Small nucleolar RNA and its potential role in the oncogenesis and development of colorectal cancer

Small nucleolar RNAs(snoRNAs)represent a class of non-coding RNAs that play pivotal roles in post-transcriptional RNA processing and modification,thereby contributing significantly to the maintenance of cellular functions related to protein synthesis.SnoRNAs have been discovered to possess the ability to influence cell fate and alter disease progression,holding immense potential in controlling human diseases.It is suggested that the dysregulation of snoRNAs in cancer exhibits differential expression across various cancer types,stages,metastasis,treatment response and/or prognosis in patients.On the other hand,colorectal cancer(CRC),a prevalent malignancy of the digestive system,is characterized by high incidence and mortality rates,ranking as the third most common cancer type.Recent research indicates that snoRNA dysregulation is associated with CRC,as snoRNA expression significantly differs between normal and cancerous conditions.Consequently,assessing snoRNA expression level and function holds promise for the prognosis and diagnosis of CRC.Nevertheless,current comprehension of the potential roles of snoRNAs in CRC remains limited.This review offers a comprehensive survey of the aberrant regulation of snoRNAs in CRC,providing valuable insights into the discovery of novel biomarkers,therapeutic targets,and potential tools for the diagnosis and treatment of CRC and furnishing critical cues for advancing research into CRC and the judicious selection of therapeutic targets.

Generation of elliptical airy vortex beams based on all-dielectric metasurface

Elliptical airy vortex beams(EAVBs) can spontaneously form easily identifiable topological charge focal spots. They are used for topological charge detection of vortex beams because they have the abruptly autofocusing properties of circular airy vortex beams and exhibit unique propagation characteristics. We study the use of the dynamic phase and Pancharatnam–Berry phase principles for generation and modulation of EAVBs by designing complex-amplitude metasurface and phase-only metasurface, at an operating wavelength of 1500 nm. It is found that the focusing pattern of EAVBs in the autofocusing plane splits into |m| + 1 tilted bright spots from the original ring, and the tilted direction is related to the sign of the topological charge number m. Due to the advantages of ultra-thin, ultra-light, and small size of the metasurface, our designed metasurface device has potential applications in improving the channel capacity based on orbital angular momentum communication, information coding, and particle capture compared to spatial light modulation systems that generate EAVBs.