2种治疗方案妊娠期糖尿病患者Betatrophin与糖脂代谢的相关性

目的探讨妊娠期糖尿病(GDM)孕妇血浆Betatrophin与糖脂代谢的关系,以及其评价治疗效果的预测价值。方法选取2016年12月-2018年2月于青岛市市立医院进行规范产检并分娩的GDM孕妇60例,分为医学营养治疗组和胰岛素治疗组,每组30例。ELISA法检测血浆Betatrophin水平,全自动生化分析仪检测空腹血糖(FPG)、糖化血红蛋白(HbA1c)、糖化血清蛋白(GSP)、空腹胰岛素(FINS)、甘油三酯(TG)、总胆固醇(TC),根据公式计算稳态胰岛素评价指数(HOMA-IR)。结果医学营养治疗组GDM孕妇血浆Betatrophin与FPG、TG、FINS、HOMA-IR呈正相关(r=0.621、0.417、0.380和0.624,均P<0.05),与TC无关(P>0.05);胰岛素治疗组GDM孕妇围分娩期血浆Betatrophin与TG、TC、FINS、HOMA-IR呈负相关(r=-0.128、-0.236、-0.200和-0.387,均P<0.05),与FPG无关(P>0.05)。所有GDM孕妇治疗后血浆Betatrophin、Hb A1c、GSP与治疗前比较,差异有统计学意义(P<0.05),均降低。Betatrophin与GSP呈正相关(r=0.406,P<0.05),与HbA1c无关(P>0.05)。结论GDM不同治疗方案中血浆Betatrophin参与糖脂代谢程度不同,Betatrophin或可作为一种监测和评估治疗效果的指标。

Participation of microbiota in the development of gastric cancer

There are a large number of bacteria inhabiting the human body,which provide benefits for the health.Alterations of microbiota participate in the pathogenesis of diseases.The gastric microbiota consists of bacteria from seven to eleven phyla,predominantly Proteobacteria,Firmicutes,Bacteroidetes,Actinobacteria and Fusobacteria.Intrusion by Helicobacter pylori(H.pylori)does not remarkably interrupt the composition and structure of the gastric microbiota.Absence of bacterial commensal from the stomach delays the onset of H.pylori-induced gastric cancer,while presence of artificial microbiota accelerates the carcinogenesis.Altered gastric microbiota may increase the production of N-nitroso compounds,promoting the development of gastric cancer.Further investigation of the carcinogenic mechanisms of microbiota would benefit for the prevention and management of gastric cancer.

Helicobacter Infection and Chronic Liver Diseases

This paper reviews the recent Helicobacter infection associated with chronic liver disease. The bacteriology, prevalence, pathogenesis and diagnosis were reviewed. Future work should be conducted on the pathogenesis and treatment of this disease.