Facilitating prelithiation of silicon carbon anode by localized high-concentration electrolyte for high-rate and long-cycle lithium storage

The commercialization of silicon-based anodes is affected by their low initial Coulombic efficiency(ICE)and capacity decay,which are attributed to the formation of an unstable solid electrolyte interface(SEI)layer.Herein,a feasible and cost-effective prelithiation method under a localized highconcentration electrolyte system(LHCE)for the silicon-silica/graphite(Si-SiO_(2)/C@G)anode is designed for stabilizing the SEI layer and enhancing the ICE.The thin SiO_(2)/C layers with-NH_(2) groups covered on nano-Si surfaces are demonstrated to be beneficial to the prelithiation process by density functional theory calculations and electrochemical performance.The SEI formed under LHCE is proven to be rich in ionic conductivity,inorganic substances,and flexible organic products.Thus,faster Li+transportation across the SEI further enhances the prelithiation effect and the rate performance of Si-SiO_(2)/C@G anodes.LHCE also leads to uniform decomposition and high stability of the SEI with abundant organic components.As a result,the prepared anode shows a high reversible specific capacity of 937.5 mAh g^(-1)after 400 cycles at a current density of 1 C.NCM 811‖Li-SSGLHCE full cell achieves a high-capacity retention of 126.15 mAh g^(-1)at 1 C over 750 cycles with 84.82%ICE,indicating the great value of this strategy for Si-based anodes in large-scale applications.

Prognostic value and predictive model of tumor markers in stageⅠtoⅢgastric cancer patients

BACKGROUND Preoperative serum tumor markers have been widely used in the diagnosis and treatment of gastric cancer patients.However,few studies have evaluated the prognosis of gastric cancer patients by establishing statistical models with multiple serum tumor indicators.AIM To explore the prognostic value and predictive model of tumor markers in stage I and III gastric cancer patients.METHODS From October 2018 to April 2020,a total of 1236 patients with stage I to III gastric cancer after surgery were included in our study.The relationship between serum tumor markers and clinical and pathological data were analyzed.We established a statistical model to predict the prognosis of gastric cancer based on the results of COX regression analysis.Overall survival(OS)was also compared across different stages of gastric cancer.RESULTS The deadline for follow-up was May 31,2023.A total of 1236 patients were included in our study.Univariate analysis found that age,clinical stage,T and N stage,tumor location,differentiation,Borrmann type,size,and four serum tumor markers were prognostic factors of OS(P<0.05).It was shown that clinical stage,tumor size,alpha foetoprotein,carcinoembryonic antigen,CA125 and CA19-9(P<0.05)were independent prognostic factors for OS.According to the scoring results obtained from the statistical model,we found that patients with high scores had poorer survival time(P<0.05).Furthermore,in stage I patients,the 3-year OS for scores 0-3 ranged from 96.85%,95%,85%,and 80%.In stage II patients,the 3-year OS for scores 0-4 were 88.6%,76.5%,90.5%,65.5%and 60%.For stage III patients,3-year OS for scores 0-6 were 70.9%,68.3%,64.1%,50.9%,38.4%,18.5%and 5.2%.We also analyzed the mean survival of patients with different scores.For stage I patients,the mean OS was 55.980 months.In stage II,the mean OS was 51.550 months.The mean OS for stage III was 39.422 months.CONCLUSION Our statistical model can effectively predict the prognosis of gastric cancer patients.

A novel method for gamma spectrum analysis of low-level and intermediate-level radioactive waste

The uncertainty of nuclide libraries in the analysis of the gamma spectra of low-and intermediate-level radioactive waste(LILW)using existing methods produces unstable results.To address this problem,a novel spectral analysis method is proposed in this study.In this method,overlapping peaks are located using a continuous wavelet transform.An improved quadratic convolution method is proposed to calculate the widths of the peaks and establish a fourth-order filter model to estimate the Compton edge baseline with the overlapping peaks.Combined with the adaptive sensitive nonlinear iterative peak,this method can effectively subtracts the background.Finally,a function describing the peak shape as a filter is used to deconvolve the energy spectrum to achieve accurate qualitative and quantitative analyses of the nuclide without the aid of a nuclide library.Gamma spectrum acquisition experiments for standard point sources of Cs-137 and Eu-152,a segmented gamma scanning experiment for a 200 L standard drum,and a Monte Carlo simulation experiment for triple overlapping peaks using the closest energy of three typical LILW nuclides(Sb-125,Sb-124,and Cs-134)are conducted.The results of the experiments indicate that(1)the novel method and gamma vision(GV)with an accurate nuclide library have the same spectral analysis capability,and the peak area calculation error is less than 4%;(2)compared with the GV,the analysis results of the novel method are more stable;(3)the novel method can be applied to the activity measurement of LILW,and the error of the activity reconstruction at the equivalent radius is 2.4%;and(4)The proposed novel method can quantitatively analyze all nuclides in LILW without a nuclide library.This novel method can improve the accuracy and precision of LILW measurements,provide key technical support for the reasonable disposal of LILW,and ensure the safety of humans and the environment.

Efficacy and safety of sacubitril/valsartan after six months in patients with heart failure with reduced ejection fraction and asymptomatic hypotension

BACKGROUND It is not clear whether sacubitril/valsartan is beneficial for patients with heart failure(HF)with reduced ejec-tion fraction(HFrEF)and low systolic blood pressure(SBP).This study aimed to investigate the efficacy and tolerability of sacu-bitril/valsartan in HFrEF patients with SBP<100 mmHg.METHODS&RESULTS An observational study was conducted on 117 patients,40.2%of whom had SBP<100 mmHg wit-hout symptomatic hypotension,and 59.8%of whom had SBP≥100 mmHg in an optimized HF follow-up management system.At the 6-month follow-up,52.4%of patients with SBP<100 mmHg and 70.0%of those with SBP≥100 mmHg successfully rea-ched the target dosages of sacubitril/valsartan.A reduction in the concentration of N-terminal pro-B-type natriuretic peptide was similar between patients with SBP<100 mmHg and SBP≥100 mmHg(1627.5 pg/mL and 1340.1 pg/mL,respectively;P=0.75).The effect of sacubitril/valsartan on left ventricular ejection fraction was observed in both SBP categories,with a 10.8%increase in patients with SBP<100 mmHg(P<0.001)and a 14.0%increase in patients with SBP≥100 mmHg(P<0.001).The effects of sac-ubitril/valsartan on SBP were statistically significant and inverse across both SBP categories(P=0.001),with an increase of 7.5 mmHg in patients with SBP<100 mmHg and a decrease of 11.5 mmHg in patients with SBP≥100 mmHg.No statistically signi-ficant differences were observed between the two groups in terms of the occurrence of symptomatic hypotension,deteriorating re-nal function,hyperkalemia,angioedema,or stroke.CONCLUSIONS Within an optimized HF follow-up management system,sacubitril/valsartan exhibited excellent tolerability and prompted left ventricular reverse remodeling in patients with HFrEF who presented asymptomatic hypotension.

Simulation-driven Wind Load Analysis and Prediction for Large Steerable Radio Telescopes

Large steerable radio telescopes can rotate in azimuth and elevation,with various upwind postures and complex wind load characteristics.In order to obtain the wind load distribution on the reflector and the wind force coefficients in different upwind postures,this work took the reflector of the Qi Tai Telescope in Xinjiang as the object.The wind pressure distribution,drag coefficient,side force coefficient,lift coefficient,and total force coefficient of 361 groups of reflectors with different upwind postures were calculated and analyzed by a numerical simulation method.The results show that the force on the reflector when the concave surface faces the wind is significantly greater than when the convex surface faces the wind.The surrogate models for calculating wind force coefficients were established based on the polynomial response surface model(PRSM) and regularized minimumenergy tensor-product spline(RMTS).The adjusted R-squared of RMTS is 0.98,and the root mean square error is below 0.1,which proves RMTS is significantly better than PRSM.Compared with the numerical simulation values,the absolute errors of the drag coefficient,side force coefficient,lift coefficient,and total force coefficient of the reflector with azimuth and elevation of 45° predicted by RMTS are 0.02,0.027,0.032,and 0.046,respectively.The relative errors are 2.42%,2.76%,2.23%,and 2.43%,respectively.It is proved that the RMTS surrogate model is reliable and that the predicted data can fast provide sufficient information for the wind-resistant design of the large steerable radio telescopes.

A network pharmacology approach to explore the mechanism of action of Yiqi Fumai lyophilized injection in the treatment of novel coronavirus disease

Background:Shengmai decoction,which has been included in the diagnosis and treatment of coronavirus disease 2019(COVID-19),is effective in the early treatment of patients with severe COVID-19.Yiqi Fumai lyophilized injection(YQFM)is a modern Chinese medicine preparation of the Shengmai decoction.The mechanism of its intervention at the molecular level in the severe stage of COVID-19 remains unclear.Therefore,it is necessary to investigate the mechanism of YQFM in the treatment of patients with severe COVID-19.Methods:The corresponding target genes of the main active ingredients in YQFM and COVID-19 were obtained by using multiple databases and literature retrieval.A protein-protein interaction network was constructed,and enrichment analysis of the target was performed using Cytoscape 3.8.1.Lastly,the docking of all the identified compounds with angiotensin-converting enzyme II was confirmed by applying molecular docking technology.Results:YQFM has anti-inflammatory effects on RAW267.4 macrophages.The main active compounds of YQFM are all effective anti-inflammatory agents,and these active compounds also show beneficial physiological functions,such as anti-oxidation,anti-bacterial,and anticancer activities.Gene Ontology analysis showed enrichment in the following pathways:lipopolysaccharides,interleukins,NF-kappa B,interleukin-2 and others,revealing that YQFM may play a role in the treatment of patients with severe COVID-19 through these pathways.Conclusion:YQFM has multicomponent and multitarget characteristics,and it could reduce lung injury by inhibiting inflammatory reactions,promoting antiviral activities,and regulating immunity,among other functions,to treat patients with severe COVID-19.

Effect of salvianolic acid B-loaded mesoporous silica nanoparticles on myocardial ischemia-reperfusion injury

Background:Currently,no drugs can specifically improve clinical cardiac ischemia-reperfusion injury or the prognosis of hemodialysis.Salvianolic acid B(SalB)is a widely used cardiac protectant;however,its clinical application is limited by its low oral bioavailability and poor intestinal absorption.The exploration of its preparation and clinical applications has become a research hotspot in recent years.Methods:To determine whether mesoporous silica nanoparticles(MSNs)efficiently delivered SalB to the heart and SalB@MSNs-RhB reduced myocardial ischemia-reperfusion injury,we constructed a myocardial ischemia-reperfusion male rat model,hypoxia/reoxygenation cardiomyocytes,and treated them with SalB@MSNs-RhB.Results:SalB@MSNs-RhB showed improved bioavailability,therapeutic effect,heightened JAK2/STAT3-dependent pro-survival signaling,and antioxidant responses,thereby protecting cardiomyocytes from ischemia-reperfusion injury-induced oxidative stress and apoptosis.Conclusion:This use of SalB-loaded nanoparticles and investigation of their mechanism of action may provide a new strategy for treating cardiomyocytes.Thus,hypoxia/reoxygenation promotes the clinical application of SalB.

Effect of cerebralcare granule®combined with donepezil on Alzheimer’s disease

Background:The current prevalence of Alzheimer’s disease(AD)in the elderly has risen from 1%at 65 to 40%to 50%at 95,and the overall proportion is rising.Emerging evidence suggests that ros-driven oxidative stress is a crucial mediator of the aging process.Thus,in recent years,oxidative damage and inflammation have become targets for exploring pharmacological strategies for treating age-related diseases.Methods:In C57BL/6J mice,to determine whether the mechanism of action of cerebralcare granule®(CG)combined with donepezil(Don)treatment is better than dementia alone,we constructed a mouse model and treated it with CG in combination with Don.Results:A combination of Don and CG significantly reduces the damage caused by lipid peroxidation in the hippocampus of AD mice,reduces oxidative damage,and reduces inflammation,increases the activity of antioxidant enzymes,which is finally manifested as the improvement effect on the learning and memory impairment of AD mice.Conclusion:CG combined with Don has a better effect on improving cognitive and behavioral deficits caused by D-galactose in AD mice than Don alone.The mechanism may be related to reducing inflammation via the NF-κB pathway,resisting oxidative damage and increasing acetylcholine levels.

Liver injury associated with acute pancreatitis:The current status of clinical evaluation and involved mechanisms

Acute pancreatitis(AP)is a very common acute disease,and the mortality rate of severe AP(SAP)is between 15%and 35%.The main causes of death are multiple organ dysfunction syndrome and infections.The mortality rate of patients with SAP related to liver failure is as high as 83%,and approximately 5%of the SAP patients have fulminant liver failure.Liver function is closely related to the progression and prognosis of AP.In this review,we aim to elaborate on the clinical manifestations and mechanism of liver injury in patients with AP.

Numerical simulation and experimental verification of large-sized Zr-based bulk metallic glass ring-shaped parts in casting process

An outer ring of 29320 self-aliging roller bearing was used in an experimental study on the casting of Zr_(41)Ti_(14)Cu_(12.5)Ni_(10)Be_(22.5) amorphous alloy.Numerical simulations of mold filling and solidification processes were carried out to determine the velocity fields and temperature fields of the alloy melt during mold filling process as well as the temperature fields and temperature gradient fields in the course of the solidification.According to the results,a cast with a complete shape can be obtained at 1200℃under the condition that the cooling rate is greater than the critical cooling rate.The ring-shaped part with a thickness of 25 mm,an equivalent diameter of 22 mm,and a mass of 1.32 kg was prepared by gravity casting in a copper mold.X-ray diffraction and differential scanning calorimetry data revealed that the produced cast had the amorphous structure.

Measurements of non-equilibrium and equilibrium temperature behind a strong shock wave in simulated martian atmosphere

Non-equilibrium radiation measurements behind strong shock wave for simulated Martian atmosphere are presented in this paper. The shock wave is established in a hydrogen oxygen combustion driven shock tube. Time- resolved spectra of the Av = 0 sequence of the B^2∑^＋ → X^2∑^＋ electronic transition of CN have been observed through optical emission spectroscopy （OES）. A new method, which is based on fitting high resolution spectrum for rotational and vibrational temperatures measurement, is proposed to diag- nose temperature distribution behind the shock wave. It is estimated that the current scheme has the maximum deviation less than 8% （lσ） for vibrational temperature measurement through detailed analysis of the influence of the uncertainties of spectroscopic constants and spectral resolution. Radiation structure of the shock layer, including induction, relaxation and equilibrium process, and corresponding rotational and vibrational temperatures are obtained through time gating OES diagnostics with sub-microsecond temporal resolution. The present extensive results will strongly benefit the reaction rate estimation and computational fluid dynamics （CFD） code validation in high enthalpy Mars reentry chemistry.

Fabrication,microstructures and mechanical properties of ZrO_2 dispersion-strengthened Q345 steel

ZrO2 dispersion-strengthened Q345 steel with different ZrO2 contents（0%, 0.5% and 1.2%, mass fraction） was fabricated through combining middle frequency induction furnace melting and cored-wire injection technologies. The microstructure and fracture surface morphology of ZrO2 dispersion-strengthened Q345 steel in casting, normalizing and quenching states were observed using optical microscopy, scanning electron microscopy and transmission electron microscopy. Also, strengthening and fracture mechanisms of the alloys were analyzed. Results showed that the dispersed ZrO2 particles added into Q345 matrix significantly enhanced its strength, and the main strengthening mechanism was the formation of dislocation cells and pinning effect caused by the addition of ZrO2 particles. Apart from that, the hard martensite phase, grain refinement and high ZrO2 particles content also played important roles in strengthening effect. Furthermore, the nanoindentation was also performed to further reveal the strengthening effect and mechanism of dispersed ZrO2 particles in Q345 steel. Results showed that the hardness of ZrO2 dispersion-strengthened Q345 steel increased with the increase of ZrO2 content.

Electrochemical behavior of tungsten in(NaCl–KCl–NaF–WO_3)molten salt

Abstract The electrochemical reaction mechanism and electrocrystaUization process of tungsten in the NaCl- KCl-NaF-WO3 molten salt were investigated at 973 K （700℃） by means of cyclic voltammetry, chronopotentiometry, and chronoamperometry techniques. The results show that the electrochemical reaction process of tungsten in the NaCl-KCl-NaF-WO3 molten salt system is a quasireversible process mix-controlled by ion diffusion rate and electron transport rate. Tungsten ion in this system is reduced to W（0） in two steps. The electrocrystallization process of tungsten is found to be an instantaneous, hemispheroid three-dimensional nucleation process and the tungsten ion diffusion coefficient of 2.361 × 10^-4 cm2.s^-1 is obtained at experimental conditions.

Management of procedural pain in the intensive care unit

Pain is a common experience for inpatients,and intensive care unit(ICU)patients undergo more pain than other departmental patients,with an incidence of 50%at rest and up to 80%during common care procedures.At present,the management of persistent pain in ICU patients has attracted considerable attention,and there are many related clinical studies and guidelines.However,the management of transient pain caused by certain ICU procedures has not received sufficient attention.We reviewed the different management strategies for procedural pain in the ICU and reached a conclusion.Pain management is a process of continuous quality improvement that requires multidisciplinary team cooperation,painrelated training of all relevant personnel,effective relief of all kinds of pain,and improvement of patients'quality of life.In clinical work,which involves complex and diverse patients,we should pay attention to the following points for procedural pain:(1)Consider not only the patient's persistent pain but also his or her procedural pain;(2)Conduct multimodal pain management;(3)Provide combined sedation on the basis of pain management;and(4)Perform individualized pain management.Until now,the pain management of procedural pain in the ICU has not attracted extensive attention.Therefore,we expect additional studies to solve the existing problems of procedural pain management in the ICU.

Patient outcomes in the field of nursing: A concept analysis

Purpose:This paper reports an analysis of the concept of patient outcomes.Methods:The Walker and Avant concept analysis approach was applied.Results:The attributes of patient outcomes include(1)patient functional status(maintained or improved),(2)patient safety(protected or unharmed),and(3)patient satisfaction(patient reporting of comfort and contentment).These attributes are influenced by the antecedents of individual patient characteristics and health problems,the structure of healthcare organizations and received health interventions.Additionally,patient outcomes do significantly impact the quality of nursing care,the cost of effective care and healthcare policy making formulation.Conclusion:Providing good nursing care to all patients is a central goal of nursing.Patient outcomes in nursing are primarily about the results for the patient receiving nursing care.This analysis provides nurses with a new perspective by helping them to understand all the components within the concept of patient outcomes.

Blocking VEGF signaling augments interleukin-8 secretion via MEK/ERK/1/2 axis in human retinal pigment epithelial cells

AIM:To identify proangiogenic factors engaged in neovascular age-related macular degeneration(AMD)except vascular endothelial growth factor(VEGF)from human retinal pigment epithelial(h RPE)cells and investigate the underlying mechanisms.METHODS:VEGF receptor 2(VEGFR2)in ARPE-19 cells was depleted by si RNA transfection or overexpressed through adenovirus infection.The m RNA and the protein levels of interleukin-8(IL-8)in ARPE-19 cells were measured by quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay respectively.The protein levels of AKT,p-AKT,MEK,p-MEK,ERK1/2,p-ERK1/2,JNK,p-JNK,p38 and p-p38 were detected by Western blotting.A selective chemical inhibitor,LY3214996,was employed to inhibit phosphorylation of ERK1/2.Cell viability was determined by MTT assay.RESULTS:Knockdown of VEGFR2 in ARPE-19 cells robustly augmented IL-8 production at both the m RNA and the protein levels.Silencing VEGFR2 substantially enhanced phosphorylation of MEK and ERK1/2 while exerted no effects on phosphorylation of AKT,JNK and p38.Inhibiting ERK1/2 phosphorylation by LY3214996 reversed changes in VEGFR2 knockdown-induced IL-8 upregulation at the m RNA and the protein levels with no effects on cell viability.VEGFR2 overexpression significantly reduced IL-8 generation at the m RNA and the protein levels.CONCLUSION:Blockade of VEGF signaling augments IL-8 secretion via MEK/ERK1/2 axis and overactivation of VEGF pathway decreases IL-8 production in h RPE cells.Upregulated IL-8 expression after VEGF signaling inhibition in h RPE cells may be responsible for being incompletely responsive to anti-VEGF remedy in neovascular AMD,and IL-8 may serve as an alternative therapeutic target for neovascular AMD.

Study on the Outdoor Wind Environment Simulation and Design Strategies of Rural Settlements in Cold Areas

To improve the outdoor environment of rural settlement and reduce the energy consumption of rural houses in winterin cold areas,the seriously bad wind environment should been controlled and considered. This paper applies the method of numerical simulation to simulate the wind environment of some typical arrangement of building and courtyard in winter,and concludes the optimal building and courtyard arrangement types and strategies. It aims to provide some technical supports for improving the wind environment of rural settlements in cold regions.

A novel Norrie disease pseudoglioma gene mutation,c.-1_2delAAT,responsible for Norrie disease in a Chinese family

AIM:To Investigate the genetic findings and phenotypic characteristics of a Chinese family with Norrie disease（ND）.METHODS:Molecular genetic analysis and clinical examinations were performed on a Chinese family with ND.Mutations in the Norrie disease pseudoglioma（NDP）gene were detected by direct sequencing.Haplotypes were constructed and compared with the phenotypes in the family.Evolutionary comparisons and mutant open reading frame（ORF）prediction were also undertaken.RESULTS:Two family members with ocular manifestations were diagnosed with ND.No signs of sensorineural hearing loss were observed in either patient,while one of them showed signs of mild mental retardation.A novel heterozygous mutation in the NDP gene,c.-12delAAT,was detected in both patients.The mutation and the mutation bearing hapiotype cosegregated with the ND phenotype in males and was transmitted from their mothers and/or grandmothers（Ⅱ:2）.The male without ND did not harbor the mutation.The mutation occurred at the highly conserved nucleotides.DRF finder predicted that the mutation would lead to the production of a truncated protein that lacks the first 11N-terminal amino acids.CONCLUSION:A novel mutation,c.-12delAAT in the NDP gene,was identified in a Chinese family with ND.This mutation caused ND without obvious sensorineural hearing loss.Mental disorder was found in one but not the other patients.The clinical heterogeneity in the family indicated that other genetic variants and epigenetic factors may also play a role in the disease presentation.

Influence of periodic pressure on dendritic morphology and sidebranching

The influence of periodic pressure with low and high frequencies on microstructure and dendritic sidebranching was studied by using 3-D phase field method. In both low and high frequency cases, the variation trend of SDAS (secondary dendritic arm spacing) with increasing pressure frequency is opposite to that of sidebranching frequency, while the variation trend of the average length of secondary arms is consistent with that of sidebranching frequency. The high sidebranching frequency indicates that more secondary arms share the whole driving force of dendrite growth, resulting in lower driving force for each one and leading to less developed secondary arms. The smallest SDAS is obtained when perturbed by the periodic pressure with the frequency of 0.157/τ0 (τ0 is the physical unit of time in the dimensionless phase field model) and 2.200/τ0 in low and high frequency cases, respectively. Comparisons of dendritic morphology and secondary arms are made between the low and high frequency cases. Firstly, in the low frequency case, secondary arms are luxuriant especially when pressure frequency is low, with many high-order side branches stretching out. Secondly, the average length of secondary arms in primary dendrite is longer in the low frequency case than that without pressure, and much longer than that in the high frequency case. Thirdly, the dendrite tip without side branches in the high frequency case is much longer than that in the low frequency case. All of the differences in dendritic morphology and sidebranching in the two cases can be attributed to the different modulation mechanism. In the low frequency case, periodic pressure determines tip velocity and then modulates sidebranching directly. While in the high frequency case, periodic pressure cannot determine sidebranching directly, but via modulating tiny protuberances in dendrite tip, part of which evolves into side branch. In this case, the tiny protuberances take part of the whole driving force, leading to less developed secondary arms.

A Meta-analysis of Dachaihu Decoction combined with western medicine in the treatment of acute pancreatitis with the TCM syndrome of liver qi depression and liver-gallbladder dampness-heat

Backgroud:To evaluate the clinical efficacy and safety of Dachaihu Decoction in the treatment of acute pancreatitis(AP)with the traditional Chinese medicine(TCM)syndrome of liver qi depression and liver-gallbladder dampness-heat.Methods:We searched randomized controlled trials of Dachaihu Decoction in the treatment of AP with the TCM syndrome of liver qi depression and liver-gallbladder dampness-heat from databases in CNKI,WanFang,VIP,Embase,PubMed,and Cochrane Library(from established to August 2019).All the retrieved documents were imported into the Noteexpress software for screening and management,and the included documents were evaluated for quality and data extracted.Statistical analysis was performed with RevMan(version 5.3).Results:A total of 132 articles were retrieved and 8 studies were included to analysis,including 679 patients.Quality evaluation of included studies suggested that the quality of the literatures is generally not high.Meta-analysis showed that the total clinical effective rate of AP was higher in the treatment group than in the control group[OR=5.00,95%CI(2.86,8.73)],and the difference was statistically significant(P<0.00001).The patient's abdominal pain relief time[MD=-0.57,95%CI(-0.86,-0.27),P=0.0002],bloating relief time[MD=-0.71,95%CI(-1.05,-0.37),P=0.04],time of serum amylase returning to normal[MD=-1.00,95%CI(-1.60,-0.40),P=0.001]and time of urinary amylase returning to normal[MD=-1.62,95%CI(-2.88,-0.37),P=0.01]all lower than the control group.But there was no statistically significant difference between the treatment group and the control group at the first defecation time[MD=-0.86,95%CI(-1.75,-0.03),P=0.06].The patient's serum TNF-a levels on the 3rd[MD=-28.53,95%CI(-49.57,-7.49),P=0.008]and 7th day[MD=-26.13,95%CI(-49.76,-2.50),P=0.03]in the treatment group were statistically lower in the treatment group than in the control group.Similarly,the patient's serum IL-6 levels on the 3rd[MD=-6.62,95%CI(-12.49,-0.75),P=0.03]and 7th day[MD=-11.98,95%CI(-22.25,-1.71),P=0.02]were also statistically lower in the treatment group than in the control group.No serious complications or adverse reactions were observed.Conclusion:Dachaihu Decoction combined with western medicine in the treatment of AP with the TCM syndrome of liver qi depression and liver-gallbladder dampness-heat can improve clinical efficacy compared with western medicine alone.In addition,the combination therapy method is safe and can be used for syndrome differentiation of AP patients in the clinic.