BACKGROUND Major depression disorder(MDD)constitutes a significant mental health concern.Epidemiological surveys indicate that the lifetime prevalence of depression in adolescents is much higher than that in adults,wi...BACKGROUND Major depression disorder(MDD)constitutes a significant mental health concern.Epidemiological surveys indicate that the lifetime prevalence of depression in adolescents is much higher than that in adults,with a corresponding increased risk of suicide.In studying brain dysfunction associated with MDD in adolescents,research on brain white matter(WM)is sparse.Some researchers even mistakenly regard the signals generated by the WM as noise points.In fact,studies have shown that WM exhibits similar blood oxygen level-dependent signal fluctuations.The alterations in WM signals and their relationship with disease severity in adolescents with MDD remain unclear.AIM To explore potential abnormalities in WM functional signals in adolescents with MDD.METHODS This study involved 48 adolescent patients with MDD and 31 healthy controls(HC).All participants were assessed using the Patient Health Questionnaire-9 Scale and the mini international neuropsychiatric interview(MINI)suicide inventory.In addition,a Siemens Skyra 3.0T magnetic resonance scanner was used to obtain the subjects'image data.The DPABI software was utilized to calculate the WM signal of the fractional amplitude of low frequency fluctuations(fALFF)and regional homogeneity,followed by a two-sample t-test between the MDD and HC groups.Independent component analysis(ICA)was also used to evaluate the WM functional signal.Pearson’s correlation was performed to assess the relationship between statistical test results and clinical scales.RESULTS Compared to HC,individuals with MDD demonstrated a decrease in the fALFF of WM in the corpus callosum body,left posterior limb of the internal capsule,right superior corona radiata,and bilateral posterior corona radiata[P<0.001,family-wise error(FWE)voxel correction].The regional homogeneity of WM increased in the right posterior limb of internal capsule and left superior corona radiata,and decreased in the left superior longitudinal fasciculus(P<0.001,FWE voxel correction).The ICA results of WM overlapped with those of regional homogeneity.The fALFF of WM signal in the left posterior limb of the internal capsule was negatively correlated with the MINI suicide scale(P=0.026,r=-0.32),and the right posterior corona radiata was also negatively correlated with the MINI suicide scale(P=0.047,r=-0.288).CONCLUSION Adolescents with MDD involves changes in WM functional signals,and these differences in brain regions may increase the risk of suicide.展开更多
With the development of Unmanned Aerial Vehicles(UAVs), the applications of UAVs have been extensively explored. In the field of wireless communications, the relay nodes are often used to extend network coverage. Howe...With the development of Unmanned Aerial Vehicles(UAVs), the applications of UAVs have been extensively explored. In the field of wireless communications, the relay nodes are often used to extend network coverage. However, traditional fixed ground relays cannot be flexibly deployed due to their low heights and fixed locations. Hence, deploying UAV as relay node is a promising solution and has become a research hotspot. In this paper, we consider an UAVenabled relaying network in which a fixed-wing UAV is deployed between the Base Station(BS)and Ground Users(GUs). We study the energy-efficiency gap between the link “BS-UAV-GUs”and the link “BS-GUs”, and jointly optimize UAV relay transmission power and flight radius to achieve the highest energy-efficiency. Firstly, the UAV/BS-GUs channels models and the UAV energy consumption model are built. Secondly, the optimization objective function is formulated to maximize the energy-efficiency gap. Then, the solution of the optimization problem is divided into a two-step iteration process, in which the UAV relay transmission power and flight radius are adjusted to maximize the energy-efficiency gap. Finally, the experimental results under different simulation scenarios(such as cities, forests, deserts, oceans, etc.) are shown to illustrate the effectiveness of the proposed algorithm. The results show that the proposed algorithm can always find the optimal UAV relay transmission power and flight radius settings, and achieve the largest energy-efficiency gap. The convergency speed of the proposed algorithm is fast, and can obtain the optimal solution within only a few iterations.展开更多
基金Supported by the Suzhou Clinical Medical Center for Mood Disorders,No.Szlcyxzx202109Jiangsu Provincial Department of Science and Technology for Social Development-General Project,No.BE2022735.
文摘BACKGROUND Major depression disorder(MDD)constitutes a significant mental health concern.Epidemiological surveys indicate that the lifetime prevalence of depression in adolescents is much higher than that in adults,with a corresponding increased risk of suicide.In studying brain dysfunction associated with MDD in adolescents,research on brain white matter(WM)is sparse.Some researchers even mistakenly regard the signals generated by the WM as noise points.In fact,studies have shown that WM exhibits similar blood oxygen level-dependent signal fluctuations.The alterations in WM signals and their relationship with disease severity in adolescents with MDD remain unclear.AIM To explore potential abnormalities in WM functional signals in adolescents with MDD.METHODS This study involved 48 adolescent patients with MDD and 31 healthy controls(HC).All participants were assessed using the Patient Health Questionnaire-9 Scale and the mini international neuropsychiatric interview(MINI)suicide inventory.In addition,a Siemens Skyra 3.0T magnetic resonance scanner was used to obtain the subjects'image data.The DPABI software was utilized to calculate the WM signal of the fractional amplitude of low frequency fluctuations(fALFF)and regional homogeneity,followed by a two-sample t-test between the MDD and HC groups.Independent component analysis(ICA)was also used to evaluate the WM functional signal.Pearson’s correlation was performed to assess the relationship between statistical test results and clinical scales.RESULTS Compared to HC,individuals with MDD demonstrated a decrease in the fALFF of WM in the corpus callosum body,left posterior limb of the internal capsule,right superior corona radiata,and bilateral posterior corona radiata[P<0.001,family-wise error(FWE)voxel correction].The regional homogeneity of WM increased in the right posterior limb of internal capsule and left superior corona radiata,and decreased in the left superior longitudinal fasciculus(P<0.001,FWE voxel correction).The ICA results of WM overlapped with those of regional homogeneity.The fALFF of WM signal in the left posterior limb of the internal capsule was negatively correlated with the MINI suicide scale(P=0.026,r=-0.32),and the right posterior corona radiata was also negatively correlated with the MINI suicide scale(P=0.047,r=-0.288).CONCLUSION Adolescents with MDD involves changes in WM functional signals,and these differences in brain regions may increase the risk of suicide.
基金supported in part by Shanghai Rising-Star Program(No.19QA1409100)in part by the National Natural Science Foundation of China(Nos.62071332,61631017 and U1733114)+1 种基金in part by the Fundamental Research Funds for the Central Universities,China。
文摘With the development of Unmanned Aerial Vehicles(UAVs), the applications of UAVs have been extensively explored. In the field of wireless communications, the relay nodes are often used to extend network coverage. However, traditional fixed ground relays cannot be flexibly deployed due to their low heights and fixed locations. Hence, deploying UAV as relay node is a promising solution and has become a research hotspot. In this paper, we consider an UAVenabled relaying network in which a fixed-wing UAV is deployed between the Base Station(BS)and Ground Users(GUs). We study the energy-efficiency gap between the link “BS-UAV-GUs”and the link “BS-GUs”, and jointly optimize UAV relay transmission power and flight radius to achieve the highest energy-efficiency. Firstly, the UAV/BS-GUs channels models and the UAV energy consumption model are built. Secondly, the optimization objective function is formulated to maximize the energy-efficiency gap. Then, the solution of the optimization problem is divided into a two-step iteration process, in which the UAV relay transmission power and flight radius are adjusted to maximize the energy-efficiency gap. Finally, the experimental results under different simulation scenarios(such as cities, forests, deserts, oceans, etc.) are shown to illustrate the effectiveness of the proposed algorithm. The results show that the proposed algorithm can always find the optimal UAV relay transmission power and flight radius settings, and achieve the largest energy-efficiency gap. The convergency speed of the proposed algorithm is fast, and can obtain the optimal solution within only a few iterations.