Type 2 diabetes mellitus(T2DM)is a common clinical endocrine and metabolic disease characterized by elevated blood sugar and insulin resistance.The onset of T2DM will affect the metabolic balance of the body,and uric ...Type 2 diabetes mellitus(T2DM)is a common clinical endocrine and metabolic disease characterized by elevated blood sugar and insulin resistance.The onset of T2DM will affect the metabolic balance of the body,and uric acid metabolism is one of them.Hyperuricemia(HUA)is very common in type 2 diabetes.Based on HUA,gout is a crystal-related disease caused by urate deposition,and its clinical manifestations are complex and varied.Professor zhao quanlin has rich experience in clinical experience,and he has made good use of traditional Chinese medicine system to treat type 2 diabetes mellitus with gout in the acute phase of clinical effect.展开更多
Fracture propagation is affected by multi-metal-veins formed by geological diagenesis in shale during the hydraulic fracturing.However,the influence of multi-metal-veins on fractures propagation remains unclear.To sol...Fracture propagation is affected by multi-metal-veins formed by geological diagenesis in shale during the hydraulic fracturing.However,the influence of multi-metal-veins on fractures propagation remains unclear.To solve the problem,based on the semi-circle bending(SCB)test and the extended finite element(XFEM)theory,the interaction between multi-metal-veins and fractures is investigated.The experimental results reveal that the fractures usually deflect at the upper or lower interfaces between metal veins and rocks(e.g.the specimen S-2),which is different from the propagation behavior of fractures in calcite veins.Meanwhile,the fracture toughness of the specimen S-1 is 24.40%higher than that of the specimen S-2,indicating that the increasing of total thickness of multiple metal veins in-creases the resistance to the fracture vertical propagation.The simulation results show that the increasing of the number,total thickness of veins,the modulus difference between veins and rock,the approach angle and the notch angle all increase the resistance of the fracture passing through metal veins.The maximum deviation distance(Dmax)of the fracture decreases with the number of veins,while thickness combination types of metal veins do not affect Dmax.The reduction of the notch angle leads to the more tortuous fracture propagation path.Finally,we propose a new comprehensive fracture network pattern.Fracture networks are divided into two categories,including orthogonal fracture networks and sub-orthogonal fracture networks,and then divided into six sub-categories further.The research results will provide reference for hydraulic fracturing of shale reservoirs containing multi-metal-veins.展开更多
Artificial soft actuators,featured with non-equilibrium internal circumstance and fast,programmable shape transformations,have attracted strong research interest recently due to their flexibility,highly controllable,a...Artificial soft actuators,featured with non-equilibrium internal circumstance and fast,programmable shape transformations,have attracted strong research interest recently due to their flexibility,highly controllable,and designability.However,wireless soft actuators,achieving the locomotion on different large slopes with multiple energy conversion,have been rarely reported.Herein,we create a asymmetric bilayer strategy to construct autonomous soft crawler via“breathing”moisture to motivate the mechanical deformation.The soft crawlers present conspicuous performances including periodic tumbler locomotion predicted via improved Timoshenko’s equation,multiple reversible shape-morphing(circle,helix,despiralization,etc.)determined by their fiber orientation,controlled drive mode(front drive and rear drive)and rapid climb speed(4.76 cm/min)at wide slope angles.Through architecture design,they can be series-wound or shunt-wound to construct multijoint complex actuators.Besides climbing,a intelligent soft ring-pull with admirable cycle performance for preventing overheating or something untouchable,has been proposed.The soft crawlers also realize multiple energy conversion to be actuated by light irradiation.We envision that this soft crawler system has an enormous potential in intelligent machine,microscopic diagnosis and treatment,biosensing,energy harvesting and conversion.展开更多
基金National natural science foundation of China(No.81774254)。
文摘Type 2 diabetes mellitus(T2DM)is a common clinical endocrine and metabolic disease characterized by elevated blood sugar and insulin resistance.The onset of T2DM will affect the metabolic balance of the body,and uric acid metabolism is one of them.Hyperuricemia(HUA)is very common in type 2 diabetes.Based on HUA,gout is a crystal-related disease caused by urate deposition,and its clinical manifestations are complex and varied.Professor zhao quanlin has rich experience in clinical experience,and he has made good use of traditional Chinese medicine system to treat type 2 diabetes mellitus with gout in the acute phase of clinical effect.
基金support from the China University of Petroleum(Beijing)School for Young Talent Startup Fund(No.ZX20190183).
文摘Fracture propagation is affected by multi-metal-veins formed by geological diagenesis in shale during the hydraulic fracturing.However,the influence of multi-metal-veins on fractures propagation remains unclear.To solve the problem,based on the semi-circle bending(SCB)test and the extended finite element(XFEM)theory,the interaction between multi-metal-veins and fractures is investigated.The experimental results reveal that the fractures usually deflect at the upper or lower interfaces between metal veins and rocks(e.g.the specimen S-2),which is different from the propagation behavior of fractures in calcite veins.Meanwhile,the fracture toughness of the specimen S-1 is 24.40%higher than that of the specimen S-2,indicating that the increasing of total thickness of multiple metal veins in-creases the resistance to the fracture vertical propagation.The simulation results show that the increasing of the number,total thickness of veins,the modulus difference between veins and rock,the approach angle and the notch angle all increase the resistance of the fracture passing through metal veins.The maximum deviation distance(Dmax)of the fracture decreases with the number of veins,while thickness combination types of metal veins do not affect Dmax.The reduction of the notch angle leads to the more tortuous fracture propagation path.Finally,we propose a new comprehensive fracture network pattern.Fracture networks are divided into two categories,including orthogonal fracture networks and sub-orthogonal fracture networks,and then divided into six sub-categories further.The research results will provide reference for hydraulic fracturing of shale reservoirs containing multi-metal-veins.
基金financially supported by the National Natural Science Foundation of China(Nos.22001175,51973118,22175121 and 52003160)Key-Area Research and Development Program of Guangdong Province(Nos.2019B010929002 and 2019B010941001)+3 种基金the Natural Science Foundation of Guangdong Province(No.2020A1515010644)the Program for Guangdong Introducing Innovative and Enterpreneurial Teams(No.2019ZT08C642)Shenzhen Science and Technology Program(Nos.JCYJ20210324095412035,JCYJ20190808113005643,JCYJ20170818093832350 and JCYJ20180507184711069)the start-up fund of Shenzhen University(No.000002110820)。
文摘Artificial soft actuators,featured with non-equilibrium internal circumstance and fast,programmable shape transformations,have attracted strong research interest recently due to their flexibility,highly controllable,and designability.However,wireless soft actuators,achieving the locomotion on different large slopes with multiple energy conversion,have been rarely reported.Herein,we create a asymmetric bilayer strategy to construct autonomous soft crawler via“breathing”moisture to motivate the mechanical deformation.The soft crawlers present conspicuous performances including periodic tumbler locomotion predicted via improved Timoshenko’s equation,multiple reversible shape-morphing(circle,helix,despiralization,etc.)determined by their fiber orientation,controlled drive mode(front drive and rear drive)and rapid climb speed(4.76 cm/min)at wide slope angles.Through architecture design,they can be series-wound or shunt-wound to construct multijoint complex actuators.Besides climbing,a intelligent soft ring-pull with admirable cycle performance for preventing overheating or something untouchable,has been proposed.The soft crawlers also realize multiple energy conversion to be actuated by light irradiation.We envision that this soft crawler system has an enormous potential in intelligent machine,microscopic diagnosis and treatment,biosensing,energy harvesting and conversion.
