A new class of m-hydroxybenzyl alcohols has been designed as competent three-carbon building blocks and achieved their applica-tion in 2-indolylmethanol-involved regioselective(3+3)cycloadditions under the catalysis o...A new class of m-hydroxybenzyl alcohols has been designed as competent three-carbon building blocks and achieved their applica-tion in 2-indolylmethanol-involved regioselective(3+3)cycloadditions under the catalysis of Br?nsted acids.By this appoach,a series of indole-fused six-membered cycloadducts have been synthesized in overall good yields(up to 98%)with excellent regioselectivity(all>95:5 rr),thus affording a powerful method for the construction of indole-fused six-membered rings.Moreover,a catalytic asymmetric version of this(3+3)cycloaddition has been preliminarily investigated,which revealed the potential of the reaction for constructing chiral indole-fused six-membered rings in an enantioselective manner.This work not only has accomplished the first design of m-hydroxybenzyl alcohols as competent reactants,but also represents the first application of m-hydroxybenzyl alcohols as three-carbon building blocks in cycloadditions.In addition,this work provides a good example for regioselective and C3-nucleophilic(3+3)cycloadditions of 2-indolylmethanols,which will substantially enrich the chemistry of 2-indolylmethanols.展开更多
Rosa roxburghii juice is of increasing importance in recent years and has become a favorite fruit juice in the market due to its extremely high Vc content.Meanwhile,a large amount of pomace from juice process is usual...Rosa roxburghii juice is of increasing importance in recent years and has become a favorite fruit juice in the market due to its extremely high Vc content.Meanwhile,a large amount of pomace from juice process is usually treated as waste.However,the pomace still contains a lot of nutrients and has great reuse value.In this study,the Rosa roxburghii pomace was fermented with Bacillus natto to develop a new healthy food ingredient rich in high quality dietary fiber(soluble dietary fiber,SDF).Under the optimal fermentation process conditions(inoculum concentration 4%,temperature 38.7℃,time 12 h,and pH 4.97),SDF content of R.roxburghii pomace increased from 7.68%to 10.68%.SEM and FTIR analysis revealed that the fermentation can lead to degradation of cellulose and hemicellulose,resulting in the formation of more porous lax structure,the related functions such as water holding,oil holding,substance adsorption and cation exchange capacity were obviously increased.In addition,19 phytochemicals from R.roxburghii pomace were quantified by UPLC-QqQ-MS/MS,which demonstrated the fruit pomace also could be used as a functional ingredient in food field.展开更多
基金financial support from the National Natural Science Foundation of China(22125104 and 21831007)the Natural Science Foundation of Jiangsu Province(BK20210916)+1 种基金the High Education Natural Science Foundation of Jiangsu Province(No.21KJB150009)Undergraduate Students Project of Jiangsu Province(No.202110320019Z).
文摘A new class of m-hydroxybenzyl alcohols has been designed as competent three-carbon building blocks and achieved their applica-tion in 2-indolylmethanol-involved regioselective(3+3)cycloadditions under the catalysis of Br?nsted acids.By this appoach,a series of indole-fused six-membered cycloadducts have been synthesized in overall good yields(up to 98%)with excellent regioselectivity(all>95:5 rr),thus affording a powerful method for the construction of indole-fused six-membered rings.Moreover,a catalytic asymmetric version of this(3+3)cycloaddition has been preliminarily investigated,which revealed the potential of the reaction for constructing chiral indole-fused six-membered rings in an enantioselective manner.This work not only has accomplished the first design of m-hydroxybenzyl alcohols as competent reactants,but also represents the first application of m-hydroxybenzyl alcohols as three-carbon building blocks in cycloadditions.In addition,this work provides a good example for regioselective and C3-nucleophilic(3+3)cycloadditions of 2-indolylmethanols,which will substantially enrich the chemistry of 2-indolylmethanols.
基金the financial supports by the State Key Program of National Natural Science Foundation of China(31930076)the 111 Project(B20088)Heilongjiang Touyan Innovation Team Program(Tree Genetics and Breeding Innovation Team).
文摘Rosa roxburghii juice is of increasing importance in recent years and has become a favorite fruit juice in the market due to its extremely high Vc content.Meanwhile,a large amount of pomace from juice process is usually treated as waste.However,the pomace still contains a lot of nutrients and has great reuse value.In this study,the Rosa roxburghii pomace was fermented with Bacillus natto to develop a new healthy food ingredient rich in high quality dietary fiber(soluble dietary fiber,SDF).Under the optimal fermentation process conditions(inoculum concentration 4%,temperature 38.7℃,time 12 h,and pH 4.97),SDF content of R.roxburghii pomace increased from 7.68%to 10.68%.SEM and FTIR analysis revealed that the fermentation can lead to degradation of cellulose and hemicellulose,resulting in the formation of more porous lax structure,the related functions such as water holding,oil holding,substance adsorption and cation exchange capacity were obviously increased.In addition,19 phytochemicals from R.roxburghii pomace were quantified by UPLC-QqQ-MS/MS,which demonstrated the fruit pomace also could be used as a functional ingredient in food field.
