescence,excellent stability,and tunable absorption wavelengths.Hence,these dyes are attracting the increasing attention.Aza-BODIPYs having the maxima...The typical aza-BODIPYs in the dye family are known for bright fluorescence,excellent stability,and tunable absorption wavelengths.Hence,these dyes are attracting the increasing attention.Aza-BODIPYs having the maxima absorption in the near-infrared(NIR)region(650-900 nm)are very favorable for bioimaging in vivo due to the less photo-damage,deeper tissue penetration,and less interference from background auto-fluorescence by biomolecules in the living systems.Many strategies have been employed to modify the structures of the aza-BODIPY core to provide the NIR absorbing dyes.Among these,the most effective method is the fusion of the aromatic rings in aza-BODIPY system.This review allsidedly summarizes the recent development of ring-fused aza-BODIPY dyes(λ_(abs)>700 nm)focusing on the design,synthesis,and potential applications in the NIR region since 2002.展开更多
Dipyrrolyldiketone difluoroboron complexes(BONEPYs)were synthesized by condensation of the corresponding pyrroles and malonyl chloride followed by treatment with BF3·OEt2.The aryl-substituted pyrrole is introduce...Dipyrrolyldiketone difluoroboron complexes(BONEPYs)were synthesized by condensation of the corresponding pyrroles and malonyl chloride followed by treatment with BF3·OEt2.The aryl-substituted pyrrole is introduced to form a cyclic system in order to investigate anion binding studies.In BONEPYs 1-3 the o-H of the aryl group forms hydrogen bonding with F to give a more table complex.In contrast,the intramolecular hydrogen-bonded BONEPY endo-4 is more stable than its exo isomer.While adding F,the hydrogen bonds must be broken first to give 4·(3)F.Owing to the electron-rich group(-OMe),the o-H of the phenyl group can hardly interact with F via hydrogen bonding to give the less stable complex4-(5)F.The energy diffe rences between the different conformations were calculated using DFT methods,which is consistent to the experimental observations.展开更多
基金supported by the National Natural Science Foundation of China(Nos.22078201,U1908202)Natural Science Foundation of Liaoning(No.2021NLTS1206)+2 种基金Serving Local Project of Education Department of Liaoning Province(No.LZ2020005)Liaoning&Shenyang Key Laboratory of Functional Dye and Pigment(Nos.2021JH13/10200018,21-104-0-23)the Distinguished Professor Project Liaoning Province(No.20183532)。
文摘Forming J-aggregates by organic monomer is a fascinating strategy to urge spectroscopic redshift with respect to that of the monomer.Herein,we designed 1,7-diphenyl-substituted meso–CF_(3)-BDP monomer confirmed by X-ray crystallographic analysis.The low-barrier rotation of the–CF_(3)group in meso–CF_(3)-BDP1 significantly enhances the non-radiative efficiency,and the photothermal conversion efficiency(PCE)of the self-assembled nanoparticles(1-NPs:λ_(abs)=746 nm)by J-aggregates was 82%.1-NPs could effectively block cell cycle progression,inhibit cancer cell proliferation and trigger cell apoptosis under low power laser irradiation(0.2 W/cm^(2)).This study proposes an alternate molecular design platform by J-aggregates to promote PCE through the insertion of rotating segment and trigger the cancer cells apoptosis in photothermal therapy at low power laser density.
基金supported by NNSFC (No. 21372063)Program for Changjiang Scholars and Innovative Research Team in University (No. PCS IRT1126)+1 种基金the Foundation of the Education Department of Henan Province for Science and Technology Research Projects (No. 13A150046)the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
文摘Mono- and bis-dialkylaminophenylbuta-1,3-dienyl boron-dipyrromethenes(BODIPYs) 1–12 were synthesized in 36%–42% yields by a Knoevenagel-type condensation. The absorption and emission maxima(labs= 614–739 nm; lem= 655–776 nm in CHCl3) of 1–12 covered from the visible to the nearinfrared region. Probe 1 was ratiometric Vis p H probes. Such probe was almost non-fluorescent. Upon the protonation of the tertiary amine function of 1, the strong fluorescence(Φf= 0.97) was released and the florescence intensity was dramatically increased by one thousand folds. The sharp isosbestic points were discovered at 590 nm, which was a ratiometric p H probe.
基金supported by NNSFC (No. 21542004)the Program for Liaoning Excellent Talents in University (No. LJQ2015087)+4 种基金the Public Research Foundation of Liaoning Province for the Cause of Science (No. 2014003009)Educational Department of Liaoning Province (No. L2014170)Science and Technology Key Project of Liaoning Province (No. 2013304007)the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministrythe start-up funds from Shenyang University of Chemical Technology
文摘A dibromo substituted BOPHY derivative(2) was prepared and found to exhibit photo-sensitization capability. Rapid oxidation of 80% DPBF at the first 6 min was observed suggesting that 2 is a superior photo-sensitizer than methylene blue. The HOMO–LUMO band gap for the lowest energy absorption bands of the BOPHY 1 is smaller than that of PS 2, which is in good agreement with the red shift in the absorption observed between 1 and 2.
基金supported by the Public Research Foundation of Liaoning Province for the Cause of Science (No. 2014003009)Science and Technology Key Project of Liaoning Province (No. 2013304007)+2 种基金the Foundation of the Education Department of Henan Province for Science and Technology Research Projects (No. 13A150046)the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministrythe startup funds from Shenyang University of Chemical Technology
文摘The phosphorus-containing PODIPY 1 as a chemosensor can detect Hg^(2+) by a color change from pink to violet red without the use of any instrumentation. PODIPY 1 was selective to Hg^(2+)with a remarkable absorption change, and addition of other relevant metal ions caused almost no absorption change. The new PODIPY dye 1 was sensitive to various concentrations of Hg^(2+). The energy gap between the HOMO and LUMO of the metal complex 1–Hg^(2+)is smaller than that of chemosensor 1, which is in good agreement with the red shift in the absorption observed upon treatment of 1 with Hg^(2+). The 1-based test strips were easily fabricated and low-cost, useful in practical and efficient Hg^(2+)test kits.
基金supported by the National Natural Science Foundation of China(Nos.22078201,U1908202)“Chunhui Program”cooperative research project of Education Ministry+2 种基金Liaoning BaiQianWan Talents ProgramServing local project of Education Department of Liaoning Province(No.LZ2020005)the Distinguished Professor Project Liaoning Province(No.20183532)。
文摘The typical aza-BODIPYs in the dye family are known for bright fluorescence,excellent stability,and tunable absorption wavelengths.Hence,these dyes are attracting the increasing attention.Aza-BODIPYs having the maxima absorption in the near-infrared(NIR)region(650-900 nm)are very favorable for bioimaging in vivo due to the less photo-damage,deeper tissue penetration,and less interference from background auto-fluorescence by biomolecules in the living systems.Many strategies have been employed to modify the structures of the aza-BODIPY core to provide the NIR absorbing dyes.Among these,the most effective method is the fusion of the aromatic rings in aza-BODIPY system.This review allsidedly summarizes the recent development of ring-fused aza-BODIPY dyes(λ_(abs)>700 nm)focusing on the design,synthesis,and potential applications in the NIR region since 2002.
基金supported by the National Natural Science Foundation of China(No.21542004)Young and middle-aged scientific and technological innovation talents of Shenyang Science and Technology Bureau(No.RC170140)+3 种基金Liaoning Province Natural Science Foundation(No.20170540721)Basic research on the application of Industrial Development of Shenyang Science and Technology Bureau(No.18013027)Liaoning BaiQianWan Talents Program,and the Distinguished Professor Project of Liaoning province(No.20183532)the Chinese Scholarship Council(No.20183058)for financial support。
文摘Dipyrrolyldiketone difluoroboron complexes(BONEPYs)were synthesized by condensation of the corresponding pyrroles and malonyl chloride followed by treatment with BF3·OEt2.The aryl-substituted pyrrole is introduced to form a cyclic system in order to investigate anion binding studies.In BONEPYs 1-3 the o-H of the aryl group forms hydrogen bonding with F to give a more table complex.In contrast,the intramolecular hydrogen-bonded BONEPY endo-4 is more stable than its exo isomer.While adding F,the hydrogen bonds must be broken first to give 4·(3)F.Owing to the electron-rich group(-OMe),the o-H of the phenyl group can hardly interact with F via hydrogen bonding to give the less stable complex4-(5)F.The energy diffe rences between the different conformations were calculated using DFT methods,which is consistent to the experimental observations.