Comparative metabolomics plays a crucial role in investigating gene function,exploring metabolite evolution,and accelerating crop genetic improvement.However,a systematic platform for intra-and crossspecies comparison...Comparative metabolomics plays a crucial role in investigating gene function,exploring metabolite evolution,and accelerating crop genetic improvement.However,a systematic platform for intra-and crossspecies comparison of metabolites is currently lacking.Here,we report the Plant Comparative Metabolome Database(PCMD;http://yanglab.hzau.edu.cn/PCMD),a multilevel comparison database based on predicted metabolic profiles of 530 plant species.The PCMD serves as a platform for comparing metabolite characteristics at various levels,including species,metabolites,pathways,and biological taxonomy.The database also provides a number of user-friendly online tools,such as species comparison,metabolite enrichment,and ID conversion,enabling users to perform comparisons and enrichment analyses of metabolites across different species.In addition,the PCMD establishes a unified system based on existing metabolite-related databases by standardizing metabolite numbering.The PCMD is the most speciesrich comparative plant metabolomics database currently available,and a case study demonstrates its ability to provide new insights into plant metabolic diversity.展开更多
基金supported by the National Natural Science Foundation of China(32322061 and 32070559)the Fundamental Research Funds for the Central University HZAU(2662022XXYJ007 and 2662023XX PY001)the China Postdoctoral Science Foundation(2024M751038)。
文摘Comparative metabolomics plays a crucial role in investigating gene function,exploring metabolite evolution,and accelerating crop genetic improvement.However,a systematic platform for intra-and crossspecies comparison of metabolites is currently lacking.Here,we report the Plant Comparative Metabolome Database(PCMD;http://yanglab.hzau.edu.cn/PCMD),a multilevel comparison database based on predicted metabolic profiles of 530 plant species.The PCMD serves as a platform for comparing metabolite characteristics at various levels,including species,metabolites,pathways,and biological taxonomy.The database also provides a number of user-friendly online tools,such as species comparison,metabolite enrichment,and ID conversion,enabling users to perform comparisons and enrichment analyses of metabolites across different species.In addition,the PCMD establishes a unified system based on existing metabolite-related databases by standardizing metabolite numbering.The PCMD is the most speciesrich comparative plant metabolomics database currently available,and a case study demonstrates its ability to provide new insights into plant metabolic diversity.
